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    • Dendrimer-Based Nanotherapeutics

      • 1st Edition
      • April 14, 2021
      • Prashant Kesharwani
      • English
      • Paperback
        9 7 8 0 1 2 8 2 1 2 5 0 9
      • eBook
        9 7 8 0 1 2 8 2 1 2 5 1 6
      Dendrimer-Based Nanotherapeutics delivers a comprehensive resource on the use of dendrimer-based drug delivery. Advances in the application of nanotechnology in medicine have given rise to multifunctional smart nanocarriers that can be engineered with tunable physicochemical characteristics to deliver one or more therapeutic agent(s) safely and selectively to cancer cells, including intracellular organelle-specific targeting. This book compiles the contribution of dendrimers in the field of nanotechnology to aid researchers in exploring dendrimers in the field of drug delivery and related applications. This book covers the history of the area to the most recent research. The starting chapter covers detailed information about basic properties about dendrimers i.e. properties, nomenclature, synthesis methods, types, characterization of dendrimers, safety and toxicity issues of dendrimers. Further chapters discuss the most recent advancements in the field of dendrimer i.e. dendrimer-drug conjugates, PEGylated dendrimer, dendrimer surface engineering, dendrimer hybrids, dendrimers as solubility enhancement, in targeting and delivery of drugs, as photodynamic therapy, in tissue engineering, as imaging contrast agents, as antimicrobial agents, advances in targeted dendrimers for cancer therapy and future considerations of dendrimers. Dendrimer-Based Nanotherapeutics will help the readers to understand the most recent progress in the field of dendrimer-based research, suitable for pharmaceutical scientists, advanced students, and those working in related healthcare fields.

    • Lanzkowsky's Manual of Pediatric Hematology and Oncology

      • 7th Edition
      • June 1, 2021
      • Jonathan D. Fish + 2 more
      • English
      • Hardback
        9 7 8 0 1 2 8 2 1 6 7 1 2
      • eBook
        9 7 8 0 3 2 3 9 9 7 6 0 7
      • eBook
        9 7 8 0 3 2 3 8 5 3 6 1 3
      Lanzkowsky’s Manual of Pediatric Hematology and Oncology, Seventh Edition remains the go-to clinical manual for the treatment and management of childhood cancers and blood disorders. It is a comprehensive book on patient management, replete with algorithms and flow diagrams, and includes a new section on vascular anomalies. Reflecting the considerable advances in the treatment and management of hematologic and oncologic diseases in children, the seventh edition of this successful clinical manual is entirely updated to incorporate all current treatment protocols, new drugs, and management approaches. Its concise and easy-to-read format, again, enables readers to make accurate diagnoses and treatment decisions without having to reference larger medical textbooks.

    • Cellular Endocrinology in Health and Disease

      • 2nd Edition
      • February 2, 2021
      • Alfredo Ulloa-Aguirre + 1 more
      • English
      • Paperback
        9 7 8 0 1 2 8 1 9 8 0 1 8
      • eBook
        9 7 8 0 1 2 8 1 9 8 0 2 5
      Cellular Endocrinology in Health and Disease, Second Edition, describes the underlying basis of endocrine function, providing an important tool to understand the fundamentals of endocrine diseases. Delivering a comprehensive review of the basic science of endocrinology, from cell biology to human disease, this work explores and dissects the function of a number of cellular systems. The new edition provides an understanding of how endocrine glands function by integrating information resulting in biological effects on both local and systemic levels, also providing new information on the molecular physiopathogenesis of endocrine neoplasic cells. The new edition expands the most used chapters from the first edition and proposes a series of substitutions and additions to the table of contents. New chapters cover signaling, brown adipose tissue, hypothalamic cell models, cellular basis of insulin resistance, genetics and epigenetics of neuroendocrine tumors, and a series of chapters on endocrine-related cancer. Providing content that crosses disciplines, Cellular Endocrinology in Health and Disease, Second Edition, details how cellular endocrine function contributes to system physiology and mediates endocrine disorders. A methods section proves novel and useful approaches across research focus that will be attractive to medical students, residents, and specialists in the field of endocrinology, as well as to those interested in cellular regulation. Editors Alfredo Ulloa-Aguirre and Ya-Xiong Tao, experts in molecular and cellular aspects of endocrinology, deliver contributions carefully selected for relevance, impact, and clarity of expression from leading field experts

