Life sciences print books and ebooks | Elsevier

Production of Biologicals from Animal Cells in Culture

1st Edition
September 24, 2013
R. E. Spier + 2 more
English
Hardback
9 7 8 0 7 5 0 6 1 1 0 3 9
eBook
9 7 8 1 4 8 3 1 6 5 1 5 8

Production of Biologicals from Animal Cells in Culture reviews the state of the art in animal cell biotechnology, with emphasis on the sequence of events that occur when generating a biological from animal cells in culture. Methods that enable adjustment of nutrient feed streams into perfusion bioreactors so as to increase productivity are described. A number of issues are also addressed, such as the usefulness of the fingerprint method for cell characterization. Comprised of 135 chapters, this book begins with an overview of the problems and benefits of animal cell culture, followed by a discussion on the isolation of immortal murine macrophage cell lines. The reader is systematically introduced to the use of DNA fingerprinting to characterize cell banks; immortalization of cells with oncogenes; lipid metabolism of animal cells in culture; and energetics of glutaminolysis. Subsequent chapters explore serum-free and protein-free media; the physiology of animal cells; gene expression in animal cell systems; and animal cell bioreactors. The monitoring and assay of animal cell parameters are also considered, along with downstream processing and regulatory issues. This monograph will be of interest to students, practitioners, and investigators in the fields of microbiology and biotechnology.

Forensic Toxicology

1st Edition
October 22, 2013
Bryan Ballantyne
English
Paperback
9 7 8 0 7 2 3 6 0 3 5 6 6
eBook
9 7 8 1 4 8 3 1 8 3 3 7 4

Forensic Toxicology presents the legal and medical aspects of the detrimental effects of chemicals on humans. This book discusses the immediate and long-term consequences of accident or deliberate poisoning, the detection of such poisoning, and the interpretation of the possible importance of demonstrating exogenous substances in biological fluids and tissues. Organized into 14 chapters, this compilation of papers begins with an overview of the fundamental procedure and interpretation in forensic toxicology. This text then examines the ways in which enzymes may be used in the analysis of drugs. Other chapters consider the equipment and reagents required in the rapid tests for drugs in urine. This book presents as well barbiturate poisoning from the viewpoint of the forensic pathologist performing the post mortem over the cause of death. The final chapter deals with further advances in forensic toxicology. This book is a valuable resource for general practitioners, forensic toxicologists, forensic pathologists, and police officers.

Methods in Behavioral Pharmacology

1st Edition
Volume 10
October 22, 2013
F. van Haaren
English
Paperback
9 7 8 0 4 4 4 8 1 4 4 5 6
eBook
9 7 8 1 4 8 3 2 9 0 2 4 9

Methods in Behavioral Pharmacology is unique in offering a complete description and critical evaluation of most, if not all, methods available to study the effects of drugs on behavior. It stands apart in that it is not limited to the analysis of a particular class of pharmacological agents in a limited number of paradigms. Methods in Behavioral Pharmacology covers all paradigms without reference to specific pharmacological compounds.The book provides a comprehensive overview of the methodology used to study the behavioral effects of legal and illegal drugs. It also provides an in-depth presentation of dependent variables, their quantification and a critical evaluation of their advantages and disadvantages. An excellent work, contributed to by well-known experts in the different fields of behavioral pharmacology.

Practical Genetic Counselling

3rd Edition
October 22, 2013
Peter S. Harper
English
eBook
9 7 8 1 4 8 3 1 8 3 6 6 4

Practical Genetic Counselling, Third Edition presents the progress in the field of medical genetics. This book covers the broad area of congenital malformation syndromes and dysmorphology. Organized into three parts encompassing 26 chapters, this edition begins with an overview of the main steps in the process of genetic counselling. This text then examines how a Mendelian inheritance may be established by a combination of clinical diagnosis. Other chapters consider the risks in specific groups of chromosomal disorders. This book discusses as well the molecular genetic approaches, which are making an impact in the treatment of major disorders by providing pure and comparatively inexpensive gene products. The final chapter deals with how genetic counselling is contributing to reducing the general burden of genetic disease in the population. This book is a valuable resource for geneticists, neurologists, clinicians, pediatricians, and obstetricians. Readers who are interested to know about genetic disorders will also find this book useful.

