
Cellular Endocrinology in Health and Disease
- 2nd Edition - February 2, 2021
- Imprint: Academic Press
- Editors: Alfredo Ulloa-Aguirre, Ya-Xiong Tao
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 1 9 8 0 1 - 8
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 1 9 8 0 2 - 5
Cellular Endocrinology in Health and Disease, Second Edition, describes the underlying basis of endocrine function, providing an important tool to understand the fundament… Read more

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Request a sales quoteCellular Endocrinology in Health and Disease, Second Edition, describes the underlying basis of endocrine function, providing an important tool to understand the fundamentals of endocrine diseases. Delivering a comprehensive review of the basic science of endocrinology, from cell biology to human disease, this work explores and dissects the function of a number of cellular systems. The new edition provides an understanding of how endocrine glands function by integrating information resulting in biological effects on both local and systemic levels, also providing new information on the molecular physiopathogenesis of endocrine neoplasic cells.
The new edition expands the most used chapters from the first edition and proposes a series of substitutions and additions to the table of contents. New chapters cover signaling, brown adipose tissue, hypothalamic cell models, cellular basis of insulin resistance, genetics and epigenetics of neuroendocrine tumors, and a series of chapters on endocrine-related cancer.
Providing content that crosses disciplines, Cellular Endocrinology in Health and Disease, Second Edition, details how cellular endocrine function contributes to system physiology and mediates endocrine disorders. A methods section proves novel and useful approaches across research focus that will be attractive to medical students, residents, and specialists in the field of endocrinology, as well as to those interested in cellular regulation. Editors Alfredo Ulloa-Aguirre and Ya-Xiong Tao, experts in molecular and cellular aspects of endocrinology, deliver contributions carefully selected for relevance, impact, and clarity of expression from leading field experts
- Explores endocrine cells biology in normal and pathologic conditions
- Covers new aspects of endocrine cell function in distinct tissues
- Provides a view into the biological effect in local and systemic levels
- 15 new chapters covering the recent developments in the field
Researchers in cell biology, biochemistry, endocrinology, pharmacology, graduate students and researchers across basic sciences and biomedicine
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Preface to the Second Edition
- Chapter 1: Endocrinology of a Single Cell: Tools and Insights
- Abstract
- Why Study Single Cells?
- Studying Cellular State
- Studying Cellular Dynamics and Stimulus Responses
- SC Studies: Application to the Anterior Pituitary and the Pituitary Gonadotropes
- Discussion
- Chapter 2: Hypothalamic Cell Models
- Abstract
- Acknowledgments
- Grants
- Disclosures
- Introduction
- Hypothalamic Regions Involved in the Regulation of Physiological Functions
- The Advantages and Limitations of Hypothalamic Neuronal Cell Models to Study Hypothalamic Function
- Generation and Characterization of Hypothalamic Neuronal Cell Models
- Hypothalamic Cell Lines for the Study of Metabolic Disorders
- Prospective Cell Models: Hypothalamic Glial Cells
- New Insights into Reproduction Using Hypothalamic Neuronal Cell Models
- Hypothalamic Cell Lines for the Study of Circadian Rhythms
- Hypothalamic Cell Lines for the Study of Stress and Psychological Disorders
- Conclusions and Future Directions
- Chapter 3: Biology of Pituitary Stem Cells
- Abstract
- Acknowledgments
- Introduction
- Location of Proliferating and Differentiating Cells During the Pituitary Development
- Historical Identification of the Pituitary Stem Cells
- Pituitary Stem Cells and Aging
- Pituitary Stem Cells and Disease Pathophysiology
- Conclusion
- Chapter 4: Epigenetics of Pituitary Cell Growth and Survival
- Abstract
- DNA Methylation
- DNA Methylation in Pituitary Tumors
- The Importance of Chromatin Remodeling Through Histone Modifications
- Epigenetic Mechanisms of Gene Silencing in Pituitary Tumors
- The Role of MicroRNAs in Pituitary Tumors
- The Role of Ikaros in the Pituitary Gland
- FGF Signaling in Pituitary Development and Pituitary Tumorigenesis
- The Melanoma-Associated Antigens in Pituitary Tumors
- MAGE-A3 as a Target of FGF Signaling
- MAGE-A3 Regulation Through Histone and DNA Modifications
- Histone Modification as Putative Therapeutic Targets in Pituitary Tumors
- Conclusions
- Chapter 5: Multi-functionality of Pituitary Cells: Biological and Clinical Implications
- Abstract
- Acknowledgments
- A New Vision of Hypothalamic-Pituitary Physiology
- Multi-hormonality
- Multi-responsiveness
- Single-Cell Analysis Data
- Clinical Implications
- Concluding Remarks
- Chapter 6: Unraveling the Neural Mechanisms Underlying the GnRH Pulse Generator: An Update
- Abstract
- Acknowledgments
- Introduction
- Early Work on the GnRH Pulse Generator
- A New Model for the Neural Elements of the GnRH Pulse Generator
- Does NKB Initiate Each GnRH/LH Pulse?
