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Elsevier

Academic Press

  • Basal Ganglia Dynamics

    From Motor Units to Networked Chaotic Oscillators
    • 1st Edition
    • Erwin B. Montgomery Jr.
    • English
    Basal Ganglia Dynamics: From Motor Units to Networked Chaotic Oscillators addresses the critical need for new theoretical frameworks in understanding the basal ganglia–thalamic cortical system, particularly in the context of movement disorders such as Parkinson’s disease. Despite significant therapeutic advances, current dopamine replacement and Deep Brain Stimulation therapies remain limited due to incomplete and oversimplified prevailing theories. This reference provides a comprehensive alternative approach grounded in complexity science, nonlinear dynamics, and Chaotic Systems theory. The contents span foundational concepts, including motor unit orchestration, networked nonlinear oscillators, information theory, and methodological considerations. Detailed chapters cover the shortcomings of current models, the application of Chaotic System mathematics to basal ganglia physiology, and the implications for pathophysiology and treatment. The book also includes extensive simulations, operational hypotheses, and a rigorous critique of existing paradigms, supported by principles such as Causational and Informational Synonymy.

  • Catalytic Methods in Flow Chemistry: Part B

    • 1st Edition
    • Volume 78
    • English
    Catalytic Methods in Flow Chemistry: Part B, Volume 78 in the Advances in Catalysis series, highlights recent breakthroughs in catalytic methods under continuous‐flow conditions. This new volume presents chapters written by an international board of authors and explores cutting-edge strategies for enabling sustainable, scalable chemical synthesis. Topics include technological innovations that enhance efficiency and selectivity in continuous flow systems, the integration of biocatalysts for greener processes, and the development of streamlined approaches for active pharmaceutical ingredient (API) synthesis. Together, these contributions provide researchers and industrial practitioners with a comprehensive overview of advances that are shaping the future of flow chemistry and catalysis.

  • Molecular Targets and Therapeutic Design

    • 1st Edition
    • Volume 153
    • English
    Molecular Targets and Therapeutic Design, Volume 152 provides a comprehensive overview of the current landscape and future directions in the identification and exploitation of molecular targets for the development of new therapeutics. This volume brings together leading experts to discuss the fundamental principles of target discovery, validation, and the strategies used to design molecules that modulate biological pathways in disease. Topics covered in this new release include Recent Strategies and Approaches for the Development of Molecularly Targeted Nanomedicine, Transcriptomic Profiling for Therapeutic Target Discovery in Neuropsychiatric Conditions, Transcriptomic Insights into Hormone-Driven Malignancies: Toward Targeted Therapeutic Strategies, and much more.Additional chapters cover Targeting Kinases in Neurodegenerative Diseases and Cancer: Structural Insights and Therapeutic Strategies, Small molecular therapeutic targets for neurodegenerative diseases, Signaling cascades of Tau protein, Understanding molecular role of lipids for Alzheimer's disease, Clinical Challenges and Therapeutic Strategies in Chordoma, Molecular Characterization and Experimental Models of Chordoma, Disordered Proteins as Fuzzy Viral Drug Targets, amongst other timely topics.

  • Applications of Artificial Intelligence in Healthcare

    The Changing Landscape
    • 1st Edition
    • Debasis Bagchi + 3 more
    • English
    Applications of Artificial Intelligence in Healthcare: The Changing Landscape takes a systematic approach, discussing the benefits and achievements of AI while also exploring the questions and challenges of AI as it relates to health and medicine. The first section provides historical context, introducing the reader to the fundamentals of AI in health care. The second section addresses the primary applications of AI in healthcare, including chatbots for tele-counseling, telemedicine, and AI assisted prediction tools. The third section focuses on the use of robotics and AI driven precision instruments to carry out complex surgical procedures.The fourth section highlights emerging AI assisted technologies for the management of diseases and disorders. The fifth section covers emerging applications of AI in medical science and holistic health management, for example ChatGPT and Natural Language Processing algorithms. Finally, the sixth section concludes with chapters dedicated to federal and regulatory issues of adopting AI as it relates to human health, along with the ethical issues and limitations.

  • Cell Death Part D

    • 1st Edition
    • Volume 209
    • English
    Cell Death, Part D, Volume 209 explores the latest advances in the mechanisms, regulation, and significance of cell death in health and disease. Covering diverse topics such as apoptosis, necrosis, autophagy, and emerging pathways, this volume presents chapters on Utilizing FLAMBE to study the structure-function relationship and regulation of monomeric BAX activation in solution, Sensitive detection of Lysosomal Membrane Permeabilization using the Galectin Puncta Assay, Assessing the activity of caspase-activated pannexin-1 channels by flow cytometry, In vitro culture of intestinal organoids for cell death assessments, Optimized Strategies for Necroptosis Induction and Evaluation, and more.Additional sections cover Ferroptosis induction via genetic approaches - CRISPR/Cas9-based disruption on key anti-ferroptotic genes, Reprogramming T cell fate through antibody-mediated galectin-1 blockade, 3D bioluminescence imaging assays for measuring in vitro CAR T cell cytotoxicity, The heat-ramp method to study regulated cell death in the pathogenic yeast Cryptococcus neoformans, High throughput assessment of cellular viability, and High-Throughput Screening for Cell Death Inducers and Inhibitors. This book will serve as a valuable resource for researchers, clinicians, and students interested in understanding cellular processes and their implications for therapy and diagnostics.