Stability and Stabilization of Enzymes

1st Edition
Volume 47
October 22, 2013
W.J.J. van den Tweel + 2 more
English
eBook
9 7 8 1 4 8 3 2 9 1 3 3 8

These proceedings contain most of the oral presentations and posters of the international symposium on Stability and Stabilization of Enzymes held in Maastricht in November 1992. They provide a comprehensive overview of the state-of-the-art in this field.The possible applications of enzymes are enormous. Years of development have seen many enzymes brought onto the market, but they are still expensive to use. Therefore, their efficient application is a prerequisite for common usage. One of the main factors for this efficiency is the stability of the enzymes. The topics thus ranged from the extensive fundamental thermodynamic knowledge gathered in academic research to the practical applied knowledge built up in industry during the time that enzymes have been produced commercially.The subject Stability and Stabilization of Enzymes was discussed from various points of view, as was reflected in the themes of the symposium sessions. In the session on Fundamentals of Enzyme Stabilisation the thermodynamic background of the phenomenon was highlighted. In yet another session, the recently developed analytical tools to measure enzyme stability and stabilisation were discussed. Further sessions comprised the physical, chemical and biological ways to obtain enzyme stabilisation and finally, the industrial practice of enzyme stabilisation was treated by representatives of the world's most important enzyme producers. The book will be of interest to researchers in universities and industry in the fields of biochemistry, enzymology and biotechnology.

Advances in Endogenous and Exogenous Opioids

1st Edition
October 22, 2013
Hiroshi Takagi + 1 more
English
Hardback
9 7 8 0 4 4 4 8 0 4 0 2 0
Paperback
9 7 8 1 4 8 3 1 2 9 1 7 4
eBook
9 7 8 1 4 8 3 1 6 1 5 9 4

Advances in Endogenous and Exogenous Opioids contains the proceedings of the International Narcotic Research Conference (Satellite Symposium of the 8th International Congress of Pharmacology) held in Kyoto, Japan on July 26-30, 1981. The conference provided a forum for discussing advances that have been made in the understanding of endogenous and exogenous opioids and tackled a wide array of topics ranging from novel opiate binding sites selective for benzomorphan drugs to the purification of opioid receptors and sequellae of receptor binding. Comprised of 156 chapters, this book begins with an analysis of the interaction of opioid peptides and alkaloid opiates with mu-, delta-, and kappa-binding sites. The reader is then systematically introduced to biochemical evidence for kappa and sigma opiate receptors; the action of morphine and oxymorphone as partial agonists on the field-stimulated rat vas deferens; mechanisms of supersensitivity in the enkephalinergic system; and properties of the solubilized opiate receptor from human placenta. Subsequent chapters explore the biosynthesis of opioid peptides as well as their localization, release, and degradation; physiological and pharmacological actions of opioids; and the use of analgesia in acupuncture. Results of behavioral and clinical studies of endogenous and exogenous opioids are also presented, and the structure-activity relationships of opioids are examined. This monograph will be of interest to students, practitioners, and researchers in the fields of psychiatry and pharmacology.

Genetics in Aquaculture

1st Edition
October 22, 2013
Graham A.E. Gall + 1 more
English
eBook
9 7 8 1 4 8 3 2 9 0 2 9 4

This volume, the proceedings of the Fourth International Symposium on Genetics in Aquaculture, builds on the foundations laid down at the first symposium, held in Galway, Ireland in 1982 (Aquaculture, Volume 33), as well as those laid down at the second, held in Davis, California, USA in 1985 (Genetics in Aquaculture II), and the third, held in Trondheim, Norway in 1988 (Genetics in Aquaculture III). It addresses specific problems and developments in this field, demonstrating the tremendous breadth of research activity as well as the complexity of issues in aquaculture genetics. This book will be of great value to aquaculturists, fisheries scientists and marine biologists.(The above-mentioned proceedings of the first three conferences are still available).