- Does Dynorphin Terminate Each GnRH/LH Pulse?
- Does Kisspeptin Affect the Pulse Generator or Simply Drive GnRH Release?
- Major Unresolved Issues
- Conclusions
- Chapter 7: Gonadotropin-Releasing Hormone Receptors and Signaling
- Abstract
- Funding
- Gonadotropin-Releasing Hormone and Its Receptors
- The Canonical GnRHR Signaling Pathway and Regulation of Gonadotropin Secretion
- GnRHR Compartmentalization and Desensitization to GnRH
- The Extended GnRHR Signaling Network
- GnRH Signaling and Gene Expression
- Pulsatile GnRH Signaling
- An Information-Theoretic Approach to GnRH Signaling
- Summary
- Chapter 8: Effects of Nutrition on Pubertal Timing at the Neuroendocrine and Cellular Levels
- Abstract
- Acknowledgments
- Disclosure Statement
- Introduction
- Peripheral Signals Linking Metabolism and Puberty Onset
- Neuropeptide Systems Integrating Metabolism and Puberty Onset
- Novel Molecular Mediators in the Metabolic Control of Puberty
- Conclusions and Future Directions
- Chapter 9: Sensing Calcium Levels: The Biology of the Parathyroid Cells
- Abstract
- Introduction
- Biosynthesis and Metabolism of PTH
- Regulation of PTH Secretion and Transcription
- Calcium-Sensing Properties of the Parathyroids: The CaSR
- Phosphate/FGF23 Regulation of the Parathyroids
- Vitamin D Regulation of the Parathyroids
- MicroRNAs Regulation of the Parathyroids
- Main Mechanisms of Parathyroid Gland Hyperplasia in SHPT
- Conclusions
- Chapter 10: GPCR Signaling in Ca2+ Homeostasis: The PTH Type 1 and Calcium-Sensing Receptors
- Abstract
- Introduction
- Endosomal cAMP Signaling by the PTHR
- Ca2 + Allostery in PTHR Signaling and Disease
- Gq/11-Dependent Regulation of PTH-Mediated cAMP
- CaSR-GABAB1R Heteromers Regulate PTH Hypersecretion
- Phosphate Sensing by the CaSR
- Concluding Remarks
- Chapter 11: Thyroid Hormone Receptors and their Role in Cell Proliferation and Cancer
- Abstract
- Acknowledgment
- Thyroid Hormone Action
- TRs and Cancer
- Inhibition of Tumor Cell Proliferation by the Thyroid Hormone Receptors
- The Thyroid Hormone Receptor Antagonizes Ras-Induced Proliferation
- The Thyroid Hormone Receptors Antagonize Transformation and Tumorigenesis by Oncogenic Ras
- Functional Domains Involved in TR Antagonism of Ras Responses
- TRβ1 Induces Cellular Senescence
- TRβ1 Suppresses Tumor Cell Proliferation, Migration, and Invasion
- TRβ1 Suppresses Tumor Growth, Lymphangiogenesis, and Metastasis. Role of NCoR
- Hypothyroidism Retards Tumor Growth but Increases Metastasis Development
- Divergent Effects of TRs on Normal and Transformed Cell Proliferation
- Chapter 12: Endocrine Regulation of Brown and Beige Adipose Tissue
- Abstract
- Classical Brown Adipose Tissue and Thermogenesis
- Beige Adipocytes as the Third Type of Adipocyte
- Differentiation of Brown and Beige Adipocytes
- Endocrine Factors Regulating Brown and Beige Fat
- Potential Therapeutic Approach of Brown and Beige Fat
- Chapter 13: Adiponectin and Adiponectin Signaling
- Abstract
- Acknowledgments
- Introduction
- Adiponectin Structure
- Adiponectin Receptors
- APPL Proteins Mediate Adiponectin Signaling Downstream of Adiponectin Receptors
- The Crosstalk Between Adiponectin and Insulin Signaling Pathways
- Adiponectin Signaling in Regulating Glucose Metabolism
- Adiponectin Signaling in Regulating Lipid Metabolism
- Adiponectin Signaling Mediates the Protective Role of Adiponectin Against Metabolism-Derived Oxidative Stress
- Adiponectin Signaling Mediates the Anti-inflammatory Role of Adiponectin
- Concluding Remarks
- Chapter 14: Epigenetic and Developmental Basis of Risk of Obesity and Metabolic Disease
- Abstract
- Global Burden of Obesity and Metabolic Disease
- Developmental Origins of Health and Disease
- Conceptual Framework
- Epigenetics and Development
- The Paternal Role
- Epigenetic Dysregulation in Later-Life Metabolic Disease
- Developmental Epigenomics and Human Health
- Chapter 15: Cellular Basis of Insulin Resistance: A Tale of the Microvasculature
- Abstract
- Acknowledgments
- Introduction
- Insulin, Insulin Receptor, and Insulin Signaling
- Insulin’s Metabolic Actions
- Vascular Actions of Insulin
- Links Between Vascular and Metabolic Actions of Insulin
- Metabolic Insulin Resistance and Microvascular Abnormalities
