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    • Connectomic Deep Brain Stimulation

      • 1st Edition
      • September 10, 2021
      • Andreas Horn
      • English
      • Paperback
        9 7 8 0 1 2 8 2 1 8 6 1 7
      • eBook
        9 7 8 0 1 2 8 2 1 8 6 2 4
      Connectomic Deep Brain Stimulation (DBS) covers this highly efficacious treatment option for movement disorders such as Parkinson’s Disease, Essential Tremor and Dystonia. The book examines its impact on distributed brain networks that span across the human brain in parallel with modern-day neuroimaging concepts and the connectomics of the brain. It asks several questions, including which cortical areas should DBS electrodes be connected in order to generate the highest possible clinical improvement? Which connections should be avoided? Could these connectomic insights be used to better understand the mechanism of action of DBS? How can they be transferred to individual patients, and more. This book is suitable for neuroscientists, neurologists and functional surgeons studying DBS. It provides practical advice on processing strategies and theoretical background, highlighting and reviewing the current state-of-the-art in connectomic surgery.

    • Scientific Principles of Adipose Stem Cells

      • 1st Edition
      • August 19, 2021
      • Lauren Kokai + 2 more
      • English
      • Paperback
        9 7 8 0 1 2 8 1 9 3 7 6 1
      • eBook
        9 7 8 0 1 2 8 1 9 3 7 7 8
      Scientific Principles of Adipose Stem Cells provides readers with in-depth and expert knowledge on adipose stem cells, their developmental biologic origins, foundational research on ASC signaling mechanisms and immunomodulatory properties, and clinical insights into applications in regenerative medicine. Topics covered include basic adipose stem cell developmental biology and mechanisms of regulating self-renewal and activation in the stem cell niche, important methods for isolation and characterizing ASCs, and data on the impact on human demographics (age, sex, BMI) on ASC phenotype. A section devoted to ASC biology, ASCs for stem cell therapy and regenerative medicine, and ASCs in tissue engineering applications are also included. The book is written for scientists and clinicians who are broadly familiar with stem cells and basic cell biology principles and those seeking advanced information on adipose stem cells.

    • Recent Advances in iPSC Technology

      • 1st Edition
      • March 31, 2021
      • Alexander Birbrair
      • English
      • Paperback
        9 7 8 0 1 2 8 2 2 2 3 1 7
      • eBook
        9 7 8 0 1 2 8 2 2 3 2 6 0
      The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology.Recent Advances in iPSC Technology, Volume 5 addresses the progress in induced pluripotent stem cells (iPSCs) technologies.Somatic cells can be reprogrammed into iPSCs by the expression of specific transcription factors. These cells are transforming biomedical research in the last 15 years. The volume teaches readers about current advances in the field. This book describes different technologies and strategies to use iPSCs for biological and clinical benefit. In recent years, remarkable progress has been made in the obtention of iPSCs and their differentiation into several cell types, tissues, and organs using state-of-the-art techniques. These advantages facilitated identification of key targets and definition of the molecular basis of several disorders. This volume will cover hot topics in the iPSC field, such as iPSCs for modeling the cardiovascular toxicities of anticancer therapies, iPSC differentiation through the lens of the noncoding genome, modeling of blood–brain barrier with iPSCs, mathematical modeling of iPSCs, iPSCs to study human brain evolution, selfrenewal in iPSCs, differences and similarities between iPSCs and embryonic stem cells, and more.The volume is written for researchers and scientists interested in stem cell therapy, cell biology, regenerative medicine, and organ transplantation and is contributed by world-renowned authors in the field.

    • Synuclein and the Coelacanth

      • 1st Edition
      • January 31, 2021
      • James M. Gruschus
      • English
      • Paperback
        9 7 8 0 3 2 3 8 5 7 0 7 9
      • eBook
        9 7 8 0 3 2 3 8 9 9 6 8 0
      Most neurodegenerative diseases have animal parallels such as Alzheimer’s in chimpanzees, multiple sclerosis in macaques, Lou Gehrig’s disease in dogs, but nothing like Parkinson’s has ever been seen in any species but humans. Synuclein and the Coelacanth: The Molecular and Evolutionary Origins of Parkinson's Disease delves into the causes of Parkinson’s disease and how the evolution of the human brain has left us uniquely vulnerable. Genetic risk factors, environmental toxins, and neuroanatomy are woven together in a multidisciplinary discussion that ranges from subatomic physics to socioeconomics. Connections between neurodegenerative disease, neural pathways, and innate immunity are explored. Finally, the author discusses new therapeutic agents are being developed that hope to go beyond just treating the symptoms of Parkinson’s and actually halt the disease.

    • Heterogeneous Contributions to Numerical Cognition

      • 1st Edition
      • May 27, 2021
      • Wim Fias + 1 more
      • English
      • Hardback
        9 7 8 0 1 2 8 1 7 4 1 4 2
      • eBook
        9 7 8 0 1 2 8 1 7 4 1 5 9
      Arithmetic disability stems from deficits in neurodevelopment, with great individual differences in development or function of an individual at neuroanatomical, neuropsychological, behavioral, and interactional levels. Heterogeneous Contributions to Numerical Cognition: Learning and Education in Mathematical Cognition examines research in mathematical education methods and their neurodevelopmental basis, focusing on the underlying neurodevelopmental features that must be taken into account when teaching and learning mathematics. Cognitive domains and functions such as executive functions, memory, attention, and language contribute to numerical cognition and are essential for its proper development. These lines of research and thinking in neuroscience are discussed in this book to further the understanding of the neurodevelopmental and cognitive basis of more complex forms of mathematics – and how to best teach them. By unravelling the basic building blocks of numerical thinking and the developmental basis of human capacity for arithmetic, this book and the discussions within are important for the achievement of a comprehensive understanding of numerical cognition, its brain basis, development, breakdown in brain-injured individuals, and failures to master mathematical skills.

