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    • Chemical Pathways of Metabolism

      • 1st Edition
      • May 12, 2014
      • David M. Greenberg
      • English
      • Paperback
        9 7 8 1 4 8 3 2 5 4 7 3 9
      • eBook
        9 7 8 1 4 8 3 2 7 4 2 8 7
      Chemical Pathways of Metabolism, Volume II focuses on the chemical processes involved in the metabolism of the essential components of living organisms, including catabolism, deamination, bonds, and synthetic processes. The selection first elaborates on nitrogen metabolism and carbon catabolism of amino acids, including deamination, urea synthesis, amino acids linked with the citric acid cycle, sulfur amino acids, and arginine and ornithine. The book then ponders on the synthetic processes involving amino acids and metabolism of sulfur-containing compounds. Discussions focus on reactions of sulfur-containing coenzymes, relationships of methionine and cysteine, desulfhydrase reaction, formation of phosphatide bases, and interconversions of glutamic acid, ornithine, and proline. The manuscript takes a look at the enzymatic syntheses of peptide bonds, purines and pyrimidines, and nucleotides and nucleosides. Topics include enzymatic splitting of coenzyme nucleotides, deamination of nucleosides and nucleotides, enzymatic synthesis of coenzyme nucleotides, purines, and pyrimidines. The selection is a valuable source of information for researchers interested in the chemical pathways of metabolism.

    • Immunological Aspects of Reproduction in Mammals

      • 1st Edition
      • May 20, 2014
      • D. B. Crighton
      • English
      • Paperback
        9 7 8 1 4 8 3 1 3 0 5 3 8
      • eBook
        9 7 8 1 4 8 3 1 6 2 9 5 9
      Immunological Aspects of Reproduction in Mammals contains papers presented during a symposium at the University of Nottingham Easter School. The scholarly presentations provide a wealth of information on the field of reproductive immunology and indicate just how complex this field is and how many questions still remain to be answered. The book begins with reviews of the current status of the complexities and uncertainties of the cellular basis of the immune response and the structure and function of antibodies. This is followed by separate chapters on the assessment and interpretation of the phenomena surrounding autoimmune and isoimmune reactions to spermatozoa; advances in defining the distribution and degree of exposure of major histocompatibility antigens; the reproductive immunology of the mouse, horse, and sheep; and fetal and neonatal immunity. Subsequent chapters present studies of immunization of several species with either the hypothalamic hormone LH-RH, pituitary gonadotrophins, or ovarian steroids; and studies directed towards efforts to enhance animal production by either active or passive immunization of female farm animals against steroid hormones. This book will be a valuable reference text for those already involved in the field and a stimulus for others to enter this complex and fascinating area of research.

    • The Shikimate Pathway

      • 1st Edition
      • May 20, 2014
      • Edwin Haslam
      • Gordon Kirby
      • English
      • Paperback
        9 7 8 1 4 8 3 1 2 8 7 6 4
      • eBook
        9 7 8 1 4 8 3 1 6 1 1 8 1
      The Shikimate Pathway gives a bird's eye view of the shikimate pathway and its implications for the life of a range of organisms. Topics covered in this book include the chemistry of intermediates in the shikimate pathway; biosynthesis of aromatic amino acids in this pathway; its metabolites; and its role in higher plants. This book is comprised of six chapters and begins by introducing the reader to shikimic acid, a natural product derived from the plant Illicium religiosum, along with the mechanistic and stereochemical aspects of the reactions of the shikimate pathway. The biosynthesis of aromatic amino acids from chorismate is also described, and then the discussion turns to the chemical properties and the detailed stereochemistry of intermediates and enzymes in the shikimate pathway. The next chapter examines the biosynthesis of isoprenoid quinones involved in electron transport and the folic acid group of co-enzymes in the shikimate pathway. The metabolism of the aromatic amino acids in microorganisms and higher organisms is considered, along with the biosynthesis and physiological functions of phenylpropanoid compounds and their derivatives in the shikimate pathway in higher plants. This book will be of general value to practitioners in the many and varied areas of biochemical research associated with metabolism.

