Chitosan in Drug Delivery

1st Edition - October 25, 2021
Editors: Md Saquib Hasnain, Sarwar Beg, Amit Kumar Nayak
Language: English
Paperback ISBN:
9 7 8 - 0 - 1 2 - 8 1 9 3 3 6 - 5
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 1 9 3 3 7 - 2

Chitosan in Drug Delivery provides thorough insights into chitosan chemistry, collection, chemical modifications, characterization and applications in the pharmaceutical industry… Read more

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Chitosan in Drug Delivery provides thorough insights into chitosan chemistry, collection, chemical modifications, characterization and applications in the pharmaceutical industry and healthcare fields. The book explores molecular weight, degree of deacetylation and molecular geometry, emphasizing recent advances in the field as written by academic, industry and regulatory scientists. It will be a useful resource for pharmaceutical scientists, including industrial pharmacists, analytical scientists, postgraduate students, health care professionals and regulatory scientists actively involved in pharmaceutical product and process development in natural polymers containing drug delivery.

Cover image
Title page
Table of Contents
Copyright
List of contributors
Preface
Chapter 1. Chitosan: source, chemistry, and properties
Abstract
1.1 Introduction
1.2 Sources of chitosan
1.3 Chemistry of chitosan
1.4 Properties of chitosan
1.5 Conclusion
References
Chapter 2. Chitosan-based systems for oral drug delivery applications
Abstract
2.1 Introduction
2.2 Chitosan-based oral delivery systems
2.3 Conclusion and future prospective
References
Chapter 3. Chitosan-based nanoparticles in drug delivery
Abstract
3.1 Introduction
3.2 Chitosan as drug delivery biopolymer
3.3 Factors affecting the efficacy of chitosan-based nanoparticles
3.4 Applications of chitosan-based nanoparticles for drug delivery
3.5 Conclusions and future prospects
References
Chapter 4. Role of chitosan in transdermal drug delivery
Abstract
4.1 Introduction
4.2 Chitosan-based transdermal drug delivery systems
4.3 Conclusion
References
Chapter 5. Chitosan in colon-targeted drug delivery
Abstract
5.1 Introduction
5.2 Mechanism of action of chitosan on colonic mucosa
5.3 Chitosan as colon-specific drug carrier biopolymeric material
5.4 Conclusion
References
Chapter 6. Chitosan as a biomaterial for implantable drug delivery
Abstract
6.1 Introduction
6.2 Implantable drug delivery system
6.3 Nontypical implantable drug delivery system
6.4 Chitosan: as a biomaterial
6.5 Conclusion
Acknowledgment
Conflict of Interest
References
Chapter 7. Chitosan-based drug delivery systems in cancer therapeutics
Abstract
7.1 Introduction
7.2 Sources and isolation of chitosan
7.3 Chemical structure and properties of chitosan
7.4 Chitosan: as a polymer in anticancer treatment
7.5 Different chemical derivatives of chitosan having anticancer activities
7.6 Targeting of nanotherapeutics
7.7 Conclusion
References
Chapter 8. In situ gelling systems of chitosan for potential drug delivery applications
Abstract
8.1 Introduction
8.2 Various chitosan-mediated in situ gel systems
8.3 Conclusion and future scope
References
Chapter 9. Chitosan as mucoadhesive polymer in drug delivery
Abstract
9.1 Introduction
9.2 Mucoadhesion
9.3 Chitosan as polymeric excipients
9.4 Chitosan and its derivatives as mucoadhesive agents
9.5 Conclusion
References
Chapter 10. Thiolated chitosan as an improved bioadhesive polymer in drug delivery
Abstract
10.1 Introduction
10.2 Synthesis of thiolated chitosan
10.3 Thiolated chitosan derivatives
10.4 Properties of thiolated chitosan
10.5 Applications of thiolated chitosan
10.6 Conclusion and future perspective
References
Chapter 11. Cross-linking of chitosan in drug delivery
Abstract
11.1 Introduction
11.2 General properties of chitosan
11.3 The limitations of native chitosan as a carrier in drug delivery system
11.4 Cross-linking of chitosan
11.5 Conclusion
References
Chapter 12. Graft copolymers of chitosan in drug delivery applications
Abstract
12.1 Introduction
12.2 Chitosan: structure and chemistry
12.3 Rational for graft copolymerizations of chitosan
12.4 Various graft copolymers of chitosan in drug delivery
12.5 Conclusions
References
Chapter 13. Carboxymethyl chitosan in advanced drug-delivery applications
Abstract
13.1 Introduction
13.2 Applications of carboxymethyl chitosan and its derivatives
13.3 Conclusions and future prospects
References
Chapter 14. Chitosan-based hydrogels in drug delivery
Abstract
14.1 Introduction
14.2 Chitosan as biopolymer
14.3 Preparation of chitosan-based hydrogels
14.4 Drug delivery applications of chitosan hydrogels
14.5 Conclusion
References
Chapter 15. Chitosan as a responsive biopolymer in drug delivery
Abstract
15.1 Introduction
15.2 Responsive polymers
15.3 Chitosan
15.4 Chitosan-based responsive carrier systems for drug delivery
15.5 Conclusion
References
Chapter 16. Chitosan-based nanobiocomposites in drug delivery
Abstract
16.1 Introduction
16.2 Nanobiocomposites
16.3 Chitosan
16.4 Chitosan-based nanobiocomposites
16.5 Conclusion
References
Chapter 17. Chitosan for delivery of biomolecules
Abstract
17.1 Introduction
17.2 Chitosan
17.3 Biomolecules
17.4 Biological activity of chitosan
17.5 Functions of chitosan
17.6 Delivery of proteins and peptides using chitosan system
17.7 Delivery of vaccines using chitosan system
17.8 Delivery of siRNA using chitosan system
17.9 Delivery of growth factors using chitosan system
17.10 Conclusion
Acknowledgment
Conflict of interest
References
Chapter 18. Novel chitosan-based strategies for insulin nanoencapsulation
Abstract
18.1 Introduction
18.2 Macromolecular self-assembly
18.3 Nanoparticles design
18.4 Encapsulation via nanospray drying
18.5 Conclusion
Acknowledgment
References
Chapter 19. Chemically modified chitosan for biomolecule delivery
Abstract
19.1 Conclusion
19.2 Future perspective
Acknowledgments
References
Index