  • Omega-3 and Omega-6 Polyunsaturated Fatty Acids in Food Systems

    Advances and Opportunities in Product Formulation, Technology, and Delivery
    • 1st Edition
    • Pothiyappan Karthik + 3 more
    • English
    Omega-3 and Omega-6 Polyunsaturated Fatty Acids in Food Systems: Advances and Opportunities in Product Formulation, Technology and Delivery introduces readers to the health and nutritional benefits for DHA and EPA in inflammation regulation, advances in new delivery systems, commercialization strategies, and the use of PUFAs in functional foods and new product development. The book not only provides practical guidance for formulating PUFA-enriched products for maximum health benefits, but also explores emerging trends and opportunities, including the development of novel functional foods, nutraceuticals, the role of microorganisms as a promising source of microbial oils, and personalized nutrition solutions.With detailed information on how PUFAs can be effectively and sustainably sourced, processed, formulated, and marketed in the food industry, readers will better understand and learn how to overcome the challenges of scaling up PUFA production for industrial use and maximum nutritional value. Researchers, grad students working in the fields of nutrition, food science, and biochemistry, and industry professionals in the food and pharmaceutical industries involved in product development, functional foods, and formulation will benefit from this book.

  • Get to Know Your Employee

    Secrets of A Successful Company
    • 1st Edition
    • Janek Musek
    • English
    Get to Know Your Employee: Secrets of a Successful Company addresses the critical and often overlooked psychological factors that influence organizational performance and employee relations. Drawing on cutting-edge research in organizational psychology, neuroscience, and developmental science, this reference provides a comprehensive analysis of how early life experiences, repressed fears, and defensive behaviors can undermine workplace efficiency, creativity, and well-being. The book fills a crucial gap by revealing the hidden causes of organizational challenges that traditional management strategies often overlook. The reference is structured to guide readers through a logical progression, beginning with foundational concepts and the unknowns that must be recognized.Subsequen... chapters examine the role of early experiences and brain development, the impact of parenting styles, and the mechanisms by which early stress translates into defensive behaviors. The text further explores motivational loops, approach-avoidance behaviors, and the neuroscientific underpinnings of workplace dynamics. Practical solutions are presented for managers and leaders, including methods for reassuring employees, building job satisfaction, and strengthening organizational culture. Appendices, references, and supportive figures enhance the utility of the content.

  • Phytotoxicity of Organic Pollutants

    Impacts and Management
    • 1st Edition
    • Golam Jalal Ahammed + 1 more
    • English
    Phytotoxicity of Organic Pollutants: Impacts and Management provides a comprehensive and up‑to‑date overview of how diverse organic pollutants affect plant physiology, growth, and development. Bringing together contributions from leading experts, the book examines the sources, environmental behavior, and biological impacts of major classes of organic pollutants. The volume highlights recent advances in understanding the physiological, biochemical, and molecular mechanisms underlying plant responses to organic pollutant exposure. It also explores plant‑ and microbe‑based remediation strategies, emphasizing their potential to safeguard food quality and ecosystem health. Phytotoxicity of Organic Pollutants: Impacts and Management serves as an interdisciplinary resource for researchers, academics, graduate students, environmental professionals, and industry practitioners working in plant science, ecotoxicology, environmental chemistry, and sustainable remediation.

  • Brain Energy Metabolism in Alzheimers Disease - Part B

    • 1st Edition
    • Volume 187
    • English
    Brain Energy Metabolism in Alzheimer’s Disease – Part B, Volume 187 in the International Review of Neurobiology series, presents current advances and comprehensive reviews on metabolic dysfunction in neurodegenerative diseases. This volume brings together contributions from an international panel of experts, focusing on the molecular and cellular mechanisms underlying energy imbalance in Alzheimer’s disease and related disorders.Chapters in this release explore key processes such as autophagy and ESCRT pathways, tau modifications, insulin resistance, and mitochondrial dysfunction. Additional sections examine neurovascular–glial interactions, genetic and epigenetic factors in neurodegeneration, and the roles of metallospecies, noncoding RNAs, and phase separation in disease progression.Further contributions address neuroprotective signaling pathways, metabolic impairments in glucose and lipid homeostasis, and emerging diagnostic and therapeutic approaches, including liquid biopsy markers and targeted metabolic interventions. Together, these chapters provide an integrated overview of the mechanisms, biomarkers, and therapeutic opportunities associated with brain energy metabolism in neurodegenerative diseases, making this volume an essential reference for researchers and clinicians in neuroscience and neurobiology.

  • Advances in Parasitology

    • 1st Edition
    • Volume 132
    • English
    The discipline of parasitology is undergoing a profound paradigm shift as anthropogenic pressures dissolve the boundaries separating wildlife, domestic animals, and human populations. This Volume brings together three foundational chapters on vector-borne parasite transmission, wildlife reservoirs, and the ecological frameworks necessary to combat global zoonoses. In the opening Chapter, Sarah N. Farrell and colleagues propose that treating the mosquito vector rather than the human host with antimalarial compounds may represent a suitable and sustainable strategy for malaria control. By attacking the Plasmodium parasite at its bottleneck oocyst stage within the vector, this approach exploits a lower parasite population size to drastically minimize the evolutionary selection pressure for drug resistance. Transitioning from micro-level vector dynamics to macro-level landscape epidemiology, Andrea Springer and colleagues document how conservation successes and urban adaptation have shifted the distribution of zoonotic pathogens. Focusing on the red fox as primary sentinel, the authors illustrate how wild reservoirs dynamically interact with domestic animals and humans, highlighting the importance of the health triangle connecting wild carnivores to urban public health. Finally, Alicia Rojas and Alberto Solano-Barquero dissect the micro- and macroevolutionary events, such as host-switching and hybridization, that allow multi-host parasites to overcome human physiological defenses, and propose instead a balanced "One Health pentad" that gives equal weight to wildlife reservoirs, intermediate bridge hosts, vectors, and complex environmental stages.

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