    • Cellular Pathology Technique

      • 4th Edition
      • May 19, 2014
      • C. F. A. Culling + 2 more
      • English
      • Paperback
        9 7 8 1 4 8 3 1 7 6 3 8 3
      • eBook
        9 7 8 1 4 8 3 1 9 2 1 9 2
      Cellular Pathology Technique aims to maintain the twin objectives of producing a comprehensive bench book and a text for students that will take the Special Examination in Cellular Pathology of the Institute of Medical Laboratory Sciences. The organization of this fourth edition has been reshaped. Some sections were expanded such as those about the theory of staining, and new chapters were added dealing with immunolocalization, the endocrine system, and quantification. This book is organized into 10 parts. The introductory part provides basic information on cells and tissues and outlines the methodology in cellular pathology techniques. This is followed by chapters that deal with various aspects of cellular pathology including tissues, cells and cell products of special interests, electron microscopy, and immunocytochemistry. This book will be of interest to students of cellular pathology and those in the medical profession.

    • Therapeutic Risk Management of Medicines

      • 1st Edition
      • March 13, 2014
      • Stephen J. Mayall + 1 more
      • English
      • Hardback
        9 7 8 1 9 0 7 5 6 8 4 8 0
      • Paperback
        9 7 8 0 0 8 1 0 1 4 1 7 2
      • eBook
        9 7 8 1 9 0 8 8 1 8 2 7 0
      Therapeutic risk management of medicines is an authoritative and practical guide on developing, implementing and evaluating risk management plans for medicines globally. It explains how to assess risks and benefit-risk balance, design and roll out risk minimisation and pharmacovigilance activities, and interact effectively with key stakeholders.A more systematic approach for managing the risks of medicines arose following a number of high-profile drug safety incidents and a need for better access to effective but potentially risky treatments. Regulatory requirements have evolved rapidly over the past decade. Risk management plans (RMPs) are mandatory for new medicinal products in the EU and a Risk Evaluation and Mitigation Strategy (REMS) is needed for certain drugs in the US.This book is an easy-to-read resource that complements current regulatory guidance, by exploring key areas and practical implications in greater detail. It is structured into chapters encompassing a background to therapeutic risk management, strategies for developing RMPs, implementation of RMPs, and the continuing evolution of the risk management field.The topic is of critical importance not only to the pharmaceutical and biotechnology industries, but also regulators and healthcare policymakers.Some chapters feature contributions from selected industry experts.

    • A History of Medical Bacteriology and Immunology

      • 1st Edition
      • May 20, 2014
      • W. D. Foster
      • English
      • Paperback
        9 7 8 1 4 8 3 1 3 0 0 3 3
      • eBook
        9 7 8 1 4 8 3 1 6 2 4 5 4
      A History of Medical Bacteriology and Immunology provides the account of the history of bacteriology from the year 1900 to 1938. This book presents details about the discovery of the important pathogenic bacteria of man, of how they were shown to be causally related to disease, and of the use of these discoveries in the diagnosis, treatment, and prevention of disease. Other topics discussed include the development of the germ theory of infectious diseases; contribution of Louis Pasteur and Robert Koch to medical bacteriology; and discovery of the more important human pathogenic bacteria. This text also discusses the scientific basis and practical application of immunology to medicine; main developments in bacteriology during the early 20th century; and chemotherapy of bacterial disease. This medically oriented text is beneficial for students and individuals conducting study on medical bacteriology and immunology.

    • An Introduction to Microbiology for Nurses

      • 3rd Edition
      • May 12, 2014
      • N. A. Simmons
      • English
      • Paperback
        9 7 8 0 4 3 3 3 0 3 0 1 5
      • eBook
        9 7 8 1 4 8 3 1 8 3 0 1 5
      An Introduction to Microbiology for Nurses is an introductory text on microbiology for nurses, written in simple language and restricting those sections on the fundamentals of bacteriology (for example, the physiology of bacteria) to a minimum. Instead of presenting systematic bacteriology and describing organisms genus by genus, disease-causing bacteria are considered together in each particular part of the human body. Only the common and important infections are included. Comprised of 16 chapters, this book begins with a historical background on bacteriology, followed by a discussion on the biology of bacteria. A classification of bacteria is then presented, and infections caused by bacteria are described. Subsequent chapters focus on body defenses against bacterial infections; killing of bacteria through disinfection and sterilization; antibacterial therapy; and collection of bacteriological specimens as part of bacteriological diagnosis. Infections of the respiratory tract, gastrointestinal tract, and the nervous system are also analyzed. The final chapter is devoted to elementary parasitology. This monograph is intended for nurses interested in learning more about microbiology and bacteriology.

