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Elsevier Science

  • Inositol Phospholipid Metabolism and Phosphatidyl Inositol Kinases

    • 1st Edition
    • Volume 30
    • A. Kuksis
    • English
    This book offers a wide ranging and review of cutting edge developments along with tried and tested methods for isolation, resolution and quantification of inositol phospholipids and inositol polyphosphates in both cells and tissues. It includes detailed and rigorous methodology for identification of molecular species of inositol phospholipids, including their phosphates and glycans, with numerous examples of specific applications. Wherever available, both chromatographic and mass spectrometricevidenc... is presented for specific phospholipid involvement in the biochemical transformations accompanying metabolic signalling events and, where possible, controversies have been resolved on basis of analytical ambiguity. The review of the lipidanalyses extends to products of phosphatidylinositol kinases, phosphatases and lipases. A general review chapter is included on metabolic signalling with special emphasis on the lipid products of 3-kinases. In view of the general lack of commercially available standards for inositol phospholipids and inositol phosphates, the book concludes with a chapter on the preparation and collection of chromatographic and mass spectrometric proof of their purity and identity.This book complements recent books and reviews on the mechanisms metabolic signalling, receptor binding and the polypeptide structure of the proteins involved in the various signalling pathways. It also complements those texts that deal exclusively with the chemical synthesis of the phosphatidylinositol... and their polyphosphates and glycans.

  • Concepts and Challenges in Retinal Biology

    • 1st Edition
    • Volume 131
    • H. Kolb + 2 more
    • English
    In August 2000 a Festschrift was held at the Marine Biological Laboratory, Woods Hole, Massachusetts to celebrate the career of Professor John E. Dowling on the occasion of his 65th birthday. Containing contributions from more than 50 of John's colleagues, representing a Who's Who of the vision research community, this work not only provides a memento of the occasion, but will hopefully serve as a basic reference for future researchers in retinal biology.The volume is divided somewhat arbitrarily into seven areas of retinal research containing chapters that present in some cases a broad overview of a particular topic, and in others an account of current research and studies in progress. These chapters exemplify the richness, diversity, and excitement of contemporary retinal research. They also remind us of how much more needs to be done before we understand fully the interrelationship between retinal neurons, the complex interactions between neurons and glial cells, and the mechanisms that govern retinal development.A final chapter contributed by John Dowling provides an overview of past accomplishments, and offers some future perspectives on retinal research in the 21st century.

  • Thermally Activated Mechanisms in Crystal Plasticity

    • 1st Edition
    • Volume 8
    • D. Caillard + 1 more
    • English
    KEY FEATURES:A unified, fundamental and quantitative resource. The result of 5 years of investigation from researchers around the worldNew data from a range of new techniques, including synchrotron radiation X-ray topography provide safer and surer methods of identifying deformation mechanisms Informing the future direction of research in intermediate and high temperature processes by providing original treatment of dislocation climb DESCRIPTION:Thermall... Activated Mechanisms in Crystal Plasticity is a unified, quantitative and fundamental resource for material scientists investigating the strength of metallic materials of various structures at extreme temperatures. Crystal plasticity is usually controlled by a limited number of elementary dislocation mechanisms, even in complex structures. Those which determine dislocation mobility and how it changes under the influence of stress and temperature are of key importance for understanding and predicting the strength of materials. The authors describe in a consistent way a variety of thermally activated microscopic mechanisms of dislocation mobility in a range of crystals. The principles of the mechanisms and equations of dislocation motion are revisited and new ones are proposed. These describe mostly friction forces on dislocations such as the lattice resistance to glide or those due to sessile cores, as well as dislocation cross-slip and climb. They are critically assessed by comparison with the best available experimental results of microstructural characterization, in situ straining experiments under an electron or a synchrotron beam, as well as accurate transient mechanical tests such as stress relaxation experiments. Some recent attempts at atomistic modeling of dislocation cores under stress and temperature are also considered since they offer a complementary description of core transformations and associated energy barriers.In addition to offering guidance and assistance for further experimentation, the book indicates new ways to extend the body of data in particular areas such as lattice resistance to glide.

  • Proceedings of the 15th IFAC World Congress

    • 1st Edition
    • L Basenez + 1 more
    • E.F Camacho
    • English
    The 15th IFAC World Congress in Barcelona is the largest to date, and has attracted contributions from renowned scientists at top research institutions from around the world.The Proceedings provide the official record of the Congress, and contain all of the papers that were presented. Published in 20 subject-oriented volumes plus a Plenary Volume the proceedings provide a fully comprehensive overview of latest research into control engineering theory practice and applications. The Plenary Volume also contains 'milestone reports' and surveys by IFAC's technical committees on the state of research in their technical areas. In addition, the Proceedings include a CD-ROM containing all papers in fully searchable format. The volumes and CD are also availble to purchase individually.