Neuroendocrine Perspectives

1st Edition
October 22, 2013
Eugenio E. Müller + 1 more
English
Hardback
9 7 8 0 4 4 4 9 0 3 7 7 8
Paperback
9 7 8 1 4 8 3 2 4 9 8 6 5
eBook
9 7 8 1 4 8 3 2 7 8 1 3 1

Neuroendocrine Perspectives, Volume 3 provides information on amine and peptide biochemistry. This book discusses the availability of specific biochemical and histochemical techniques that have greatly advanced knowledge of central nervous system neurotransmitter and neuropeptide systems. Organized into nine chapters, this volume begins with an overview of the structure of corticotropin releasing hormone. This text then examines the possible role of the cerebrospinal fluid in the regulation of pituitary function. Other chapters consider the importance of cerebrospinal fluid as a route for the hypothalamic regulation of pituitary function. This book discusses as well the available information concerning the neuroendocrine mechanisms involved in the onset of female puberty in primate and subprimate species. The final chapter deals with pineal indole metabolism and its controlling mechanisms as well as information on the interactions of the pineal hormones with neuroendocrine-repro... axis. This book is a valuable resource for pharmacologists, research workers, and students.

Neuroparasitology and Tropical Neurology

1st Edition
Volume 114
July 3, 2013
Hector H. Garcia + 2 more
English
Hardback
9 7 8 0 4 4 4 5 3 4 9 0 3
eBook
9 7 8 0 4 4 4 5 3 4 9 9 6

Neuroparasitology and Tropical Neurology, a new volume in The Handbook of Clinical Neurology, provides a comprehensive and contemporary reference on parasitic infections of the human nervous system. Parasitic infections are varied and some are resolved by the host’s immune system, other infections may become established even though unnoticed, and some cause severe disease and death. In our modern world, neuroparasitoses are no longer geographically isolated and these infections now appear worldwide. Outside of a very few well understood pathologies, most parasitic infections have been neglected in the neurological literature and most neurologists have never diagnosed such an infection. This volume details how, with the advent of modern neuroimaging techniques, improved diagnostic applications of molecular biology, more accurate immunodiagnosis, and minimally invasive neurosurgery, human nervous system parasitoses are now diagnosed and treated, with increasing frequency. The book is divided into six sections, and begins with an introduction to the mechanisms of infection, diagnosis, and pathology of parasitic diseases. Subsequent chapters detail protozoan diseases and a section covering each of the major classes of human-infecting helminths: nematodes (roundworms), trematodes (flukes), and cestodes (tapeworms). The final section contains chapters on other important areas of tropical clinical medicine including the neurological complications of venomous bites and tropical nutritional deficiencies. Neuroparasitology and Tropical Neurology will be of interest to neurologists, neurosurgeons and other health professionals encountering patients with parasitic infections.

Spinal Degenerative Disease

1st Edition
October 22, 2013
R. S. Maurice-Williams
English
Paperback
9 7 8 1 4 8 3 1 7 7 5 9 5
eBook
9 7 8 1 4 8 3 1 9 3 4 0 3

Spinal Degenerative Disease aims to provide a guide to the subject of spinal degenerative disease in all its aspects and to provide a balanced account of the more controversial parts of this field. It was written to fill the lack of books that deal with the degenerative disease of the vertebral column. This book is organized into 14 chapters that attempt to cover not only the pathology, clinical features, and treatment of spinal degenerative disease but also some relevant topics such as radiological techniques used in spinal investigation and the relationship between spinal arachnoiditis and degenerative disease. The book also discusses the relevant aspects of normal spinal physiology and anatomy and the differential diagnosis of spinal pain and sciatica. It also provides case histories to illustrate various points. This book will be of interest to students, medical professionals, and others interested in understanding the pathology and treatment of spinal degenerative disease.

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