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Elsevier

Academic Press

  • Atlas of Histology of the Juvenile Rat

    • 1st Edition
    • George A Parker + 1 more
    • English
    Atlas of Histology of the Juvenile Rat should be of interest to toxicologic pathologists, toxicologists, and other biological scientists who are interested in the histomorphology of juvenile rats. For several decades the laboratory rat has been used extensively in nonclinical toxicology studies designed to detect potential human toxicity of drugs, agrochemicals, industrial chemicals, and environmental hazards. These studies traditionally have involved young adult rats that are 8-10 weeks of age as studies are started. It is becoming increasingly apparent that children and young animals may have different responses to drug/chemical exposures, therefore, regulatory agencies are emphasizing toxicology studies in juvenile animals. While the histologic features of organs from young adult and aged laboratory rats are well known, less is known about the histologic features of organs from juvenile rats. Final histologic maturity of many organs is achieved postnatally, thus immature histologic features must be distinguished from chemical- or drug-related effects. While this postnatal organ development is known to exist as a general concept, detailed information regarding postnatal histologic development is not readily available. The Atlas includes organs that are typically sampled in nonclinical toxicology studies and presents the histologic features at weekly intervals, starting at birth and extending through postnatal day 42.

  • Pediatric Brain Stimulation

    Mapping and Modulating the Developing Brain
    • 1st Edition
    • Adam Kirton + 1 more
    • English
    Pediatric Brain Stimulation: Mapping and Modulating the Developing Brain presents the latest on this rapidly expanding field that has seen an exponential growth in publications over the past 10 years. Non-invasive modalities like TMS can painlessly map and measure complex neurophysiology in real patients. Neuromodulatory applications like rTMS and tDCS carry increasingly proven therapeutic applications. Rapidly advancing technological methodologies are increasing opportunities and indications. Despite all these benefits, applications in the more plastic developing brains of children are only just emerging. This book provides a comprehensive overview of brain stimulation in children. Chapters include Transcranial Magnetic Stimulation (TMS) fundamentals, brain stimulation in pediatric neurological conditions, and invasive brain stimulation. The main audience for this research will be those interested in applying brain stimulation technologies to advance clinical research and patient care, although a wide variety of clinicians and scientist will find this to be a valuable reference on brain stimulation with specific chapters on a variety of conditions.

  • Mustard Lung

    Diagnosis and Treatment of Respiratory Disorders in Sulfur-Mustard Injured Patients
    • 1st Edition
    • Mostafa Ghanei + 1 more
    • English
    Mustard Lung: Diagnosis and Treatment of Respiratory Disorders in Sulfur-Mustard Injured Patients brings together the details regarding pathophysiology, medication, and protective issues to provide a comprehensive look at health problems associated with sulfur mustard injury. It provides a bench-to-bedside look at the long term complications of vesicant exposure in humans as well as how mustard gas exposure affects lung function. By providing guidelines and approaches for the diagnosis, pathogenesis, and treatment of SM injury cases, this book is helpful for a wide range of medical researchers and clinicians. For decades, chemical respiratory disorders were diagnosed and managed traditionally similar to other chronic respiratory diseases. However, the exact nature of chemical respiratory disorders is different and needs to be treated as such.

  • Congenital Heart Disease and Neurodevelopment

    Understanding and Improving Outcomes
    • 1st Edition
    • Christopher McCusker + 1 more
    • English
    Congenital Heart Disease and Neurodevelopment: Understanding and Improving Outcomes brings together the work of leading researchers from the U.K., Europe, and the U.S. to provide a comprehensive examination of the causes, risks, and neurodevelopmental and psychological outcomes in children with congenital heart disease. The book includes longitudinal studies which have tracked outcomes from birth through late childhood and explores the emergent phenotype and etiologies, risk, and protective factors that strengthen proposed models. Medical and surgical advances have meant that greater numbers of children with even the most severe congenital heart disease (CHD) now survive well into adulthood. Studies over the past 20 years have suggested certain neurodevelopmental and psychological features are common, with clinical interventions being internationally articulated. The U.K. Belfast Center has developed and evaluated unique early intervention programs to circumvent the common problems discerned and promote optimal adjustment and outcomes. The first edition of Congenital Heart Disease and Neurodevelopment: Understanding and Improving Outcomes describes these programs in detail and outlines promising results obtained by researchers worldwide. Such interventions, together with the U.S. consensus statement (Circulation, 2012) on neurodevelopmental screening, hold great promise for clinical interventions.

