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    • Immunological Methods

      • 1st Edition
      • June 28, 2014
      • Ivan Lefkovits + 1 more
      • English
      • Paperback
        9 7 8 1 4 8 3 2 4 2 5 4 5
      • eBook
        9 7 8 1 4 8 3 2 6 9 9 9 3
      Immunological Methods a compendium of basic research techniques being used in one of the largest immunology research institutes, the Basel Institute for Immunology, with particular emphasis given to new methodology. The procedures have been described by individuals judged to be highly expert in their specialties. In many instances the methods developed or adapted to unique uses by the contributors have not previously been described in detail. The book contains 34 chapters covering techniques for detection, isolation, and purification of antibodies (including dansylation, two-dimensional chromatography, isoelectric focusing, polyacrylamide gel electrophoresis, and isotachophoresis); measurement of equilibrium constants (equilibrium dialysis, filtration, and sedimentation); and isotope and fluorescent labeling and detection of cell-surface components. Techniques such as isotope laboratory maintenance; chemical modification of proteins, haptens, and solid supports, and haptenation of viable biological carriers; production of antisera against allotypes and histocompatibility antigens and production of antibody with clonai dominance; histocompatibility and MLR testing; and cell separation by haptenated gels and by velocity sedimentation of rosette-forming cells are also discussed. Other chapters cover detection of antibody-secreting and alloantigen-binding cells; immune responses in vitro and their analysis by limiting dilution; production of T-cell factors; hybridoma production by cell fusion; maintenance of cell lines and cloning in semisolid media; and the mathematical analysis of immunological data.

    • Clinical Tumor Immunology

      • 1st Edition
      • May 18, 2014
      • Joseph Wybran + 1 more
      • English
      • eBook
        9 7 8 1 4 8 3 1 4 0 1 5 5
      Clinical Tumor Immunology contains the proceedings of the Symposium of Clinical Tumor Immunology held in Brussels, Belgium, on May 26-29, 1975) and organized by the European Organization for Research on Treatment of Cancer in cooperation with the Department of Immunology of the University Hospital of Brussels. The papers explore progress in the field of clinical tumor immunology and cover topics ranging from general mechanisms in tumor immunity to tumor antigens and immunotherapy. A classification of leukemias and lymphomas is also presented. Comprised of 48 chapters, this book begins with an overview of the biological activities of the circulating thymic hormone, followed by a discussion on macrophage secretions affecting the growth of other cells. The reader is then introduced to immune cellular mechanisms at the site of the tumor; the use of the leukocyte migration technique in studies of tumor-directed cellular immunity in malignant melanoma; and immunological approaches to the identification of leukemic cells. Subsequent chapters deal with preclinical approaches in tumor immunochemotherapy; mediation of immune responses to human tumor antigens with "immune" RNA; and the role of transfer factor in human cancer. This monograph will be of interest to oncologists and immunologists.

    • The Structure of Mitochondria

      • 1st Edition
      • June 28, 2014
      • E. A. Munn
      • English
      • Paperback
        9 7 8 1 4 8 3 2 4 3 8 1 8
      • eBook
        9 7 8 1 4 8 3 2 7 2 6 0 3
      The Structure of Mitochondria provides an extensive account of the structure of mitochondria. This book illustrates the variety of mitochondrial structure revealed by electron microscopy of intact cells. Organized into nine chapters, this book begins with an overview of the application of electron microscopy to the study of the structure of cells and their mitochondria. This text then explains the short-term changes of the type revealed by phase contrast microscopy of living cells. Other chapters consider the rationale behind the procedures generally employed for the isolation of mitochondria and other sub-cellular components. This book discusses as well the important component of mitochondria. The final chapter describes the interesting similarities of mitochondria, chloroplasts, and bacteria and the bearing these have on the concept about the way in which the relationships between mitochondria and the rest of the eukaryotic cell have evolved. This book is a valuable resource for biologists, physiologists, and bacteriologists.

    • Cancer

      • 1st Edition
      • March 1, 2014
      • Victor R Preedy
      • English
      • Paperback
        9 7 8 0 1 2 8 1 0 2 6 7 1
      • Hardback
        9 7 8 0 1 2 4 0 5 2 0 5 5
      • eBook
        9 7 8 0 1 2 4 0 5 5 2 4 7
      Cancer: Oxidative Stress and Dietary Antioxidants bridges the trans-disciplinary divide and covers in a single volume the science of oxidative stress in cancer and then the potentially therapeutic usage of natural antioxidants in the diet or food matrix. The processes within the science of oxidative stress are described in concert with other processes such as apoptosis, cell signaling, and receptor mediated responses. This approach recognizes that diseases are often multifactorial and that oxidative stress is a single component of this. Oncologists, cancer researchers, and nutritionists are separated by divergent skills and professional disciplines that need to be bridged in order to advance preventative as well as treatment strategies. While oncologists and cancer researchers may study the underlying pathogenesis of cancer, they are less likely to be conversant in the science of nutrition and dietetics. On the other hand, nutritionists and dietitians are less conversant with the detailed clinical background and science of oncology. This book addresses this gap and brings each of these disciplines to bear on the processes inherent in the oxidative stress of cancer.

