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Elsevier

Books in Immunology

Elsevier's Immunology collection equips researchers with valuable insights to address the complexities of the immune system and its role in health and disease, offering original research, insightful analysis, and current theory on diagnosing, managing, and advancing treatments for allergies, asthma, and immunologic disorders.

  • Immunoglobulin Genes

    • 2nd Edition
    • Tasuku Honjo + 1 more
    • English
    The immunoglobulin gene complex is responsible for generating an extraordinarily wide range of antibodies, each possessing a unique antigen specificity. The Second Edition of Immunoglobulin Genes brings the reader up to date with the rapid progress in our understanding of this system. Firmly established as the definitive book on the topic, it provides a fully comprehensive account of the organization, function, rearrangement and expression of these and related genes. Since the publication of the first edition, the work has been extensively revised and updated to cover new research data on human immunoglobulin genes as well as mammalian and lower vertebrate systems. New chapters include "Somatic mutation and B cell Maturation", "Antigen receptors" and "B lymphocyte tolerance in the mouse."For the immunologist, there are detailed descriptions of the molecular mechanisms which generate this diverse range of antibodies and the tight regulation of the genes encoding them. Molecular biologists will find discussions of important phenomena including gene rearrangement, differential splicing and deletion in the context of immunoglobulin genes.The excitement of research on immunoglobulin genes is conveyed by the range and complexity of issues discussed here; the book contains invaluable information for clinicians and research scientists with an interest in the immune response.

  • Advances in Immunology

    • 1st Edition
    • Volume 59
    • English
    With contributions from Steven A. Porcelli and other internationally recognized leaders in the field, this volume continues the tradition of indispensable reviews. Papers on the CD1 family, positive selection of thymocytes, and molecular and cellular aspects of XLA highlight the latest volume.

  • Immunology: The Making of a Modern Science

    The Making of a Modern Science
    • 1st Edition
    • Richard B. Gallagher + 3 more
    • English
    Immunology has progressed in spectacular fashion in the last four decades. Studies of the response to infectious agents, transplanted organs and tumours (and the potential to manipulate that response), and the study of the immune system as a model system in molecular cell biology have yielded dramatic advances in our understanding of the mechanisms of immunity.The field has attracted a continuous stream of the brightest theoretical and experimental scientists for over forty years. This book conveys the philosophies and approaches of sixteen of the most successful of these scientists in the form of a series of narratives that describe the circumstances that led to a major discovery in immunology. Contributors not only recall an exciting period of research that helped shape modern immunology, but set it in the personal context of place and time. Jacques Miller, for example, describes the discovery of the function of the thymus, Rolf Zinkernagel explains how experiments on viral immunity led to the discovery of MHC restriction and Susumu Tonegawa provides an account of how antibody gene structure was defined. Medically-important discoveries include descriptions of early studies of autoimmunity by Noel Rose and of tumour immunology by George and Eva Klein.Far from being a collection of disinterested, historical accounts, this volume comprises a series of passionately biographical, personal essays that provide an unusually intimate insight into the scientific process. This book will be essential, and fascinating, reading for all those with an interest in immunology, and in the life sciences in general. For students and teachers, this will provide the background necessary for a true understanding of immunology, and to place subsequent discoveries in perspective.

  • Immunopharmacology of Platelets

    • 1st Edition
    • M. Joseph
    • English
    Platelets have long been the subject of much investigation in the areas of vascular physiology, biochemistry, immunology and physiopathology. Their ability to react to environmental stimuli, to modify their shape and metabolism despite being anuclear, has fascinated scientists.This volume looks specifically at the involvement of blood platelets outside their 'classical' field of application, in the physiopathological mechanics of allergy and inflammation. The coverage includes the role of platelets in bacterial, parasitic and viral diseases and in tumour cell interactions.