    • Prosopis as a Heat Tolerant Nitrogen Fixing Desert Food Legume

      • 1st Edition
      • December 7, 2021
      • Maria Cecilia Puppo + 1 more
      • English
      • Paperback
        9 7 8 0 1 2 8 2 3 3 2 0 7
      • eBook
        9 7 8 0 1 2 8 2 3 6 3 2 1
      Prosopis describes the enormous historical importance of these trees as a human food source and reviews the contemporary food science of the fruit derived from these trees. As well, this treatise reviews the native genetic resources of this genus on 4 continents and classical genetic and horticultural techniques that could help stabilize the environment and alleviate human suffering on some of the world’s most destitute agro-ecosystems. This book is an essential read for researchers interested in forestry and plant science, environmental science, and functional foods. The legume family (Fabaceae) contains many genera and species that through their nitrogen fixing process provide high protein food and feed for humans and animals. As evidenced by its presence in Death Valley, California, which holds the record for the highest temperatures in the world, these types of plants can thrive in extreme environments.

    • New Horizons in Evolution

      • 1st Edition
      • July 30, 2021
      • Solomon P. Wasser + 1 more
      • English
      • Paperback
        9 7 8 0 3 2 3 9 0 7 5 2 1
      • eBook
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      New Horizons in Evolution is a compendium of the latest research, analyses, and theories of evolutionary biology. Chapters are collected from the international symposium held by the Board of Governors of the University of Haifa to honor Dr. Eviatar Nevo, founder and director of the Institute of Evolution. This book includes material written by top global scientists. Such detailed summaries and recent advances include topics like genomics, epigenetics, evolutionary theory, and the evolution of cancer. This book analyzes evolutionary biology of animals, such as lizards and subterranean mammals. It also discusses agricultural evolution, specifically the vital wheat crop in various climates and locations. Each chapter contributes the most up-to-date knowledge of evolution’s role in speciation, adaptation, and regulation. New Horizons in Evolution is a valuable resource for researchers involved in evolution, evolutionary biology, and evolutionary theory. Advanced undergraduate and graduate students in evolutionary biology courses will also find this useful due to the high expertise level and latest knowledge available through this resource.　

    • Epigenetic Regulation in Overcoming Chemoresistance

      • 1st Edition
      • Volume 16
      • June 25, 2021
      • Chunfu Wu + 1 more
      • English
      • Hardback
        9 7 8 0 1 2 8 2 3 6 8 4 0
      • eBook
        9 7 8 0 1 2 8 2 3 6 8 5 7
      Epigenetic Regulation in Overcoming Chemoresistance, Volume 19, explains how epigenetic agents can enhance the chemotherapy sensitivity of diverse types of cancers. The book provides a comprehensive delineation and the recent development of the scientific studies on the epigenetic regulation in enhancing chemo-sensitivity. In addition, it discusses several topics such as DNA methyltransferase inhibitors (DNMTi), Histone deacetylases inhibitors (HDACi), Histone lysine demethylases inhibitors (HDMi), Histone lysine methyltransferases inhibitors (HMTi) and drugs regulating the microRNA, long non-coding RNA (lncRNA) or RNA methylation. Finally, recent and future developments of the field of epigenetic regulation are explored. This is a valuable resource for cancer researchers, clinicians, graduate students and several members of biomedical field who are interested in learning about epigenetic regulation methods to reverse chemo-resistance in cancers.

    • Plant Breeding and Cultivar Development

      • 1st Edition
      • January 21, 2021
      • D. P. Singh + 2 more
      • English
      • Paperback
        9 7 8 0 1 2 8 1 7 5 6 3 7
      • eBook
        9 7 8 0 1 2 8 1 7 5 6 4 4
      Plant Breeding and Cultivar Development features an optimal balance between classical and modern tools and techniques related to plant breeding. Written for a global audience and based on the extensive international experience of the authors, the book features pertinent examples from major and minor world crops. Advanced data analytics (machine learning), phenomics and artificial intelligence are explored in the book's 28 chapters that cover classical and modern plant breeding. By presenting these advancements in specific detail, private and public sector breeding programs will learn about new, effective and efficient implementation. The insights are clear enough that non-plant breeding majoring students will find it useful to learn about the subject, while advanced level students and researchers and practitioners will find practical examples that help them implement their work.

    • Second-Order Consensus of Continuous-Time Multi-Agent Systems

      • 1st Edition
      • February 18, 2021
      • Huaqing Li + 6 more
      • English
      • Paperback
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      • eBook
        9 7 8 0 3 2 3 9 0 1 3 2 1
      Second-Order Consensus of Continuous-Time Multi-Agent Systems focuses on the characteristics and features of second-order agents, communication networks, and control protocols/algorithms in continuous consensus of multi-agent systems. The book provides readers with background on consensus control of multi-agent systems and introduces the intrinsic characteristics of second-order agents’ behavior, including the development of continuous control protocols/algorithms over various types of underlying communication networks, as well as the implementation of computation- and communication-effici... strategies in the execution of protocols/algorithms... The book's authors also provide coverage of the frameworks of stability analysis, algebraic criteria and performance evaluation. On this basis, the book provides an in-depth study of intrinsic nonlinear dynamics from agents’ perspective, coverage of unbalanced directed topology, random switching topology, event-triggered communication, and random link failure, from a communication networks’ perspective, as well as leader-following control, finite-time control, and global consensus control, from a protocols/algorithms... perspective. Finally, simulation results including practical application examples are presented to illustrate the effectiveness and the practicability of the control protocols and algorithms proposed in this book.

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