    • Nonfood Sensory Practices

      • 1st Edition
      • August 28, 2021
      • Anne-Marie Pense-Lheritier + 2 more
      • English
      • Paperback
        9 7 8 0 1 2 8 2 1 9 3 9 3
      • eBook
        9 7 8 0 1 2 8 2 1 9 6 8 3
      Sensory evaluation is applied in very diverse and sometimes unexpected sectors. Nonfood Sensory Practices aims to show how sensory professionals from sectors other than food have embraced sensory evaluation methods for product development and communication of their products’ sensory properties. This book is thus intended as a first assessment of what is happening in nonfood sectors. It will open perspectives to those sensory professionals who wish to apply and adapt their expertise in food sensory science to other types of products, as well as to those working in nonfood sectors but with lesser background in sensory evaluation. Many nonfood products are intrinsically complex. They can be used in diverse ways, often in strong interaction with context and – unlike food – over several hours, days or months. This book shows how sensory professionals have adapted to these specificities, not to mention specific needs in terms of panel management and different ways to deal with consumers, users, customers or even sometimes with patients. First chapters present general methodological principles that will allow readers to fully apprehend the use of sensory practices. Then, contributions from many professionals in nonfood sectors will help to realize and promote the potential added value of sensory evaluation to their own field of application.

    • Red Panda

      • 2nd Edition
      • October 27, 2021
      • Angela R. Glatston
      • English
      • Hardback
        9 7 8 0 1 2 8 2 3 7 5 3 3
      • eBook
        9 7 8 0 1 2 8 2 3 7 5 4 0
      Red Panda: Biology and Conservation of the First Panda, Second Edition, provides the most up-to-date research, data, and conservation solutions for the red pandas, Ailurus species. Since the publication of the previous edition in 2010, the International Union for Conservation of Nature (IUCN) updated the threat level of red pandas, and they are now considered to be endangered. This latest edition is updated to provide an in-depth look at the scientific and conservation-based issues urgently facing the red panda today. Led by one of the world’s leading authorities and advocates for red panda conservation, this new edition includes data from the Population and Habitat Viability (PHVA) workshops conducted in three of the species’ range states, Nepal, China, and India; these workshops utilized firsthand information on the decrease of red panda populations due to factors including deforestation, illegal pet trade, human population growth, and climate change. This book also includes updated information from the first edition on reproduction, anatomy, veterinary care, zoo management, and fossil history.

    • Plant Perspectives to Global Climate Changes

      • 1st Edition
      • September 30, 2021
      • Tariq Aftab + 1 more
      • English
      • Paperback
        9 7 8 0 3 2 3 8 5 6 6 5 2
      • eBook
        9 7 8 0 3 2 3 8 8 5 8 8 1
      Plant Perspectives to Global Climate Changes: Developing Climate-Resilient Plants reviews and integrates currently available information on the impact of the environment on functional and adaptive features of plants from the molecular, biochemical and physiological perspectives to the whole plant level. The book also provides a direction towards implementation of programs and practices that will enable sustainable production of crops resilient to climatic alterations. This book will be beneficial to academics and researchers working on stress physiology, stress proteins, genomics, proteomics, genetic engineering, and other fields of plant physiology. Advancing ecophysiological understanding and approaches to enhance plant responses to new environmental conditions is critical to developing meaningful high-throughput phenotyping tools and maintaining humankind’s supply of goods and services as global climate change intensifies.

    • Microbial Metabolism and Disease

      • 1st Edition
      • March 13, 2021
      • Elena L. Paley
      • English
      • Paperback
        9 7 8 0 3 2 3 8 8 4 4 5 7
      • eBook
        9 7 8 0 3 2 3 8 8 4 4 6 4
      Microbiome Metabolic Pathways and Disease provides insight into the interaction of microbial metabolic pathways in the human body and the impact these can have on a variety of diseases. By analyzing these pathways the book seeks to investigate how these metabolic processes can be targeted and manipulated in order to treat various disorders and diseases. Topics covered in the book include microbial shikimate pathways, protein biosynthesis, tryptophan metabolites, microbiome metabolic engineering, fecal microbiota transplantation, and virulence factors. Additionally, a variety of conditions are covered, such as disorders associated with metabolic syndromes, serotonin syndromes, Alzheimer’s disease, and Covid-19, providing a detailed overview of how metabolic pathways of microbiome can impact health and disease in the human body.