  • Glycoproteins I

    • 1st Edition
    • Volume 29
    • J. Montreuil + 2 more
    • English
    Part I covers modern advances in the determination ofglycoprotein structure and in the biosynthesis of mammalian,bacterial, yeast, plant and insect glycoproteins. There are alsotwo chapters on functional aspects (glycoprotein hormones andcollagens).The content of the volume is very comprehensive in that, mostcontributors have focussed on discussing, in depth, the wealthof most recent advances in their field, and referring to previousreviews of older work for background information. This method caneffectively produce a very wide subject coverage in a smallernumber of chapters/volumes.The volume is an importantinformation source for all glycobiologist researchers (seniorinvestigators... post-doctoral fellows and graduate students), andas a good, comprehensive, reference text for scientists working inthe life sciences.

  • Dictionary of Immunology 4E

    • 4th Edition
    • W. John Herbert + 2 more
    • English
    This is the fourth edition of a well-established dictionary of Immunology which has been completely revised and updatedto include key terms arising from new discoveries in the fast-developing fields of molecular and cellular immunology. It also contains brief descriptions of the most commonly used immunological techniques, as well as definitions, useful in clinical immunology, of immunodeficiency states, autoimmune diseases etc. Clear illustrations and tables have been added to illustrate the text where appropriate. The book should be readily understandable by anyone with a background in biology and many of the definitions should be understandable to the general reader, especially as terms are extensively cross-referenced.It should be useful to those attending immunological meeting or reading immunological journals, especially as scientists communicating to specialized audiences rarely define their terms.It will also be invaluable to undergraduate and postgraduate students in biological and medical sciences, since immunological methods, such as use of monoclonal antibodies, are in wide use throughout biology and medicine.

  • Immunopharmacology of Free Radical Species

    • 1st Edition
    • English
    Free radicals have been implicated in a entire host of different human disease states, which suggests that although they may not have a pivotal causal role, they are involved in the perpetuation of disease. In recentyears, it has become evident that although free radicals most certainly do have this role in perpetuating inflammatory reactions, they have perhaps a far more important role in acting as second messenger systems to maintain normal cell function. It is theperturbations of these reactions which pose the most intriguing therapeutic challenges. This volume deals with various basic mechanisms of free radical processes and injury. The emphasis in each case is on potential therapeutic strategies developing fromthis new knowledge.

  • Mechanisms and Models in Rheumatoid Arthritis

    • 1st Edition
    • B. Henderson + 2 more
    • English
    Rheumatoid arthritis is a bewilderingly complex disease involving the interactions of many, and varied, cell populations and multiple families of low and high molecular mass mediators. We are only slowly beginning to understand the mechanisms that produce the local and systematic pathology clinically recognized as rheumatoid arthritis. Increasingly, use is being made of experimental models of this disease in an effort to test hypotheses about putative pathological mechanisms and to investigate the effect of novel therapeutic agents. A major section of this book covers these experimental models in great detail from their development through to reviews of the most recent information on each model.Mechanisms and Models in Rheumatoid Arthritis brings together a group of eminent researchers from the fields of clinical rheumatology, pathology, experimental pathology, immunology, connective tissue biochemistry, microbiology, pharmacology and developmental biology to describe the current views of the cellular and humoral mechanisms that drive the pathology of rheumatoid arthritis and experimental models of rheumatoid arthritis.

  • Advances in Immunology

    • 1st Edition
    • Volume 58
    • English
    This text should be a useful guide for researchers in immunology, cell and molecular biology and development biology.

  • Advances in Immunology

    • 1st Edition
    • Volume 57
    • English

  • Autoimmune Disease Models

    • 1st Edition
    • Irun R. Cohen + 1 more
    • English
    Because autoimmune disorders can wreak havoc in both humans and animals, these disorders are now the objects of intense and focused research. This book details specific animal models for a variety of autoimmune disorders. The contributors are recognized authorities who deal with the panoply of experimentally induced autoimmune disorders, including encephalomyelitis, allergic neuritis, uveoretinitis, myocarditis, and hepatitis. Also included are discussions of spontaneously appearing diseases such as autoimmune thyroiditis and systemic lupus erythematosus. Many other disorders are also covered in this comprehensive guide. Certain to be an aid in the planning of individual experiments and broader research programs, this book will be a valuable addition to the library of all practicing immunologists interested in immune system function and dysfunction.

