Books in Life sciences

Fate of Pesticides in Large Animals

1st Edition
December 2, 2012
G. Wayne Ivie
English
eBook
9 7 8 0 3 2 3 1 5 7 7 8 0

Fate of Pesticides in Large Animals covers the proceedings of the 1976 Fate of Pesticides in Large Animals symposium. The symposium is held at the Centennial Meeting of American Chemical Society and sponsored by the Pesticide Chemistry Division of the ACS. It aims to focus on the fate of pesticides in large animals and to assemble a thesis on the subject covering its theoretical and practical significance. In this book, large animals are particularly considered, because they often metabolize chemicals differently than small laboratory rodents. These differences may prove a basis for the development of concepts pertinent to the phenomenon of selective toxicity. This book is divided into three sections encompassing 14 chapters. The first section delineates the rationale of the symposium and presents topics applicable to all facets of large animal metabolism. The second section focuses on comparative metabolism of selected groups of pesticides, including phenoxy herbicides, insect growth regulators, fungicides, and halogenated hydrocarbons. The third section deals with specific compounds and/or specific large animal species. It includes mirex, chlordane, dieldrin, and polychlorinated biphenyls; p,p'-DDT and p,p'-DDE in pig; phenyl N,N'-dimethylphospho... croneton; and Vacor rodenticide. This book is an invaluable resource for chemists, biochemists, researchers, and toxicologists.

G Proteins

2nd Edition
December 2, 2012
Ravi Iyengar
English
eBook
9 7 8 0 3 2 3 1 6 1 4 0 4

G Proteins is an introduction to one class of systems used for signal transduction at the cell surface, with emphasis on its utilization of a heterotrimeric GTP-binding protein (G protein) to mediate the transfer of information across the plasma membrane, from receptor to effector. Topics covered include the structure and function of G-protein α chains, ADP-ribosylation factor of adenylyl cyclase, and G protein-mediated effects on ionic channels. The organization of genes coding for G-protein α subunits in higher and lower eukaryotes is also discussed. This book is comprised of 25 chapters and begins with an overview of G proteins and their role in signal transduction. The next section focuses on the structural aspects of G proteins, with substantial emphasis on ? subunits. The mechanism of G protein coupling to effector systems is also considered, using the hormone-regulated adenylyl cyclase and light-regulated cGMP phosphodiesterase as models. Subsequent chapters deal with receptors and effector systems, together with the cellular functions that may be regulated by heterotrimeric G proteins. In particular, the interaction of insulin with G proteins is discussed, along with receptor regulation of cell calcium and phospholipase C activity. This monograph should be useful to students and scientists interested in G proteins.

Methods of Hormone Radioimmunoassay

2nd Edition
December 2, 2012
Bernard Jaffe
English
eBook
9 7 8 0 3 2 3 1 6 1 2 6 8

Methods of Hormone Radioimmunoassay, Second Edition is a compilation of radioimmunoassay techniques for the quantification of hormones. Various kinds of hormones are considered, namely: intracellular messengers; hypothalamic and pineal hormones; pituitary hormones; thyroid and parathyroid hormones; renal hormones; hormones of the gastrointestinal tract; pancreatic hormones; steroid hormones; uterine and placental hormones; vasoactive peptide hormones; and growth factors. The corresponding method of radioimmunoassay for each hormone is described. This book is comprised of 49 chapters and begins with a discussion on the radioimmunoassay of cyclic adenosine-3',5-monop... (cAMP) and cyclic guanosine-3,5'-monop... (cGMP), together with problems related to measuring both compounds. The reader is then introduced to prostaglandins and prostaglandin metabolites, thyrotropin-releasin... hormone, and gonadotropin-releasi... hormone. Pituitaty gonadotropins, prolactin, and thyrotropin are also discussed. The remaining chapters deal with hormones of the gastrointestinal tract, pancreatic hormones, steroid hormones, and growth factors. This monograph is intended for both clinicians and investigators interested in methods of hormone radioimmunoassay.

