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Academic Press

Microbial Transformations of Steroids
A Handbook
1st Edition
William Charney + 1 more
English
Microbial Transformations of Steroids: A Handbook aims to provide those who wish to use microbial transformations of steroids with a single source book starting from 1937 to the present. The handbook first offers information on the history of the microbial transformations of organic compounds, including earliest works on the study of nonsteroids and steroids; significance of discovery of anti-inflammatory action of cortisone; first hydroxylations and dehydrogenations; manufacture of natural and synthetic corticosteroids; and trends in research. The text then ponders on chemical classification of microbial transformations of steroids, as well as the role of enzymes in microbial transformations and the classes of reactions. The publication elaborates on the construction and use of the table. Topics include order of the table, nomenclature, description of the transformation leading to the product, yield, organism, and constants. The book also focuses on taxonomy and use of the table, including system of classification, specific notes on divisions of the table, and source of cultures. The handbook is a valuable source of data for readers interested in the microbial transformations of steroids.
Game Theory for Economic Analysis
1st Edition
Tatsuro Ichiishi
English
Game Theory for Economic Analysis provides information pertinent to the more general game-theoretical concept. This book discusses fundamental aspects of a social coalitional equilibrium. Organized into six chapters, this book begins with an overview of the mathematical tools and theorems that play critical roles in n-person game theory. This text then provides a systematic account for the first strand of n-person game theory and presents the mathematical foundation for economic analysis. Other chapters consider the concept of Nash equilibrium of a game in normal form, wherein a solution of a game is based on the postulate that each player behaves individualistically and passively. This book discusses as well the central concept of the core of a game in characteristic function form, with or without side-payments. The final chapter deals with the Shapley value of a side-payment game. This book is a valuable resource for economists, economic theorists, and research workers.
Membranes and Viruses in Immunopathology
1st Edition
Stacey B. Day + 1 more
English
Membranes and Viruses in Immunopathology covers the proceedings of the 1972 symposium by the same title, held at the University of Minnesota Medical School, sponsored by the Bell Museum of Pathology. This book is composed of 40 chapters that highlight the significant advances in fundamental experiments of membrane structure chemistry. Considerable chapters explore the diagnosis and analysis of slow and oncogenic virus infections, as well as the role of immunobiologic processes in the pathogenesis, prevention, and treatment of disease. The remaining chapters contain research works on the detailed mechanisms that may contribute to cancer induction and dissemination. This book will prove useful to immunopathologists and practicing physicians.
Immunological Tolerance
Mechanisms and Potential Therapeutic Applications
1st Edition
David H. Katz + 1 more
English
Immunological Tolerance: Mechanisms and Potential Therapeutic Applications documents the proceedings of a conference held at Brook Lodge, Michigan, April 27-May 1, 1974. The conference brought together many of the investigators who have actively contributed to furthering knowledge and understanding of immunological tolerance. It will be immediately clear to the reader that the conference was structured in a way to consider phenomena of tolerance and immune suppression as interrelated entities with a certain degree of emphasis on the possible common cellular mechanisms involved. The volume contains 36 contributions presented during the seven sessions of the conference. The papers presented in Session I examined T-cell tolerance. The presentations in Session II focused on B cell tolerance. The papers in Sessions III and IV focused on the mechanisms of B cell and T cell tolerance, respectively. Session V dealt with the activity of suppressor cells as a mechanism of tolerance. The papers in Session VI investigated the suppressive activity of antibody and antigen-antibody complexes. In Session VII a final General Discussion was held in order to identify what has been established concerning the phenomenology and mechanisms of specific immunological tolerance, what are the major unresolved issues, and what approaches appear most promising to answer these questions.
Current Topics in Cellular Regulation
1st Edition
Volume 5
Bernard L. Horecker + 1 more
English
Current Topics in Cellular Regulation, Volume 5 presents the fundamental mechanisms involved in the regulation of diverse cellular activities, including cellular differentiation, intermediary metabolism, and the transfer of genetic information. This book provides information pertinent to the various aspects of cellular regulation. Organized into eight chapters, this volume begins with an overview of the role of phosphofructokinase in the regulation of glycolysis. This text then outlines the structural aspects of phosphofructokinase, its main kinetic properties, and the various mechanisms that have been proposed for its regulation. Other chapters consider the four-stage approach to analysis of control mechanisms. This book discusses as well the regulation of cellular function through the mechanism of protein phosphorylation. The final chapter deals with the pathway for histidine biosynthesis in Salmonella typhimurium, which consists of a series of reactions, each catalyzed by a specific enzyme. This book is a valuable resource for biologists and biochemists.
Immunological Methods
1st Edition
Ivan Lefkovits + 1 more
English
Immunological Methods a compendium of basic research techniques being used in one of the largest immunology research institutes, the Basel Institute for Immunology, with particular emphasis given to new methodology. The procedures have been described by individuals judged to be highly expert in their specialties. In many instances the methods developed or adapted to unique uses by the contributors have not previously been described in detail. The book contains 34 chapters covering techniques for detection, isolation, and purification of antibodies (including dansylation, two-dimensional chromatography, isoelectric focusing, polyacrylamide gel electrophoresis, and isotachophoresis); measurement of equilibrium constants (equilibrium dialysis, filtration, and sedimentation); and isotope and fluorescent labeling and detection of cell-surface components. Techniques such as isotope laboratory maintenance; chemical modification of proteins, haptens, and solid supports, and haptenation of viable biological carriers; production of antisera against allotypes and histocompatibility antigens and production of antibody with clonai dominance; histocompatibility and MLR testing; and cell separation by haptenated gels and by velocity sedimentation of rosette-forming cells are also discussed. Other chapters cover detection of antibody-secreting and alloantigen-binding cells; immune responses in vitro and their analysis by limiting dilution; production of T-cell factors; hybridoma production by cell fusion; maintenance of cell lines and cloning in semisolid media; and the mathematical analysis of immunological data.
