Life sciences print books and ebooks | Elsevier

An Innovative Approach to Understanding and Treating Cancer: Targeting pH

1st Edition
January 16, 2020
Tomas Koltai + 2 more
English
Paperback
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eBook
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An Innovative Approach to Studying and Treating Cancer: Targeting pH describes one of the few characteristics of cancer that is not shared by normal tissues: the reversal or inversion of the pH gradient when intracellular pH becomes alkaline and extracellular pH becomes acid. This is now recognized as one of the most selective and differential hallmarks of all cancer cells and tissues, being the opposite of the condition found in normal tissues and a potential target in order to achieve either a stable disease or even regression with no toxicity. The book discusses topics such as lactic acid and its transport system in the pH paradigm, mechanisms to decrease extra cellular pH and increase intracellular pH, NHE-1 activity in cancer, carbonic anhydrases, vacuolar ATPase proton pump, and the sodium-bicarbonate cotransporter system. Additionally, it discusses complementary pharmacological interventions, cellular acidification and extracellular alkalinization as a new and integral approach to cancer treatment.

Advances in Marine Biology

1st Edition
Volume 86
June 26, 2020
English
Hardback
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eBook
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Advances in Marine Biology, Volume 86, the latest release in a series that has been providing in-depth and up-to-date reviews on all aspects of marine biology since 1963, updates on many topics that will appeal to postgraduates and researchers in marine biology, fisheries science, ecology, zoology and biological oceanography. Chapters in this new release include Marine Environmental DNA: Approaches, Applications, and Opportunities, and The Biology and Ecology of the Banana Prawns.

Controlled Release Fertilizers for Sustainable Agriculture

1st Edition
October 14, 2020
F.B Lewu + 3 more
English
Paperback
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eBook
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Controlled Release Fertilizers for Sustainable Agriculture provides a comprehensive examination of precision fertilizer applications using the 4-R approach—the right amount of fertilizer at the right time to the right plant at the correct stage of plant growth. This volume consolidates detailed information on each aspect of controlled release fertilizers, including up-to-date literature citations, the current market for controlled release fertilizers and patents. Presenting the tremendous advances in experimental and theoretical studies on sustainable agriculture and related areas, this book provides in-depth insight into state-of-the-art controlled release mechanisms of fertilizers, techniques, and their use in sustainable agriculture. Conventional release mechanisms have historically meant waste of fertilizers and the adverse effects of that waste on the environment. Controlled release delivery makes significant strides in enhancing fertilizer benefit to the target plant, while protecting the surrounding environment and increasing sustainability.

Diabetología

3rd Edition
September 15, 2020
Louis Monnier + 1 more
Spanish
Paperback
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eBook
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La obra insiste en los aspectos prácticos del abordaje y en los nuevos métodos de exploración, seguimiento y tratamiento. Las estrategias diagnósticas y terapéuticas novedosas se han desarrollado siguiendo los avances científicos más recientes. Se han incluido cinco capítulos nuevos, sobre los efectos de los tratamientos antihiperglucemiant... en las complicaciones cardiovasculares y renales del paciente diabético de tipo 2; la monitorización glucémica continua en las diabetes de tipos 1 y 2; la disbiosis intestinal y las enfermedades metabólicas; las complicaciones hepáticas, y Ramadán y diabetes. Asimismo, se ha profundizado en las nuevas recomendaciones diagnósticas y terapéuticas. A ellas se les han dedicado dos capítulos totalmente actualizados: «Árboles terapéuticos y de decisión en la diabetes de tipo 2» e «Insulinoterapia en la diabetes de tipos 1 y 2». Práctica y didáctica, esta obra está dirigida al conjunto de los profesionales sanitarios que tienen que tratar con pacientes diabéticos.

The Ethics of Everyday Medicine

1st Edition
September 22, 2020
Erwin B. Montgomery Jr.
English

Ethics of Everyday Medicine: Explorations of Justice examines and analyses the relatively unexplored domain of ethics involved in the everyday practice of medicine. From the author’s clinical experience, virtually every decision made in the day-to-day practice of medicine is fundamentally an ethical question, as virtually every decision hinge on some value judgment that goes beyond the medical facts of the matter. The first part of the book is devoted to medical decision cases in several areas of medicine. These cases highlight elements of the current healthcare ecosystem, involving players other than the physician and patient. Insurers (private, commercial, and governmental), administrators, and regulators’ perspectives are surfaced in point of care case analysis. Part two contributes to the development of actionable tools to develop better ethical systems for the everyday practice of medicine by providing a critical analysis of Reflective Equilibrium and ethical induction from the perspective of logic and statistics. The chapter on Justice discusses the neurophysiological representations of just and unjust behaviours. The chapter on Ethical Theories follows, describing the epistemic conundrum, principlism, reproducibility, abstraction, chaos and complexity. The following chapter approaches ethical decisions from the logic and statistic perspectives. The following chapter, The Patient as Parenthetical, the author discusses patient-centric ethics, and the rise of business- and government-cetric ethics. The final chapter, A Framework to Frame the Questions for Explore Further, proposes a working framework to deal with current ethical issues. Ethics of everyday Medicine: Explorations of Justice acknowledges that there are no answers yet to the ethical dilemmas that confront the everyday practice of medicine, but proposes a framework for deeper analysis and action. This reading would be useful to all healthcare professionals. Regulators and policy makers could also benefit from understanding how the complex healthcare environment influences medical decisions at point of care.

