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Elsevier

Academic Press

  • Reliability and Failure of Electronic Materials and Devices

    • 2nd Edition
    • Milton Ohring + 1 more
    • English
    Reliability and Failure of Electronic Materials and Devices is a well-established and well-regarded reference work offering unique, single-source coverage of most major topics related to the performance and failure of materials used in electronic devices and electronics packaging. With a focus on statistically predicting failure and product yields, this book can help the design engineer, manufacturing engineer, and quality control engineer all better understand the common mechanisms that lead to electronics materials failures, including dielectric breakdown, hot-electron effects, and radiation damage. This new edition adds cutting-edge knowledge gained both in research labs and on the manufacturing floor, with new sections on plastics and other new packaging materials, new testing procedures, and new coverage of MEMS devices.

  • Decision Information

    • 1st Edition
    • Chris Tsokos
    • English
    Decision Information is a collection of manuscripts presented at the 1976 Workshop on Decision Information for Tactical Command and Control, held at the Airlie House in Airlie, Virginia. This workshop provides the scientific managers of the Service Office of Research with the knowledge allowing them to formulate research programs relevant to military problems in decision information. This book is organized into three parts encompassing 28 chapters. The first part consists of presentations in systems approach to large-scale human and man-machine systems, benefit-cost models for decision makers, team decision models, and cubic interpolation processes. The contributors highlight the various theoretical aspects of the models and illustrate their scientific usefulness to many problems in the society. The second part explores the statistical models in the areas of scheduling systems, combat models, logistic structures, inventory systems, Bayesian and empirical Bayesian reliability models, parameter estimation schemes, and memory models. This part also presents a broad spectrum of mathematical sciences that illustrate the two main facts that make most problems, namely, the number of variates in the model and the degree of uncertainty. The third part is devoted to military presentations, emphasizing the problem in command, control, and communication. This part also considers the implementation of fuzzy sets in military command analysis, decision support in a conflict environment, and data-poor modeling.

  • Design Theory and Methods using CAD/CAE

    The Computer Aided Engineering Design Series
    • 1st Edition
    • Kuang-Hua Chang
    • English
    The fourth book of a four-part series, Design Theory and Methods using CAD/CAE integrates discussion of modern engineering design principles, advanced design tools, and industrial design practices throughout the design process. This is the first book to integrate discussion of computer design tools throughout the design process. Through this book series, the reader will: Understand basic design principles and all digital modern engineering design paradigms Understand CAD/CAE/CAM tools available for various design related tasks Understand how to put an integrated system together to conduct All Digital Design (ADD) product design using the paradigms and tools Understand industrial practices in employing ADD virtual engineering design and tools for product development

  • Bursting Neurons and Fading Memories

    An Alternative Hypothesis of the Pathogenesis of Alzheimer’s Disease
    • 1st Edition
    • Michael R. D'Andrea
    • English
    Advances in Alzheimer’s disease (AD) research have been challenging and without major breakthroughs in understanding its pathological basis. The reigning hypothesis suggests AD is the result of extracellular amyloid deposition that seed to form amyloid plaques, which then grow and kill neighboring neurons. However, there are several inconsistencies with this hypothesis, not to mention the inability to show clinical benefit in several failed clinical trials by pharmaceuticals (i.e., from Pfizer, Eli Lilly, etc.), and it is in the field’s best interest to explore and test multiple hypotheses for pathology rather than drive the majority of research on this single amyloid theory. Reviewing many scientifically peer-reviewed publications, this book describes the "Inside-Out" hypothesis on how amyloid escapes the circulatory system through a dysfunctional blood-brain barrier to bind to the alpha 7 nicotinic acetylcholine receptor on pyramidal neurons. Over time, excessive amounts of amyloid appear to be internalized, resulting in neuron death and lysis. This simple mechanism readily explains plaque composition, size, shape, and location. Based on the current direction of research in the field, this hypothesis appears years from any research and development.