  • Proceedings of the 15Th Ifac World Congress Volume Q

    • 1st Edition
    • Mohhamad Reza Kiani
    • English

  • Bioanalytical Separations

    • 1st Edition
    • Volume 4
    • English
    Bioanalytical Separations is volume 4 of the multi-volume series, Handbook of Analytical Separations, providing reviews of analytical separation methods and techniques used for the determination of analytes across a whole range of applications. The theme for this volume is bioanalysis, in this case specifically meaning the analysis of drugs and their metabolites in biological fluids.

  • Fungal Genomics

    • 1st Edition
    • Volume 3
    • English
    The purpose of this volume is to highlight wide-ranging applications of genomics in the area of applied mycology and biotechnology.The volume covers: a brief overview on fungal genomics; meiotic recombination in fungi; molecular genetics of circadian rhythms; genome sequencing; transposable elements; mitochondrial genomes; ribosome biogenesis; pathogenicity genes; genetic improvement of yeasts; microarrays: techniques and applications; fungal germplasm and data bases. Although it is difficult to develop a comprehensive volume on fungal genomics because of the range and complexity of the emerging knowledge, an attempt has been made to bring together pertinent information that will serve the needs of the reader, provide a quick reference to material that might otherwise be difficult to locate, and furnish a starting point for further study.

  • Geosciences, Environment and Man

    • 1st Edition
    • Volume 1
    • H. Chamley
    • English
    Geosciences, Environment and Man has three major objectives, which determine the division in three parts of this volume: I. To consider the main natural geological processes interfering with and therefore threatening the activities of man: earthquakes, volcanic eruptions, land movements, floods, wind and coastal risks; main prevention and mitigation measures against these natural hazards are presented. II. To examine the exploitation of earth's natural resources such as materials, ores and minerals, fossil fuels, water, radioactivity, and the resulting consequences on solid Earth balance and future. III. To assess the hold level reached by the activities of man on planet surface envelopes through agriculture, urbanization, industrialization, and communication; the local to global effects of human influence triggered by recent demographic growth on underground, soils, water and air characters are taken into account. Both deteriorating and beneficial aspects of Earth - the interactions of man are emphasized, as well as mitigation or restoration measures and perspectives.

  • Side Effects of Drugs Annual

    A world-wide yearly survey of new data and trends in adverse drug reactions
    • 1st Edition
    • Volume 26
    • English
    The Side Effects of Drugs Annual was first published in 1977. It has been published continuously since then, as a yearly update to the encyclopaedic volume Meyler's Side Effects of Drugs. Each new Annual provides clinicians and medical investigators with a reliable and critical yearly survey of new data and trends in the area of Adverse Drug Reactions and Interactions. An international team of specialists have contributed to the Annuals by selecting critically from each year's publications all that is truly new and informative, by critically interpreting it, and by pointing out whatever is misleading. The use of the book is enhanced by separate indexes, allowing the reader to enter the text via the drug name, adverse effect, or drug interaction.Special features of the Annuals are the Side Effects of Drugs Essay, usually written by a guest author, and the special reviews: short articles, within the different chapters, that give extra attention to topics of current interest.The Essay in Annual 26 is entitled 'How safe is cannabis?' (by Professor L.L. Iversen) and there is a Historical Essay entitled 'From thalidomide to pharmacovigilance: a personal account' (by Professor D.J. Finney).The special reviews in this volume include, among others: The cognitive effects of Ecstasy Antipsychotic drugs and weight gain Vigabatrin-related visual abnormalities Managing the adverse effects of morphine The cardiotoxic effects of antihistamines Inhaled corticosteroids and growth inhibition in children Bioterrorism and its prevention through immunization

  • Advances in Neural Network Research: IJCNN 2003

    • 1st Edition
    • D.C. Wunsch II + 3 more
    • English
    IJCNN is the flagship conference of the INNS, as well as the IEEE Neural Networks Society. Ithas arguably been the preeminent conference in the field, even as neural network conferenceshave proliferated and specialized. As the number of conferences has grown, its strongestcompetition has migrated away from an emphasis on neural networks. IJCNN has embraced theproliferation of spin-off and related fields (see the topic list, below), while maintaining a coreemphasis befitting its name. It has also succeeded in enforcing an emphasis on quality.

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