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A Comprehensive Guide to Toxicology in Nonclinical Drug Development

  • 3rd Edition
  • February 11, 2024
  • Ali S. Faqi
  • English
  • Hardback
    9 7 8 - 0 - 3 2 3 - 8 5 7 0 4 - 8
  • eBook
    9 7 8 - 0 - 3 2 3 - 9 8 4 6 2 - 1
A Comprehensive Guide to Toxicology in Nonclinical Drug Development, Third Edition is a valuable reference providing a complete understanding of all aspects of nonclinical toxicology in pharmaceutical research. This updated edition has been expanded and re-developed covering a wide-range of toxicological issues in small molecules and biologics. Topics include ADME in drug discovery, pharmacokinetics, toxicokinetics, formulations, and genetic toxicology testing. The book has been thoroughly updated throughout to reflect the latest scientific advances and includes new information on antiviral drugs, anti-diabetic drugs, immunotherapy, and a discussion on post-pandemic drug development challenges and opportunities. This is an essential and practical resource for all toxicologists involved in nonclinical testing in industry, academic, and regulatory settings.

Dysphagia

  • 1st Edition
  • February 9, 2024
  • Michael B. Ujiki + 1 more
  • English
  • Paperback
    9 7 8 - 0 - 4 4 3 - 1 9 0 6 3 - 6
  • eBook
    9 7 8 - 0 - 4 4 3 - 1 9 0 6 4 - 3
Dysphagia: A Clinical Guide will help practitioners and surgeons learn and understand how best to diagnose and treat dysphagia. It provides a complete picture of dysphagia through the experiences of leaders who cover the latest techniques and evidence-based outcomes in the field. Coverage includes recent advances in the diagnosis and treatment of the disease processes that cause dysphagia, gastric problems, and surgical intervention. The book includes the latest research and perspectives from both gastroenterologists and surgeons to enable clinicians to stay up-to-date on the most current and effective management strategies. Each chapter provides summary statements and recommendations based on recent literature.Recent discoveries regarding the diagnosis and management of dysphagia are exemplified by illustrations of both diagnostic methods and descriptions of interventional techniques. This an important reference for general surgeons, general practitioners, and ENT surgeons while also bringing new data dedicated specifically to gastroenterologists and foregut surgeons.

Inmunología básica

  • 7th Edition
  • February 9, 2024
  • Abul K. Abbas + 2 more
  • Spanish
  • eBook
    9 7 8 - 8 4 - 1 3 8 2 - 7 0 9 - 4
Nueva edición del texto derivado de la obra de referencia en Inmunología, "Abbas, Inmunología molecular y celular" en el que se presenta de una forma concisa y visual el nivel de información adecuado para el estudiante de Medicina o de Farmacia, Biotecnología o Ciencias Biomédicas que se enfrenta por primera vez a la asignatura, o en cuya Facultad, la asignatura haya perdido créditos. El valor añadido del título es que sigue la misma estructura, organización y filosofía del libro de referencia, y ha sido actualizado de forma paralela al libro de referencia. Otro de los puntos fuertes y diferenciales de la obra, es su gran riqueza y calidad iconográfica. Así mismo incorpora tablas prácticas, esquemas, puntos clave en negrita y preguntas de autoevaluación. En cuanto a las principales novedades cabe destacar la inclusión de contenidos nuevos y ampliados sobre pandemias, COVID-19 e inmunidad de rebaño, resistencia y susceptibilidad a COVID-19, vacunas de ARN y vacunas híbridas, inmunoterapia tumoral, respuestas inmunitarias innatas a los virus, mecanismos de tolerancia inmunológica e inmunoterapia para enfermedades autoinmunes, alérgicas y otras enfermedades inflamatorias y el cáncer. La nueva edición ofrece acceso a material adicional online en inglés a través de e-book+

Diabetes. Secretos

  • 1st Edition
  • February 8, 2024
  • Michael T. McDermott + 1 more
  • Spanish
  • eBook
    9 7 8 - 8 4 - 1 3 8 2 - 5 7 8 - 6
Nuevo título de la serie “Secretos” que presenta el popular formato de preguntas y respuestas, incluyendo también listas, tablas, perlas, ayudas para la memoria y un estilo fácil de leer, lo que hace que la consulta, la referencia y la revisión sean rápidas y  fáciles. Contiene todas las preguntas que el lector podría llegar a plantearse sobre cualquiera de los temas relacionados con la Diabetes y la lista de los 100 Secretos Top en Diabetes.  Cobertura actualizada de los temas relacionados con la diabetes (diabetes durante el embarazo; control de la diabetes en pacientes con cáncer; durante el ejercicio, los deportes y la competición; en pacientes hospitalizados, etc.). Acceso al contenido del e-book en inglés a través de la plataforma de e-book+

Huntington’s Disease

  • 1st Edition
  • February 7, 2024
  • X. William Yang + 2 more
  • English
  • Paperback
    9 7 8 - 0 - 3 2 3 - 9 5 6 7 2 - 7
  • eBook
    9 7 8 - 0 - 3 2 3 - 9 5 6 7 3 - 4
Huntington's disease (HD) is one of the most common dominantly inherited neurodegenerative disorders, characterized by a clinical triad of movement disorder, cognitive deficits, and psychiatric symptoms. Huntington’s Disease: Pathogenic Mechanisms and Implications for Therapeutics reviews the most up-do-date content on HD pathogenic mechanisms and cutting-edge thinking on therapeutic strategies for HD. Chapters explore areas that include the clinical features and genetic studies of HD, the cellular and molecular biology of normal huntingtin, a range of HD models, the diverse pathogenic mechanisms linked to mutant huntingtin, new approaches to HD pathogenesis, as well as emerging preclinical therapeutic approaches and clinical programs in the field.

