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Elsevier

Academic Press

  • Anticandidal Agents

    • 1st Edition
    • Awanish Kumar
    • English
    Anticandidal Agents provides the latest information on candida drug resistance and its remedial implications. In this compilation, users will find a comprehensive view on overcoming resistance in anticandidal drugs, along with information on novel molecules. Candida albicans is an opportunistic pathogenic fungus responsible for life threating invasive and nosocomial infections across the globe. Candidiasis is a major cause of morbidity among immunocompromised patients. Infections caused by non-albicans candida like C. glabrata, C. parapsilosis, and C. tropicalis have also imposed a serious threat in the last few decades. Current treatment of candidiasis relies primarily on antifungal agents broadly categorized as azoles, polyenes, echinocandins, allylamines, and pyrimidines. Lately, antifungal resistance has emerged to be an obstruction of current treatment regime. A number of reasons are described in detail. Understanding the mechanisms of resistance is crucial for developing strategies for overcoming the hindrance in current therapeutics.

  • On Human Nature

    Biology, Psychology, Ethics, Politics, and Religion
    • 1st Edition
    • Michel Tibayrenc + 1 more
    • English
    On Human Nature: Biology, Psychology, Ethics, Politics, and Religion covers the present state of knowledge on human diversity and its adaptative significance through a broad and eclectic selection of representative chapters. This transdisciplinary work brings together specialists from various fields who rarely interact, including geneticists, evolutionists, physicians, ethologists, psychoanalysts, anthropologists, sociologists, theologians, historians, linguists, and philosophers. Genomic diversity is covered in several chapters dealing with biology, including the differences in men and apes and the genetic diversity of mankind. Top specialists, known for their open mind and broad knowledge have been carefully selected to cover each topic. The book is therefore at the crossroads between biology and human sciences, going beyond classical science in the Popperian sense. The book is accessible not only to specialists, but also to students, professors, and the educated public. Glossaries of specialized terms and general public references help nonspecialists understand complex notions, with contributions avoiding technical jargon.

  • Closed Loop Neuroscience

    • 1st Edition
    • Ahmed El Hady
    • English
    Closed Loop Neuroscience addresses the technical aspects of closed loop neurophysiology, presenting the implementation of these approaches spanning several domains of neuroscience, from cellular and network neurophysiology, through sensory and motor systems, and then clinical therapeutic devices. Although closed-loop approaches have long been a part of the neuroscientific toolbox, these techniques are only now gaining popularity in research and clinical applications. As there is not yet a comprehensive methods book addressing the topic as a whole, this volume fills that gap, presenting state-of-the-art approaches and the technical advancements that enable their application to different scientific problems in neuroscience.

  • Genome Stability

    From Virus to Human Application
    • 1st Edition
    • Igor Kovalchuk + 1 more
    • English
    Every species has to preserve the integrity of its genome to ensure faithful passage of genetic information to the progeny. At the same time, there are times during the life of the organism and population in general when a fine balance in genome stability and diversification has to be made to benefit the survival of the species. Genome Stability teaches the reader how various species maintain this fine balance in genome stability and genome diversification in response to their environments. Genome Stability covers a wide range of topics, including the genome stability of DNA/RNA viruses, prokaryotes, single cell eukaryotes, lower multicellular eukaryotes and mammals. Topics also include major DNA repair mechanisms, the role of chromatin in genome stability, human diseases associated with genome instability as well as changes in genome stability in response to aging. Finally, Genome Stability covers how epigenetic factors contribute to genome stability and how the species pass the memory of the encounters to the progeny, thus influencing the genome of the progeny in an indirect manner. This volume is an essential resource for geneticists, epigeneticists, and molecular biologists who are looking to gain a deeper understanding of this rapidly-expanding field, and can also be of great use to advanced students who are looking to gain additional expertise in genome stability.

  • Microbial Control of Insect and Mite Pests

    From Theory to Practice
    • 1st Edition
    • Lawrence A. Lacey
    • English
    Microbial Control of Insect and Mite Pests: From Theory to Practice is an important source of information on microbial control agents and their implementation in a variety of crops and their use against medical and veterinary vector insects, in urban homes and other structures, in turf and lawns, and in rangeland and forests. This comprehensive and enduring resource on entomopathogens and microbial control additionally functions as a supplementary text to courses in insect pathology, biological control, and integrated pest management. It gives regulators and producers up-to-date information to support their efforts to facilitate and adopt this sustainable method of pest management. Authors include an international cadre of experts from academia, government research agencies, technical representatives of companies that produce microbial pesticides, agricultural extension agents with hands on microbial control experience in agriculture and forestry, and other professionals working in public health and urban entomology.

