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Elsevier

Academic Press

  • Astrocytes and Epilepsy

    • 1st Edition
    • Jacqueline A. Hubbard + 1 more
    • English
    Epilepsy is a devastating group of neurological disorders characterized by periodic and unpredictable seizure activity in the brain. There is a critical need for new drugs and approaches given than at least one-third of all epilepsy patients are not made free of seizures by existing medications and become "medically refractory". Much of epilepsy research has focused on neuronal therapeutic targets, but current antiepileptic drugs often cause severe cognitive, developmental, and behavioral side effects. Recent findings indicate a critical contribution of astrocytes, star-shaped glial cells in the brain, to neuronal and network excitability and seizure activity. Furthermore, many important cellular and molecular changes occur in astrocytes in epileptic tissue in both humans and animal models of epilepsy. The goal of Astrocytes and Epilepsy is to comprehensively review exciting findings linking changes in astrocytes to functional changes responsible for epilepsy for the first time in book format. These insights into astrocyte contribution to seizure susceptibility indicate that astrocytes may represent an important new therapeutic target in the control of epilepsy. Astrocytes and Epilepsy includes background explanatory text on astrocyte morphology and physiology, epilepsy models and syndromes, and evidence from both human tissue studies and animal models linking functional changes in astrocytes to epilepsy. Beautifully labelled diagrams are presented and relevant figures from the literature are reproduced to elucidate key findings and concepts in this rapidly emerging field. Astrocytes and Epilepsy is written for neuroscientists, epilepsy researchers, astrocyte investigators as well as neurologists and other specialists caring for patients with epilepsy.

  • Advances in Computers

    • 1st Edition
    • Volume 102
    • English
    Advances in Computers, an ongoing series since 1960, presents detailed coverage of innovations in computer hardware, software, theory, design, and applications. It has also provided contributors with a medium in which they can explore their subjects in greater depth and breadth than journal articles usually allow. As a result, many articles have become standard references and continue to be of significant, lasting value in this rapidly expanding field.

  • Methods in Neurosciences

    Quantitative and Qualitative Microscopy
    • 1st Edition
    • Volume 3
    • P. Michael Conn
    • English
    Because of the significance of morphology and cellular communication unique to the functioning and interdependence of neural systems, many of the advances in the neurosciences rely on classic as well as new microscopy techniques.

  • Electrophysiology and Microinjection

    • 1st Edition
    • Volume 4
    • P. Michael Conn
    • English
    Electrical activity is central to the functioning and nature of neural cells. Every effort has been made in this volume to provide representative examples of useful techniques that have made this area a productive component of the neurosciences.

  • Statistical Aspects of the Microbiological Examination of Foods

    • 3rd Edition
    • Basil Jarvis
    • English
    Statistical Aspects of the Microbiological Examination of Foods, Third Edition, updates some important statistical procedures following intensive collaborative work by many experts in microbiology and statistics, and corrects typographic and other errors present in the previous edition. Following a brief introduction to the subject, basic statistical concepts and procedures are described including both theoretical and actual frequency distributions that are associated with the occurrence of microorganisms in foods. This leads into a discussion of the methods for examination of foods and the sources of statistical and practical errors associated with the methods. Such errors are important in understanding the principles of measurement uncertainty as applied to microbiological data and the approaches to determination of uncertainty. The ways in which the concept of statistical process control developed many years ago to improve commercial manufacturing processes can be applied to microbiological examination in the laboratory. This is important in ensuring that laboratory results reflect, as precisely as possible, the microbiological status of manufactured products through the concept and practice of laboratory accreditation and proficiency testing. The use of properly validated standard methods of testing and the verification of ‘in house’ methods against internationally validated methods is of increasing importance in ensuring that laboratory results are meaningful in relation to development of and compliance with established microbiological criteria for foods. The final chapter of the book reviews the uses of such criteria in relation to the development of and compliance with food safety objectives. Throughout the book the theoretical concepts are illustrated in worked examples using real data obtained in the examination of foods and in research studies concerned with food safety.

  • Ubiquitination and Transmembrane Signaling

    • 1st Edition
    • Volume 141
    • English
    Progress in Molecular Biology and Translational Science provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology. It contains contributions from leaders in their fields and abundant references.

  • Enzymes of Epigenetics

    • 1st Edition
    • Volume 573
    • English
    Enzymes of Epigenetics, one of two new volumes in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods that are employed to study epigenetic regulation and includes structural, biochemical, molecular, biological, cellular, computational, and systems approaches. Topics include chromatin structure and histones, posttranslational histone modification enzymes and complexes, histone modification binders, DNA modifications and nucleic acid regulators, epigenetic technologies and small molecule epigenetic regulators, and biological connections

  • Thermal Solar Desalination

    Methods and Systems
    • 1st Edition
    • Vassilis Belessiotis + 2 more
    • English
    Thermal Solar Desalination: Methods and Systems presents numerous thermal seawater desalination technologies varying from the very simple, easy to construct and operate solar stills, to the more advance membrane and indirect distillation methods. All types of solar thermal desalination technologies are presented in detail to enable readers to comprehend the subject, from design details to enabling further research to be carried out in this area. The various units used in desalination are outlined, along with diagrams of all detailed working principles of desalination methods and systems. The authors consider the economic aspects of these processes, demonstrating successful implementation of desalination units suitable for areas where supplies of fresh water in natural ways is limited or non-existent.

  • Percutaneous Surgery of the Upper Urinary Tract

    Handbook of Endourology
    • 1st Edition
    • Petrisor Aurelian Geavlete
    • English
    Percutaneous Surgery of the Upper Urinary Tract: Handbook of Endourology contains five focused, review-oriented volumes that are ideal for students and clinicians looking for a comprehensive review rather than a whole course. Each volume is easily accessible through eBook format. Topics covered review both the endourological diagnosis and treatment of prostate, urethral, urinary bladder, upper urinary tract, and renal pathology. All chapters describe the most recent techniques, review the latest results, and analyze the most modern technologies. In the past ten years, the field of endourology has expanded beyond the urinary tract to include all urologic minimally invasive surgical procedures. Recent advancements in robotic and laparoscopic bladder surgery make this one of the fastest moving fields in medicine. As current textbooks are too time-consuming for busy urologists or trainees who also need to learn other areas of urology, this collection provides quick references and over 4000 images that are appropriate for fellows as well as those teaching in the field.

  • Positive Mental Health, Fighting Stigma and Promoting Resiliency for Children and Adolescents

    • 1st Edition
    • Matthew Hodes + 1 more
    • English
    Positive Mental Health for Children and Adolescents: Fighting Stigma and Promoting Resiliency examines the main mechanisms involved in improving mental health in children and adolescents, including social and biological processes, as well as effective treatments. By taking into account diverse settings and cultures, the book combines academic, research, and clinical contributions and sets forth how it can be translated into effective clinical practice. In addition, the book promotes the study, treatment, care, and prevention of mental and emotional disorders and disabilities involving children, adolescents, and their families, and includes emerging knowledge on mental health problems and good practice in child and adolescent psychiatry as relayed by experts from around the world.

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