Advances in the Biosciences

Introduction


1. Biosynthesis

Quantitative Aspects on Prostaglandin Synthesis in Man

Inhibition of Prostaglandin Biosynthesis

Catecholamine Induced Increase in Prostaglandin E Biosynthesis in Homogenates of the Rat Stomach Fundus

Comparative Aspects of Prostaglandin Biosynthesis in Animal Tissues


2. Metabolism

Structures of New Metabolites of Prostaglandin E2 in Man

Structures of C14 Metabolites of Prostaglandin F2α

Purification, Properties, and Biological Significance of Prostaglandin A Isomerase


3. Analytical Methods

Specific Antibodies: Reagents for Quantitative Analysis of Prostaglandins

Specificity of Prostaglandin Binding Sites in Rat Forestomach Tissue and Their Possible Use as a Quantitative Assay

Quantitative Mass Spectrometric Analysis of Prostaglandins

Differentiation between Endogenous and Exogenous (Administered) Prostaglandins in Biological Fluids

The Analysis of Prostaglandins Using a Computer for Plotting Ion Abundance Versus Time


4. Round Table Discussion on Analytical Methods


5. Biological Activity and Structure

The Synthesis and Biological Activity of a Series of 15-Methyl Prostaglandins

On the Prostaglandin Inhibitory Action of Polyphloretin Phosphate

Structure-Activity Relationship of Some Dibenzoxazepine Derivatives as Prostaglandin Antagonists

Relation of Prostaglandin Structure to Vascular Resistance in the Isolated Rat Pancreas


6. Metabolic Effects

The Regulatory Role of the Prostaglandins on the Cyclic 3', 5'-AMP System

Prostaglandins, Cyclic AMP, and Transformed Fibroblasts


7. Prostaglandins and Adenylcyclase System

Prostaglandin Production by Cells In Vitro


8. Metabolic Effects

Erythropoietic Effects of Prostaglandins

Prostaglandins and Sickle Cell Anemia

Inhibition of Vasopressin Action in Toad Bladder

Effects of Prostaglandin E1 and Arginine Vasotocin on Sodium Transport and Adenyl Cyclase Activity in Developing Tadpole Skin

Prostaglandin Modification of Membrane-Bound Enzyme Activity


9. Respiratory System

The Effects of Inhaled Prostaglandins on Bronchial Tone in Man

Opposite Effects of Prostaglandins E and F on Tracheal Smooth Muscles and Their Interaction with Calcium Ions

Comparative Studies on the Bronchodilating Properties of the Prostaglandin F2ß

The Regulatory Function of Prostaglandins in the Release of Histamine and SRS-A From Passively Sensitized Human Lung Tissue

Prostaglandin F2α: Effect on Airway Conductance in Healthy Subjects and Patients with Bronchial Asthma


10. Gastro-intestinal System

15-Methyl PGE2 and 16, 16-Dimethyl PGE2: Potent Inhibitors of Gastric Secretion

Effect of Orally and Intravenously Administered Prostaglandin 15 (R) 15-Methyl E2 on Gastric Secretion in Man

PGE2 and Gastric Acid Secretion in Man

The Relationship between Rat Gastric Mucosal Blood Flow and Acid Secretion during Oral or Intravenous Administration of Prostaglandins and Dibutyryl Cyclic AMP


11. Renal System

Introduction

A Histochemical Study of the Prostaglandin Biosynthesis in the Urinary System of Rabbit, Guinea Pig, Goldhamster, and Rat

Metabolic Mechanisms of Action of the Renal Prostaglandins

Effects of PGE2 on Renal Tubular Function

Prostaglandinlike Renal Vasodepressor Lipids and Electrolyte Exchange in the Kidney

The Effect of Prostaglandin (PGA1) on Adrenal Function in Man

Occurrence of Prostaglandins in Human Urine

Effect of PGE1 on Contrast Visualization of the Renal Vascular Bed: Comparison with Other Vasodilators

Inhibition of Prostaglandin Synthesis in the Kidneys by Aspirinlike Drugs

Synthesis of Prostaglandins (PGs) by Renomedullary Interstitial Cells (RIC) Grown in Tissue Culture


12. Circulatory System

Introduction

Effects of Prostaglandin E2 and F2α on Cutaneous Arteries and Veins In Vivo in the Isolated Rabbit Ear

Prostaglandin Induced Vasoconstriction of Cerebral Arteries and Its Reversal by Ethanol

Vasodepressor Action of Renomedullary Prostaglandins (PGE2 and PGA2) in the Spontaneously Hypertensive Rat (SH Rat): Evidence for a Central Action Mediated by the Vagus

Effect of Prostaglandin E1 on the Transmembrane Potentials of the Mammalian Heart

Effects of PGE1, PGE2, and PGF2α on Isolated Normal and Damaged Heart Preparations

Antiarrhythmic Properties of PGE2: Preliminary Results


13. Inflammation

Inhibition of Prostaglandin Biosynthesis as the Mechanism of Action of Aspirinlike Drugs

Arachidonic Acid and the Analgesic Action of Aspirinlike Drugs

Effect of Various Prostaglandins on Two Laboratory Models of Chronic Arthritic Inflammation

Prostaglandin Release in Ocular Inflammation in Rabbits and Man

Effect of Prostaglandin E1 on Lysosomal Enzyme Release from Human Leucocytes in the Presence of Dytochalasin B

Prostaglandins in Burn Injury

Antianaphylactic Effect of a Prostaglandin Antagonist, Polyphloretin Phosphate

The Effect of Prostaglandin E1 on the Production of Interferon

Prostaglandin E2 Biosynthesis in Human Skin: Subcellular Localization and Inhibition by Unsaturated Fatty Acids and Anti-inflammatory Agents