    • Joint Replacement Technology

      • 2nd Edition
      • June 2, 2014
      • Peter A. Revell
      • English
      • Paperback
        9 7 8 0 8 5 7 0 9 8 4 1 2
      • Paperback
        9 7 8 0 0 8 1 0 1 5 1 5 5
      • eBook
        9 7 8 0 8 5 7 0 9 8 4 7 4
      This second edition of Joint Replacement Technology provides a thoroughly updated review of recent developments in joint replacement technology. Joint replacement is a standard treatment for joint degradation and has improved the quality of life of millions of patients. Collaboration between clinicians and researchers is critical to its continued success and to meet the rising expectations of patients and surgeons. Part one introduces the advances in joint replacement technology, tribological considerations and experiments, and immune and regenerative responses to joint replacements. Part two covers the materials and techniques used in joint replacement. The advantages and disadvantages of different metals are explained here, as well as the use of ceramics. This section also addresses challenges in joint bearing surfaces, design, and cementless fixation techniques. Biological and mechanical issues are considered in part three, including healing responses to implants and biological causes of prosthetic joint failure, and a new chapter on imaging of joint prostheses. Each chapter in part four describes the clinical challenges of replacing specific joints, with specific focus on hip, knee, intervertebral disc joint, shoulder arthroplasty, elbow arthroplasty, and pyrocarbon small joint arthroplasty. Thanks to its widespread collaboration and international contributors, Joint Replacement Technology is useful for materials scientists and engineers in both academia and biomedical industry. Chemists, clinicians, and other researchers in this area will also find it invaluable.

    • Biochemistry and Physiology of Protozoa

      • 1st Edition
      • May 12, 2014
      • André Lwoff
      • English
      • Paperback
        9 7 8 1 4 8 3 2 5 4 6 4 7
      • eBook
        9 7 8 1 4 8 3 2 6 3 6 6 3
      Biochemistry and Physiology of Protozoa, Volume I focuses on the chemical and physiological features of Protozoa, including nutrition, metabolism, and growth of phytoflagellates, Trypanosomidae and Bodonidae, biochemistry of ciliates and Plasmodium, and the influence of antimalarials. The selection first offers information on the biochemistry of Protozoa and phytoflagellates, including sexuality in Chlamydomonas, growth factors and chemical asepsis, descriptive chemistry and phylogenetic relationships, evolutionary aspects of photosynthesis, nutrition and biochemistry of Protozoa, and the biochemical evolution of Protozoa. The text then ponders on the nutrition of parasitic flagellates and metabolism of Trypanosomidae and Bodonidae. The publication takes a look at the nutrition of parasitic amebae, biochemistry of Plasmodium and the influence of antimalarials, and the biochemistry of ciliates in pure culture. Topics include carbon metabolism and respiration, nitrogen metabolism, antimalarial compounds and their influence on the metabolism of malarial parasites, metabolism of malarial parasites, and nutrition of the dysentery ameba, Entamoeba histolytica. The selection is a valuable reference for cytologists, geneticists, and pathologists interested in the biochemistry and physiology of protozoa.

    • Introduction to Enzymology

      • 1st Edition
      • May 12, 2014
      • Alan H. Mehler
      • English
      • Paperback
        9 7 8 1 4 8 3 2 5 5 2 1 7
      • eBook
        9 7 8 1 4 8 3 2 5 8 4 7 8
      Introduction to Enzymology focuses on the processes, methodologies, reactions, and approaches involved in enzyme chemistry. The book first offers information on the hydrolysis of peptides and proteins and fermentation and oxidation of major metabolic fuels. Discussions focus on oxidation of fatty acids, alternative pathways of carbohydrate metabolism, Krebs citric acid cycle, free energy and the concept of bond energy, pyruvate oxidation and acetyl coenzyme A formation, and glycolysis. The text then elaborates on the transfer of oxygen, hydrogen, and electrons and sugars and sugar derivatives. The publication takes a look at polynucleotides and their components, amino acids, and acids and acid derivatives. Topics include carbonic anhydrase, mechanism of action of pyridoxal phosphate enzymes, aromatic ring biosynthesis and metabolism of phenylalanine and tyrosine, metabolism of sulfur-containing amino acids, and oxidation of amino acids. The book is a valuable reference for chemists and researchers interested in enzymology.

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