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Elsevier

Academic Press

  • The Organic Chemistry of Drug Design and Drug Action

    • 4th Edition
    • Richard B. Silverman + 2 more
    • English
    The Organic Chemistry of Drug Design and Drug Action, Fourth Edition presents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action. The book's coverage allows readers to extrapolate core principles and mechanisms to many related classes of drug molecules. It reflects the significant changes in the process of drug design over the last decade and preserves the successful approach of the previous editions while also including significant changes in format and coverage.It is designed for undergraduate and graduate students in chemistry who are studying medicinal chemistry or pharmaceutical chemistry. Users, including research chemists and biochemists working in pharmaceutical and biotechnology industries will find this update to be useful in their daily work.

  • Mastering Supraventricular Tachycardia Diagnostics in the Electrophysiology Lab

    • 1st Edition
    • Konstantinos P. Letsas + 1 more
    • English
    Mastering Supraventricular Tachycardia Diagnostics in the Electrophysiology Lab provides a comprehensive, practical, and systematically organized guide to diagnostic pacing maneuvers for the differential diagnosis of supraventricular tachycardias during electrophysiology studies.Emerging from the need to provide a complete collection of literature on diagnostic pacing maneuvers published over the last 40 years, this book includes more than 30 diagnostic pacing maneuvers, with detailed instructions on when and how to perform them, how to interpret the findings, and how to recognize their potential pitfalls.This book aspires to serve as a thorough and comprehensive guide, structured both as a benchside reference companion for the electrophysiology lab and as an educational resource for cardiac electrophysiology fellows newly introduced to the fascinating yet challenging world of invasive cardiac electrophysiology.

  • ESKAPE Pathogens

    Virulence, Resistance, and Management
    • 1st Edition
    • Karthikeyan Ramalingam
    • English
    ESKAPE Pathogens: Virulence, Resistance, and Management provides comprehensive coverage on ESKAPE pathogens, including their virulence mechanisms, resistance patterns, and challenges in their management. The book offers the latest information on ESKAPE pathogens' pathogenicity, mechanisms of antibiotic resistance, and innovative approaches to manage these pathogens. It explores recent advancements in the field of genomics, proteomics, and transcriptomics that could potentially provide valuable insights into the mechanisms and genetic basis of antibiotic resistance in ESKAPE pathogens. Finally, the book highlights the need for alternative treatment options and innovative management strategies to combat the emergence of multidrug-resistant strains.This is a helpful resource to researchers, clinicians, educators, industry professionals, and advanced students interested in the latest research and strategies for combating multidrug-resistant pathogens.

  • Advances in the Study of Behavior

    • 1st Edition
    • Volume 58
    • English
    Advances in the Study of Behavior, Volume 58, an annual volume in the field of behavior science, brings together cutting-edge research, theoretical advances, and surveys the latest findings across learning, conditioning, memory, perception, decision-making, and related areas, while also blending behavioral analysis with neuroscience, genetics, and computational modeling. Chapters in this new release include Staying in Sync: Behavioral Synchrony and Cooperation in Dolphins, Bridging human and primate culture: toward a comparative evolutionary framework, Natural and sexual selection on reproduction in the sand goby – a dynamic mosaic in time and space, and Beyond protection from predators: the perks of being warningly colored.

  • Protein Misfolding and Human Diseases

    Deciphering the Central Role of Pathological Aggregation
    • 1st Edition
    • Pranav Kumar Prabhakar + 2 more
    • English
    Protein Misfolding and Human Diseases: Deciphering the Central Role of Pathological Aggregation investigates the misfolding of proteins and implications for a variety of debilitating conditions. The book comprehensively overviews pathological protein aggregation, exploring its mechanisms in specific illnesses, including Alzheimer's disease, Parkinson’s disease, Huntington’s disease, prion diseases, ALS, and systemic amyloidosis. It addresses disrupted cellular pathways and failures in protein homeostasis during aging, delineating the unifying principles across protein conformational disorders. Sections feature structural insights into protein aggregates from amyloid fibrils to inclusion bodies and offer therapeutic strategies to disrupt aggregation pathways, enhance cellular protein quality control, and provide immunotherapy solutions.Finally, the book closes with a discussion of the latest advances in research and considerations for future directions to combat protein aggregation. It will serve as an invaluable reference on the intricacies of protein misfolding and its clinical implications. Researchers, academics and graduate students working across these fields will benefit from this comprehensive guide. Additionally, clinicians and healthcare professionals will find it invaluable for understanding the molecular basis of protein misfolding disorders.

  • Protein-Based Nanoparticles in Drug Delivery

    • 1st Edition
    • Prashant Kesharwani
    • English
    Protein-based Nanoparticles in Drug Delivery is a comprehensive book aimed at pharmaceutical scientists and researchers both in academia and corporate environments focused on nanotechnology drug delivery and pharmaceutical-relat... disciplines. The book covers the design and characterization of various protein nanoparticles, sheds light on the power of an endogenous substance as a drug delivery system, and highlights the possible future trends in the use of protein-based drug delivery. It covers in-depth novel applications of protein-based drug delivery from fundamental to most current use cases. The book comprises three parts. Part one is devoted to the foundations of protein-based drug delivery, including nanocarriers development, drug encapsulation, targetability, and in vivo properties. Part two explores the applications of protein-based nanoparticles in drug delivery, covering topics such as protein nanoparticles in cancer therapy, genetic material delivery, and nanocarriers based on milk protein, silk, and gliadin. Part three addresses recent advances and regulatory aspects of protein-based nanoparticles in drug delivery, including clinical translation, challenges, biological toxicity, and environmental hazards associated with protein-based nanoparticles. Protein-based Nanoparticles in Drug Delivery provides a complete journey of protein-based drug delivery, offers an in-depth understanding of the design and characterization of various protein nanoparticles, and highlights possible future trends in this field. Pharmaceutical scientists will benefit from the novel applications of protein-based nanoparticles drug delivery approaches in the biological field. Nanotechnologists, biologists, chemists, physicists, engineers, and clinicians will also benefit from the foundational content provided as a basis to support communication and tackle the multidisciplinary challenges associated with research in this exciting field.