  • Functional Neuromarkers for Psychiatry

    Applications for Diagnosis and Treatment
    • 1st Edition
    • Juri D. Kropotov
    • English
    Functional Neuromarkers for Psychiatry explores recent advances in neuroscience that have allowed scientists to discover functional neuromarkers of psychiatric disorders. These neuromarkers include brain activation patterns seen via fMRI, PET, qEEG, and ERPs. The book examines these neuromarkers in detail—what to look for, how to use them in clinical practice, and the promise they provide toward early detection, prevention, and personalized treatment of mental disorders. The neuromarkers identified in this book have a diagnostic sensitivity and specificity higher than 80%. They are reliable, reproducible, inexpensive to measure, noninvasive, and have been confirmed by at least two independent studies. The book focuses primarily on the analysis of EEG and ERPs. It elucidates the neuronal mechanisms that generate EEG spontaneous rhythms and explores the functional meaning of ERP components in cognitive tasks. The functional neuromarkers for ADHD, schizophrenia, and obsessive-compulsive disorder are reviewed in detail. The book highlights how to use these functional neuromarkers for diagnosis, personalized neurotherapy, and monitoring treatment results.

  • Developing the Global Bioeconomy

    Technical, Market, and Environmental Lessons from Bioenergy
    • 1st Edition
    • Patrick Lamers + 3 more
    • English
    Developing the Global Bioeconomy: Technical, Market, and Environmental Lessons from Bioenergy brings together expertise from three IEA-Bioenergy subtasks on pyrolysis, international trade, and biorefineries to review the bioenergy sector and draw useful lessons for the full deployment of the bioeconomy. Despite the vast amount of politically driven strategies, there is little understanding on how current markets will transition towards a global bioeconomy. The question is not only how the bioeconomy can be developed, but also how it can be developed sustainably in terms of economic and environmental concerns. To answer this question, this book’s expert chapter authors seek to identify the types of biorefineries that are expected to be implemented and the types of feedstock that may be used. They also provide historical analysis of the developments of biopower and biofuel markets, integration opportunities into existing supply chains, and the conditions that would need to be created and enhanced to achieve a global biomass trade system that could support a global bioeconomy. As expectations that a future bioeconomy will rely on a series of tradable commodities, this book provides a central accounting of the state of the discussion in a multidisciplinary approach that is ideal for research and academic experts, and analysts in all areas of the bioenergy, biofuels, and bioeconomy sectors, as well as those interested in energy policy and economics.

  • Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability

    • 1st Edition
    • Carlo Sala + 1 more
    • English
    Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability provides the latest information on Autism spectrum disorders (ASDs), the lifelong neurodevelopmental disorders that present in early childhood and affect how individuals communicate and relate to others and their surroundings. In addition, three quarters of ASD patients also manifest severe intellectual disability. Though certain genes have been implicated, ASDs remain largely a mystery, and research looking into causes and cellular deficits are crucial for better understanding of neurodevelopmental disorders. Despite the prevalence and insidious nature of this disorder, this book remains to be an extensive resource of information and background on the state of current research in the field. The book serves as a reference for this purpose, and discusses the crucial role synaptic activity plays in proper brain function. In addition, the volume discusses the neurodevelopmental synaptopathies and serves as a resource for scientists and clinicians in all biomedical science specialties. This research has been crucial for recent studies that have provided a rationale for the development of pharmacological agents able to counteract functional synaptic anomalies and potentially ameliorate some ASD symptoms.

  • Advances in Pathobiology and Management of Paget’s Disease of Bone

    • 1st Edition
    • Sakamuri V. Reddy
    • English
    Advances in Pathobiology and Management of Paget’s Disease of Bone presents an essential collection of up-to-date knowledge about the pathophysiology, genetics, and treatment of Paget’s disease. It covers the comprehensive information related to clinical perspectives, epidemiology, genetics, environmental factors such as viral etiology, molecular abnormalities, complications such as osteosarcoma, and current and future treatment for Paget’s disease. This book serves as a useful volume for basic scientists, graduate students, and practicing clinicians in understanding the pathobiology, etiology, and treatment of this disease.

  • Pine Bark Beetles

    • 1st Edition
    • Volume 50
    • English
    Pine Bark Beetles, the latest release in the Advances in Insect Physiology series, provides readers with the latest interdisciplinary reviews on the topic. It is an essential reference source for invertebrate physiologists, neurobiologists, entomologists, zoologists, and insect chemists.

  • Advances in Bacterial Electron Transport Systems and Their Regulation

    • 1st Edition
    • Volume 68
    • Robert K. Poole
    • English
    Advances in Microbial Physiology: Advances in Bacterial Electron Transport Systems and Their Regulation, the latest volume in the Advances in Microbial Physiology series, continues the long tradition of topical and important reviews in microbiology, with this latest volume focusing on the advances in bacterial electron transport systems and their regulation.

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