    • Biological and Biochemical Oscillators

      • 1st Edition
      • June 28, 2014
      • Britton Chance + 2 more
      • English
      • eBook
        9 7 8 1 4 8 3 2 7 1 1 9 4
      Biological and Biochemical Oscillators compiles papers on biochemical and biological oscillators from a theoretical and experimental standpoint. This book discusses the oscillatory behavior, excitability, and propagation phenomena on membranes and membrane-like interfaces; two-dimensional analysis of chemical oscillators; and chemiluminescence in oscillatory oxidation reactions catalyzed. The problems associated with the computer simulation of oscillating systems; mechanism of single-frequency glycolytic oscillations; excitation wave propagation during heart fibrillation; and biochemical cycle of excitation are also elaborated. This compilation likewise covers the physiological rhythms in Saccharomyces cerevisiae populations; integral and indissociable property of eukaryotic gene-action systems; and role of actidione in the temperature jump response of the circadian rhythm in Euglena gracilis. This publication is valuable to biochemists interested in biochemical and biological oscillations.

    • Erectile Dysfunction as a Cardiovascular Impairment

      • 1st Edition
      • March 6, 2014
      • Robert Fried
      • English
      • Hardback
        9 7 8 0 1 2 4 2 0 0 4 6 3
      • Paperback
        9 7 8 0 1 2 8 1 0 3 4 7 0
      • eBook
        9 7 8 0 1 2 4 2 0 0 4 1 8
      Erectile Dysfunction as a Cardiovascular Impairment organizes and summarizes the many aspects of biology and metabolism in cardiovascular and sexual function. Coverage includes how blood vessels are discovered to work, their role in hypertension, atherosclerosis, type-2 diabetes, oxidative stress, metabolic syndrome, and erectile dysfunction.

    • Biomarkers in Toxicology

      • 1st Edition
      • January 25, 2014
      • Ramesh C. Gupta
      • English
      • Hardback
        9 7 8 0 1 2 4 0 4 6 3 0 6
      • eBook
        9 7 8 0 1 2 4 0 4 6 4 9 8
      Biomarkers in Toxicology is a timely and comprehensive reference dedicated to all aspects of biomarkers that relate to chemical exposure and their effects on biological systems. This book includes both vertebrate and non-vertebrate species models for toxicological testing and development of biomarkers. Divided into several key sections, this reference volume contains chapters devoted to topics in molecular-cellular toxicology, as well as a look at the latest cutting-edge technologies used to detect biomarkers of exposure and effects. Each chapter also contains several references to the current literature and important resources for further reading. Given this comprehensive treatment, Biomarkers in Toxicology is an essential reference for all those interested in biomarkers across several scientific and biomedical fields.

    • Adapting High Hydrostatic Pressure (HPP) for Food Processing Operations

      • 1st Edition
      • June 21, 2014
      • Tatiana Koutchma
      • English
      • Paperback
        9 7 8 0 1 2 4 2 0 0 9 1 3
      • eBook
        9 7 8 0 1 2 4 2 0 0 9 9 9
      Adapting High Hydrostatic Pressure (HPP) for Food Processing Operations presents commercial benefits of HPP technology for specific processing operations in the food industry, including raw and ready-to-eat (RTE) meat processing, dairy and seafood products, drinks and beverages, and other emerging processes. The book presents high hydrostatic pressure processing (HPP) for treatment of different groups of raw and finished products, focusing on specific pressure-induced effects that will lead to different biological impacts, and the information necessary for specifying HPP process and equipment. It also discusses phenomena of compression heating, the HPP in-container principle, requirements for plastic materials, factors affecting efficacy of HPP treatments, and available commercial systems. Additionally, the book provides updated information on the regulatory status of HPP technology around the world. This book is an ideal concise resource for food process engineers, food technologists, product developers, federal and state regulators, equipment manufacturers, graduate students, and educators involved in research and development.

    • The Biology of B-Lactam Antibiotics

      • 1st Edition
      • May 10, 2014
      • Robert B. Morin + 1 more
      • English
      • Paperback
        9 7 8 1 4 8 3 2 4 3 7 2 6
      • eBook
        9 7 8 1 4 8 3 2 7 6 6 9 4
      The Biology of ß-Lactam Antibiotics

    • Tissue Engineering

      • 2nd Edition
      • December 10, 2014
      • Clemens van Blitterswijk + 1 more
      • English
      • Hardback
        9 7 8 0 1 2 4 2 0 1 4 5 3
      • Paperback
        9 7 8 0 1 2 8 1 0 0 2 8 8
      • eBook
        9 7 8 0 1 2 4 2 0 2 1 0 8
      Tissue Engineering is a comprehensive introduction to the engineering and biological aspects of this critical subject. With contributions from internationally renowned authors, it provides a broad perspective on tissue engineering for students coming to the subject for the first time. In addition to the key topics covered in the previous edition, this update also includes new material on the regulatory authorities, commercial considerations as well as new chapters on microfabrication, materiomics and cell/biomaterial interface.

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