  • Cytokine-Induced Tumor Immunogenicity

    From Exogenous Molecules to Gene Therapy
    • 1st Edition
    • Guido Forni + 3 more
    • English
    This remarkable book focuses on the field of cytokines and tumor immunogenicity, in which there has been a recent resurgence of interest, especially with the advent of gene therapy. With major sections devoted to concepts, experimental models, and clinical perspectives, this volume includes chapters from nearly every research group actively contributing to this area. The excitement that pervades the field is captured, and the prospects for the future discussed. The information presented here will provide essential reading for a wide spectrum of basic as well as clinical investigators interested in cytokines and the prospects for successful cancer therapy.

  • Advances in Cancer Research

    • 1st Edition
    • Volume 63
    • English
    This latest volume of the biannual serial continues rapid, current coverage of all aspect of the molecular basis of human cancer, functions of oncogenes , and research strategies of cancer drug development and treatment

  • Immunopharmacology of Macrophages and Other Antigen-Presenting Cells

    • 1st Edition
    • English
    The consequences for diseases involving the immune system such as AIDS, and chronic inflammatory diseases such as bronchial asthma, rheumatoid arthritis, and atherosclerosis, now account for a considerable economic burden to governments worldwide. In response there has been an enormous research effort investigating the basic mechanisms underlying such diseases, and a tremendous drive to identify novel therapeutic applications for their prevention and treatment. Though a plethora of immunological studies have been published in recent years, little has been written about the implications of such research for drug development. As a consequence, this area has not gained the prominence of other new fields such as molecular pharmacology or neuropharmacology, and a focal information source for the many pharmacologists interested in diseases of the immune system remains unpublished.The Handbook of Immunopharmacology Series provides such a source through the commissioning of a comprehensive collection of volumes on all aspects of immunopharmacology. Editors have been sought after for each volume who are not only active in their respective areas of expertise, but who also have a distinctly pharmacological bias to their research.The Series follows three main themes, each represented by volumes on individual component topics. The first covers each of the major cell types and classes of inflammatory mediators ("cells and mediators"). The second covers each of the major organ systems and the diseases involving the immune and inflammatory responses that can affect them ("systems"). The third covers different classes of drugs currently used to treat these diseases as well as those under development ("drugs").

  • Immunopharmacology of Epithelial Barriers

    • 1st Edition
    • English
    The realisation that epithelial tissues are not simply passive barriers to the adsorption of materials into internal environments has brought about an enormous growth of investigation of mucosal functions and their active and passive protective roles. Epithelia are highly organized but complex structures, subserving numerous functions, including immunological defence. The use of pharmacological tools in these systems is increasing, which is improving our understanding of epithelial immunobiology. This volume adopts a step-by-step approach, whereby each chapter builds upon the previous one, progressively adding important foundation information, culminating in a series of chapters concerning particular epithelia, including respiratory, gastrointestinal, renal and ocular. The result is a comprehensive but integrated treatise of epithelial function and its immunopharmacology, which aims to serve as an appropriate starting point at which the clinical pulmonologist and the research scientist can obtain an appreciation of some aspects of epithelial immunopharmacology as they are currently understood.

  • Advances in Immunology

    • 1st Edition
    • Volume 55
    • English
    Approx.455 pages

  • Advances in Cancer Research

    • 1st Edition
    • Volume 62
    • English
    This latest volume of the biannual serial continues rapid, current coverage of all aspects of the molecular basis of human cancer, functions of oncogenes, and research strategies for cancer drug development and treatment. Topics reviewed in Volume 62 include chromosomes and cancer; pathways in Ras function; APC gene in human cancer; molecular cytogenetics of renal cell tumors; reverse transformation, genome exposure, and cancer; peptide-binding heat shock proteins in endoplasmic reticulum; new developments in the Epstein-Barr virus field; direct cellular communication and humoral immune response.