Insect Sex Pheromones

1st Edition
December 2, 2012
Martin Jacobson
English
eBook
9 7 8 0 3 2 3 1 5 2 4 1 9

Insect Sex Pheromones is a revised and expanded edition of the book ""Insect Sex Attractants"" and covers greater discoveries in the field of sex pheromones. It is discovered that many sex pheromones are sexually excitatory rather than attractive. This discovery prompted the substitution of the more accurate and encompassing term ""pheromones"" for the term ""attractants"" in the title of this edition. Composed of 13 chapters, this book has chapters that cover the occurrence in female and production in male of sex pheromones in various insect species. The insect orders considered include Acarina, Orthoptera, Hemiptera, Homoptera, Diptera, Isoptera, Neuroptera, Siphonaptera, Coleoptera, Hymenoptera, Lepidoptera, Trichoptera, and Mecoptera. The following chapter discusses pheromones produced by one sex that lure to assemble for mating. This book goes on discussing the anatomy and physiology of scent glands of male and female insects; the attractant perception mechanism; and the behavioral and electrophysiological responses of insects to sex pheromones. Other chapters are devoted to the influence of several factors on the presence of chemical sex attraction or excitation in any insect. The concluding chapters deal with the collection, isolation, identification, synthesis, and analysis of sex pheromones. This book will greatly appeal to research and economic entomologists, insect physiologists, chemists, and ecologists.

Bioregulators of Reproduction

1st Edition
December 2, 2012
David Jagiello
English
eBook
9 7 8 0 3 2 3 1 4 0 9 9 7

Bioregulators of Reproduction focuses on the biological regulators of reproductive processes. Discussions are grouped based on sex differentiation and determination, germ cell reproduction, gonadotropins, nonsteroidal gonadal hormones, in vitro fertilization, and post-fertilization. This text is organized into six sections and comprised of 31 chapters, beginning with a discussion on the most important regulatory mechanisms underlying reproduction. The reader is then methodically introduced to the role of the H-Y antigen in primary sex determination, H-Y antigenic determinants of human testis-organizing protein, and how H-Y antibodies confuse antigenic complexes with unaltered self or allo-MHC antigens. The cellular mechanisms of sexual differentiation of the brain, meiosis in female mammals, and interspecies comparisons in molecular reproductive biology are also considered. Other chapters explore the role of haplodins in the ovarian and extraovarian control of meiosis; the link between nucleoprotein transitions and chromatin changes during rat spermatogenesis; and gonadotropin secretion in primates. This book will be of interest to students and scientists in fields ranging from biology and neuroendocrinology to genetics, biochemistry, biophysics, pathology, and zoology.

Enzymatic Basis of Detoxication Volume 1

1st Edition
December 2, 2012
William B. Jakoby
English
eBook
9 7 8 0 3 2 3 1 3 7 9 8 0

Enzymatic Basis of Detoxication, Volume I focuses on the catalytic mechanisms and physiological expression of the enzymes that are involved in the detoxication of foreign compounds. The book explores foreign compound metabolism at the level of what specific enzymes can do. This book is organized into three sections and comprised of 17 chapters. The discussion begins with an overview of detoxication and covers both catalytic and non-catalytic removal of foreign substances, along with the general properties of the enzymes that are active in detoxication. The reader is then introduced to the physiological aspects of detoxication, paying particular attention to the kinetic aspects of metabolism and elimination of foreign compounds in animals, human genetic variation in detoxication enzymes, and how such enzymes are induced. The next section focuses on mixed function oxygenase systems and includes chapters on cytochrome P-450 and the detoxication reactions it catalyzes. The book also considers other oxidation-reduction systems, with reference to alcohol dehydrogenase, aldehyde reductase, aldehyde oxidizing enzymes, ketone reductases, xanthine oxidase and aldehyde oxidase, glutathione peroxidase, and superoxide dismutases. The final chapter is devoted to monoamine oxidase, its properties, substrate specificity, inhibitors, kinetics and mechanism, and multiple forms. Pharmacologists, toxicologists, and biochemists will find this book extremely helpful.

Enzymatic Basis of Detoxication Volume 2

1st Edition
December 2, 2012
William B. Jakoby
English
eBook
9 7 8 0 3 2 3 1 3 8 2 0 8

Enzymatic Basis of Detoxication, Volume II, reviews the state of knowledge on foreign compound metabolism at the level of what specific enzymes can do. The book attempts to provide a holistic view of the information gleaned from work with specific, purified enzymes encompassing as many mammalian sources as have been studied. The book is organized into two parts. Part I on conjugation reactions and related systems includes studies on the properties of glucuronide formation; the physiological function, assay, and purificatgion of function of bilirubin-glucuronos... glucuronosyltransfer... the roles of N- and O-methylation reactions and glutathione transferases in detoxication; and amino acid conjugation. Part II presents studies on hydrolytic systems, covering the role of epoxide hydrolase, carboxylesterases, and amidases in detoxication and the regulatory effects of these enzymes. This book provides pharmacologists and toxicologists with the biochemical view of detoxication, and biochemists with the corresponding pharmacological and toxicological aspects.

