Skip to main content
Elsevier

Elsevier Science

  • Progress in Medicinal Chemistry

    • 1st Edition
    • Volume 46
    • English
    Appropriate selection of biochemical targets is one of the most important drivers of cost effectiveness in the discovery of new medicines. Despite the many advances in genetics, genomics and systems biology, ‘validation’ of a target is not achieved until therapeutic efficacy is demonstrated by a drug candidate. Volume 46 of this series reviews the medicinal chemistry aimed at six diverse targets from which important new medicines are emerging: * HIV integrase (discovery of the first-in-class inhibitor drug raltegravir)* 11-beta-Hydroxystero... dehydrogenase (new approach to glucocorticoid regulation)* Nicotinic a7 choline receptor (agonists and positive allosteric modulators). * Bradykinin receptor (new approach to pain therapy)* Histone deacetylase (new drugs for cancer)* 5-HT2c receptor modulators (various CNS indications)

  • Reviving the Living

    Meaning Making in Living Systems
    • 1st Edition
    • Volume 6
    • Yair Neuman
    • English
    Reviving the Living: Meaning Making in Living Systems presents a novel perspective that relates to current biological knowledge and issues. Written by polymath Dr. Yair Neuman, the book challenges the dogmas that frame our understanding of living systems and presents a radical alternative approach to understanding the world around us, one that avoids the pitfalls of non-scientific perspectives such as Vitalism and Creationism. In this thought provoking and iconoclastic manuscript, Neuman follows the footsteps of Gregory Bateson, Mikhail Bakhtin, Michael Polanyi and others, to suggest that living systems are meaning making systems. The book delves into the unique processes of meaning making that characterize organisms as a unique category of nature, and offers new and fascinating insights into a variety of enigmatic biological phenomena from immune memory to hidden life (cryptobiosis). It consists of four parts divided into 18 chapters and covers topics ranging from reductionism and its pitfalls to genetics; why organisms are irreducible; immunology; meaning making in language and biology; meaning-bridging the gap between physics and semantics; context and memory; and the poetry of living. Core concepts and themes are illustrated using examples based in current science. This text would be of high interest to biologists, philosophers, cognitive scientists, psychologists, and semioticians, as well as to any reflective individual who is willing to examine the realm of the living from a novel and fascinating perspective.

  • Chemical Bioavailability in Terrestrial Environments

    • 1st Edition
    • Volume 32
    • English
    This book begins with an overview of current thinking on bioavailability, its definition, cutting-edge research in speciation and advancement in tools for assessing chemical bioavailability in the terrestrial environment. The second section of the book focuses on the role of chemical speciation in bioavailability. Section three addresses bioavailability and ecotoxicity of contaminants and leads into the next section on bioavailability of nutrients and agrichemicals. Subsequent sections provide an overview of tools currently being used and new cutting-edge techniques to assess contaminant bioavailability. The last section of the book builds on previous sections in relating bioavailability to risk assessment and how this could be used for managing risks associated with contaminated land.

  • Handbook of Anxiety and Fear

    • 1st Edition
    • Volume 17
    • D. Caroline Blanchard + 2 more
    • English
    This Handbook brings together and integrates comprehensively the core approaches to fear and anxiety. Its four sections: Animal models; neural systems; pharmacology; and clinical approaches, provide a range of perspectives that interact to produce new light on these important and sometimes dysfunctional emotions. Fear and anxiety are analyzed as patterns that have evolved on the basis of their adaptive functioning in response to threat. These patterns are stringently selected, providing a close fit with environmental situations and events; they are highly conservative across mammalian species, producing important similarities, along with some systematic differences, in their human expression in comparison to that of nonhuman mammals. These patterns are described, with attention to both adaptive and maladaptive components, and related to new understanding of neuroanatomic, neurotransmitter, and genetic mechanisms. Although chapters in the volume acknowledge important differences in views of fear and anxiety stemming from animal vs. human research, the emphasis of the volume is on a search for an integrated view that will facilitate the use of animal models of anxiety to predict drug response in people; on new technologies that will enable direct evaluation of biological mechanisms in anxiety disorders; and on strengthening the analysis of anxiety disorders as biological phenomena.

  • Metallic Multilayers and their Applications

    Theory, Experiments, and Applications related to Thin Metallic Multilayers
    • 1st Edition
    • Volume 4
    • Gayanath Fernando
    • English
    Thin Metallic multilayer films have become an important part in today's computer technology. The giant magnetoresistance (GMR) effect, which plays a central role here, was discovered in the late 1980s. This can be essentially described as the effect of a magnetic field on the electron transport leading to significant changes in the resistance. Other aspects of multilayers systems, such as stability, growth, confinement are also addressed. Theoretical and experimental methods used in such work are described in some detail, with special emphasis on density functional and spin density functional theories. Magnetic anisotropy in thin films is also discussed while addressing unresolved issues and new results from exchange-bias experiments.

