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Elsevier

Books in Life sciences

  • Determination of the Size and Shape of Protein Molecules

    A Laboratory Manual of Analytical Methods of Protein Chemistry (Including Polypeptides), Vol. 3
    • 1st Edition
    • P. Alexander + 1 more
    • English
    Analytical Methods of Protein Chemistry, Volume 3: Determination of the Size and Shape of Protein Molecules provides information pertinent to the analysis and isolation of protein. This book deals with the measurement of the macromolecular properties of proteins. Organized into seven chapters, this volume begins with an overview of the theory and practice of the electron microscope to allow an understanding of the type of object that may be examined. This text then describes the methods of making protein molecules conform to such an ideal, which are the techniques of specimen preparation. Other chapters consider the determinations of osmotic pressures of proteins. This book discusses as well the experimental basis for the theory of the diffusion process in liquids. The final chapter deals with the technical problem characteristics of light-scattering. This book is a valuable resource for electron microscopists, protein chemists, biologists, physicist, physico-chemists, scientists, and research workers.

  • Immunological and Blood Products

    Pharmaceutical Monographs
    • 1st Edition
    • Mary Dawson + 1 more
    • J. B. Stenlake
    • English
    Pharmaceutical Monographs, Volume 5: Immunological and Blood Products provides an introduction to immunology and immunological products. This monograph describes various tissue culture techniques, which are important both in the preparation and standardization of certain immunological products. Organized into two parts encompassing 13 chapters, this volume begins with an overview of the types of immunity. This text then examines the substances which when introduced parenterally into the tissues, stimulates the production of an antibody. Other chapters consider antibodies as substances appearing in the blood or body fluids in response to the stimulus provided by the introduction of an antigen. This monograph discusses as well the preparations capable of stimulating active immunity. The final chapter deals with the causation of hemolytic disease of the newborn. This monograph is a valuable resource for medical students as well as undergraduate students of pharmacy. Students of veterinary medicine will also find this book extremely useful.

  • Mammalian Protein Metabolism

    Volume II
    • 1st Edition
    • H. N. Munro + 1 more
    • English
    Mammalian Protein Metabolism, Volume II focuses on the processes, methodologies, and reactions involved in mammalian protein metabolism, including toxicities, amino acid imbalance, and digestion and absorption. The selection first offers information on the nutritive value of dietary proteins, amino acid toxicities and imbalances, and protein requirements. Discussions focus on the protein requirements of adults, infants, and children, amino acid requirements, protein requirements in pregnancy, amino acid imbalance, mixed diets, and nutritive value and maintenance. The text then ponders on protein metabolism and requirements in pregnancy and lactation and protein metabolism and requirements in the newborn. The publication examines protein metabolism and requirements in the elderly; anomalies of amino acid metabolism; and physical injury and its effects on protein metabolism. Topics include general disturbance of protein metabolism following physical injury, nature of inflammatory reaction, acquired disturbances of amino acid metabolism, plasma proteins, nitrogen balance, digestion and absorption, and protein withdrawal. The text then elaborates on protein metabolism and tumor growth, experimental protein-calorie deficiency, and the clinical aspects of protein malnutrition. The selection is a dependable source of data for researchers interested in mammalian protein metabolism.

  • Carbohydrate Metabolism

    And Its Disorders
    • 1st Edition
    • F. Dickens + 2 more
    • English
    Carbohydrate Metabolism and its Disorders focuses on the processes and methodologies involved in carbohydrate metabolism, including detection of diabetes, hypoglycemic syndromes, cardiovascular diseases, and atherosclerosis. The selection first takes a look at the detection of diabetes in man, hormonal disturbances in diabetes, and hypoglycemia. Topics include indications for testing for diabetes, reasons for early detection, testing for diabetes with tolbutamide, glucagon, corticosteroids, and hypoglycemic syndromes. The book also ponders on the physiological aspects of carbohydrate metabolism in the fetus and newborn and glycogen-storage diseases. The publication examines dietary intake of carbohydrate in relation to diabetes and atherosclerosis and glucose tolerance in ischemic cardiovascular disease. Discussions focus on epidemiological studies of diabetes and atherosclerosis, overt diabetes mellitus, and effects of selection, age, obesity, and other factors. The book also identifies disturbances of the digestion and absorption of carbohydrates; insulin antagonists and disturbances in carbohydrate metabolism; and glycosaminoglycans in joint disorders. The selection is a valuable reference for readers interested in carbohydrate metabolism.

  • The Alkaloids

    Chemistry and Physiology
    • 1st Edition
    • R. H. F. Manske + 1 more
    • English
    The Alkaloids: Chemistry and Physiology, Volume IV contains an account of the chemistry and biosynthesis of the various classes of isoquinolines. This book discusses the extraction and separation of the anhalonium alkaloids, other natural simple isoquinolines, and anhalonium isoquinolines. The location of the alkaloids in tissues of the cacti, monophenolic bases of the laudanosine type, and extraction of cactus alkaloids are elaborated in detail. This text also describes the several types of alkaloids such as protoberberine, aporphine, protopine, phthalideisoquinolin... and bisbenzylisoquinolin... The cularine, a-naphthaphenanthrid... erythrophleum, aconitum, and delphinium alkaloids are likewise included. This publication is recommended for chemists, specialists, and students interested in isoquinolines.

