Skip to main content
Elsevier
View Cart

Books in Life sciences

BooksJournals

    • Recent Advances in Steroid Biochemistry

      • 1st Edition
      • May 18, 2014
      • J. R. Pasqualini
      • English
      • eBook
        9 7 8 1 4 8 3 1 4 0 1 4 8
      Recent Advances in Steroid Biochemistry contains the proceedings of the Second International Symposium of the Journal of Steroid Biochemistry. Separating 38 papers as chapters, this book discusses the partial purification of steroid-receptor complexes; enzymatic techniques in steroid assay; mass fragmentography of steroid hormones; biological consequences of 18-hydroxylation; and steroidogenesis in adrenal cells. This text also explores the regulation of steroidogenesis in testis; androgen binding proteins in different testis compartments; nuclear acceptor sites for glucocorticoid receptors; estrogen receptors in the pancreas; and molecular mechanisms of steroid hormone action.

    • Re-Engineering Clinical Trials

      • 1st Edition
      • December 16, 2014
      • Peter Schueler + 1 more
      • English
      • Hardback
        9 7 8 0 1 2 4 2 0 2 4 6 7
      • eBook
        9 7 8 0 1 2 8 0 0 7 9 0 7
      The pharmaceutical industry is currently operating under a business model that is not sustainable for the future. Given the high costs associated with drug development, there is a vital need to reform this process in order to provide safe and effective drugs while still securing a profit. Re-Engineering Clinical Trials evaluates the trends and challenges associated with the current drug development process and presents solutions that integrate the use of modern communication technologies, innovations and novel enrichment designs. This book focuses on the need to simplify drug development and offers you well-established methodologies and best practices based on real-world experiences from expert authors across industry and academia. Written for all those involved in clinical research, development and clinical trial design, this book provides a unique and valuable resource for streamlining the process, containing costs and increasing drug safety and effectiveness.

    • Opioid Peptides: Biology, Chemistry, and Genetics

      • 1st Edition
      • May 10, 2014
      • Sidney Udenfriend + 1 more
      • English
      • Paperback
        9 7 8 1 4 8 3 2 0 4 5 6 7
      • eBook
        9 7 8 1 4 8 3 2 1 7 9 9 4
      The Peptides: Analysis, Synthesis, Biology, Volume 6: Opioid Peptides: Biology, Chemistry, and Genetics presents a biological topic of peptide research. This book is divided into nine chapters. Chapter 1 reviews the opioid peptide precursors and their genes. The proenkephalin and products of its processing are discussed in Chapter 2. In Chapter 3, the role of pro-opiomelanocortin (POMC) as a protein at the interface of the endocrine and nervous systems is examined. Chapter 4 provides a comprehensive account of the biology and chemistry of the dynorphin peptides. The opioid receptors are described in Chapter 5. Chapter 6 evaluates the structure-activity relationships of ?-endorphin, while Chapter 7 considers the conformational analysis of enkephalins and conformation-activit... relationships. The structure-activity relationships among enkephalin peptides are elaborated in Chapter 8. The last chapter is devoted to the clinical significance of opioid peptides in humans. This publication is a good reference for biologists, specialists, and researchers concerned with peptides and proteins.

    • Advances in Lipid Research

      • 1st Edition
      • Volume 22
      • June 28, 2014
      • Rodolfo Paoletti + 1 more
      • English
      • Paperback
        9 7 8 1 4 8 3 2 0 2 0 0 6
      • eBook
        9 7 8 1 4 8 3 2 1 5 4 3 3
      Advances in Lipid Research, Volume 22 provides information pertinent to the fundamental aspects of lipid research. This book covers a variety of topics, including lipid secretion, lipids in platelet function, lipid transfer proteins, serum cholesterol, and cholesterol metabolism. Organized into five chapters, this volume begins with an overview of the lipid secretion of the meibomian glands, with emphasis on its chemical composition and physical properties. This text then explains the influence of lipids in platelet function and considers the metabolism of arachidonic acid in disease states, such as diabetes, nephrosis, and atherosclerosis. Other chapters examine the manner in which dietary cholesterol contributes to regulation of cholesterol metabolism. This book discusses as well the identification, isolation, and metabolism of sterol carrier proteins and lipid transfer proteins. The final chapter deals with the underlying problems that militate against a simple dose–response relationship. This book is a valuable resource for biologist, biochemists, and clinicians.

    • A Laboratory Manual of Analytical Methods of Protein Chemistry

      • 1st Edition
      • May 9, 2014
      • P. Alexander + 1 more
      • English
      • Paperback
        9 7 8 1 4 8 3 1 6 9 8 3 5
      • eBook
        9 7 8 1 4 8 3 1 8 5 6 4 4
      A Laboratory Manual of Analytical Methods of Protein Chemistry, Volume 4 provides information pertinent to the fundamental aspects of protein chemistry. This book discusses the simple and accurate methods of estimating specific proteins. Organized into six chapters, this volume begins with an overview of the composition of acids and experimental conditions for the acid hydrolysis of proteins. This text then examines the advantages of high-voltage electrophoresis for amino acid analysis, which are paralleled by equal advantages in the peptide separation field. Other chapters consider the simple technique of estimating specific proteins, which is one of several based on the phenomenon of antigen-antibody precipitation in gels. This book discusses as well the summations of analyses in weight percentages of the various residues and of the nitrogen of each constituent. The final chapter deals with the electrical properties of molecules. This book is a valuable resource for physicists and research workers.

