Books in Life sciences

Drug-Like Properties

2nd Edition
December 17, 2015
Li Di + 1 more
English
Hardback
9 7 8 0 1 2 8 0 1 0 7 6 1
eBook
9 7 8 0 1 2 8 0 1 3 2 2 9

Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, only a fraction have sufficient ADME (absorption, distribution, metabolism, elimination) properties, and acceptable toxicology properties, to become a drug product that will successfully complete human Phase I clinical trials. Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization, Second Edition, provides scientists and students the background and tools to understand, discover, and develop optimal clinical candidates. This valuable resource explores physiochemical properties, including solubility and permeability, before exploring how compounds are absorbed, distributed, and metabolized safely and stably. Review chapters provide context and underscore the importance of key concepts such as pharmacokinetics, toxicity, the blood-brain barrier, diagnosing drug limitations, prodrugs, and formulation. Building on those foundations, this thoroughly updated revision covers a wide variety of current methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties for process and product improvement. From conducting key assays for interpretation and structural analysis, the reader learns to implement modification methods and improve each ADME property. Through valuable case studies, structure-property relationship descriptions, and structure modification strategies, Drug-Like Properties, Second Edition, offers tools and methods for ADME/Tox scientists through all aspects of drug research, discovery, design, development, and optimization.

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging

1st Edition
December 17, 2015
M. A. Hayat
English
Hardback
9 7 8 0 1 2 8 0 2 9 3 7 4
eBook
9 7 8 0 1 2 8 0 2 9 5 2 7

Volume 8 Autophagy and Human Diseases, concentrates on the role of Autophagy in human diseases, including tumorigenesis. The diseases discussed include melanoma, liver cancer, pancreatic cancer, and neurodegenerative disorders. Loss of autophagy in the central nervous system causes neurodegeneration (Alzheimers disease, Huntington’s disease, Parkin’s disease, and Amyotrophic Lateral Sclerosis). Melanoma is one of the most serious diseases in humans. Autophagy plays a key role in the anticancer response to Chemotherapy. However, autophagy can increase or decrease the effectiveness of chemotherapy. The reasons for these contradictory effects are explained. Autophagy also plays a role in idiopathic inflammatory diseases, infection, and immunity. An explanation is given how autophagy is closely linked to control of innate and adaptive immune responses in host defense in part by regulating cytokine production. The role of autophagy in cutaneous malignant melanoma is discussed in detail and expression of Beclin 1 and LC3 autophagic genes in melanoma is included to explain the molecular mechanisms underlying this very serious disease, which tends to metastasize to the brain. The effect of the treatment of this disease using Terfenadine through the induction of autophagy and apoptosis is also included. Autophagy and apoptosis are two main mechanisms involved in programmed cell death.

Hydrogenation of Fats and Oils

2nd Edition
December 9, 2015
Gary R. List + 1 more
English
Hardback
9 7 8 1 8 9 3 9 9 7 9 3 6
eBook
9 7 8 0 1 2 8 0 4 3 4 9 3

As in the first edition, discussion is not confined to vegetable oils, and the hydrogenation technique is considered in detail. The "why" as well as the "how" of hydrogenation are addressed. Written for both production staff who need advice on specific problems and development personnel who seek directions, if not solutions, the book offers direct practical advice along with explanations of why changes occur as they do. The glossary of technical terms contains a more detailed explanation of some features mentioned throughout the text.

The Fungi

3rd Edition
December 8, 2015
Sarah C. Watkinson + 2 more
English
Paperback
9 7 8 0 1 2 3 8 2 0 3 4 1
eBook
9 7 8 0 1 2 3 8 2 0 3 5 8

The Fungi, Third Edition, offers a comprehensive and thoroughly integrated treatment of the biology of the fungi. This modern synthesis highlights the scientific foundations that continue to inform mycologists today, as well as recent breakthroughs and the formidable challenges in current research. The Fungi combines a wide scope with the depth of inquiry and clarity offered by three leading fungal biologists. The book describes the astonishing diversity of the fungi, their complex life cycles, and intriguing mechanisms of spore release. The distinctive cell biology of the fungi is linked to their development as well as their metabolism and physiology. One of the great advances in mycology in recent decades is the recognition of the vital importance of fungi in the natural environment. Plants are supported by mycorrhizal symbioses with fungi, are attacked by other fungi that cause plant diseases, and are the major decomposers of their dead tissues. Fungi also engage in supportive and harmful interactions with animals, including humans. They are major players in global nutrient cycles. This book is written for undergraduates and graduate students, and will also be useful for professional biologists interested in familiarizing themselves with specific topics in fungal biology.

CAPA in the Pharmaceutical and Biotech Industries

1st Edition
December 8, 2015
J Rodriguez
English
Hardback
9 7 8 1 9 0 7 5 6 8 5 8 9
eBook
9 7 8 1 9 0 8 8 1 8 3 7 9

CAPA in the Pharmaceutical and Biotech Industries: How to Implement an Effective Nine Step Program contains the most current information on how to implement, develop, and maintain an effective Corrective Action and Preventive Action (CAPA) and investigation program using a nine step closed-loop process approach for medical devices and pharmaceutical and biologic manufacturers, as well as any anyone who has to maintain a quality system.This book addresses how companies often make the mistake of fixing problems in their processes by revising procedures or, more commonly, by retraining employees that may or may not have caused the problem. This event-focused fix leads to the false assumption that the errors have been eradicated and will be prevented in the future. The reality is that the causes of the failure were never actually determined, therefore the same problem will recur over and over. CAPA is a complete system that collects information regarding existing and potential quality problems. It analyzes and investigates the issues to identify the root cause of nonconformities. It is not just a quick-fix, simple approach, it is a process and has to be understood throughout organizations.

