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    • Sirtuin Biology in Cancer and Metabolic Disease

      • 1st Edition
      • February 20, 2021
      • Kenneth Maiese
      • English
      • Paperback
        9 7 8 0 1 2 8 2 2 4 6 7 0
      • eBook
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      Sirtuin Biology in Cancer and Metabolic Disease: Cellular Pathways for Clinical Discovery offers a compelling and thought-provoking perspective for the examination of the intriguing biology of sirtuins that ties cancer and metabolic disease together and provides a critical platform for the development of sirtuin-based novel therapeutic strategies to effectively treat cancer and metabolic disorders with precision in order to minimize any potentially detrimental clinical outcomes. An exciting prospect for the development of innovative therapeutics for cancer and metabolic disorders involves sirtuins. Sirtuins are histone deacetylases that have an intricate role in the onset and development of cancer and metabolic disease. Implementing a translational medicine format, this innovative reference highlights the ability of sirtuins to oversee critical pathways that involve stem cell maintenance, cellular proliferation, metabolic homeostasis, apoptosis, and autophagy that can impact cellular dysfunction and unchecked cellular growth that can occur during cancer and metabolic disease. Each chapter offers an intuitive perspective of advances on the application of sirtuin pathways for cancer and metabolic disease that will be become a "go-to" resource for a broad audience of scientists, physicians, pharmaceutical industry experts, nutritionists, and students.

    • Covid-19 Infection and Pregnancy

      • 1st Edition
      • July 18, 2021
      • Ahmed M. Maged El-Goly
      • English
      • Paperback
        9 7 8 0 3 2 3 9 0 5 9 5 4
      • eBook
        9 7 8 0 3 2 3 9 0 7 1 8 7
      Covid-19 Infections and Pregnancy provides the latest research on pregnant women and their potential increased risk for severe COVID-19 illness. Research has show that pregnant women have a greater instance of intensive care unit admission and receipt of mechanical ventilation. The book provides up-to-date information on the epidemiology, control, diagnosis and treatment of covid-19 in pregnancy, while also discussing evidence presented in the literature regarding the potential risks of COVID-19 infection among pregnant women and consequent fetal transmission.

    • Methods in iPSC Technology

      • 1st Edition
      • June 2, 2021
      • Alexander Birbrair
      • English
      • Paperback
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      • eBook
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      The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. Methods in iPSC Technology, Volume 9 addresses the different methods used for induced pluripotent stem cell (iPSC) formation, maintenance, expansion, and differentiation. The ability to reprogram different cell types to iPSCs offers an opportunity to generate pluripotent patient-specific cell lines that can help in the understanding of multiple human disorders. This volume addresses a variety of current methods used in the generation and manipulation of iPSCs, such as magnetic nanoparticles, piggyBac vectors, lentiviral vectors, bioscaffolds, somatic cell nuclear transfer, CRISPR/Cas9, bacteria, and much more. This volume is written for researchers and scientists interested in stem cell therapy, cell biology, regenerative medicine, and organ transplantation and is contributed by world-renowned authors in the field.

    • Proteolytic Signaling in Health and Disease

      • 1st Edition
      • October 13, 2021
      • Andre Zelanis
      • English
      • Paperback
        9 7 8 0 3 2 3 8 5 6 9 6 6
      • eBook
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      In recent years, powered by evolving technologies and experimental design, studies have better illuminated the regulating role of proteolytic enzymes across human development and pathologies. Proteolytic Signaling in Health and Disease provides an in-depth discussion of fundamental physiological and developmental processes regulated by proteases, from protein turnover and autophagy to antigen processing and presentation and major histocompatibility complex (MHC) molecules. Moving on from basic biology, international chapter authors examine a range of pathological conditions associated with proteolysis, including inflammation, wound healing, and cancer. Later chapters discuss the newly discovered network of connected events among proteases (and their inhibitors), the so-called ‘protease web’, and how best to study it. This book also empowers new research with up-to-date analytical methods and step-by-step protocols for studying proteolytic signaling events.

    • Oncological Functional Nutrition

      • 1st Edition
      • August 20, 2021
      • Maira Rubi Segura Campos + 1 more
      • English
      • Paperback
        9 7 8 0 1 2 8 1 9 8 2 8 5
      • eBook
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      Oncological Functional Nutrition: Phytochemicals and Medicinal Plants presents the anticancer activities, metabolism, mechanism of action, doses, and sources of various phytochemicals and medicinal plants. Broken into five parts, this book addresses cancer epidemiology, molecular and therapeutic bases of cancer, macro and micronutrients in cancer prevention and treatment, phytochemicals in the cancer treatment, and medical plants as potential functional foods or resources for the obtention of metabolites with anticancer activity. Written for nutritionists, food scientists, health professionals, oncologists, endocrinologists, natural product chemists, ethnobotanists, chemists, pharmacists, biochemists, and students studying relating fields, Oncological Functional Nutrition: Phytochemicals and Medicinal Plants will be a useful reference for those interested in learning more about functional nutrition and cancer.