    • Cellular Senescence in Disease

      • 1st Edition
      • November 27, 2021
      • Manuel Serrano + 1 more
      • English
      • Paperback
        9 7 8 0 1 2 8 2 2 5 1 4 1
      • eBook
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      Winner of the 2023 PROSE award in Biomedicine and Neuroscience!Researc... in the field of senescence has boomed recently due to the gradual realization that senescent cells are associated with a significant number of diseases. The genetic or pharmacological elimination of senescent cells can cause widespread benefits and improves outcomes for most of those diseases. Cellular Senescence in Diseases presents an updated review of the role of cellular senescence in multiple pathologies. Focus is given to those diseases where the implication of senescence has been more extensively documented, such as (cancer, lung and liver diseases, diabetes, Neurodegenerative diseases and others).The Editors recruited a group of worldwide experts in each individual pathology to review the role of cellular senescence in each one of them, aiming at identifying potential therapeutic pathways. The first two chapters provide an overview of the cellular senescence principles. Next, the chapters are divided into specific diseases. Cancer, including premalignant lesions (OIS), Advanced disease (TIS), and Metastasis are covered. The following condition covered is Lung diseases, including IPF, COPD, and Pulmonary Hypertension. Next Liver Diseases are covered, including Fibrosis and Cirrhosis, and Fatty liver disease. Next there is coverage for Kidney implications, including fibrosis and transplantation. Vascular diseases are covered next including infarction and hear fibrosis, and atherosclerosis. Both diabetes types 1 and 2 are covered next. Following chapters cover Obesity, Sarcopenia, and Bone and Cartilage disorders, respectively. Neurodegenerative diseases are covered next, focusing on Alzheimer's and Parkinson's. The next chapter discusses accumulation of senescent cell in tissues during aging. The two final chapters cover current developments and conclusions.Cellular Senescence in Diseases is designed for researchers and clinicians with a focus on the cellular mechanisms of diseases. All chapters cover current experimental therapeutic approaches to eliminate or cancel the pathological effects of senescent cells. Pharmaceutical scientists may also benefit from the contents of the book in the exploration of novel therapeutic opportunities.

    • Molecular Mechanisms of Nutritional Interventions and Supplements for the Management of Sexual Dysfunction and Benign Prostatic Hyperplasia

      • 1st Edition
      • August 7, 2021
      • Bilal Chughtai
      • English
      • Paperback
        9 7 8 0 1 2 8 1 9 7 6 5 3
      • eBook
        9 7 8 0 1 2 8 2 2 6 0 2 5
      Molecular Mechanisms of Nutritional Interventions and Supplements for the Management of Sexual Disfunction and Benign Prostatic Hyperplasia presents the epidemiologic data linking diet with BPH and ED, along with a deep explanation on why nutritional approaches and different macronutrients may modify the pathogenesis of the disease. Coverage includes the relevance/epidemiolo... of the disease, pathophysiological events causing the disease, available therapeutic options, molecular mechanisms of action of available treatments, epidemiological and intervention studies suggesting the benefit of diet as therapeutic option for BPH and ED, and potential mechanisms of action of nutritional based approaches as treatment for BPH and ED. By combining medicine, diet and lifestyle options, this title provides a truly multidisciplinary approach to BPH and ED, making it a unique resource for those treating BPH and an irreplaceable reference guide for those in research.

    • Microbial Cell Factories Engineering for Production of Biomolecules

      • 1st Edition
      • February 13, 2021
      • Vijai Singh
      • English
      • Paperback
        9 7 8 0 1 2 8 2 1 4 7 7 0
      • eBook
        9 7 8 0 1 2 8 2 1 4 7 8 7
      Microbial Cell Factories Engineering for Production of Biomolecules presents a compilation of chapters written by eminent scientists worldwide. Sections cover major tools and technologies for DNA synthesis, design of biosynthetic pathways, synthetic biology tools, biosensors, cell-free systems, computer-aided design, OMICS tools, CRISPR/Cas systems, and many more. Although it is not easy to find relevant information collated in a single volume, the book covers the production of a wide range of biomolecules from several MCFs, including Escherichia coli, Bacillus subtilis, Pseudomonas putida, Streptomyces, Corynebacterium, Cyanobacteria, Saccharomyces cerevisiae, Pichia pastoris and Yarrowia lipolytica, and algae, among many others. This will be an excellent platform from which scientific knowledge can grow and widen in MCF engineering research for the production of biomolecules. Needless to say, the book is a valuable source of information not only for researchers designing cell factories, but also for students, metabolic engineers, synthetic biologists, genome engineers, industrialists, stakeholders and policymakers interested in harnessing the potential of MCFs in several fields.

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