FORWARD to Professorship in STEM

1st Edition
December 7, 2015
Rachelle S. Heller + 2 more
English
Paperback
9 7 8 0 1 2 8 0 0 8 5 5 3
eBook
9 7 8 0 1 2 8 0 1 1 2 8 7

FORWARD to Professorship in STEM: Inclusive Faculty Development Strategies That Work provides best practices on how to design and implement inclusive workshops aimed at supporting faculty and staff in their career development. The book addresses fundamental skills and strategies to excel in academia, with a focus on assisting women and other underrepresented groups to succeed in obtaining tenure-track faculty positions, and in acquiring tenure. Contributors from wide geographical, disciplinary, and career backgrounds offer their insights on challenges in academia, lessons learned, successes, and outcomes, with chapters devoted to tenure and beyond, collaborations and funding, impact on, and of, the deaf culture, and engaging differences.

Molecular Nutrition and Diabetes

1st Edition
December 7, 2015
Didac Mauricio
English
Hardback
9 7 8 0 1 2 8 0 1 5 8 5 8
eBook
9 7 8 0 1 2 8 0 1 7 6 1 6

Molecular Nutrition and Diabetes: A Volume in the Molecular Nutrition Series focuses on diabetes as a nutritional problem and its important metabolic consequences. Fuel metabolism and dietary supply all influence the outcome of diabetes, but understanding the pathogenesis of the diabetic process is a prelude to better nutritional control. Part One of the book provides general coverage of nutrition and diabetes in terms of dietary patterns, insulin resistance, and the glucose-insulin axis, while Part Two presents the molecular biology of diabetes and focuses on areas such as oxidative stress, mitochondrial function, insulin resistance, high-fat diets, nutriceuticals, and lipid accumulation. Final sections explore the genetic machinery behind diabetes and diabetic metabolism, including signaling pathways, gene expression, genome-wide association studies, and specific gene expression. While the main focus of each chapter is the basic and clinical research on diabetes as a nutritional problem, all chapters also end with a translational section on the implications for the nutritional control of diabetes.

Introduction to Protein Mass Spectrometry

1st Edition
December 7, 2015
Pradip K. Ghosh
English
Hardback
9 7 8 0 1 2 8 0 5 1 2 3 8
eBook
9 7 8 0 1 2 8 0 2 1 1 2 5

Introduction to Protein Mass Spectrometry provides a comprehensive overview of this increasingly important, yet complex, analytical technique. Unlike many other methods which automatically yield an absolutely unique protein name as output, protein mass spectrometry generally requires a deduction of protein identity from determination of peptide fragmentation products. This book enables readers to both understand, and appreciate, how determinations about protein identity from mass spectrometric data are made. Coverage begins with the technical basics, including preparations, instruments, and spectrometric analysis of peptides and proteins, before exploring applied use in biological applications, bioinformatics, database, and software resources. Citing the most recent and relevant work in the field of biological mass spectrometry, the book is written for researchers and scientists new to the field, but is also an ideal resource for those hoping to hone their analytical abilities.

Introduction to Protein Mass Spectrometry

1st Edition
December 7, 2015
Pradip K. Ghosh
English
Hardback
9 7 8 0 1 2 8 0 5 1 2 3 8
eBook
9 7 8 0 1 2 8 0 2 1 1 2 5

Amphioxus Immunity

1st Edition
December 7, 2015
An-Long Xu
English
Hardback
9 7 8 0 1 2 8 4 9 9 0 3 0
eBook
9 7 8 0 1 2 8 0 9 6 4 7 5

Amphioxus Immunity: Tracing the Origin of Human Immunity covers a remarkable range of information about Amphioxus and its evolutionary context. This compilation of what is currently known about Amphioxus, with a sharp focus on its immune system, includes 13 topics, such as: Amphioxus as a model for understanding the evolution of vertebrates basic knowledge of immunology immune organs and cells of amphioxus a genomic and transcriptomic view of the Amphioxus immunity pattern recognition system in Amphioxus transcription factors in Amphioxus the complement system of Amphioxus the oxidative burst system in Amphioxus immune effectors in Amphioxus lipid signaling of immune response in Amphioxus apoptosis in amphioxus; primitive adaptive immune system of Amphioxus and future research directions This valuable reference book is loaded with information that will be useful for anyone who wishes to learn more about the origin of vertebrates and adaptive immunity.

Related subjects

Agricultural and biological sciences

Drug discovery

Immunology

Microbiology and virology

Neuroscience

Pharmaceutical sciences

Pharmacology

Toxicology

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health

Books in Life sciences

Drug-Like Properties

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging

Hydrogenation of Fats and Oils

The Fungi

CAPA in the Pharmaceutical and Biotech Industries

FORWARD to Professorship in STEM

Molecular Nutrition and Diabetes

Introduction to Protein Mass Spectrometry

Introduction to Protein Mass Spectrometry

Amphioxus Immunity

Related subjects