    • Haschek and Rousseaux's Handbook of Toxicologic Pathology, Volume 1: Principles and Practice of Toxicologic Pathology

      • 4th Edition
      • October 20, 2021
      • Wanda M. Haschek + 3 more
      • English
      • Hardback
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      • eBook
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      Haschek and Rousseaux's Handbook of Toxicologic Pathology, recognized by many as the most authoritative single source of information in the field of toxicologic pathology, has been extensively updated to continue its comprehensive and timely coverage. The fourth edition has been expanded to four separate volumes due to an explosion of information in this field requiring new and updated chapters. Completely revised with a number of new chapters, Volume 1, "Principles and the Practice of Toxicologic Pathology," covers the practice of toxicologic pathology in three parts: Principles of Toxicologic Pathology, Methods in Toxicologic Pathology, and the Practice of Toxicologic Pathology. Other volumes in this work round out the depth and breadth of coverage.Volume 2 encompasses "Toxicologic Pathology in Safety Assessment" and "Environmental Toxicologic Pathology". These two sections cover the application of toxicologic pathology in developing specific product classes, principles of data interpretation for safety assessment, and toxicologic pathology of major classes of environmental toxicants. Volumes 3 and 4 provide deep and broad treatment of "Target Organ Toxicity", emphasizing the comparative and correlative aspects of normal biology and toxicant-induced dysfunction, principal methods for toxicologic pathology evaluation, and major mechanisms of toxicity. These volumes comprise the most authoritative reference on toxicologic pathology for pathologists, toxicologists, research scientists, and regulators studying and making decisions on drugs, biologics, medical devices, and other chemicals, including agrochemicals and environmental contaminants. Each volume is being published separately.　

    • Food Security, Poverty and Nutrition Policy Analysis

      • 3rd Edition
      • September 21, 2021
      • Suresh Babu + 1 more
      • English
      • Hardback
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      • eBook
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      Food Security, Poverty and Nutrition Policy Analysis: Statistical Methods and Applications, Third Edition combines statistical data analysis and computer literacy, applying the results to develop policy alternatives through a series of statistical methods for real world food insecurity, malnutrition and poverty problems. The book presents the latest uses of statistical methods for policy analysis using the open source statistical environment R, in addition to having the original Stata files and applications. A new chapter on obesity brings in new datasets for analysis to effectively demonstrate the use of such data for addressing policy issues. Finally, program evaluation methods which can be directly applied to the data on food security, nutrition, poverty indicators and causal factors are included. This unique, real-world data takes the reader through a "hands-on" approach toward econometric practice whereby they can also test the effects of policy and program interventions. Further, this is the first book to explore actual data with STATA and R statistical packages that also provides a line-by-line guide to the programming and interpretation of results.

    • Chitosan in Drug Delivery

      • 1st Edition
      • October 25, 2021
      • Md Saquib Hasnain + 2 more
      • English
      • Paperback
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      • eBook
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      Chitosan in Drug Delivery provides thorough insights into chitosan chemistry, collection, chemical modifications, characterization and applications in the pharmaceutical industry and healthcare fields. The book explores molecular weight, degree of deacetylation and molecular geometry, emphasizing recent advances in the field as written by academic, industry and regulatory scientists. It will be a useful resource for pharmaceutical scientists, including industrial pharmacists, analytical scientists, postgraduate students, health care professionals and regulatory scientists actively involved in pharmaceutical product and process development in natural polymers containing drug delivery.

    • Molecular Imaging

      • 2nd Edition
      • August 2, 2021
      • Brian D. Ross + 1 more
      • English
      • Hardback
        9 7 8 0 1 2 8 1 6 3 8 6 3
      • eBook
        9 7 8 0 1 2 8 1 6 3 8 7 0
      The detection and measurement of the dynamic regulation and interactions of cells and proteins within the living cell are critical to the understanding of cellular biology and pathophysiology. The multidisciplinary field of molecular imaging of living subjects continues to expand with dramatic advances in chemistry, molecular biology, therapeutics, engineering, medical physics and biomedical applications. Molecular Imaging: Principles and Practice, Volumes 1 and 2, Second Edition provides the first point of entry for physicians, scientists, and practitioners. This authoritative reference book provides a comprehensible overview along with in-depth presentation of molecular imaging concepts, technologies and applications making it the foremost source for both established and new investigators, collaborators, students and anyone interested in this exciting and important field.

    • Handbook of Hormones

      • 2nd Edition
      • July 27, 2021
      • Hironori Ando + 2 more
      • English
      • Paperback
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      • eBook
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      Handbook of Hormones: Comparative Endocrinology for Basic and Clinical Research, Second Edition presents a catalog of fundamental information on the structure and function of hormones from basic biology to clinical use, offering a rapid way to obtain specific facts about the chemical and molecular characteristics of hormones, their receptors, signaling pathways, and the biological activities they regulate. The book's stellar editorial board, affiliated with the Japan Society for Comparative Endocrinology, brings together authors that present a compelling structure of each hormone with a consistent presentation that provides a primer surrounding the plethora of hormones that now exist. Comparative endocrinology continues to rapidly expand and new information about hormones is being produced almost daily, making it important to stay up-to-date. Hormone, paracrine, and autocrine factors have been identified as key players in a range of different systems, including immune, musculoskeletal and cardiovascular. Frontiers between disciplines are being blurred and many scientists in fields other than endocrinology are interested in hormones. Scientists now have the unprecedented opportunity to look from invertebrates to vertebrate and identify novel regulatory factors and understand their function and how they determine an organism’s physiology and survival.

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