14. Nervous System

Prostaglandin Mediated Control of Sympathetic Neuroeffector Transmission

Prostaglandins on Cyclic-AMP Formation in Cerebral Cortex of Different Mammalian Species

Actions of Prostaglandin E1 on Spinal Neurons in the Frog

The Effects of Prostaglandin E2 on Conditioned Avoidance Response Behavior and the Electroencephalogram

Prostaglandin E1 and Endotoxin Fever, and the Effects of Aspirin, Indomethacin, and 4-Acetamidophenol

Effect of Prostaglandins E1 and F2α on Adrenergic Responses in the Pulmonary Circulation


15a. Termination of Pregnancy - Extra- and Intra-amniotic Administration of Prostaglandins

Termination of Pregnancy by Extraamniotic Prostaglandins and the Synergistic Action of Oxytocin

Induction of Abortion 1. by Intravenous and 2. by Intrauterine Administration of PGF2α (Extra- and Intraamniotic)

Intrauterine Administration of Prostaglandin F2α for Induction of Abortion

Therapeutic Abortion by Intraamniotic Administration of Prostaglandin F2α

Midtrimester Therapeutic Abortion Using Intraamniotic PGF2α

Induction of Abortion by Intraamniotic PGF2α: a Comparison of Dose Schedules

Intraamniotic Prostaglandin F2α for Midtrimester Abortion

Therapeutic Abortion by Intraamniotic Injection of Prostaglandins


15b. Termination of Pregnancy - Intravaginal Administration of Prostaglandins

Vaginal Administration of Prostaglandins to Induce Early Abortion

Postconceptional Fertility Control by Prostaglandins

Abortifacient Activity of Vaginally Administered Prostaglandin F2α

Prostaglandin F2α Vaginal Pessaries for Midtrimester Abortion


15c. Induction of Labor - Oral and Intravenous Administration of Prostaglandins

The Results of Using Prostaglandins F2α for Induction and Stimulation Labor

Oral Prostaglandin E 2 and Amniotomy for Induction of Labor


15d. Effects of Prostaglandins on Steroidogenesis1

The Physiological Role of Prostaglandin F2α in Corpus Luteum Regression

Prostaglandin F Group (PGF), Progesterone, and Estrogen Concentrations in the Utero-ovarian Venous Plasma of the Conscious Ewe during the Estrous Cycle

The Formation of Prostaglandins by the Guinea-Pig Uterus and the Effect of Indomethacin

Cyclic Changes in Uterine Venous and Peripheral Plasma Levels of F Prostaglandins Correlated with Peripheral Progesterone Levels in the Golden Hamster

A Comparative Study of Some Effects of Prostaglandin F2α, F1α, E2, and E1 on Reproductive Processes of Rats and Hamsters


15e. Effects of Prostaglandins on Steroidogenesis

Prostaglandins and Steroidogenesis

Prostaglandins and Myometrial Contractility

Effect of Prostaglandin F2α on Progestin Synthesis in the Human and Rabbit Ovary

Induction of Abortion by Extraamniotic Administration of Prostaglandin F2α

Alterations in Biosynthesis of Progesterone in Human Corpora Lutea of Pregnancy by Prostaglandins

The Effect of Prostaglandin F2α Administration on Plasma Steroid and LH Levels in the Luteal Phase of the Menstrual Cycle

Plasma Progestin and Plasma Estrogen Levels during Infusion of PGF2α in the Human

Plasma Hormone Changes during Infusions of Prostaglandins F2α, and E2 for Therapeutic Abortion

Effects of Prostaglandins and Gonadotrophins on Luteal Prostaglandin and Steroid Biosynthesis


15f. Effects of Prostaglandins on Other Ovarian Functions

Possible Role of Prostaglandins in Ovulation

Effects of PGE1 and 7-OXA-13-Porstynoic Acid on the Isolated Prepubertal Rat Ovary

Effect of Prostaglandins E1, E2 , and F2α on Gonadotrophin-Induced Ovulation in Immature Female Rats

Effects of PGF2α on Periovular Cervical Mucus


15g. Effects of Prostaglandins on the Male Reproduction

Prostaglandins (E1 and E2) and Reproduction in the Male Rat


15h. Effects of Prostaglandins on the Human Uterine Contractility

The Effect of a ß-Adrenergic Agent on Prostaglandin Stimulated Labor

Comparative Studies of the Effect of Oxytocin and Prostaglandin F2α in the Uterus

Interrelationship between Oxytocin (Endogenous and Exogenous) and Prostaglandins

Quantitation of Uterine Activity after Vaginal Administration of Prostaglandins


15i. Effects of Prostaglandins on the Animal Reproductive Tract Tachyphylactic Response of the Rat Uterus In Vivo to Prostaglandins E2 and F2α

Effects of Prostaglandins E1 and F2α on Uterine Hemodynamics and Motility

Effects of Prostaglandins and Oxytocin on the Uterine Motility of the Living Rat Under Various Hormonal Conditions

The Role of Prostaglandin in Endotoxin-Induced Abortion and Fetal Death

Immediate and Late Effect of PGE1 on the Rabbit Oviduct (In Vivo Studies)

Effects of Prostaglandins (PGs) on Sperm and Egg Transport in the Rabbit


15k. Termination of Pregnancy by Prostaglandin Analogues

Termination of Pregnancy with Prostaglandin Analogs

15(S)-15-Methyl-Prostaglandin F2α: Myometrial Response and Abortifacient Efficacy


15l. Summary of Round Table Discussion on Fertility Regulation

A Note on Nomenclature

Stability of Prostaglandins

Chairmen and Principal Lecturers

Speakers

Subject Index