Magnetoencephalography, An Issue of Neuroimaging Clinics of North America

1st Edition
Volume 30-2
April 30, 2020
Roland Lee + 1 more
English
Hardback
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eBook
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This issue of Neuroimaging Clinics of North America focuses on Magnetoencephalograp... (MEG), and is edited by Drs. Roland Lee and Mingxiong Huang. Articles will include: MEG signal processing, forward modeling, MEG inverse source imaging, and Coherence analysis; Magnetoencephalograp... for pre-surgical functional mapping; Magnetoencephalograp... for mild TBI and PTSD; Magnetoencephalograp... for autism; Magnetoencephalograp... for schizophrenia; Magnetoencephalograp... for Alzheimer's disease; Pediatric Magnetoencephalograp... The MEG Measurement Techniques; MEG and Language/Linguistics... MEG for Epilepsy; Integration of MEG results into the patient workup – Merging multiple modalities; and more!

Extracellular Vesicles

1st Edition
Volume 645
October 24, 2020
English
Hardback
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eBook
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Extracellular Vesicles, Volume 645 in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Chapters in this new release include Genetic labeling of extracellular vesicle exosomes for studying biogenesis and uptake in living mammalian cells, Fluorescent Labeling of Extracellular Vesicles, Isolation of extracellular vesicles from lymph, Transgenic rats for tracking body fluid/tissue-derived extracellular vesicles, Isolation of amniotic extracellular vesicles, Urinary extracellular vesicle isolation, Immunocapture-based ELISA to Characterize and Quantify Extracellular Vesicles in Both Cell Culture Supernatants and Body Fluids, and much more.

Human Reproductive Genetics

1st Edition
April 19, 2020
Juan A. Garcia-Velasco + 1 more
English
Paperback
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eBook
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Human Reproductive Genetics: Emerging Technologies and Clinical Applications presents a great reference for clinicians and researchers in reproductive medicine. Part I includes a brief background of genetics and epigenetics, probability of disease, and the different techniques that are being used today for analysis and genetic counseling. Part II focuses on the analysis of the embryo, current controversies and future concepts. Part III comprises different clinical scenarios that clinicians frequently face in practice. The increasing amount of genetic tests available and the growing information that patients handle makes this section a relevant part of the fertility treatment discussion. Finally, Part IV concludes with the psychological aspects of genetic counseling and the role of counselor and bioethics in human reproduction.

RNA-Based Regulation in Human Health and Disease

1st Edition
August 19, 2020
English
Paperback
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eBook
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RNA-based Regulation in Human Health and Disease offers an in-depth exploration of RNA mediated genome regulation at different hierarchies. Beginning with multitude of canonical and non-canonical RNA populations, especially noncoding RNA in human physiology and evolution, further sections examine the various classes of RNAs (from small to large noncoding and extracellular RNAs), functional categories of RNA regulation (RNA-binding proteins, alternative splicing, RNA editing, antisense transcripts and RNA G-quadruplexes), dynamic aspects of RNA regulation modulating physiological homeostasis (aging), role of RNA beyond humans, tools and technologies for RNA research (wet lab and computational) and future prospects for RNA-based diagnostics and therapeutics. One of the core strengths of the book includes spectrum of disease-specific chapters from experts in the field highlighting RNA-based regulation in metabolic & neurodegenerative disorders, cancer, inflammatory disease, viral and bacterial infections. We hope the book helps researchers, students and clinicians appreciate the role of RNA-based regulation in genome regulation, aiding the development of useful biomarkers for prognosis, diagnosis, and novel RNA-based therapeutics.

Diagnosis and Management in Parkinson's Disease

1st Edition
August 13, 2020
Colin R. Martin + 1 more
English
Hardback
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eBook
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Diagnosis and Management in Parkinson's Disease: The Neuroscience of Parkinson’s, Volume 1 provides a single source of material covering different scientific domains of neuropathology underlying this condition. The book covers a wide range of subjects and unravels the complex relationships between genetics, molecular biology, pharmaceutical chemistry, neurobiology, imaging, assessments, and treatment regimens. It fills a much-needed gap as a "one-stop" synopsis of everything concerning the neurology and neuroscience related to Parkinson’s disease, from chemicals and cells to individuals. The book is an invaluable resource for neuroscientists, neurologists, and anyone in the field.

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