Pathogenesis of Leprosy and Related Diseases

ContentsForeword Preface Abbreviations 1 Introduction The Study of Pathogenesis The Calibration of A Histopathological PicturePart I General Considerations 2 The Structure of Skin The Skin Biopsy The Normal Skin 3 The Structure of Peripheral Nerve Microanatomy Response To Disease 4 Inflammation Inflammatory Cells Acute and Chronic Inflammation Granuloma Formation Necrosis and Fibrosis Immune Complexes and Inflammation 5 Concepts of the Spectrum Part II Leprosy 6 The Leprosy Bacillus Growth Characteristics Morphology and Constitution 7 The Disease Called Leprosy Introduction The Pathogenesis of the Clinical Picture Immunology 8 The Early Skin Lesion of Leprosy The Evolution of the Lesion Protected and Optimal Sites The Portal of Entry 9 Neuropathy in Leprosy The Pathway of Nerve Involvement The Neuropathology of Leprosy The Pathogenesis of the Lesion Neural Affinity, Immunological Protection and Autoimmunity 10 Leprosy As A Systemic Disease Respiratory Tract Vascular Disease Reticuloendothelial System Other Organs and Tissues 11 Nature of the Leprosy Spectrum Basis of the Ridley-Jopling Classification Immunopathology of the Spectrum Evolution of the Response 12 Activity of the Infection Phases of Bacterial Multiplication The Macrophage Cycle Viable and Dead Bacilli Reactivity and Relapse 13 Reactions Type 1 (Borderline) Reactions Erythema Nodosum Leprosum Exacerbation Reactions 14 The Defect in Leprosy Epidemiological Considerations Genetic Inheritance Portal of Entry The Evolution of the Response Immunosuppression 15 Histological Diagnosis Principles of Diagnosis Early Lesions Tuberculoid Lesions Differentiation of Reaction and Relapse 16 Classification Histological Classification in Skin Histological Classification in NervePart III Related Diseases 17 Leishmania and Leishmaniasis Speciation and Form of Disease The Spectrum of Cutaneous Leishmaniasis 18 Leishmaniasis: The Tissue Response Onset of Infection General Pathology of Cutaneous Leishmaniasis Alternative Modes of Evolution Mucocutaneous Leishmaniasis Visceral Leishmaniasis 19 Leishmaniasis: Pathogenesis Initiation of the Infection Mechanisms of Parasite Elimination Immunosuppression 20 Tuberculosis and Its Pathology The Tubercle Bacillus General Pathology The Spectrum of Tuberculosis 21 Pathogenesis of Tuberculosis Mechanisms of Necrosis Killing Mechanisms 22 Some Other Granulomas Other Mycobacterial Granulomas Granulomas of Unknown Aetiology Granulomas Due To Known Molecules Modes of Cell Death 23 Determinants of the Course of Infection Appendix: Technical Methods Fixation of Tissues Staining of Organisms in Sections Identification of Antigen in TissuesIndex