  • Parasitic Infections and the Immune System

    • 1st Edition
    • Felipe Kierzenbaum
    • English
    Featuring the work of several world authorities, this volume places primary emphasis on the mechanism of parasite produced changes in the immune response (i.e. immunosuppression). The text covers parasitic diseases on which the World Health Organization has aggressively promoted research through its Program on Research and Training In Tropical Diseases. Chapters cover parasitic diseases such as malaria, American trypanosomiasis (Chagas' disease), African trypanosomiasis (sleeping sickness), leishmaniasis, schistosomiasis and onchocerciasis. Also included are discussions of toxoplasmosis and amebiasis. The material is drawn from the body of literature that has been rapidly accumulating for the last 15 years. An important feature of this text is that the contributors first outline existing knowledge about the immunology of each infection, thereby enabling the reader to more easily appreciate why and how the immunological alterations that accompany a disease are important, and then, to review the postulated mechanisms for such alterations. Consequently, the impact that each parasitic infection has on the immune system is always described in the "heart" of each chapter rather than at the beginning.

  • Immunopharmacology of Mast Cells and Basophils

    • 1st Edition
    • English
    There has been a steady and continued research effort directed to understanding both the function and the role of mast cells and basophils ever since these cells were first described at the end of the nineteenth century. One of the most significant advances has perhaps been the appreciation of the fact that mast cells do not represent a single homogenous population of cells: they display heterogeneity at the morphological, biochemical and functional levels. The one characteristic that unites all types of mast cells and basophils appears to be the possession of the high affinity membrane receptor for immunoglobulin E, through which the cells may be stimulated. This volume begins with a review of the origin and development of mast cells and basophils. It continues by reviewing our knowledge of the stimuli to mast cells and basophils and the biochemical mechanisms which link the signal generated by stimulus to the response machinery of the cell. Further chapters deal with the drug control of mast cell and basophil responses, the heterogeneity of the cells' functions and the mediators' release by the cells, along with the morphological aspects of the cells' function. This book is completed by a selection of examples which examine the role of the mast cells or basophils in lung, skin and gastrointestinal tract. However, the role of the mast cell with regard to normal physiology, remains an open question. This book aims to provide an up-to-date account of mast cell and basophil biology, together with an insight into the functional relevance of these cells in some tissue types.

  • Advances in Immunology

    • 1st Edition
    • Volume 54
    • English

  • Advances in Immunology

    • 1st Edition
    • Volume 53
    • English
    For 30 years, this esteemed serial has provided students and researchers with the latest information in Immunology. You can continue to rely on Advances in Immunology to provide you with critical reviews that examine subjects of vital importance to the field through summary and evaluation of current knowledge and research. The articles stress fundamental concepts, but also evaluate the experimental approaches. Each volume of Advances in Immunology contains a subject index as well as the contents of recent volumes. Each chapter includes references.Researche... and students in microbiology, genetics and immunocology will use this invaluable serial to stay updated on the latest advances for years to come.

  • Immunopharmacology of the Gastrointestinal System

    • 1st Edition
    • John L. Wallace
    • English
    Diseases of the digestive system have a higher morbidity rate than any other group of disorder. There is a growing body of evidence that the immune system participates in the pathogenesis of a wide range of these diseases, including peptic ulcer disease and the gastropathy induced by nonsteroidal anti-inflammatory drugs (NSAIDS). For these reasons, efforts to develop novel therapies for digestive diseases are increasingly focused on the immune system. This volume reviews the immunopharmacology of the gastrointestinal tract at four distinct levels: Immunomodulation at a cellular level Cellular targers for immunomodulating drugs Specific classes of inflammatory mediators Utility and mechanisms of action of glucocorticoids in the treatment of diseases of the gastrointestinal tract.