  • Successful Private Practice in Neuropsychology and Neuro-Rehabilitation

    A Scientist-Practitioner Model
    • 2nd Edition
    • Mary Pepping
    • English
    This second edition (of the original Successful Private Practice in Neuropsychology) provides an updated overview of key principles and processes for establishing, maintaining and developing neuropsychology practice and neuro-rehabilitation program (NRP) treatment in medical center and/or private practice settings. Essential elements of an entrepreneurial model that work well in the medical center context and the necessary role of variety and peer review in the private practice setting are also discussed.

  • Design and Manufacture of Pharmaceutical Tablets

    • 1st Edition
    • Reynir Eyjolfsson
    • English
    Design and Manufacture of Pharmaceutical Tablets offers real world solutions and outcomes of formulation and processing challenges of pharmaceutical tablets. This book includes numerous practical examples related to actual formulations that have been validated and marketed and covers important data in the areas of stability, dissolution, bioavailibity and processing. It provides important background and theoretical information on design and manufacturing and includes a full section dedicated to design experimental methodology and statistics. In addition, this book offers a a general discussion of excipients used in proper tablet design along with practical examples related to excipients. Drug development scientists in industry and academia, as well as students in the pharmaceutical sciences will greatly benefit from the practical knowledge and case examples provided throughout this book.

  • Molecular Biology of B Cells

    • 2nd Edition
    • Tasuku Honjo + 3 more
    • English
    Molecular Biology of B Cells, Second Edition is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All of these developmental and stimulatory processes are described in molecular, immunological, and genetic terms to give a clear understanding of complex phenotypes. Molecular Biology of B Cells, Second Edition offers an integrated view of all aspects of B cells to produce a normal immune response as a constant, and the molecular basis of numerous diseases due to B cell abnormality. The new edition continues its success with updated research on microRNAs in B cell development and immunity, new developments in understanding lymphoma biology, and therapeutic targeting of B cells for clinical application. With updated research and continued comprehensive coverage of all aspects of B cell biology, Molecular Biology of B Cells, Second Edition is the definitive resource, vital for researchers across molecular biology, immunology and genetics.

  • Advances in Genetics

    • 1st Edition
    • Volume 87
    • English
    The field of genetics is rapidly evolving, and new medical breakthroughs are occurring as a result of advances in our knowledge of genetics. Advances in Genetics continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines. Volume 87 presents an eclectic mix of articles of use to all human and molecular geneticists on topics including: gene transfer, fruiting body development and the genetics of Alzheimer’s disease; and more.

  • Dictionary of Toxicology

    • 3rd Edition
    • Ernest Hodgson + 1 more
    • English
    Dictionary of Toxicology, Third Edition presents a compendium of definitions of all current toxicological terminology. This authoritative reference illustrates and describes words, concepts, acronyms and symbols for both the toxicological theory and applied risk assessment, as well as providing guidance on the correct selection of problematic, similar and frequently-misused terms. Written by one of the world’s foremost experts in toxicology, and with each entry peer reviewed, Dictionary of Toxicology, Third Edition is an essential reference for all scientific, medical and legal professionals who work with or encounter the toxicological effects of contaminants on biological systems. New to this edition: an update on every entry and the inclusion of all terminology and concepts relating to molecular toxicology, nanotoxicology and computational toxicology.

  • Translational Systems Biology

    Concepts and Practice for the Future of Biomedical Research
    • 1st Edition
    • Yoram Vodovotz + 1 more
    • English
    Are we satisfied with the rate of drug development? Are we happy with the drugs that come to market? Are we getting our money’s worth in spending for basic biomedical research? In Translational Systems Biology, Drs. Yoram Vodovotz and Gary An address these questions by providing a foundational description the barriers facing biomedical research today and the immediate future, and how these barriers could be overcome through the adoption of a robust and scalable approach that will form the underpinning of biomedical research for the future. By using a combination of essays providing the intellectual basis of the Translational Dilemma and reports of examples in the study of inflammation, the content of Translational Systems Biology will remain relevant as technology and knowledge advances bring broad translational applicability to other diseases. Translational systems biology is an integrated, multi-scale, evidence-based approach that combines laboratory, clinical and computational methods with an explicit goal of developing effective means of control of biological processes for improving human health and rapid clinical application. This comprehensive approach to date has been utilized for in silico studies of sepsis, trauma, hemorrhage, and traumatic brain injury, acute liver failure, wound healing, and inflammation.

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