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Elsevier

Books in Life sciences

  • Approaches to the Purification, Analysis and Characterization of Antibody-Based Therapeutics

    • 1st Edition
    • Allan Matte
    • English
    Approaches to the Purification, Analysis and Characterization of Antibody-Based Therapeutics provides the interested and informed reader with an overview of current approaches, strategies and considerations relating to the purification, analytics and characterization of therapeutic antibodies and related molecules. While there are obviously other books published in and around this subject area, they seem to be either older (c.a. year 2000 publication date) or are more limited in scope. The book will include an extensive bibliography of the published literature in the respective areas covered. It is not, however, intended to be a how-to methods book.

  • Odorant Binding and Chemosensory Proteins

    • 1st Edition
    • Volume 642
    • English
    This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field.

  • Biomaterials for 3D Tumor Modeling

    • 1st Edition
    • Subhas C. Kundu + 1 more
    • English
    Biomaterials for 3D Tumor Modeling reviews the fundamentals and most relevant areas of the latest advances of research of 3D cancer models, focusing on biomaterials science, tissue engineering, drug delivery and screening aspects. The book reviews advanced fundamental topics, including the causes of cancer, existing cancer models, angiogenesis and inflammation during cancer progression, and metastasis in 3D biomaterials. Then, the most relevant biomaterials are reviewed, including methods for engineering and fabrication of biomaterials. 3D models for key biological systems and types of cancer are also discussed, including lung, liver, oral, prostate, pancreatic, ovarian, bone and pediatric cancer. This book is suitable for those working in the disciplines of materials science, biochemistry, genetics, molecular biology, drug delivery and regenerative medicine.

  • RNA-Based Regulation in Human Health and Disease

    • 1st Edition
    • English
    RNA-based Regulation in Human Health and Disease offers an in-depth exploration of RNA mediated genome regulation at different hierarchies. Beginning with multitude of canonical and non-canonical RNA populations, especially noncoding RNA in human physiology and evolution, further sections examine the various classes of RNAs (from small to large noncoding and extracellular RNAs), functional categories of RNA regulation (RNA-binding proteins, alternative splicing, RNA editing, antisense transcripts and RNA G-quadruplexes), dynamic aspects of RNA regulation modulating physiological homeostasis (aging), role of RNA beyond humans, tools and technologies for RNA research (wet lab and computational) and future prospects for RNA-based diagnostics and therapeutics. One of the core strengths of the book includes spectrum of disease-specific chapters from experts in the field highlighting RNA-based regulation in metabolic & neurodegenerative disorders, cancer, inflammatory disease, viral and bacterial infections. We hope the book helps researchers, students and clinicians appreciate the role of RNA-based regulation in genome regulation, aiding the development of useful biomarkers for prognosis, diagnosis, and novel RNA-based therapeutics.

  • Emerging Technologies for Heart Diseases

    Volume 1: Treatments for Heart Failure and Valvular Disorders
    • 1st Edition
    • Udi Nussinovitch
    • English
    The increasing pace of advances in cardiology throughout the last few decades has fundamentally altered the natural course of heart patients. In the last few years, available therapies have been revolutionized completely by new transcatheter therapeutic approaches, novel ventricular assist devices, and new drugs. Also, molecular biology and genetics have a rapidly growing impact on cardiovascular diseases, enabling the field of regenerative medicine to become increasingly closer to routine clinical implementation. Emerging Technologies for Heart Diseases was conceived to cover the recent extensive literature on current and novel therapeutic options for cardiac patients. The first volume is dedicated to heart failure and valvular disorders, and the second covers myocardial ischemia and arrhythmias. The clinical topic is addressed in several chapters divided according to the therapeutic approach (mechanical or electrical device-based, or cell and gene-based). Each of the 46 chapters focuses on clinically available solutions, new therapies currently under evaluation in clinical trials, promising preclinical technologies, and emerging concepts and innovations that have not yet been tested in a preclinical model. Also, the book discusses future challenges and opportunities for clinical implementation. Lessons learned from abandoned experimental practices are also covered, giving the readers the widest possible perspective of current therapeutic dilemmas. Overall, this textbook was designed for physicians who want to stay up-to-date with current therapies and those of the future, for biomedical companies, and for those who wish to broaden their knowledge of new cardiovascular therapeutic options.

  • Dancing Protein Clouds: Intrinsically Disordered Proteins in Health and Disease, Part B

    • 1st Edition
    • Volume 174
    • English
    Dancing Protein Clouds: Intrinsically Disordered Proteins in Health and Disease, Part B, represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this update include structural and functional characterization of several important intrinsically disordered proteins, such as 14-3-3 proteins and their partners, as well as proteins from muscle sarcomere; representation of intrinsic disorder-related concept of protein structure-function continuum; discussion of the role of intrinsic disorder in phenotypic switching; consideration of the role of intrinsically disordered proteins in the pathogenesis of neurodegenerative diseases and cancer; discussion of the roles of intrinsic disorder in functional amyloids; demonstration of the usefulness of the analysis of translational diffusion of unfolded and intrinsically disordered proteins; consideration of various computational tools for evaluation of functions of intrinsically disordered regions; and discussion of the role of shear stress in the amyloid formation of intrinsically disordered regions in the brain.

