Dendrimer-Based Nanotherapeutics
- 1st Edition - April 14, 2021
- Imprint: Academic Press
- Editor: Prashant Kesharwani
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 2 1 2 5 0 - 9
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 1 2 5 1 - 6
Dendrimer-Based Nanotherapeutics delivers a comprehensive resource on the use of dendrimer-based drug delivery. Advances in the application of nanotechnology in medicine have give… Read more
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Request a sales quoteDendrimer-Based Nanotherapeutics delivers a comprehensive resource on the use of dendrimer-based drug delivery. Advances in the application of nanotechnology in medicine have given rise to multifunctional smart nanocarriers that can be engineered with tunable physicochemical characteristics to deliver one or more therapeutic agent(s) safely and selectively to cancer cells, including intracellular organelle-specific targeting. This book compiles the contribution of dendrimers in the field of nanotechnology to aid researchers in exploring dendrimers in the field of drug delivery and related applications. This book covers the history of the area to the most recent research. The starting chapter covers detailed information about basic properties about dendrimers i.e. properties, nomenclature, synthesis methods, types, characterization of dendrimers, safety and toxicity issues of dendrimers. Further chapters discuss the most recent advancements in the field of dendrimer i.e. dendrimer-drug conjugates, PEGylated dendrimer, dendrimer surface engineering, dendrimer hybrids, dendrimers as solubility enhancement, in targeting and delivery of drugs, as photodynamic therapy, in tissue engineering, as imaging contrast agents, as antimicrobial agents, advances in targeted dendrimers for cancer therapy and future considerations of dendrimers. Dendrimer-Based Nanotherapeutics will help the readers to understand the most recent progress in the field of dendrimer-based research, suitable for pharmaceutical scientists, advanced students, and those working in related healthcare fields.
- Discusses various routes such as oral, pulmonary, transdermal, delivery and local administration of dendrimer delivery of bioactive
- Explores a wide range of applications of dendrimer-based drug delivery using the latest advancements in nanomedicine
- Provides the most recent research on dendrimers as well as context and background, providing a useful resource for all levels of researcher
Young scientists starting to work in the field of dendrimers. Academic researchers and students working on the basic research field at the Chemistry Department, Engineering departments (for example, Chemical Engineering, Materials Science and Engineering, and Biomedical Engineering, etc.), and the Pharmaceutics Department. Researcher and graduate students working in the area of nanotechnology, pharmaceutical sciences, polymer science, chemistry, materials, engineering, medicine, and physicians can read or go through the recent advances in this field of research
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- Contributors
- Preface
- Acknowledgments
- Chapter 1: History and introduction of dendrimers
- Abstract
- Acknowledgment
- 1: Introduction
- 2: History and discovery of dendrimers
- 3: Synthesis of dendrimers
- 4: Types of dendrimers
- 5: Properties of dendrimers
- 6: Application of dendrimers
- 7: Conclusion
- Chapter 2: Design and properties of dendrimers for pharmaceutical applications
- Abstract
- 1: Introduction
- 2: Critical nanoscale design parameters
- 3: Drug delivery interaction
- 4: Dendrimer functionalization
- 5: Monodispersity
- 6: Biocompatibility
- 7: Pharmacokinetic of dendrimers
- 8: Nanosize implications
- 9: Multivalence
- 10: Solubility
- 11: End groups: Reactivity
- 12: Physicochemical properties
- Chapter 3: Magnetic properties and applications of dendrimer systems
- Abstract
- 1: Introduction
- 2: Model and formulation
- 3: Monte Carlo simulations
- 4: Results and discussion
- 5: Conclusion
- Chapter 4: Ferroelectric properties and applications of dendrimer systems
- Abstract
- 1: Introduction
- 2: Model and Monte Carlo simulations
- 3: Results and discussion
- 4: Conclusion
- Chapter 5: Biological interaction of dendrimers
- Abstract
- Acknowledgment
- 1: Introduction
- 2: Interactions between dendrimers and model membranes
- 3: Dendrimer interaction with red blood cells
- 4: Dendrimer protein (serum albumin) interaction
- 5: Dendrimer-target/receptor interactions
- 6: Dendrimers and their interactions with the biological environment
- 7: Molecular modeling of dendrimer-target complexes interactions
