Anticandidal Agents
- 1st Edition - September 12, 2016
- Imprint: Academic Press
- Author: Awanish Kumar
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 1 1 3 1 1 - 0
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 1 1 3 1 2 - 7
Anticandidal Agents provides the latest information on candida drug resistance and its remedial implications. In this compilation, users will find a comprehensive view on overcomin… Read more
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Request a sales quoteAnticandidal Agents provides the latest information on candida drug resistance and its remedial implications. In this compilation, users will find a comprehensive view on overcoming resistance in anticandidal drugs, along with information on novel molecules.
Candida albicans is an opportunistic pathogenic fungus responsible for life threating invasive and nosocomial infections across the globe. Candidiasis is a major cause of morbidity among immunocompromised patients. Infections caused by non-albicans candida like C. glabrata, C. parapsilosis, and C. tropicalis have also imposed a serious threat in the last few decades. Current treatment of candidiasis relies primarily on antifungal agents broadly categorized as azoles, polyenes, echinocandins, allylamines, and pyrimidines.
Lately, antifungal resistance has emerged to be an obstruction of current treatment regime. A number of reasons are described in detail. Understanding the mechanisms of resistance is crucial for developing strategies for overcoming the hindrance in current therapeutics.
- Presents a complete understanding of candida resistance to help in the development of therapeutic expansion and novel drugs
- Provides thorough information on candida drug resistance and its remedial implications
- Covers crucial mechanisms of resistance that will help develop strategies for overcoming the hindrance in current therapeutics
Researchers in applied microbiology, molecular biology, mycology, biotechnology, and biochemistry
- List of Figures
- List of Tables
- Chapter 1. Introduction
- Abstract
- Pathogenesis and Virulence
- Genome and Proteome
- Genetics
- Metabolome
- Chapter 2. Host–Pathogen Interaction
- Abstract
- Morphogenesis
- Immune Responses
- Chapter 3. Antifungals Used Against Candidiasis
- Abstract
- Azoles
- Polyenes
- Echinocandins
- Allylamines
- Pyrimidines
- Thiocarbamates and Morpholines
- Other Inhibitors
- Novel Inhibitors
- Differential Expression of Genes in Response to Drugs
- Chapter 4. Drug Resistance in Candida
- Abstract
- Emergence of Drug Resistance
- Spread of Drug Resistance
- Persistence of Drug Resistance
- Multidrug Resistance
- Chapter 5. Multidrug Resistance and Transporters
- Abstract
- Overview of Efflux Pumps
- Fungal Efflux-Mediated Drug Resistance
- Overcoming Efflux-Mediated Drug Resistance
- Chapter 6. Potential Anticandidal Targets
- Abstract
- Surface Targets
- Key Factors
- Cellular Targets
- Cross Talk
- Chapter 7. Drug Development Strategies
- Abstract
- In Vitro Based
- In Vivo Based
- In Silico Based
- Chapter 8. Conclusion
- Abstract
- Abbreviations
- Bibliography
- Edition: 1
- Published: September 12, 2016
- No. of pages (Paperback): 94
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780128113110
- eBook ISBN: 9780128113127
AK
Awanish Kumar
Dr. Awanish Kumar is currently an Associate Professor in the Department of Biotechnology at the National Institute of Technology, Raipur (CG), India. He has more than 13 years of research experience. He received his PhD in molecular parasitology from the CSIR-Central Drug Research Institute, Lucknow, India, and Jawaharlal Nehru University, Delhi, India, and completed his postdoctoral studies at McGill University, Montreal, Canada. His research interests are infection biology, drug targeting, and drug discovery. He has served on various national and international organizations in different academic and research capacities. He has also served on many national committees and scientific advisory panels, as a member of many international professional research societies, and as a reviewer and editorial board member of reputed and refereed journals. He has authored or edited several monographs, books, and book chapters.
Affiliations and expertise
Associate Professor, Department of Biotechnology, National Institute of Technology Raipur, IndiaRead Anticandidal Agents on ScienceDirect