Speech and Language
Advances in Basic Research and Practice
1st Edition
Volume 5
Norman J. Lass
English
Speech and Language: Volume 5, Advances in Basic Research and Practice is a collection of papers dealing with clinical issues, theories, and pathology of language and speech. Several papers discuss developmental apraxia of speech, relapse of stuttering therapy, the single subject research design, and the implications of the physiologic, acoustic, and perceptual aspects of coarticulation. Other papers analyze language development, language training, the three aspects of voice quality element, and the issue of disputed communication origins. One paper notes that intervention programs for stuttering produces mostly short-term benefits. The paper discusses the known risks of relapse following the end of stuttering therapy and the independent variables that influence this risk. Another paper examines voice quality in terms of perceptual, acoustic, and physiologic features of the different voice modes. By using the "Black Box" model, in which frequency, intensity, laryngeal waveform, pharyngeal prefiltering, and formant frequency can be controlled, the paper shows that a measure of interaction among all the controls exist. For example, a voice mode represented by a laryngeal waveform and pharyngeal prefiltering still interacts with frequency and intensity. Therefore, knowledge of the differences in physiology that attend to each voice mode can be valuable in effecting changes in voice production. The collection will prove valuable for linguists, speech therapists, neurologists, neuropsychologists, neurolinguists, speech pathologists, or investigators whose works involve linguistics, learning, communications, and syntax.
Current Topics in Cellular Regulation
1st Edition
Volume 29
Bernard L. Horecker + 1 more
English
Current Topics in Cellular Regulation: Volume 29 is a collection of papers that deals with dynamic macromolecular interactions, ligand binding, multi-enzyme complex formation, the regulation of fatty acid uptake, and synthesis in mammary or adipose tissues. Other papers explain the functional relationships of guanosine triphosphate binding proteins, the glycogen storage disease, the regulation of the pentose phosphate pathway in the brain, as well as the regulation of carotenoid biosynthesis. One paper discusses the dissociable enzyme complexes stabilized by weak interactions, particularly on the interaction of cytosolic enzymes with the contractile apparatus, with membranes, or with functionally related enzymes. Another paper investigates the mechanism of acute regulation, in mammary epithelial cells, of the processes which collaborate to supply fatty acids for esterification to form glycerolipids (which is predominantly triacylglycerol). Glycerolipids comprise mostly the total lipid content of the secretory product of those cells—mammalian milk. The paper notes that a counter-regulatory hormone collaborating with insulin in the regulation of lipid metabolism in the lactating mammary cell, does not act via cyclic AMP. The collection can prove beneficial for biochemists, micro-biologists, bio-physicists, cellular researchers, and academicians involved in the study of cellular biology or physiology.
Speech and Language
Advances in Basic Research and Practice
1st Edition
Volume 4
Norman J. Lass
English
Speech and Language: Volume 4, Advances in Basic Research and Practice is a collection of papers that deals with the theories, clinical issues, and pathology of language and speech. Several papers discuss nonlinguistic and linguistic processing in children, phonological development in infants, and the development of speech fluency in children. Other papers examine the four major speech production models, the physiological and acoustical aspects of speech adaptation, spatial-temporal model of velopharyngeal function, and variations in the supraglottal air pressure waveform. One paper notes the relationships of two systems of development as follows: language development is dependent upon cognitive products and cognitive development is dependent upon language development. Such relationship leads to the hypotheses that language and cognitive developments are independent, are interdependent, and are both dependent upon some X abilities. One paper suggests that speech clinicians should have as a goal the achievement of speech that is as normal as possible in all respects, and not just for patients to sound normal. The collection will benefit linguists, ethnologists, psychologists, speech therapists, neurologists, neuropsychologists, neurolinguists, or speech pathologists.
Current Topics in Cellular Regulation
1st Edition
Volume 3
Bernard L. Horecker + 1 more
English
Current Topics in Cellular Regulation, Volume 3 presents the fundamental mechanisms involved in the regulation of diverse cellular activities, including cellular differentiation, intermediary metabolism, and the transfer of genetic information. This book provides information pertinent to the various aspects of cellular regulation. Organized into five chapters, this volume begins with an overview of the classification of the various pathways of intermediary metabolisms from a physiological standpoint. This text then examines the immunological surface disparities between normal and tumor cells. Other chapters consider a general nomenclature for enzyme systems that exist in interconvertible phosphorylated and dephosphorylate forms. This book discusses as well the correlation between yeast pyruvate kinase activity and ADP concentration at various KCI levels. The final chapter deals with the systematic investigation concerning the fluctuations of pyruvate kinase in liver and muscle. This book is a valuable resource for biologists, biochemists, pathologists, and research workers.

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