- 8: Factors influencing the interaction with dendrimers with the biological environment
- 9: Conclusions and future perspectives
- Chapter 6: Dendrimer nomenclature and synthesis methods
- Abstract
- 1: Introduction
- 2: Nomenclature of dendrimers
- 3: Synthetic methods of dendrimers
- 4: Conclusion
- Chapter 7: Types of dendrimers
- Abstract
- Acknowledgments
- Disclosures
- 1: Introduction
- 2: Types of dendrimers
- 3: Conclusion and summary
- Chapter 8: Characterization of dendrimers
- Abstract
- 1: Introduction
- 2: Characterization of dendrimers
- 3: Conclusion
- Chapter 9: Safety and toxicity issues of dendrimers
- Abstract
- Acknowledgments
- 1: Introduction
- 2: Dendrimer biocompatibility
- 3: Toxicity of dendrimers
- 4: Possible ways to prevent toxicities of PAMAM and PPI dendrimers
- 5: Surface engineered dendrimers and decreasing dendrimer toxicity
- 6: Conclusion
- Chapter 10: Dendrimers and their applications in biomedicine: Dendrimer-drug interaction, a new therapeutic alternative
- Abstract
- Graphical Abstract
- 1: Introduction
- 2: Types of nanoparticles
- 3: Dendrimers
- 4: Conclusions and future prospects
- Chapter 11: Principal concept in PEGylated dendrimer-based cancer therapeutics
- Abstract
- Acknowledgments
- Conflict of interest
- 1: Introduction
- 2: Characteristics and advantages of PEGylated dendrimer-based carriers
- 3: Routes of dendrimer PEGylation
- 4: Therapeutic dendrimer-based systems
- 5: Diagnostic and theranostic dendrimer-based systems
- 6: Smart dendrimer-based systems (multiresponsive or targeted delivery)
- 7: Application of PEGylated dendrimers in gene delivery
- 8: Pharmacokinetics and toxicological concerns
- 9: Conclusion and future perspective
- Chapter 12: Surface-engineered dendrimers in targeting and delivery of drugs
- Abstract
- 1: Introduction
- 2: Dendrimers as an emerging vista in drug delivery
- 3: Dendrimer toxicity
- 4: Surface engineering of dendrimers
- 5: Various surface engineered dendrimer in drug delivery
- 6: Dendrimer-drug interactions
- 7: Dendrimer-based nanofiber as a nano-scaffold container
- 8: Conclusions
- Chapter 13: Surface engineered dendrimers as novel option for enhanced pharmaceutical and biomedical potential
- Abstract
- 1: Introduction
- 2: Surface engineering for reducing toxicity
- 3: PEG-modified PAMAM dendrimers with functional shells
- 4: Temperature-sensitive dendrimers by surface modification
- 5: Surface decoration by drug attachment
- 6: Surface engineering for targeting
- 7: Surface decoration by nucleotides
- 8: Surface decoration by diagnostic and imaging agents
- Chapter 14: Dendrimer hybrids with other nanoparticles as therapeutics
- Abstract
- 1: Introduction
- 2: NPs/dendrimers hybrids
- 3: Polymers/dendrimers hybrids
- 4: Conclusion
- Chapter 15: Dendrimer for solubility enhancement
- Abstract
- Acknowledgments
- 1: Introduction
- 2: Strategies for lipophilic drug solubilization
- 3: Nanocarriers for solubility enhancements
- 4: Dendrimer as novel tool as solubility enhancement
- 5: Conclusion
- Chapter 16: Dendrimers for gene therapy
- Abstract
- 1: Introduction
- 2: Gene therapy
- 3: Dendrimers as gene carriers
- 4: Mechanisms of gene delivery using dendriplexes
- 5: Surface modifications of dendrimers
- 6: Modification of the dendrimer core for gene delivery
- 7: In vivo administration
- 8: Conclusions
- Chapter 17: Photosensitizer-dendrimer systems in anticancer treatments: From photophysics to PDT applications
- Abstract
- 1: Photodynamic therapy
- 2: Dendrimers in photodynamic therapy
- Chapter 18: Dendrimers in tissue engineering
- Abstract
- Acknowledgments
- 1: Introduction
- 2: Fundamentals
- 3: Different approaches in TE
- 4: Final remarks and future trends
- Chapter 19: Dendrimer as imaging contrast agents
- Abstract
- 1: Introduction
- 2: Contrast agents
- Chapter 20: Dendrimer as antimicrobial agents
- Abstract
- Acknowledgments
- 1: Introduction
- 2: Types of dendrimers
- 3: Dendrimers with bactericidal properties
- 4: Functional groups with antimicrobial properties at the dendrimer periphery
- 5: Metallodendrimers
- 6: Dendrimers encapsulated nanoparticle
- 7: Fluorescent dendrimers
- 8: 1,8-Naphthalimides
- 9: Modified poly(propylenimine) dendrimers with 1,8-naphthalimides and their antimicrobial activity
- 10: Modification of PPI with benzanthrone
- 11: Modification of PPI dendrimer from the second generation with acridine
- 12: Modification of PPI dendrimer from second generation with 7-nitrobenzofurazan
- 13: Poly(amidoamine) dendrimers modified with 1,8-naphthalimide fluorophores
- 14: Fluorescent hyperbranched polymers
- 15: Cyclam complexes
- 16: Zn(II) and Cu(II) complexes with fluorescent symmetrical benzanthrone tripod (BT)