Metabolic Basis of Detoxication

1st Edition
December 2, 2012
William B. Jakoby
English
eBook
9 7 8 0 3 2 3 1 3 7 9 9 7

Metabolic Basis of Detoxication: Metabolism of Functional Groups considers the possible fates of the relatively circumscribed number of functional groups that xenobiotics bear. An understanding of the possible reactions, and the chemical and biological factors influencing them, will contribute to the overall predictability of the fate of "real" molecules. This approach attempts to knit together the understanding of metabolic pathways with that of the enzymes that catalyze the specific steps. The book contains 18 chapters and begins with a discussion of the biological oxidation of carbon atoms. This is followed by separate chapters on the metabolism of halogenated aliphatic hydrocarbons, aryl halides, heterocyclic rings, alcohols, aldehydes, and ketones. Subsequent chapters cover oxidative processes such as metabolic dealkylations and biological oxidation at nitrogen centers; the reduction of nitro and azo compounds and tertiary amine N-oxides; the oxidation, alkylation, acylation, and glycosylation of mercaptans; epoxide metabolism; and conjugation of phenols. The book aims to inform and interest the pharmacologist and toxicologist concerning the biochemical aspects and to orient the biochemist to the pharmacological insights required in dealing with the metabolism of xenobiotics.

Cognitive Processes of Nonhuman Primates

1st Edition
December 2, 2012
Leonard Jarrard
English
eBook
9 7 8 0 3 2 3 1 6 0 2 9 2

Cognitive Processes of Nonhuman Primates covers the proceedings of the Sixth Annual Symposium on Cognition, held at Carnegie-Mellon University on March 26 and 27, 1970. The symposium focuses on the status of research dealing with complex behavioral processes of monkeys and apes, providing insights into complex behavior of human and nonhuman primates. Composed of nine chapters, this book covers short-term memory in the monkey and how this relates to human short-term memory. A chapter compares memory deficits that accompany brain dysfunction in animals and man. The following chapters discuss the analysis of the development of language in a young female chimpanzee and the cogent analysis of interaction between habits and concepts in the monkey. The effects of early deprived and enriched environment on later complex behavioral processes of monkeys are also explained. Moreover, this book goes on examining the nonhuman brain capacities and the continuities with human behavior. It also discusses important research comparing delayed-response performance of several species of monkeys, age groups of children, and adults. The book will be of great help to scientists, researchers, teachers, and students who are interested in cognition processes and memory of nonhuman primates and humans.

Primate Locomotion

1st Edition
December 2, 2012
Farish A. Jr. Jenkins
English
eBook
9 7 8 0 3 2 3 1 5 2 0 2 0

Primate Locomotion discusses researches on the concept of primate locomotion. It is organized into 11 chapters that cover biomechanical principles, which are the foundation of understanding of locomotor adaptations. This book first gives an introduction to parallels and analogs between mammalian and mechanical structures. It then describes the mechanisms of arboreal mammal locomotion, as well as the behavioral observations and locomotor patterns of tree shrew. The jumping locomotion of Galago alleni and the role of wrist specialization in the locomotor evolution of the Hominoidea are also explained. The subsequent chapter discusses the relationship between the mechanical features of the scapula and shoulder region and the characteristics of locomotor behavior. A chapter also discusses the adaptive nature of postural behavior in quadrupedal primates, represented by the New and Old World monkeys. Moreover, this book examines the morphological differences between living Insectivora, Carnivora, Primates, and the relevant known fossils of Cretaceous and Early Tertiary Eutheria. This is to evaluate the origins, evolution, and function of the Tarsus. Another chapter presents a functional analysis of most of the foot skeleton, primarily, the Lemuriformes. The concluding chapters deal with electromyographical studies on gorillas; the mechanics of knuckle-walking; the theories on hominoid phylogeny; and the locomotor adaptations in prosimians. This text is intended not only for researchers dealing with primate locomotion, but equally for students and others who share an interest in mammals and locomotor adaptations.

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