  • Biophysical Chemistry

    Thermodynamics, Electrostatics, and the Biological Significance of the Properties of Matter
    • 1st Edition
    • John T. Edsall + 1 more
    • English
    Biophysical Chemistry, Volume I: Thermodynamics, Electrostatics, and the Biological Significance of the Properties of Matter focuses on the biological aspects of the properties of matter, putting emphasis on the chemical elements, water and carbon dioxide, complex molecules, and proteins. The publication first elaborates on biochemistry and geochemistry, water and its biological significance, and the problems of protein structure. Discussions focus on the number of peptide chains in the molecule and nature of terminal groups, latent heat of fusion, characteristics of the amino acids derived from proteins, expansion of water in freezing, and the relative abundance of chemical elements in the universe. The text then takes a look at thermodynamics and the application to polar molecules and ionic solutions of electrostatics, including free energy of a charged sphere, image charges, salting-out effect, expressions for the change of fundamental thermodynamic functions, and chemical potentials. The book examines the conductivity of electrolytes, acid-base equilibria, and polybasic acids, bases, and ampholytes, including proteins. Topics include ionization of cysteine, isoelectric points of polyvalent ampholytes, hemoglobin, nature of acids and bases, measurement of conductivity, electrolytes as conductors, and the moving boundary method of determining transference numbers. The manuscript is a dependable reference for chemists and researchers interested in thermodynamics, electrostatics, and the biological value of the properties of matter.

  • The Alkaloids

    Chemistry and Physiology
    • 1st Edition
    • R. H. F. Manske
    • English
    The Alkaloids: Chemistry and Physiology, Volume V: Pharmacology deals with the chemistry and pharmacology of the alkaloids. This book discusses the general pharmacology of morphine, cryptopine-like compounds, toad poisons, and respiratory stimulants. The appraisal of the utility of alkaloids as antimalarials, uterine stimulants, metabolism of cocaine, and optical isomerism-activity relationship are also elaborated. This publication likewise covers the parasympathetic blocking agents as mydriatics, methods of measuring mydriatic activity, alkaloids exhibiting curariform activity, and minor alkaloids of unknown structure. Other topics include the fate of morphine, tropane group, factors affecting cocaine anesthesia, and sympathomimetic mydriatics. This volume is intended for chemists and pharmacologists concerned with alkaloids.

  • Chemistry and Methods of Enzymes

    • 3rd Edition
    • James B. Sumner + 1 more
    • English
    Chemistry and Methods of Enzymes, Third Edition focuses on the processes, methodologies, and reactions in enzyme chemistry, as well as kinetics, nucleases, esterases, and carbohydrates. The publication first underscores the general properties of enzymes, including chemical nature, occurrence, numerical characterization of enzyme concentration, kinetics of enzyme reactions, preparation of commercial enzymes, purification and preservation of enzymes, relations of vitamins to enzymes, and zymogens and kinases. The text then takes a look at esterases and carbohydrates. Topics include pectin depolymerase, heparinase, xylanase, chitinase, dextranase, trehalase, nucleotide phosphatases, glucosulfatase, and gastric lipase. The manuscript examines nucleases, nuclein deaminases, amidases, proteolytic enzymes, and hydrases. Discussions focus on enolase, aconitase, peptidases as metalloproteins, glutaminases, aspartase, urease, adenosine deaminase, and nucleoside phosphorylase. The book also elaborates on iron and copper enzymes, dehydrogenases containing coenzymes I and II, and yellow enzymes. The text is a dependable source of data for chemists and researchers wanting to dig deeper into the chemistry and methods of enzymes.

  • Mammalian Protein Metabolism

    Volume I
    • 1st Edition
    • H. N. Munro + 1 more
    • English
    Mammalian Protein Metabolism, Volume I focuses on the processes, methodologies, biosynthesis, protein formation, and reactions involved in mammalian protein metabolism. The selection first elaborates on the origin and growth of concepts of protein metabolism, including the development of nitrogen balance as a technique for the study of protein metabolism; identification of proteins as a chemical class; discovery of nitrogen and its biological consequences; and recognition of the importance of nitrogenous compounds. The text then examines protein digestion and absorption in nonruminants and digestion and absorption of nitrogenous compounds in ruminants. Topics include passage of nitrogenous compounds from the rumen; utilization of nitrogenous compounds in the rumen; and endogenous nitrogen entering the reticulum and rumen. The book examines free amino acids and peptides in tissues, metabolic fate of amino acids, protein biosynthesis in mammalian tissues, and metabolism of plasma proteins. Discussions focus on the distribution of proteins between plasma and lymph, interpretation of plasma radioactivities, amino acid activating enzymes, ribosomes and protein synthesis, pathways of amino acid degradation, and synthesis of urea. The selection is a dependable source of data for researchers interested in mammalian protein metabolism.

  • The Peptides

    Methods of Peptide Synthesis
    • 1st Edition
    • Eberhard Schröder + 1 more
    • English
    The Peptides, Volume I: Methods of Peptide Synthesis focuses on detailed description of protecting groups, individual amino acids, and coupling reactions. The publication first offers information on amino-protecting and carboxyl-protecting groups, including carboxyl protection by salt formation, esterification, and amide formation and acyl-type, alkyl-type, and urethane protecting groups. The text then examines the formation of the peptide bond and amino acids. Discussions focus on amino acids with the alcoholic hydroxyl group, sulfur amino acids, basic and acidic amino acids, synthesis of peptides by activation of the amino group, and peptide synthesis by activation of the carboxyl group. The manuscript elaborates on the synthesis of cyclic peptides, depsipeptides, peptoids, and the plastein reaction. Topics include synthesis of plastein-active peptides, glycopeptides, phosphopeptides, and S-peptides. The publication is a dependable source of data for readers interested in the methods of peptide synthesis.

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