Md Saquib Hasnain

Prof. (Dr.) Md Saquib Hasnain has over 13 years of research experience in the field of drug delivery and pharmaceutical formulation analyses, especially systematic development and characterization of diverse nanostructured drug delivery systems, controlled release drug delivery systems, bioenhanced drug delivery systems, nanomaterials and nanocomposites employing Quality by Design approaches and many more. Till date he has authored over 100 publications in various high impact peer-reviewed journals, more than 100 book chapters and 30 books to his credit. He is also serving as the reviewer of several prestigious journals. Overall, he has earned a highly impressive publishing and cited record. He has also participated and presented his research work at over ten conferences in India, and abroad. He was also a member of scientific societies i.e., Royal Society of Chemistry, Great Britain, International Association of Environmental and Analytical Chemistry, Switzerland and Swiss Chemical Society, Switzerland.

Affiliations and expertise

Department of Pharmacy, Palamau Institute of Pharmacy, Daltonganj, Jharkhand, India

Sarwar Beg

Sarwar Beg, PhD is currently serving as AMS-DBT Newton International Fellow at University of Central Lancashire, UK, and working in the area of glioblastoma research using targeted nanomedicines. He is also serving as the Assistant Professor at Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi. He has over a decade of teaching and research experience in the field of pharmaceutics and biopharmaceutics, especially in the development of novel and nanostructured drug delivery systems using Quality-by-Design paradigms with core expertise in computational pharmaceutics, experimental designs and multivariate statistical techniques. He has authored over 200 publications, 60 book chapters, 15 books, 03 Indian patent applications and H-Index of 40 with over 5400 citations to his credit.

Affiliations and expertise

Assistant Professor, Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard University, New Delhi, India

Amit Kumar Nayak

Dr. Amit Kumar Nayak (MPharm, PhD) is working as a professor, at the Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha ‘O' Anusandhan (Deemed to be University), Odisha, India. He has earned his PhD from IFTM University, Moradabad, Uttar Pradesh, India. He has over 14 years of research experiences in the field of pharmaceutics, especially in the development and characterization of novel biopolymeric and nanostructured drug delivery systems. Till date, he has authored more than 138 research and review publications in various high-impact peer-reviewed journals and 135 book chapters. He has edited/authored 23 international books to his credit. Dr. Nayak has presented his research work at several conferences. He has received University Foundation Day Research Award, 2019 and 2022 by Biju Patnaik University of Technology, Odisha. Dr. Nayak is a life member of the Association of Pharmaceutical Teachers of India (APTI) and a registered pharmacist.

Affiliations and expertise

Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India

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Chitosan in Drug Delivery

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Md Saquib Hasnain

Sarwar Beg

Amit Kumar Nayak