The Neuroscience of Bach’s Music

  • 1st Edition
  • February 7, 2024
  • Eric Altschuler
  • English
  • Paperback
    9 7 8 - 0 - 4 4 3 - 1 3 5 1 9 - 4
  • eBook
    9 7 8 - 0 - 4 4 3 - 1 3 5 2 0 - 0
The Neuroscience of Bach’s Music: Perception, Action, and Cognition Effects on the Brain is a comprehensive study of Johann Sebastian Bach’s music through the lens of neuroscience, examining neuroscience using Bach’s music as a tool. This book synthesizes cognitive neuroscience, music theory, and musicology to provide insights into human cognition and perception. It also explores how a neuroscience perspective can improve listening and performing experiences for Bach’s music. Written by a physician-neuroscientist recognized for scholarly articles on Bach’s music, this book uses specific examples to explore neuroscience across Bach’s compositions.The book is structured to discuss the brain’s action, perception, and cognition as connected to specific Bach concertos, tones, notes, and performances. Two guest contributors provide insight into exact mathematical, or topologic, and music theoretic aspects of Bach’s music with implications for cognitive neuroscience.

Many-Sorted Algebras for Deep Learning and Quantum Technology

  • 1st Edition
  • February 3, 2024
  • Charles R. Giardina
  • English
  • Paperback
    9 7 8 - 0 - 4 4 3 - 1 3 6 9 7 - 9
  • eBook
    9 7 8 - 0 - 4 4 3 - 1 3 6 9 8 - 6
Many-Sorted Algebras for Deep Learning and Quantum Technology presents a precise and rigorousdescription of basic concepts in quantum technologies and how they relate to deep learning and quantum theory. Current merging of quantum theory and deep learning techniques provides the need for a source that gives readers insights into the algebraic underpinnings of these disciplines. Although analytical, topological, probabilistic, as well as geometrical concepts are employed in many of these areas, algebra exhibits the principal thread; hence, this thread is exposed using many-sorted algebras. This book includes hundreds of well-designed examples that illustrate the intriguing concepts in quantum systems. Along with these examples are numerous visual displays. In particular, the polyadic graph shows the types or sorts of objects used in quantum or deep learning. It also illustrates all the inter and intra-sort operations needed in describing algebras. In brief, it provides the closure conditions. Throughout the book, all laws or equational identities needed in specifying an algebraic structure are precisely described.

Migraine Management

  • 1st Edition
  • Volume 199
  • February 1, 2024
  • Jerry W. Swanson + 1 more
  • English
  • Hardback
    9 7 8 - 0 - 1 2 - 8 2 3 3 5 7 - 3
  • eBook
    9 7 8 - 0 - 1 2 - 8 2 3 4 8 1 - 5
Migraine Management, Volume 199 covers the effective treatment of migraines, including different subtypes of migraines in different patient populations. The classification and diagnostic criteria of common and uncommon subtypes of migraine is explored in detail, including childhood variants. An in-depth analysis of the pharmacology of acute and prophylactic agents is presented, along with an evidence-based review of pharmacologic management. This includes recently developed CGRP monoclonal antibodies and non-peptide small molecule CGRP antagonists. Advances in neuromodulatory treatments, both noninvasive and implantable are also critically reviewed.Finally, specific treatment-related issues in pregnancy and lactation and childhood as well as the elderly are covered. Issues related to the diagnosis and management of vestibular migraine and the co-morbid disorder of persistent postural-perceptual dizziness are also explored.

Translational Approaches to Unravelling Non-Motor Symptoms of Parkinson’s disease

  • 1st Edition
  • Volume 174
  • February 1, 2024
  • Mahmoud Iravani + 1 more
  • English
  • Hardback
    9 7 8 - 0 - 3 2 3 - 9 9 1 8 3 - 4
  • eBook
    9 7 8 - 0 - 3 2 3 - 9 9 1 8 4 - 1
Translational Approaches to Non-Motor Symptoms of Neurodegenerative Diseases, Volume 173 in the International Review on Neurobiology series, highlights new advances in the field with this new volume presenting interesting chapters on topics such as A general clinical overview of the non-motor symptoms, Stress/fatigue/cognitive decline Sleep/autonomic failure, A general clinical overview of the non-motor symptoms – psychiatric symptoms, Psychosis, Cognitive Decline, Non-clinical Aspect of non-motor symptoms: Animal Models, Assessment and treatment of cognitive decline in rodent and primate models, Pain in PD models, Affective disorders in PD models, Sleep and circadian dysregulation and EEG disruption in rodent models, and much more.

Advances in Agronomy

  • 1st Edition
  • Volume 184
  • February 1, 2024
  • Donald L. Sparks
  • English
  • Hardback
    9 7 8 - 0 - 4 4 3 - 2 9 5 2 4 - 9
  • eBook
    9 7 8 - 0 - 4 4 3 - 2 9 5 2 5 - 6
Advances in Agronomy, Volume 184, the latest release in this leading reference on agronomy, contains a variety of updates and highlights new advances in the field. Each chapter is written by an international board of authors, with this new release including new chapters on The Role of Artificial Intelligence in Crop Improvement, Dealing with the Impact of Climate Change-Induced Drought on the Management of Soil, Challenges and Emerging Opportunities of Weed Management in Organic Agriculture, The Broadbalk Wheat Experiment, Rothamsted, UK: Crop Yields and Soil Changes During the Last 50 Years.

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