  • Introduction to Robust Estimation and Hypothesis Testing

    • 4th Edition
    • Rand R. Wilcox
    • English
    Introduction to Robust Estimating and Hypothesis Testing, 4th Editon, is a ‘how-to’ on the application of robust methods using available software. Modern robust methods provide improved techniques for dealing with outliers, skewed distribution curvature and heteroscedasticity that can provide substantial gains in power as well as a deeper, more accurate and more nuanced understanding of data. Since the last edition, there have been numerous advances and improvements. They include new techniques for comparing groups and measuring effect size as well as new methods for comparing quantiles. Many new regression methods have been added that include both parametric and nonparametric techniques. The methods related to ANCOVA have been expanded considerably. New perspectives related to discrete distributions with a relatively small sample space are described as well as new results relevant to the shift function. The practical importance of these methods is illustrated using data from real world studies. The R package written for this book now contains over 1200 functions. New to this edition 35% revised content Covers many new and improved R functions New techniques that deal with a wide range of situations

  • Essential MATLAB for Engineers and Scientists

    • 6th Edition
    • Daniel T. Valentine + 1 more
    • English
    Essential MATLAB for Engineers and Scientists, Sixth Edition, provides a concise, balanced overview of MATLAB's functionality that facilitates independent learning, with coverage of both the fundamentals and applications. The essentials of MATLAB are illustrated throughout, featuring complete coverage of the software's windows and menus. Program design and algorithm development are presented clearly and intuitively, along with many examples from a wide range of familiar scientific and engineering areas. This updated edition includes the latest MATLAB versions through 2016a, and is an ideal book for a first course on MATLAB, or for an engineering problem-solving course using MATLAB, as well as a self-learning tutorial for professionals and students expected to learn and apply MATLAB.

  • Rationality

    Constraints and Contexts
    • 1st Edition
    • Tzu-Wei Hung + 1 more
    • English
    Rationality: Contexts and Constraints is an interdisciplinary reappraisal of the nature of rationality. In method, it is pluralistic, drawing upon the analytic approaches of philosophy, linguistics, neuroscience, and more. These methods guide exploration of the intersection between traditional scholarship and cutting-edge philosophical or scientific research. In this way, the book contributes to development of a suitably revised, comprehensive understanding of rationality, one that befits the 21st century, one that is adequately informed by recent investigations of science, pathology, non-human thought, emotion, and even enigmatic Chinese texts that might previously have seemed to be expressions of irrationalism.

  • Human Modeling for Bio-Inspired Robotics

    Mechanical Engineering in Assistive Technologies
    • 1st Edition
    • Jun Ueda + 1 more
    • English
    Human Modelling for Bio-inspired Robotics: Mechanical Engineering in Assistive Technologies presents the most cutting-edge research outcomes in the area of mechanical and control aspects of human functions for macro-scale (human size) applications. Intended to provide researchers both in academia and industry with key content on which to base their developments, this book is organized and written by senior experts in their fields. Human Modeling for Bio-Inspired Robotics: Mechanical Engineering in Assistive Technologies offers a system-level investigation into human mechanisms that inspire the development of assistive technologies and humanoid robotics, including topics in modelling of anatomical, musculoskeletal, neural and cognitive systems, as well as motor skills, adaptation and integration. Each chapter is written by a subject expert and discusses its background, research challenges, key outcomes, application, and future trends. This book will be especially useful for academic and industry researchers in this exciting field, as well as graduate-level students to bring them up to speed with the latest technology in mechanical design and control aspects of the area. Previous knowledge of the fundamentals of kinematics, dynamics, control, and signal processing is assumed.

  • Molecular and Cellular Basis of Metastasis: Road to Therapy

    • 1st Edition
    • Volume 132
    • English
    Molecular and Cellular Basis of Metastasis: Road to Therapy, the latest in the Advances in Cancer Research series, provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics, with this volume covering the molecular and cellular basis of metastasis.

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