Harnessing Endogenous Mechanisms for Targeted Drug Delivery
- 1st Edition - October 15, 2025
- Imprint: Academic Press
- Editors: Anisha A. D’Souza, Lara Scheherazade Milane, Mansoor M. Amiji
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 2 7 4 2 9 - 9
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 2 7 4 3 0 - 5
Harnessing Endogenous Mechanisms for Targeted Drug Delivery explores the cutting-edge advancements in the world of targeted drug delivery leveraging human biological mechan… Read more
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Request a sales quoteHarnessing Endogenous Mechanisms for Targeted Drug Delivery explores the cutting-edge advancements in the world of targeted drug delivery leveraging human biological mechanisms. This essential guide addresses the urgent need to enhance the efficiency of drug delivery and foster safe and effective therapies, particularly for biological agents like proteins, peptides, and nucleic acid molecules. The book offers a comprehensive exploration of tissue- and cell-specific delivery methods, emphasizing endogenous or biological techniques that can be utilized to improve drug delivery. It identifies the challenges associated with delivering complex molecules and accessing hard-to-reach sites, and provides practical solutions through endogenous strategies. Topics such as exploiting disease-specific stimuli to enhance delivery efficiency, the role of plasma proteins in drug delivery, and the utilization of extracellular vesicles to boost delivery efficiency are presented. Harnessing Endogenous Mechanisms for Targeted Drug Delivery emphasizes the clinical and commercial translation of these techniques, making this book an ideal resource for researchers, clinicians, and anyone interested in the future of drug delivery.
- Provides comprehensive insights into endogenous strategies for targeted drug delivery
- Highlights innovative techniques like using cells as Trojan Horse-Cloaking Particles
- Explores the clinical and commercial translation of these strategies
- Offers practical solutions to contemporary challenges in the area
- Emphasizes the role of disease-specific stimuli and plasma proteins in drug delivery
Individuals in decision-making positions within pharmaceutical companies may also benefit from the book’s novel approaches and provide strategies to adopt
Section 1: Drug Delivery Challenges and Opportunities
1. Contemporary Drug Delivery Challenges
2. Delivery Barriers
3. Strategies for Targeted Drug Delivery
Section 2: Endogenous Strategies
4. Stimuli-Responsive Delivery
5. Glyco-Targeting using Lectins
6. Delivery using Plasma Proteins or Endogenous Peptides
7. Utilizing Virus Engineering in Drug Delivery
8. Living or artificial Cells as Trojan Horse-Cloaking Particles
9. Augmenting Cellular Cargo Capacity
10. Cell- and Bacterial-Derived Extracellular Vesicles-Based Targeted Delivery
11. Nucleic acid based delivery systems
Section 3: Clinical Translation
13. Challenges Associated with Endogenous Targeting – Preclinical to clinical, scalability, toxicity
14. Current Clinical Trials
15. Clinical and Commercial Translational Challenges
1. Contemporary Drug Delivery Challenges
2. Delivery Barriers
3. Strategies for Targeted Drug Delivery
Section 2: Endogenous Strategies
4. Stimuli-Responsive Delivery
5. Glyco-Targeting using Lectins
6. Delivery using Plasma Proteins or Endogenous Peptides
7. Utilizing Virus Engineering in Drug Delivery
8. Living or artificial Cells as Trojan Horse-Cloaking Particles
9. Augmenting Cellular Cargo Capacity
10. Cell- and Bacterial-Derived Extracellular Vesicles-Based Targeted Delivery
11. Nucleic acid based delivery systems
Section 3: Clinical Translation
13. Challenges Associated with Endogenous Targeting – Preclinical to clinical, scalability, toxicity
14. Current Clinical Trials
15. Clinical and Commercial Translational Challenges
- Edition: 1
- Published: October 15, 2025
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780443274299
- eBook ISBN: 9780443274305
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Anisha A. D’Souza
Dr. D’Souza is a Research Fellow at Massachusetts Eye and Ear Infirmary, Harvard Medical School, and is a Visiting Scholar at the Northeastern University, Department of Pharmaceutical Sciences, in Boston, MA. She earned her PhD (Tech.) in Pharmaceutics from the Department of Pharmaceutical Sciences and Technology at the Institute of Chemical Technology, Mumbai (ICT, formerly UDCT). Following her postdoctoral at IIT-Bombay, she served as a Research Formulation Scientist at Piramal Enterprises Limited, Mumbai. In this role, she contributed to projects achieving successful Abbreviated New Drug Application (ANDA) approvals by the US FDA. Dr. D’Souza’s research interests primarily revolve around colloidal drug delivery systems, viz., polymeric and solid lipid nanoparticles for enhanced bioavailability, controlled delivery and targeting. Additionally, she also explores nucleic acid delivery platforms for addressing CNS-related neurodegenerative disorders. She has published research papers and reviews in peer-reviewed journals, authored numerous book chapters, and co-edited a Springer-published book titled “Targeted Intracellular Drug Delivery by Receptor-Mediated Endocytosis”.
Affiliations and expertise
Northeaster University, USALM
Lara Scheherazade Milane
Dr. Lara Milane is Assistant Teaching Professor in Biotechnology at the Bouvé College of Health Sciences at Northeastern University. She is interested in Mitochondrial Medicine. She is working on developing nanomedicines for a range of diseases (cancer, neurodegenerative disease, aging) that manipulate mitochondria for therapeutic outcomes. Dr. Milane was trained as a National Cancer Institute/ National Science Foundation Nanomedicine Fellow at Northeastern University, Boston, MA. Dr. Milane is an intuitive cancer biologist with research interests in developing translational nanomedicines that exploit the hallmarks of cancer.
Affiliations and expertise
Assistant Teaching Professor in Biotechnology, Bouve College of Health Sciences, Northeastern University, USAMA
Mansoor M. Amiji
Mansoor M. Amiji is the Distinguished Professor and Chairman of the Department of Pharmaceutical Sciences at the Bouvé College of Health Sciences at Northeastern University. Dr. Amiji has edited a number of books and is a frequently published author. His research focuses on the synthesis of novel polymeric materials for medical and pharmaceutical applications, drug delivery systems and nanomedical technologies, and his contributions in research advising, grant reviews for various organizations and editorial work for journals are invaluable.
Affiliations and expertise
Distinguished Professor and Chairman, Department of Pharmaceutical Sciences, School of Pharmacy, Bouve College of Health Sciences, Northeastern University, Boston, Massachusetts, USA