- Pathway Connection Between Microvascular and Metabolic Insulin Resistance
- Conclusions
- Chapter 16: Endocrine Regulation of the Pancreas by Insulin-like Growth Factors
- Abstract
- Acknowledgments
- IGF-1 Is an Essential Growth Factor and Insulin-like Anabolic Hormone
- IGF-1 Is a Potent Regulator of β-Cell Growth and Insulin Secretion
- Three Target Genes Specifically Regulated by IGF-1 in Pancreatic Islets
- The Roles of IGF-1 in Acinar and Ductal Cell Growth, Pancreatitis, and Cancer
- IGF-2 Promotes β-Cell Expansion and Survival, with Conflicting Evidence
- IGF-Binding Proteins (IGFBPs) and Metabolic Regulation
- Chapter 17: Transcriptome Analysis of Adrenocortical Cells in Health and Disease
- Abstract
- Acknowledgments
- Introduction
- Strategies for Determining a Transcriptome
- Data Processing
- Transcriptome Analysis of Adrenal Glands and Adrenocortical Cell Lines Under Adrenocorticotropic Hormone Stimulation
- Transcriptome Analysis of Different Zones
- Transcriptome Analysis of Adrenocortical Cell Lines with Knockdown of Steroidogenic Factor 1 (SF-1) (Also Called as Ad4BP)
- Transcriptome Analysis of Adrenocortical Cells in a Mouse Model of Human Lipoid Congenital Adrenal Hyperplasia
- Perspective
- Chapter 18: Intracellular Trafficking of G Protein-Coupled Receptors to the Cell Surface Plasma Membrane in Health and Disease
- Abstract
- Acknowledgments
- Introduction
- The ER Quality Control System
- GPCR Motifs, Post-Translational Modifications, and Structural Features Promoting/Limiting ER-Golgi Export and Anterograde Trafficking to the PM
- Downward Trafficking of GPCRs
- Protein Misfolding and Disease
- Correcting Protein Misfolding
- Chapter 19: LH/hCG and the Receptor: A Single Receptor for Two Ligands
- Abstract
- Acknowledgments
- Introduction
- Evolution and Structure of LH, hCG, and Their Receptor
- Signaling Cascades Mediated by the LHCGR: Link with the Physiology
- Single-Nucleotide Polymorphisms, Mutations, and Clinical Use of LH and hCG
- Conclusions
- Chapter 20: The Follicle-Stimulating Hormone Signaling Network in Gonadal Cells
- Abstract
- Acknowledgments
- Context
- Is cAMP the Sole Driving Force to FSH Action?
- cAMP-Independent FSH Signaling
- Developmental Regulation of FSH-Stimulated Second Messenger Synthesis
- Gene Regulation
- Cross-Talks With Other Factors to Regulate Cell Fate
- Open Questions
- Chapter 21: β-Arrestins and Endocrine-Related GPCRs
- Abstract
- Acknowledgments
- Introduction
- β-Arrestin-Mediated Control of Desensitization
- β-Arrestin-Mediated Control of Internalization
- β-Arrestin-Mediated Control of Signaling
- Role of β-arrestin in Signaling from Intracellular Compartments
- β-Arrestin- and G Protein-Biased Signaling
- Implications of β-arrestins in Endocrine Systems
- Conclusions
- Index
- Edition: 2
- Published: February 2, 2021
- Imprint: Academic Press
- No. of pages: 486
- Language: English
- Paperback ISBN: 9780128198018
- eBook ISBN: 9780128198025
AU
Alfredo Ulloa-Aguirre
the National University of Mexico (UNAM), where he heads the Research Support Network of the National Institutes of Health in Mexico City. He received his
graduate training in internal medicine and reproductive endocrinology at the National Institute of Medical Sciences and Nutrition SZ and earned the Doctoral degree in Medical Sciences from the UNAM. He received postdoctoral training at the University of Pennsylvania, Philadelphia PA, and has been visiting scientist at the Oregon National Primate Resarch Center, OHSU, Beaverton OR, and the Institut National de la Recherche Agronomique, in Tours, France (Le Studium Scientist). He is currently a member of the Studium Consortium for Research and Training in Reproductive Sciences (sCORTS, Le Studium, Orléans, France). An internationally recognized physician-scientist, Dr Ulloa-Aguirre has developed programmes in both clinical and basic research. His laboratory focuses on the structure-function relationship of gonadotropins and gonadotropin receptors as well as on the gonadotropin-releasing hormone receptor, with particular emphasis on the factors and mechanisms that control intracellular trafficking of these receptors. He is the author or co-author of over 165 research publications and several book chapters.
YT