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Academic Press

  • A Comprehensive Guide to Rodent Models of Liver Diseases

    • 1st Edition
    • Savneet Kaur + 1 more
    • English
    A Comprehensive Guide to Rodent Models of Liver Diseases provides the why, what, and how of preclinical models of liver disease. These models have not only substantially improved understanding of human liver disease pathogenesis, but also helped in developing and testing newer therapeutics as well as addressed some of the unanswered medical challenges and problems of today.This important reference gives a detailed and in-depth review of the various animal models of human liver disorders. Well-reported animal models several human liver diseases such as fatty liver disease (non-alcoholic and alcoholic) to steatohepatitis, cholestasis, fibrosis, cirrhosis and its complications are described. Preclinical models used for studying liver regeneration and liver failure are also discussed. For each model, the characteristic features, brief protocols, relevance, and limitations are provided.Preclinical models used for studying liver regeneration and liver failure are also discussed. For each model, the characteristic features, updated protocols, relevance, and limitations are provided for consideration. Finally, it provides an overview of the recently developed organoid models of liver pathology.

  • Clinical Applications of Echo Doppler Haemodynamics

    • 1st Edition
    • Edgar Argulian + 1 more
    • English
    Clinical Applications of Echo Doppler Haemodynamics is precisely the book cardiologists and cardiology trainees have been waiting for. While this essential area of echocardiography is crucial to cardiologists and all cardiac imagers, there are no dedicated books for case-based Doppler Echocardiography. This often-overlooked discipline integrates physiology with interpretation of a wide variety of real-life echo Doppler tracings. It contains critical information for professionals around the world, including contents highly relevant to their day-to-day practice as well as its unique case studies. An abundance of knowledge in this area can currently be found randomly in various textbooks, but they lack cohesive, dedicated explanations and discussions. Clinical Applications of Echo Doppler Haemodynamics presents the reader with 100 different Doppler images, exemplifying (among other things) cardiophysiology image analysis, LVOT, pulmonary pressures, shunts, congenital heart disease and ECMO. It quite literally gives medical professionals a new way to look at the heart, better allowing them to diagnose and treat previously under-identified ailments. It is a must-have for healthcare workers interested in the most accurate, up-to-date methods of cardiac imaging and Doppler interpretation.

  • Emerging Green Processing Technologies for Beverages

    • 1st Edition
    • Roji Waghmare + 1 more
    • English
    Emerging Green Processing Technologies for Beverages, Volume Seven in the Developments in Food Quality and Safety series, covers the fundamentals and recent trends in the processing of different beverages, such as herbal beverages, fresh produce-based beverages, and dairy beverages. Chapters cover a broad range of beverages to enhance knowledge in quality retention and shelf life extension. Sections summarize the influence of green technologies on nutritional quality, microbial safety, and physico-chemical characteristics. Edited by Dr. José Manuel Lorenzo and authored by a team of global experts, this book provides comprehensive knowledge to food industry personnel and scientists.This is the most up-to-date resource, covering trend topics such as Advances in the analysis of toxic compounds and control of food poisoning; Food fraud, traceability and authenticity; Revalorization of agrifood industry; Natural antimicrobial compounds and application to improve the preservation of food; Non-thermal processing technologies in the food industry; Nanotechnology in food production; and Intelligent packaging and sensors for food applications.

  • Advances in Technology-Assisted Neurorehabilitation

    • 1st Edition
    • Natalia M. López
    • English
    Advances in Technology-Assisted Neurorehabilitation introduces biomedical engineers, health professionals and researchers to the study and integration of neurorehabilitation advances, specifically focusing on applied technologies and mathematical methods. Coverage includes neuromodulation, robotic rehabilitation devices, signal processing, human-machine interfaces, software development, serious games and virtual reality. It takes an interdisciplinary approach, including real world applications and new trends. Both medical and technological fields are represented, with a focus on neurological disease. With the computerization of today's therapeutic technology, this book is a valuable asset to any student in the bioengineering or healthcare fields.

  • The Immunology of the Domestic Ruminants

    Cattle, Sheep, and Goats
    • 1st Edition
    • Ian R. Tizard
    • English
    The Immunology of Domestic Ruminants: Cattle, Sheep, and Goats provides a thorough examination of the immune systems of these animals. It explores their normal immune functions and their roles in combating infectious and parasitic diseases, chronic inflammatory conditions, and immunodeficiency disorders. The book incorporates new data from the bovine genome project and highlights significant breed differences. Both innate and adaptive immunity are systematically covered, offering insights into basic and applied aspects of bovine immunology. In addition to detailing the immunology of major bacterial, viral, and parasitic diseases in cattle, the book reviews bovine vaccines and emphasizes the importance nutrition.This essential resource caters to professionals in large animal research and practice, providing comprehensive information on the immunology of domestic cattle, sheep, and goats.

