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Books in Life sciences

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    • Genomic and Personalized Medicine

      • 2nd Edition
      • October 30, 2012
      • Geoffrey S. Ginsburg + 1 more
      • English
      • eBook
        9 7 8 0 1 2 3 8 2 2 2 8 4
      Genomic and Personalized Medicine, Second Edition — winner of a 2013 Highly Commended BMA Medical Book Award for Medicine — is a major discussion of the structure, history, and applications of the field, as it emerges from the campus and lab into clinical action. As with the first edition, leading experts review the development of the new science, the current opportunities for genome-based analysis in healthcare, and the potential of genomic medicine in future healthcare. The inclusion of the latest information on diagnostic testing, population screening, disease susceptability, and pharmacogenomics makes this work an ideal companion for the many stakeholders of genomic and personalized medicine. With advancing knowledge of the genome across and outside protein-coding regions of DNA, new comprehension of genomic variation and frequencies across populations, the elucidation of advanced strategic approaches to genomic study, and above all in the elaboration of next-generation sequencing, genomic medicine has begun to achieve the much-vaunted transformative health outcomes of the Human Genome Project, almost a decade after its official completion in April 2003.

    • Biology of Memory

      • 1st Edition
      • December 2, 2012
      • Karl Pribram
      • English
      • Paperback
        9 7 8 0 1 2 4 1 2 2 3 7 6
      • eBook
        9 7 8 0 3 2 3 1 4 1 5 0 5
      Biology of Memory investigates the biological basis of memory and covers topics ranging from short- and long-term post-perceptual memory to memory storage processes, memory microstructures, chemical transfer, and neuronal plasticity. The activity of neuronal networks in the thalamus of the monkey is also examined, along with integrative functions of the thalamocortical visual system of the cat. Comprised of 20 chapters, this book begins with an overview of the mechanisms that inhibit or interfere with short- and long-term memory, followed by a discussion on different retrieval mechanisms for short- and long-term memory. The reader is then introduced to the role of short- and long-term memory in the formation, retention, and utilization of associations, together with the link between memory and the medial temporal regions of the brain. Subsequent chapters focus on anatomical and chemical changes in the brain during primary learning; cellular models of learning and cellular mechanisms of plasticity in Aplysia; trace phenomena in single neurons of hippocampus and mammiliary bodies; and plasticity in single units in the mammalian brain. The book concludes with a description of Occam (Omnium-Gatherum Core Content Addressable Memory), a computer program for a content addressable memory in the central nervous system. This monograph will be useful to biologists, behavioral psychologists, neuropsychologists, neurophysiologists, biophysicists, and biochemists as well as computer scientists and mathematicians.

    • Advances in Genetics

      • 1st Edition
      • Volume 79
      • October 2, 2012
      • English
      • Hardback
        9 7 8 0 1 2 3 9 4 3 9 5 8
      • eBook
        9 7 8 0 1 2 3 9 8 2 8 4 1
      The field of genetics is rapidly evolving and new medical breakthroughs are occuring as a result of advances in knowledge of genetics. This series continually publishes imporatnt reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines.

    • Principles and Practice of Clinical Research

      • 3rd Edition
      • May 31, 2012
      • John I. Gallin + 1 more
      • English
      • Hardback
        9 7 8 0 1 2 3 8 2 1 6 7 6
      • eBook
        9 7 8 0 1 2 3 8 2 1 6 8 3
      The third edition of this innovative work again provides a unique perspective on the clinical discovery process by providing input from experts within the NIH on the principles and practice of clinical research. Molecular medicine, genomics, and proteomics have opened vast opportunities for translation of basic science observations to the bedside through clinical research. As an introductory reference it gives clinical investigators in all fields an awareness of the tools required to ensure research protocols are well designed and comply with the rigorous regulatory requirements necessary to maximize the safety of research subjects. Complete with sections on the history of clinical research and ethics, copious figures and charts, and sample documents it serves as an excellent companion text for any course on clinical research and as a must-have reference for seasoned researchers.

    • Structure and Functioning of Seminatural Meadows

      • 1st Edition
      • Volume 27
      • December 2, 2012
      • M. Rychnovská
      • English
      • Paperback
        9 7 8 0 4 4 4 5 6 6 2 3 2
      • eBook
        9 7 8 0 4 4 4 5 9 9 6 4 3
      Twelve years' analysis of natural grassland and experimentally managed meadows have produced this unique set of data on the structures and physiological functions of primary producers, consumers and decomposers. Obtained during the 1973-1985 Ecosystem Study on Highland Meadows in Czechoslovakia, such original information is rare in scientific literature. The aim of the study was to define the functioning of these grasslands and their changes under different impact of man, and to examine the ecological function of those ecosystems in the intensively managed catchment area. Hence, this book contains deep analyses of soil microorganisms, their functions in decomposition and soil forming processes - leading to the evaluation of the whole carbon cycle - as well as dealing with nitrogen pathways in the experimental plots - resulting in precise determination of the full nitrogen cycle. Procedures used in practical agriculture, such as cutting, fertilization and renovation, have also been applied, producing evaluations from both ecological and economical view-points.The book's integrated ecosystem approach to grasslands, its deep professional analyses in each section, along with the synthesis on each particular level and across all levels, renders it an invaluable, informative text, comprising extensive figures and tables and a substantial bibliography of world-wide sources.