  • Green Intrusion Detection Systems for IoT

    • 1st Edition
    • Saeid Jamshidi + 3 more
    • English
    Green Intrusion Detection Systems for IoT tackles the pressing security challenges posed by the rapid expansion of the Internet of Things (IoT). The book delves into innovative, lightweight security models and energy-aware IDS mechanisms that strike a balance between security efficacy, computational efficiency, and environmental sustainability. Sections discuss the transformative role of IoT and the need for sustainable security solutions, highlight the distinctions between traditional and Green IDS, focus on lightweight security models essential for resource-constrained IoT devices, and delve into energy-efficient network designs.Additional sections explore green IDS mechanisms, including machine learning and distributed approaches, IoT vulnerabilities and mitigation strategies, practical examples of sustainable IDS in various smart environments, real-world case studies, and future directions in sustainable IoT security. The book concludes with actionable recommendations that align technological advancements with global sustainability goals.

  • Intelligent Railway Alignment Design

    • 1st Edition
    • Hao Pu + 4 more
    • English
    Intelligent Railway Alignment Design offers a comprehensive exploration of intelligent railway alignment optimization. The book considers a variety of critical topics, starting with the optimal selection of key technical standards for railway design and then introduces the comprehensive geographic information model. The methods for evaluating the suitability of the railway alignment based on the comprehensive geographic information model are discussed, together with economic optimization models aimed at cost-effective railway alignment design. In addition, the book considers optimization models for managing risks related to typical geological hazards and minimizing environmental impacts.Intelligent search algorithms for solving railway alignment optimization models are explained in detail, including corridor searching algorithms and 3D alignment searching algorithms. Additionally, the book explores concurrent optimization strategies for coordinating railway alignments with stations and large temporary engineering projects. Finally, it introduces intelligent models and methods for reconstructing and optimizing existing railway alignments, ensuring that both new and updated railways operate efficiently and sustainably.

  • Bioorthogonal Labeling

    • 1st Edition
    • Volume 731
    • English
    Biorthogonal Tagging, Volume 731 in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters such as Staudinger Ligations and Related Reactions: Scope and Applications in Chemical Biology, Strain-Promoted Bioorthogonal Cycloadditions to Investigate Sialyltransferases Promiscuity Towards Unnatural Sialic Acids, Practical Guidelines for the Bioorthogonal AMI–Isonitrile Ligation, Nitrones and Other Dipoles in Bioorthogonal Chemistry Applications, 1,2-Aminothiol-Speci... Conjugation for Dual-Color Fluorescent Labeling via Ultrafast TAMMs, Genetic Incorporation of Bicyclononyne for Cell-Surface Protein Labeling via Tetrazine Ligation, and much more.Additional chapters cover Genetic Code Expansion for Single Noncanonical Amino Acid Incorporation into SARS-CoV-2 Omicron Spike on Amber-Free Lentiviral Particles, Bioorthogonal Click-Chemistry Labeling and Visualization of Dual Noncanonical Amino Acid–Incorporated HIV-1 Env on Intact Virions, Studying Bacterial Glycans with Azidosugars and Bioorthogonal Chemistry, Bioorthogonal Tagging of DNA and RNA, Efficient Labeling of Pathogenic Fungal Chitin with Bioorthogonal Probes, and many more timely topics.

  • Applied Hydrology and Green Infrastructure Systems

    • 1st Edition
    • Joseph Schulenberg + 2 more
    • English
    Applied Hydrology and Green Infrastructure Systems combines theoretical insight with practical applications. This textbook captures the latest developments in green infrastructure and offers the skills that are necessary to interpret and solve complex hydrology and hydraulics problems. Integrating traditional hydrologic principles with cutting-edge green infrastructural solutions, it provides a foundation into groundwater dynamics, hydrological processes, and sustainable sewer design. It paves the way for understanding the importance of environmentally conscious practices in water resource management.The book is divided into three parts. Part One offers a deep exploration of groundwater dynamics and describes saturated and unsaturated flow principles. It then explores steady-state and transient well hydraulics, flow nets, and strategies for ensuring sustainable groundwater availability. Part Two largely focuses on hydrology, diving into surface runoff processes, unit hydrographs, and the application of NRCS unit hydrograph methodology. Probability and statistics in hydrology are introduced followed by hydrologic frequency analyses. Lastly, Part Three describes sewer design, green infrastructure, and water transmission. The principles of sewer system design with an emphasis on sustainability and the integration of green infrastructure are discussed.Applied Hydrology and Green Infrastructure Systems is a valuable resource for upper-level undergraduate students in environmental sciences studying engineering hydrology, hydraulics and hydrology. It is also useful for engineers, urban planners, and consultants who are looking for practical guidance to incorporate green infrastructure into urban design and development. This textbook contains case studies, self-assessments, spreadsheet shells, and a solutions manual as additional resources for students and instructors.

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