  • Cholecystokinin

    From Gallbladder to Cognition and Beyond
    • 1st Edition
    • Christine Feinle-Bisset + 1 more
    • English
    Cholecystokinin: From Gallbladder to Cognition and Beyond covers the biology, physiology, and pathophysiological roles of cholecystokinin (CCK) peptides. The book begins with a historical overview before providing in-depth chapters on the biology of CCK, from biogenesis to cell expression, including intestinal and extraintestinal endocrine cells, the central and peripheral nervous system, and receptor function. CCK phylogenesis is explored across various species, including fish, birds, insects and amphibians. The physiology of CCK covers intestinal CCK secretion, the gallbladder and pancreas, and the role of CCK in the gut-brain axis, gastrointestinal motor function, appetite regulation, and cardiovascular function.Methods used for CCK research are also discussed. A number of chapters then covers the roles of CCK in various diseases, including metabolic diseases, tumors, psychiatric illness, the immune system and nociception, as well as potential therapeutic approaches targeting CCK receptors.

  • Methods for Monitoring Mitochondrial Functions During Pathogen Infection

    • 1st Edition
    • Volume 194
    • English
    Methods for Monitoring Mitochondrial Functions During Pathogen Infection, Volume 194 in the Methods in Cell Biology series highlights advances in the field, with this new volume presenting interesting chapters on timely topics, including Mitochondrial Labeling with Fluorescent Proteins for Enhanced Morphological Characterization and Visualization of Intercellular Mitochondrial Transfer, Visualizing mitochondrial electron transport chain complexes and super-complexes during infection of human macrophages with Legionella pneumophila, Quantitative assessment of mitochondrial membrane potential in macrophages in sepsis, Quantification of mitochondrial reactive oxygen species in macrophages during sepsis, and much more.Additional chapters cover Quantification of intracellular and mitochondrial ATP content in macrophages during lipopolysaccharide-i... inflammatory response, Analysis of cytosolic mtDNA release during Staphylococcus Aureus infection, Monitoring mitochondria dynamics upon infection using a tomographic approach, A screening system to determine bacterial effects on MADCAM1 expression by high endothelial venule cells, Isolation of mitochondria from Mycobacteria infected cells, Monitoring mitochondrial localization of Mycobacterial proteins, and more.

  • Near-boundary Fluid Mechanics

    • 1st Edition
    • Shu-Qing Yang
    • English
    Near-Boundary Fluid Mechanics focuses on the near-boundary region and its significance. It delves into topics like boundary shear stress, drag reduction using polymer additives, turbulence sources, secondary currents, log-law validity, sediment transport, and more. Unlike similar books, it emphasizes the importance of the near-boundary region. This book is organized into chapters covering internal flows, external flows, loose boundary flows, and density currents. It extends Prandtl's fundamental concept to internal flows, showing how potential flow theory can describe flow without a solid boundary.In addition, the book provides a theoretical analysis of boundary shear stress in three-dimensional flows and explores the turbulent structures in drag-reduction flows. A key feature is clarifying the role of wall-normal velocity in mass, moment, and energy transfer. Additionally, Archimedes' principle is covered to explain pressure drag and establishes a relationship between wake volume and hydrodynamic force.

  • Challenges in Delivery of Therapeutic Genomics and Proteomics

    • 2nd Edition
    • Aliasgar Shahiwala + 1 more
    • English
    Challenges in Delivery of Therapeutic Genomics and Proteomics, Second Edition is a complete reference on the biological principles involved in gene and protein delivery to cells and tissues. Highlighting the various chemical, physical, and biological approaches to protein and gene delivery, the book provides guidelines for pharmaceutical researchers in academia and corporate R&D. This new edition brings updates on the delivery of therapeutic proteomics and genomics in each chapter, and newly developed chapters on the regulatory aspects of related products, CRISPR/Cas9 gene editing, and computational tools in genomics and proteomics.After an overview of the barriers to genomics and proteomics delivery, the book dives into physical, chemical, and biological methods of gene delivery. Further chapters extensively discuss the delivery of proteins and therapeutic peptides through the respiratory, oral, parenteral, transdermal, topical, uterine, and rectal pathways. This book is the ideal reference for pharmaceutical scientists dealing with gene and protein/peptide delivery. Regulators and corporate researchers can also benefit from the wide coverage of delivery methods presented.

  • The Nervous System

    • 1st Edition
    • Volume 5
    • Mayeen Uddin Khandaker + 1 more
    • English
    The series Stem Cell Innovation in Health and Disease is a timely and fascinating collection of information and new discoveries and provides a contemporary snapshot album from the fast-moving field of regenerative medicine and stem cell therapeutics. The Nervous System, Volume 5 addresses the recent data accumulated on the potential applications of stem cells to treat diseases and disorders of the nervous system. This volume will highlight the recent development of cutting edge in vitro and in vivo research tools and approaches, including human and murine organoid cultures, genetic editing in vitro and in vivo, human iPSC models of disease, haploid cells for genetic as well as compound screening paradigms, genetically engineered mice, and stem cell transplantation to treat nervous system disorders and diseases. The volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation; and is contributed by world-renowned authors in the field.

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