  • Optical Biosensors

    Today and Tomorrow
    • 2nd Edition
    • Frances S. Ligler + 1 more
    • English
    Optical Biosensors, Second Edition describes the principles of successful systems, examples of applications, and evaluates the advantages and deficiencies of each. It also addresses future developments on two levels: possible improvements in existing systems and emerging technologies that could provide new capabilities in the future. The book is formatted for ease of use and is therefore suitable for scientists and engineers, students and researcher at all levels in the field.

  • Systems Self-Assembly

    Multidisciplinary Snapshots
    • 1st Edition
    • Volume 5
    • English
    Systems Self-Assembly is the only book to showcase state-of-the-art self-assembly systems that arise from the computational, biological, chemical, physical and engineering disciplines. Written by world experts in each area, it provides a coherent, integrated view of both book practice examples and new trends with a clearly presented computational flavor. The unifying thread throughout the text is the computational nature of self-assembling systems.This book consists of 13 chapters dealing with a variety of topics such as the patterns of self-organised nanoparticle assemblies; biomimetic design of dynamic self-assembling systems; computing by self-assembly involving DNA molecules, polyominoes, and cells; evolutionary design of a model of self-assembling chemical structures; self-assembly as an engineering concept across size scales; and probabilistic analysis of self-assembled molecular networks. Other chapters focus on the programming language of dynamic self-assembly; self-assembled computer architectures; simulation of self-assembly processes using abstract reduction systems; computer aided search for optimal self-assembly systems; theoretical aspects of programmable self-assembly; emergent cooperativity in large-scale patterns; and automated self-assembling programming.Systems Self-Assembly is an ideal reference for scientists, researchers and post-graduate students; practitioners in industry, engineering and science; and managers, decision-makers and policy makers.

  • Biochemistry of Lipids, Lipoproteins and Membranes

    • 5th Edition
    • Neale Ridgway + 1 more
    • English
    Research on the biochemistry and molecular biology of lipids and lipoproteins has experienced remarkable growth in the past 20 years, particularly with the realization that many different classes of lipids play fundamental roles in diseases such as heart disease, obesity, diabetes, cancer and neurodegenerative disorders. The 5th edition of this book has been written with two major objectives. The first objective is to provide students and teachers with an advanced up-to-date textbook covering the major areas of current interest in the lipid field. The chapters are written for students and researchers familiar with the general concepts of lipid metabolism but who wish to expand their knowledge in this area. The second objective is to provide a text for scientists who are about to enter the field of lipids, lipoproteins and membranes and who wish to learn more about this area of research. All of the chapters have been extensively updated since the 4th edition appeared in 2002.

  • Inorganic Membranes: Synthesis, Characterization and Applications

    • 1st Edition
    • Volume 13
    • Reyes Mallada + 1 more
    • English
    The withstanding properties of inorganic membranes provide a set of tools for solving many of the problems that the society is facing, from environmental to energy problems and from water quality to more competitive industries. Such a wide variety of issues requires a fundamental approach, together with the precise description of applications provided by those researchers that have been close to the industrial applications. The contents of this book expand the lectures given in a Summer School of the European Membrane Society. They combine an easily accessible description of the technology, suitable for the graduate level, with the most advanced developments and the prospective of future applications. The large variety of membrane types makes almost compulsory to select a specialist for each of them, and this has been the approach selected in this book. In the case of porous membranes, the advances are related to the synthesis of microporous materials such as silica, carbon and zeolite membranes and hollow fibre membranes. A chapter covers the increasingly relevant hybrid membranes. Attention is also devoted to dense inorganic membranes, experiencing constantly improved properties. The applications of all these membranes are considered throughout the book.

  • Hydrocarbon Exploration and Production

    • 2nd Edition
    • Volume 55
    • Frank Jahn + 2 more
    • English
    Hydrocarbon Exploration and Production, Second Edition is a comprehensive and current introduction to the upstream industry, drawing together the many inter-disciplinary links within the industry. It presents all the major stages in the life of an oil or gas field, from gaining access to opportunity, through exploration, appraisal, development planning, production, and finally to decommissioning. It also explains the fiscal and commercial environment in which oil and gas field development takes place. The book is written for industry professionals who wish to be better informed about the basic technical and commercial methods, concepts and techniques used in the upstream oil and gas business. The authors are the founders of TRACS International, a company which has provided training and consultancy in Exploration and Production related issues for many clients world-wide since 1992.

Browse by Publisher