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Biomaterials for 3D Tumor Modeling
1st Edition - August 20, 2020
Editors: Subhas C. Kundu, Rui L. Reis
Paperback ISBN:
9 7 8 - 0 - 1 2 - 8 1 8 1 2 8 - 7
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 1 8 1 2 9 - 4
Biomaterials for 3D Tumor Modeling reviews the fundamentals and most relevant areas of the latest advances of research of 3D cancer models, focusing on biomaterials science,… Read more
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Biomaterials for 3D Tumor Modeling reviews the fundamentals and most relevant areas of the latest advances of research of 3D cancer models, focusing on biomaterials science, tissue engineering, drug delivery and screening aspects. The book reviews advanced fundamental topics, including the causes of cancer, existing cancer models, angiogenesis and inflammation during cancer progression, and metastasis in 3D biomaterials. Then, the most relevant biomaterials are reviewed, including methods for engineering and fabrication of biomaterials. 3D models for key biological systems and types of cancer are also discussed, including lung, liver, oral, prostate, pancreatic, ovarian, bone and pediatric cancer.
This book is suitable for those working in the disciplines of materials science, biochemistry, genetics, molecular biology, drug delivery and regenerative medicine.
- Reviews key biomaterials topics, including synthetic biomaterials, hydrogels, e-spun materials and nanoparticles
- Provides a comprehensive overview of 3D cancer models for key biological systems and cancer types
- Includes an overview of advanced fundamental concepts for an interdisciplinary audience in materials science, biochemistry, regenerative medicine and drug delivery
Materials Scientists, those working in Regenerative Medicine, those working in Biochemistry, those working in drug delivery, academics and those working in the clinic
1. Trends in biomaterials for 3D cancer modeling2. Causes of cancers: physical, chemical, biological carcinogens and viruses3. Three-dimensional in vitro models of angiogenesis4. Metastasis in 3D biomaterials5. Biomatrices that mimic the cancer extracellular environment6. Marine derived biomaterials for cancer treatment7. 3D scaffold materials for skin cancer modeling8. Three-dimensional tumor model and their implication in drug screening for tackling chemoresistance9. In vitro 3D modelling for prostate cancer10. Biomaterial based in vitro models for pancreatic cancer11. Mesoporous silica nanoparticles for cancer theranostics applications12. Microfluidic systems in cancer research13. Bio-detection and sensing for cancer diagnostics14. Biomaterials as ECM-like matrices for 3D in vitro tumor models15. 3D cancer spheroids and microtissues16. Co-culture and 3D tumor models for drug and gene therapy testing17. Engineering of 3D in vitro models for cancer research18. Tissue engineered 3D cancer microenvironment for screening therapeutics19. 3D neuroblastoma models using engineered cell-derived matrices20. 3D cancer models for chemotherapy using biomaterials21. 3D tumor-on-chip devices with perfusion for anti-cancer drug testing22. A predictive oncology framework: Modelling tumor proliferation using a FEM platform23. Understanding the impact of controlled oxygen delivery to 3D cancer cell culture24. 3D full skin models for skin cancer research25. Tissue engineering strategies for treatment of skeletal maxillofacial defects resulting from neoplasms resections26. 3D culture systems as models for solid tumors and cancer metabolism27. Biofabrication of 3D tumor models in cancer research28. Engineering breast cancer models in vitro with 3D printing
- No. of pages: 772
- Language: English
- Published: August 20, 2020
- Imprint: Elsevier
- Paperback ISBN: 9780128181287
- eBook ISBN: 9780128181294
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Subhas C. Kundu
Subhas C. Kundu, PhD, is a Research Coordinator and former European Research Area Chair and Professor at the 3B´s Research Group, I3Bs – Institute on Biomaterials, Biodegradables and Biomimetics of the University of Minho, Portugal. His research interests include silk biomaterial matrices for biomedical applications, including 3D in vitro cancer models for investigating tumour growth and progression. In addition, he is using natural-based biomaterials for 3D cancer modelling and drug screening.
Affiliations and expertise
Research Coordinator and former European Research Area Chair, 3B´s Research Group, I3Bs, Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, PortugalRR
Rui L. Reis
Dr. Rui Reis is Vice-President for Research and Innovation of University of Minho, Portugal, Director of 3B’s Research Group and Director of ICVS/3B´s Associate Laboratory, both of UMinho. He’s the CEO of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, the Coordinator of the Discoveries Centre for Regenerative and Precision Medicine, the Global Past-President of the Tissue Engineering and Regenerative Medicine International Society and the Editor-in-chief of the Journal of Tissue Engineering and Regenerative Medicine. He’s edited 18 books, 10 special issue journals, 280 book chapters and has more than 1225 published works listed on ISI Web of Knowledge, being an inventor of around 70 patents. He’s been awarded many important international prizes, including the TERMIS-EU contributions to the literature Award and the TERMIS-EU Career Achievement Award, and recently the UNESCO- International Life Sciences Award and the IET A. F. Harvey Engineering Research Prize.
Affiliations and expertise
President of Institute 3B’s, University of Minho; Director of the Associated Laboratory ICVS/3B’s and of the European Institute of Excellence in Tissue Engineering and Regenerative Medicine (EXPERTISSUES); Full Professor of Tissue Engineering, Regenerative Medicine and Stem Cells, University of Minho, Barco, Portugal