  • Emerging Technologies for Heart Diseases

    Volume 2: Treatments for Myocardial Ischemia and Arrhythmias
    • 1st Edition
    • Udi Nussinovitch
    • English
    The increasing pace of advances in cardiology throughout the last few decades has fundamentally altered the natural course of heart patients. In the last few years, available therapies have been revolutionized completely by new transcatheter therapeutic approaches, novel ventricular assist devices, and new drugs. Also, molecular biology and genetics have a rapidly growing impact on cardiovascular diseases, enabling the field of regenerative medicine to become increasingly closer to routine clinical implementation. Emerging Technologies for Heart Diseases was conceived to cover the recent extensive literature on current and novel therapeutic options for cardiac patients. The first volume is dedicated to heart failure and valvular disorders, and the second covers myocardial ischemia and arrhythmias. The clinical topic is addressed in several chapters divided according to the therapeutic approach (mechanical or electrical device-based, or cell and gene-based). Each of the 46 chapters focuses on clinically available solutions, new therapies currently under evaluation in clinical trials, promising preclinical technologies, and emerging concepts and innovations that have not yet been tested in a preclinical model. Also, the book discusses future challenges and opportunities for clinical implementation. Lessons learned from abandoned experimental practices are also covered, giving the readers the widest possible perspective of current therapeutic dilemmas. Overall, this textbook was designed for physicians who want to stay up-to-date with current therapies and those of the future, for biomedical companies, and for those who wish to broaden their knowledge of new cardiovascular therapeutic options.

  • The Future of Pharmaceutical Product Development and Research

    • 1st Edition
    • English
    The Future of Pharmaceutical Product Development and Research examines the latest developments in the pharmaceutical sciences, also highlighting key developments, research and future opportunities. Written by experts in the field, this volume in the Advances in Pharmaceutical Product Development and Research series deepens our understanding of the product development phase of drug discovery and drug development. Each chapter covers fundamental principles, advanced methodologies and technologies employed by pharmaceutical scientists, researchers and the pharmaceutical industry. The book focuses on excipients, radiopharmaceuticals... and how manufacturing should be conducted in an environment that follows Good Manufacturing Practice (GMP) guidelines. Researchers and students will find this book to be a comprehensive resource for those working in, and studying, pharmaceuticals, cosmetics, biotechnology, foods and related industries.

  • Storing Digital Binary Data in Cellular DNA

    The New Paradigm
    • 1st Edition
    • Rocky Termanini
    • English
    Storing Digital Binary Data into Cellular DNA demonstrates how current digital information storage systems have short longevity and limited capacity, also pointing out that their production and consumption of data exceeds supply. Author Rocky Termanini explains the DNA system and how it encodes vast amounts of data, then presents information on the emergence of DNA as a storage technology for the ever-growing stream of data being produced and consumed. The book will be of interest to a range of readers looking to understand this game-changing technology, including researchers in computer science, biomedical engineers, geneticists, physicians, clinicians, law enforcement and cybersecurity experts.

  • Swarm Intelligence for Resource Management in Internet of Things

    • 1st Edition
    • Aboul Ella Hassanien + 1 more
    • English
    Internet of Things (IoT) is a new platform of various physical objects or “things” equipped with sensors, electronics, smart devices, software, and network connections. IoT represents a new revolution of the Internet network which is driven by the recent advances of technologies such as sensor networks (wearable and implantable), mobile devices, networking, and cloud computing technologies. IoT permits these the smart devices to collect, store and analyze the collected data with limited storage and processing capacities. Swarm Intelligence for Resource Management in the Internet of Things presents a new approach in Artificial Intelligence that can be used for resources management in IoT, which is considered a critical issue for this network. The authors demonstrate these resource management applications using swarm intelligence techniques. Currently, IoT can be used in many important applications which include healthcare, smart cities, smart homes, smart hospitals, environment monitoring, and video surveillance. IoT devices cannot perform complex on-site data processing due to their limited battery and processing. However, the major processing unit of an application can be transmitted to other nodes, which are more powerful in terms of storage and processing. By applying swarm intelligence algorithms for IoT devices, we can provide major advantages for energy saving in IoT devices. Swarm Intelligence for Resource Management in the Internet of Things shows the reader how to overcome the problems and challenges of creating and implementing swarm intelligence algorithms for each application

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