- 17: Antibacterial textile
- 18: Preparation of textile materials with antimicrobial properties
- 19: Mechanism of antimicrobial activity on textile materials determined by the antimicrobial substance-fabric interaction
- 20: Dendrimers as antibiofilm agents
- 21: Antimicrobial properties of textile materials treated with dendrimers, metallodendrimers
- 22: Hydrophilicity of cotton fabrics treated with dendrimers and metallodendrimers
- 23: Microbiological activity of treated with dendrimers cotton fabrics
- 24: Antimicrobial photodynamic therapy
- 25: Antibacterial photodynamic at textiles
- 26: Conclusion
- Chapter 21: Multifunctional dendrimers for theranostic applications
- Abstract
- Acknowledgments
- Conflict of interest
- 1: Introduction
- 2: Synthesis methods of dendrimers
- 3: Structure and properties of dendrimers
- 4: Dendrimers for theranostic applications in cancer
- 5: Conclusions and future prospects
- Chapter 22: Dendrimers formulations to enhance skin drug delivery
- Abstract
- 1: Introduction
- 2: Challenges in skin delivery of drugs
- 3: Application of dendrimers in skin delivery
- 4: Mechanism of dendrimers to enhance skin delivery of drugs
- 5: Dendrimers drug delivery to reduce side effects of drugs
- 6: The chemical structures of dendrimers used for skin delivery of drugs
- 7: Types of skin formulations using dendrimers
- 8: Combination of dendrimers with physical methods for skin delivery
- 9: Clinical applications of dendrimer topical formulation
- 10: Conclusion
- Chapter 23: Dendrimers as antiinflammatory prodrugs
- Abstract
- 1: Dendrimers
- 2: Dendrimers as drug delivery vehicles for antiinflammatory agents
- 3: Dendrimer prodrugs
- 4: Immune responses and inflammation process
- 5: Effect of structure on the affinity of dendrimers to immune cells
- 6: Various dendrimer structures with antiinflammatory activity
- 7: Peptide and glycopeptide dendrimers as antiinflammatory agents
- 8: Applications of antiinflammatory dendrimer prodrugs
- 9: Conclusion
- Chapter 24: Advances in targeted dendrimers for cancer therapy and challenges for clinical translation
- Abstract
- Acknowledgments
- 1: Introduction
- 2: Surface engineered dendrimers with targeting groups for cancer cells
- 3: Immunodendrimers
- 4: Gene therapy and delivery
- 5: Translation hurdles
- 6: Concluding remarks
- Chapter 25: Conclusion and future considerations of dendrimers
- Abstract
- Disclosures
- 1: Introduction
- 2: The phase of development of dendrimers
- 3: Synthesis of dendrimers
- 4: Structure and properties of dendrimers
- 5: Applications of dendrimers
- 6: Summary and outlook
- Index
- Edition: 1
- Published: April 14, 2021
- No. of pages (Paperback): 484
- No. of pages (eBook): 484
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780128212509
- eBook ISBN: 9780128212516
PK
Prashant Kesharwani
Dr. Prashant Kesharwani is assistant professor of Pharmaceutics at Department of Pharmaceutical Sciences, Dr. Harisingh Gour Vishwavidyalaya, Sagar, Madhya Pradesh, India. He has more than 12 years of teaching, research, and industrial experience at international levels from various countries, including the United States, Malaysia, and India. An overarching goal of his current research is the development of nanoengineered drug delivery systems for various diseases. He has more than 350 international publications in well-reputed journals and more than 25 international books (Elsevier). He is a recipient of many research grants from various funding bodies. He is also the recipient of several internationally acclaimed awards, such as “USERN Laureate award”, most prestigious “SERB-Ramanujan Fellowship Award”. He actively participates in outreach and scientific dissemination for the service of the wider community. His Number of citations is = 26779; h-index = 85; i-10 index = 370 (According to google scholar on March 2025). He has more than 30 international publications published in very high impact factor journals (Progress in Polymer Sciences IF 32.063, Molecular Sciences IF 41.444, Progress in Material Sciences IF 48.580, Advanced Materials IF 29.4, Drug Resistance Update IF 22.841 and Material Todays IF 32.072). He has presented many invited talks and oral presentations at prestigious scientific peer-conferences, received international acclaims and awards for research contribution, supervised students/junior researchers and actively participated in outreach and scientific dissemination for the service of the wider community.
Affiliations and expertise
Department of Pharmaceutical Sciences, Dr. Harisingh Gour Vishwavidyalaya, Sagar, Madhya Pradesh, 470003, IndiaRead Dendrimer-Based Nanotherapeutics on ScienceDirect