Proteolytic Signaling in Health and Disease
- 1st Edition - October 13, 2021
- Imprint: Academic Press
- Editor: Andre Zelanis
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 8 5 6 9 6 - 6
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 8 5 6 9 7 - 3
In recent years, powered by evolving technologies and experimental design, studies have better illuminated the regulating role of proteolytic enzymes across human development and… Read more
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Request a sales quoteIn recent years, powered by evolving technologies and experimental design, studies have better illuminated the regulating role of proteolytic enzymes across human development and pathologies. Proteolytic Signaling in Health and Disease provides an in-depth discussion of fundamental physiological and developmental processes regulated by proteases, from protein turnover and autophagy to antigen processing and presentation and major histocompatibility complex (MHC) molecules. Moving on from basic biology, international chapter authors examine a range of pathological conditions associated with proteolysis, including inflammation, wound healing, and cancer. Later chapters discuss the newly discovered network of connected events among proteases (and their inhibitors), the so-called ‘protease web’, and how best to study it. This book also empowers new research with up-to-date analytical methods and step-by-step protocols for studying proteolytic signaling events.
- Examines biological events triggered by proteolytic enzyme activity across human development and pathologies
- Discusses the role of proteolytic signaling in inflammation, wound healing, and cancer, among other disease types
- Features methods and protocols supporting further study of proteolytic signaling events
- Includes chapter contributions from international leaders in the field
Life science researchers in biochemistry, molecular biology, and cell biology; clinical chemists and pharmaceutical scientists; and medical and analytical chemists. Clinicians and students
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Preface
- Chapter 1: Proteolytic signaling: An introduction
- Abstract
- Acknowledgment
- Introduction
- Proteases: A brief (and incomplete) introduction
- Limited proteolysis and proteolytic signaling are seamlessly connected
- Proteolytic signaling in health and disease
- Outlook and perspectives
- References
- Chapter 2: Ubiquitin ligases: Proteolytic signaling, protein turnover, and disease
- Abstract
- Ubiquitin-proteasome system (UPS) and E3 ligases
- Cell signaling regulation by ubiquitination
- Diseases
- Conclusion
- References
- Chapter 3: Lysosomal proteases and their role in signaling pathways
- Abstract
- Acknowledgments
- Introduction
- Cathepsins
- Lysosomal trafficking and cell signaling
- Specific roles of cathepsins in disease
- Conclusion
- References
- Chapter 4: Antigen processing and presentation through MHC molecules
- Abstract
- Introduction
- Processing and presentation through class I MHC pathway
- Class II MHC-associated pathway
- Cross presentation
- Protease dysregulation during disease
- Neurodegenerative diseases
- Cardiovascular alterations
- Cancer
- Other pathological processes
- Conclusions
- Abbreviations used in this chapter
- References
- Chapter 5: Proteolytic processing in autophagy
- Abstract
- Autophagy in health and disease
- Inducing-autophagy proteases
- Inhibiting-autophagy proteases
- Conclusion remarks and perspectives
- References
- Chapter 6: Proteases are cut out to regulate acute and chronic inflammation
- Abstract
- Introduction to inflammation
- The roles of proteases in sepsis
- The roles of proteases in Crohn’s disease
- Conclusions
- References
- Chapter 7: Proteolytic processing of laminin and the role of cryptides in tumoral biology
- Abstract
- Laminin
- Laminin-111 cryptides
- Conclusion
- References
- Chapter 8: Proteolytic signaling in cutaneous wound healing
- Abstract
- Introduction
- Conclusion
- References
- Chapter 9: Proteinase imbalance in oral cancer and other diseases
- Abstract
- Acknowledgments
- Proteolysis in oral cancer
- Zinc metalloproteinases: A family of proteinases involved in the balance between health and disease
- ADAM17
- Perspectives and conclusions
- References
- Chapter 10: “Omics” approaches to determine protease degradomes in complex biological matrices
- Abstract
- Acknowledgments
- Introduction
- Experimental design for protease degradome profiling
- Quantitative bottom-up proteomics
- Selective enrichment and proteome-wide characterization of protein termini
- Peptidomics
- Conclusions
- References
- Chapter 11: The protease web
- Abstract
- Acknowledgment
- Introduction
- Classification systems of proteases
- Regulation of protease activity by proteases
- Regulation of protease activity by protease inhibitor proteins
- Conceptualization of the protease web
- Network biology and the protease web
- Data and databases of protease interactions
- Identification of protease interactions
- Outlook
- References
- Chapter 12: The puzzle of proteolytic effects in hemorrhage induced by Viperidae snake venom metalloproteinases
- Abstract
- Introduction
- Snake venom metalloproteinases related to hemorrhagic effects
- Therapeutic strategies targeting hemostatic disturbance of snake venoms: Antivenoms and new therapies
- Conclusions remarks
- References
- Index
- Edition: 1
- Published: October 13, 2021
- No. of pages (Paperback): 308
- No. of pages (eBook): 308
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780323856966
- eBook ISBN: 9780323856973
AZ
Andre Zelanis
Dr. André Zelanis is Assistant professor of Proteomics and Systems Biology, and Head of the Functional Proteomics Laboratory at the Department of Science and Technology, Federal University of São Paulo, São José dos Campos, Brazil. His research focuses in proteomics and mass spectrometry-based approaches to uncover protease function in biological signaling pathways. Currently his lab is using proteomics to explore the repertoire of substrates (degradome) of proteases secreted by melanoma cells in culture and evaluating proteolytic processing events in the plasma of patients with metastatic melanoma. He has published widely in such peer reviewed journals as the Journal of Proteome Research and Comparative Biochemistry and Physiology.
Affiliations and expertise
Assistant professor of Proteomics and Systems Biology, and Head, Functional Proteomics Laboratory, Department of Science and Technology, Federal University of Sao Paulo, Sao Jose dos Campos, BrazilRead Proteolytic Signaling in Health and Disease on ScienceDirect