  • Advances in Immunology

    • 1st Edition
    • Volume 52
    • English

  • Advances in Immunology

    • 1st Edition
    • Volume 51
    • English
    For 30 years, this esteemed serial has provided students and researchers with the latest information in Immunology. You can continue to rely on Advances in Immunology to provide you with critical reviews that examine subjects of vital importance to the field through summary and evaluation of current knowledge and research.The articles stress fundamental concepts, but also evaluate the experimental approaches. Each volume of Advances in Immunology contains a subject index as well as the contents of recent volumes. Each chapter includes references.Researche... and students in microbiology, genetics and immunocology will use this invaluable serial to stay updated on the latest advances for years to come.

  • New Strategies in Fungal Disease

    Proceedings of an International Symposium, Brocket Hall, Hertfordshire, 21-24 September 1991
    • 1st Edition
    • John E. Bennett + 2 more
    • English

  • Encyclopedia of Immunology

    MATU-Z
    • 1st Edition
    • Ivan M. Roitt + 1 more
    • English

  • Encyclopedia of Immunology

    ERY-MATE
    • 1st Edition
    • Ivan M. Roitt + 1 more
    • English

  • Encyclopedia of Immunology

    A-EPS
    • 1st Edition
    • Ivan M. Roitt + 1 more
    • English

  • Molecular Design and Modeling: Concepts and Applications, Part B: Antibodies and Antigens, Nucleic Acids, Polysaccharides, and Drugs

    • 1st Edition
    • Volume 203
    • John N. Abelson + 1 more
    • English
    Computer-based design and modeling, computational approaches, and instrumental methods for elucidating molecular mechanisms of protein folding and ligand-acceptor interactions are included in Volumes 202 and 203, as are genetic and chemical methods for the production of functional molecules including antibodies and antigens, enzymes, receptors, nucleic acids and polysaccharides, and drugs.

  • Monoclonal Antibody and Immunosensor Technology

    The production and application of rodent and human monoclonal antibodies
    • 1st Edition
    • Volume 23
    • A.M. Campbell
    • English
    This highly practical book, and successor to Volume 13 in the Laboratory Techniques series, explores further and provides more comprehensive, autoritative information on the production of Mabs. Much new and illuminating material has been included covering the concepts behind the application of recombinant DNA technology and biosensor technology to monoclonal antibodies, and all the human Mab technology facilitated by PCR of antibody genes.Also included in this latest volume is a section focussing on other methods of obtaining B cell clones such as short-term culture and oncogene transformation and an interesting section on Mab patents.

  • Advances in Immunology

    • 1st Edition
    • Volume 50
    • English

  • Advances in Immunology

    • 1st Edition
    • Volume 49
    • English

  • Advances in Immunology

    • 1st Edition
    • Volume 48
    • English

  • Advances in Immunology

    • 1st Edition
    • Volume 47
    • English

  • Advances in Immunology

    • 1st Edition
    • Volume 46
    • English

  • Advances in Immunology

    • 1st Edition
    • Volume 45
    • English

  • A History of Immunology

    • 1st Edition
    • Arthur M. Silverstein
    • English
    This is a professional-level intellectual history of the development of immunology from about 1720 to about 1970. Beginning with the work and insights of the early immunologists in the 18th century, Silverstein traces the development of the major ideas which have formed immunology down to the maturation of the discipline in the decade following the Second World War. Emphasis is placed on the philosophic and sociologic climate of the scientific milieu in which immunology has developed, providing a background to the broad culture of the discipline.