    • Plant Production and Management under Drought Conditions

      • 1st Edition
      • Volume 12
      • December 2, 2012
      • J.F. Stone + 1 more
      • English
      • eBook
        9 7 8 0 4 4 4 6 0 0 0 4 2
      For some years, workers have been investigating the possibilities of integrating knowledge from soil and atmospheric sciences, crop physiology, and genetics in order to model crop response to water stress and breed plants for drought resistance.This book turns the theory into practice. Information, gathered from recent symposia and research journals, have been built upon by the authors. Up-to-date practices are cited, new practices devised, and approaches for scientific applications specified. The authors have devised numerous examples and applications for their approaches. Attention has been given to making these approaches credible in the light of economic and energy limitations. Because application of such practice over a wide area requires wide-areal sensing and measurement, recent advances in remote sensing for these purposes are outlined with methodology for practical application.The book will be of interest to a wide readership including crop managers and producers, soil scientists, agricultural micrometeorologists, plant breeders, water managers and stress physiologists.

    • Formation and Fate of Cell Organelles

      • 1st Edition
      • December 2, 2012
      • Katherine Brehme Warren
      • English
      • Paperback
        9 7 8 0 1 2 4 3 1 6 2 0 1
      • eBook
        9 7 8 0 3 2 3 1 5 4 2 3 9
      Formation and Fate of Cell Organelles presents the proceedings of the symposia of the International Society for Cell Biology. Contributors offer their views on various aspects of the problem of spontaneous assembly, particularly how cellular structures arise from the component molecules. They consider whether all cellular organelles and cells, themselves, can arise by spontaneous assembly, or whether some regulation is involved and the mechanisms underlying such regulation. This book is organized into 16 chapters and begins with an overview of self-assembling systems of equal units and how they can be built efficiently, focusing on quasi-equivalence and helical waves on bacterial flagella. This text also discusses the differences in free energy of the molecules in their various states and the use of the free energy of a particular array of molecules to predict what arrays will form. The reader is introduced to intermolecular forces and how macromolecular lipid structures assemble in vitro, along with developments in the resolution of the spindle fibers of the mitotic apparatus. The book also looks into the mechanisms underlying the disposition of microtubules in plant cells during interphase and mitosis, and then concludes with a chapter on some studies dealing with cytoplasmic genes and cytoplasmic inheritance. This book is a valuable source of information for scientists and researchers engaged in fields ranging from cytology and biology to chemistry, pathology, and biophysics.

    • Germfree Life And Gnotobiology

      • 1st Edition
      • December 2, 2012
      • Thomas Luckey
      • English
      • Paperback
        9 7 8 0 1 2 4 1 4 3 9 2 0
      • eBook
        9 7 8 0 3 2 3 1 4 7 1 0 1
      Germfree Life and Gnotobiology focuses on the theory and general aspects of germfree research and gnotobiology. Using a phylogenetic approach, the book provides a summary of germfree work in all phyla, from bacteria and viruses to protozoans and invertebrates. It characterizes germfree vertebrates based on data on morphology, biochemistry, nutrition, serology, and physiology. This book is organized into six chapters and begins with an overview of germfree life and gnotobiology, including biological isolation as the basis of germfree life, germfree conditions in nature, and the biological significance of germfree research. A section is devoted to nomenclature and terminology. The chapters on methods and nutrition are sufficiently detailed to serve as guides for experimental work. The book concludes with a chapter on exploratory research that explores the inoculation of germfree animals with known kinds of microorganisms. Terms have been introduced to describe concepts and provide precise communication. This book is a valuable source of information for scientists and researchers engaged in germfree research as a biological tool.

    • Insecticide Mode of Action

      • 1st Edition
      • December 2, 2012
      • Joel R. Coats
      • English
      • Paperback
        9 7 8 0 1 2 4 1 2 0 8 6 0
      • eBook
        9 7 8 0 3 2 3 1 4 0 5 1 5
      Insecticide Mode of Action presents significant research on the biological activity of insecticides. The book is organized into three sections encompassing 13 chapters that summarize three major groups of insecticides, including neurotoxic, formamidine, and developmental insecticides. The first section of the book presents studies on groups of conventional neurotoxic insecticides: chlorinated hydrocarbons, pyrethroids, carbamates, and organophosphorus chemicals. This text discusses their structure, poisoning property, structure-activity relationships, and stereoselectivity. The subsequent section discusses the biochemical, biological, and neurotoxic actions of formamidines, a group of pesticides that exhibit an unusual spectrum of activity. Several modes of action of pharmacological significance as well as some important behavioral effects are included in this section. The third section addresses groups of insecticides that affect insect growth and development. Such chemicals typically demonstrate marked selectivity and represent more sophisticated strategies in the chemical control of insect pests. This book is of value to researchers, teachers, and regulatory personnel concerned with the biological activity of insecticides.

    • The Blue-Green Algae

      • 1st Edition
      • December 2, 2012
      • G Fogg
      • English
      • Paperback
        9 7 8 0 1 2 4 1 4 6 0 4 4
      • eBook
        9 7 8 0 3 2 3 1 4 9 2 3 5
      The Blue-Green Algae attempts to assemble a unified picture of blue-green algae as living organisms. It describes the organism’s general features of form and structure, cellular organization, cell biology, gas vacuoles, and movements. The book addresses the culture, nutrition, growth, photosynthesis, chemosynthesis, heterotrophy, respiration, nitrogen metabolism, differentiation, reproduction, and life cycles of the blue-green algae. The organisms’ freshwater and terrestrial ecology, pathogens, symbiosis, evolution, and phylogeny are also explained. These organisms form a substantial fraction of the biomass in several important types of habitat. Consequently, it is desirable to understand their activities if natural resources are to be conserved and used to best advantage. This book will be useful to students and research workers in this field of interest.

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