    • Lipids: Structure and Function

      • 1st Edition
      • May 10, 2014
      • P. K. Stumpf
      • English
      • Paperback
        9 7 8 1 4 8 3 2 0 6 9 1 2
      • eBook
        9 7 8 1 4 8 3 2 2 0 3 4 5
      The Biochemistry of Plants: A Comprehensive Treatise, Volume 4: Lipids: Structure and Function provides information pertinent to the fundamental aspects of plant lipid biochemistry. This book covers a variety of topics, including oxidative enzymes, glyoxylate cycle, lipoxygenases, ethylene biosynthesis, phospholipids, and carotenoids. Organized into 19 chapters, this volume begins with an overview of the different techniques for use in the analysis of plant lipids. This text then outlines the concepts of membrane lipid structure and discusses the relationship between membrane lipid structure and function. Other chapters consider the role that lipid structure plays in regulating physiological function. This book discusses as well the biochemical mechanism by which the double bond is introduced in the biosynthesis of ethylene. The final chapter deals with the results of studies on the biosynthesis of cyclopropanoid, cyclopropenoid, and cyclopentenyl fatty acids in higher plants. This book is a valuable resource for plant biochemists, neurobiochemists, molecular biologists, senior graduate students, and research workers.

    • Advances in Lipid Research

      • 1st Edition
      • Volume 13
      • June 28, 2014
      • Rodolfo Paoletti + 1 more
      • English
      • Paperback
        9 7 8 1 4 8 3 2 0 1 9 2 4
      • eBook
        9 7 8 1 4 8 3 2 1 5 3 5 8
      Advances in Lipid Research, Volume 13 is a four-chapter text that emphasizes the biological aspects of lipoproteins. The first chapter reviews the status of lipoprotein metabolism, specifically the functional, structural, and metabolic interrelationships of lipoproteins. The second chapter covers aspects of lipid metabolism in diabetes and the stresses that can cause alterations in carbohydrate metabolism. The third chapter discusses the developments in understanding the physicochemical basis of gallstone formation. The fourth chapter deals with the biosynthesis and composition of milk fat. This chapter also presents a summary of some of the important features of milk fat production processes. This book will prove useful to lipid chemists, biochemists, physicians, and researchers.

    • Methods in Virology

      • 1st Edition
      • June 28, 2014
      • Karl Maramorosch + 1 more
      • English
      • Paperback
        9 7 8 1 4 8 3 2 4 3 1 7 7
      • eBook
        9 7 8 1 4 8 3 2 6 2 2 3 9
      Methods in Virology, Volume V focuses on the methods used in virology, including hybridization, gel electrophoresis, freeze-etching technique, and ultracentrifugation. The selection first offers information on the fusion of cells for virus studies and production of cell hybrids; approaches to ultracentrifugation; and polyacrylamide gel electrophoresis of viral RNA. Discussions focus on applications to virological problems and analysis of results; analysis of the distribution of RNA on polyacrylamide gels after electrophoresis; and biological analysis of DNA components. The book then examines the polyacrylamide gel electrophoresis of viral proteins, DNA-RNA and DNA-DNA hybridization in virus research, and techniques of RNA-DNA hybridization in solution for the study of viral transcription. Topics include preparation of nucleic acids, hybridization and elution procedures that minimize RNA degradation, and procedures for acrylamide gel electrophoresis. The text takes a look at freeze-etching technique for the study of virus ultrastructure; procedures to increase virus yield from infected plants; and the immunoperoxidase technique. Concerns include principles of the immunoperoxidase technique, histochemical detection of peroxidase activity, sequence of events in virus infection, and factors affecting virus yield. The selection is a valuable source of data for researchers interested in the methods employed in virology.

    • Current Topics in Bioenergetics

      • 1st Edition
      • June 28, 2014
      • D. Rao Sanadi
      • English
      • Paperback
        9 7 8 1 4 8 3 2 0 3 5 0 8
      • eBook
        9 7 8 1 4 8 3 2 1 6 9 3 5
      Current Topics in Bioenergetics, Volume 9 presents the theoretical, thermodynamic perspective of energy transducing reactions. This book provides a detailed kinetic analysis of a specific aspect of an ion pump. Organized into seven chapters, this volume begins with an overview of the quantitative relations between measurable parameters of energy-transducing systems. This text then examines the probes for intracellular pH determination, which stimulate the development of additional methods and their application in pathology and pharmacology. Other chapters consider studies with isolated proteins or protein complexes derived from the membranes. This book discusses as well the chemistry of photosynthesis and oxidative phosphorylation. The final chapter deals with the advances in the use of photo affinity labeling in the study of the structure of ligand sites on proteins, which became possible only in conjunction with the development of methods for the isolation of peptides and their sequence determination. This book is a valuable resource for biologists and biochemists.

    • Bioinformatics for Beginners

      • 1st Edition
      • May 9, 2014
      • Supratim Choudhuri
      • English
      • Paperback
        9 7 8 0 1 2 8 0 9 9 9 9 5
      • Hardback
        9 7 8 0 1 2 4 1 0 4 7 1 6
      • eBook
        9 7 8 0 1 2 4 1 0 5 1 0 2
      Bioinformatics for Beginners: Genes, Genomes, Molecular Evolution, Databases and Analytical Tools provides a coherent and friendly treatment of bioinformatics for any student or scientist within biology who has not routinely performed bioinformatic analysis. The book discusses the relevant principles needed to understand the theoretical underpinnings of bioinformatic analysis and demonstrates, with examples, targeted analysis using freely available web-based software and publicly available databases. Eschewing non-essential information, the work focuses on principles and hands-on analysis, also pointing to further study options.

Related subjects

Agricultural and biological sciences

Drug discovery

Immunology

Microbiology and virology

Neuroscience

Pharmaceutical sciences

Pharmacology

Toxicology