  • Advances in Immunology

    • 1st Edition
    • Volume 44
    • English

  • Advances in Immunology

    • 1st Edition
    • Volume 43
    • English

  • Synthetic Polypeptides as Antigens

    • 1st Edition
    • Volume 19
    • J.P. Briand + 3 more
    • English
    Synthetic Polypeptides as Antigens is the first volume to give a comprehensive treatment under one cover of the various techniques used for synthesizing peptides by the solid phase approach, for coupling them to carrier molecules and analyzing their immunochemical activity by a variety of immunoassays. This book also describes methods for analyzing the antigenic structure of proteins and predicting the location of their antigenic sites. Recent advances in the detection of gene products with antipeptide antibodies, and the still controversial use of synthetic peptides as vaccines are also described. The book provides: - detailed descriptions of procedures - extensive bibliography - detailed analysis of the structural basis of antigenicity in proteins Synthetic Polypeptides as Antigens is intended for researchers and graduate students in molecular biology, protein structure, immunology, virology, and microbiology. Those using synthetic peptides as immunological probes will find this a most useful book, as will those wishing to overcome the difficulties of achieving antigenic mimicry by synthesis.

  • Advances in Immunology

    • 1st Edition
    • Volume 42
    • English

  • Immunodeficiency Disorders and Retroviruses

    Advances in Veterinary Science and Comparative Medicine, Vol. 32
    • 1st Edition
    • Kalman Perk
    • English
    Advances in Veterinary Science and Comparative Medicine, Volume 32: Immunodeficiency Disorders and Retroviruses provides an understanding of retrovirus morphogenesis, pathogenesis, and the processes of infection and transformation. This book discusses several issues in retrovirology and their importance in basic viral oncology, comparative medicine, veterinary medicine, and immunodeficiency syndromes. Organized into eight chapters, this volume begins with an overview of the replication cycle of retroviruses. This text then summarizes the factors responsible for the progression of the neoplastic condition through each stage in the ontogeny of lymphoid leukosis. Other chapters consider bovine leukemia virus, which is the etiological agent of a chronic lymphatic leukemia/lymphoma in sheep, cos, and goats. This book discusses as well the immunologic, virologic, and epidemiologic aspects of immunosuppressive disease caused by type D retroviruses. The final chapter deals with the involvement of DNA and RNA oncogenic viruses in animal and human neoplasias. This book is a valuable resource for scientists, oncologists, and clinicians.

  • Molecular Genetics of Immunoglobulin

    • 1st Edition
    • Volume 17
    • F. Calabi + 1 more
    • English
    Our understanding of the molecular genetics of immunoglobulins has been enormously advanced by the application of recombinant DNA technology. This new volume in the popular series New Comprehensive Biochemistry contains eight chapters that draw together reviews summarising the research into immunoglobulins and the arrangement, rearrangement and expression of their gene structure.Molecular Genetics of Immunoglobulin will be of particular importance to those working in the areas of genetics and molecular biology, immunology, and cell biology.

  • Advances in Immunology

    • 1st Edition
    • Volume 41
    • English

  • Advances in Immunology

    • 1st Edition
    • Volume 40
    • English

  • Immunochemical Techniques, Part J: Phagocytosis and Cell-Mediated Cytotoxicity

    • 1st Edition
    • Volume 132
    • Nathan P. Colowick + 1 more
    • English
    The critically acclaimed laboratory standard, Methods in Enzymology, is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. The series contains much material still relevant today - truly an essential publication for researchers in all fields of life sciences.

  • Advances in Immunology

    • 1st Edition
    • Volume 39
    • English

  • Immunochemical Techniques, Part I: Hybridoma Technology and Monoclonal Antibodies

    • 1st Edition
    • Volume 121
    • Nathan P. Colowick + 1 more
    • English
    The critically acclaimed laboratory standard, Methods in Enzymology, is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. The series contains much material still relevant today - truly an essential publication for researchers in all fields of life sciences.

  • Advances in Immunology

    • 1st Edition
    • Volume 38
    • English

  • Practice and Theory of Enzyme Immunoassays

    • 1st Edition
    • Volume 15
    • P. Tijssen
    • English
    Enzyme immunoassays have developed into a powerful assay technology, transcending several discipline boundaries, extensively applied as a tool in fields other than enzymology and immunology. This volume reflects the rapid progress in the applications of this technique, providing a basic understanding of these techniques and a practical guideline for the choice and experimental detail.

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