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Books in Life sciences

  • Epigenetic Regulation of Cancer in Response to Chemotherapy

    • 1st Edition
    • Volume 158
    • March 27, 2023
    • English
    Epigenetic Regulation of Cancer in Response to Chemotherapy, Volume 158 of the Advances in Cancer Research series, highlights new advances in the field, with this new volume presenting chapters on timely topics, including Epigenetically Programmed Resistance to Chemotherapy and Promotion of Immune Evasion in Cancer, A Role for the Epigenome in Cancer Cell Drug Tolerance, Histone Methylation and X Chromosomal Genes in Metastasis of Breast Cancer, Targeting Epigenetic Regulation Using Small Molecule Inhibitors, Histone Deacetylase Inhibitors as Sanguine Epigenetic Therapeutics against Pugnacious Lung Cancer, From ecology to oncology: To understand cancer stem cell dormancy, ask a Brine shrimp (Artemia), and more. Additional chapters cover Predictive Models of Chemoresistance Generated by Crunching the Public Drug Screen, Epigenomic and Genomic Profiling Datasets via Regression-, Machine Learning, and Knowledge-Based Methods, Probing on the Mechanisms of lncRNAs on Cancer Drug Resistance, Drug Tolerant Persister Cells in Cancer: Current Knowledge and Therapeutic Perspectives, and much more.

  • Wnt Signaling in Development and Disease

    • 1st Edition
    • Volume 153
    • March 23, 2023
    • English
    Wnt Signaling in Development and Disease, Volume 153, delves into the biology of Wnt signaling in a wide variety of model organisms. Since their first identification in 1982, Wnt proteins and their downstream effectors have captivated the attention of many researchers in a variety of fields, including developmental biology, cell signaling, structural biology, stem and cancer cell biology and regeneration. Wnt signaling, along with a small number of highly conserved signaling modules including the Hedgehog, FGF, BMP, RA and Notch pathways, orchestrates morphogenesis across all metazoans. Readers will find information on recent discoveries in the Wnt field, including interactions between Wnt and other signaling pathways, and tools and technologies to interrogate the complexity of Wnt signaling. Other chapters cover Wnt signaling in Xenopus neural development, Wnt signaling in hematopoietic stem cell development, Wnt signaling and the maintenance and regeneration of the gut epithelium, Wnt signaling in the skeleton as a basis for Wnt-based regenerative medicine, and Non-canonical Wnt5a-Ror signaling: Insights from human congenital disorders and cancer.

  • Endocrinology of the Aging Patient, An Issue of Endocrinology and Metabolism Clinics of North America

    • 1st Edition
    • Volume 52-2
    • March 23, 2023
    • Rita Rastogi Kalyani
    • English
    In this issue, guest editors bring their considerable expertise to this important topic.

  • Development and Commercialization of Biopesticides

    Costs and Benefits
    • 1st Edition
    • March 22, 2023
    • Opender Koul
    • English
    Development and Commercialization of Biopesticides: Costs and Benefits provides a uniquely comprehensive view of the commercial production of biopesticides, from research to application, featuring case studies in various developed and developing countries of the world. The book offers guidance for future strategies to researchers, along with considerations for the industry’s economic concerns, i.e., costs and benefits compared to conventional pesticides, future perspectives for application strategies, bioavailability and environmental safety, and impacts on intellectual property issues during commercialization. Finally, the book covers why the development of this industry must be strategic, comprehensive and forward-looking in order to be an accepted, safe and sustainable. There is no doubt that biopesticides are now in large-scale use, and a variety of novel techniques have been used to improve or modify existing biopesticides, which will further accelerate their development.

  • Translational Surgery

    • 1st Edition
    • March 22, 2023
    • Adam E.M. Eltorai
    • English
    Translational Surgery covers the principles of evidence-based medicine and applies these principles to the design of translational investigations. The reader will come to fully understand important concepts including case-control studies, prospective cohort studies, randomized trials, and reliability studies. Investigators will benefit from greater confidence in their ability to initiate and execute their own investigations, avoid common pitfalls in surgical research, and know what is needed for collaboration. Further, this title is an indispensable tool in grant writing and funding efforts. The practical, straightforward approach helps the translational research navigate challenging considerations in study design and implementation. The book provides valuable discussions of the critical appraisal of published studies in surgery, allowing the reader to learn how to evaluate the quality of such studies. Thus, they will improve at measuring outcomes; making effective use of all types of evidence in patient care. In short, this practical guidebook will be of interest to every surgeon or surgical researcher who has ever had a good clinical idea, but not the knowledge of how to test it.

  • Psychophysics and Experimental Phenomenology of Pattern Cognition

    • 1st Edition
    • March 22, 2023
    • Jiro Hamada
    • English
    Psychophysics and Experimental Phenomenology of Pattern Cognition examines the cognitive transformations that underly this cognitive system and the specialized subsystems for processing these transformations. Sections cover symmetry cognition, contour perception and geometric illusion. Weight sensation is also discussed, as are repetitive and dot patterns. By incorporating elements of both psychophysics and experimental phenomenology, pattern cognition is examined from both the physical and mental sensory perspective, thus providing a comprehensive view of this cognitive system.

  • Myeloid-Derived Suppressor Cells

    • 1st Edition
    • Volume 375
    • March 22, 2023
    • English
    Myeloid-Derived Suppressor Cells, Volume 375 includes comprehensive and detailed reviews on the current advances in myeloid derived suppressor cells, an immature, heterogenous cell population from the myeloid lineage that has been extensively described in the last decades due to its potent immunosuppressive activity in a variety of pathologies. Chapters in this new release include Cancer-cell-intrinsi... mechanisms regulate myeloid-derived suppressor cells through cytokine networks, Role of myeloid-derived suppressor cells in head and neck cancer, Role of myeloid-derived suppressor cells in breast cancer, Role of myeloid-derived suppressor cells in endometriosis, Role of myeloid-derived suppressor cells in ovarian cancer, Role of myeloid-derived suppressor cells in sarcoma, and more.

  • Essentials of Pharmatoxicology in Drug Research, Volume 1

    Toxicity and Toxicodynamics
    • 1st Edition
    • March 22, 2023
    • Rakesh Kumar Tekade + 1 more
    • English
    Toxicity and Toxicodynamics, Volume One in the Essentials of Pharmatoxicology in Drug Research series provides an overview on the essentials of toxicology, risk assessment and the mechanisms. Topics discussed include the types of cellular responses to chemical toxicants, mechanisms of drug toxicity, and their relevance to pharmaceutical product development. The book examines omics and computer-aided technologies for mechanistic and predictive toxicology and covers state-of-art testing in the evaluation of detrimental pathways, dose selection in toxicity studies, as well as the role of regulatory agencies in toxicity studies. In addition, there is also discussion on clinical interventions such as pharmacotherapy and managed care strategies for acute poisoning. This volume is a valuable resource to those learning more about the drug development process related to toxicology and those who want to get an update on newer concepts on the toxicology aspect of drug research.

  • Human Reproductive and Prenatal Genetics

    • 2nd Edition
    • March 22, 2023
    • Peter C.K. Leung + 1 more
    • English
    **Selected for Doody’s Core Titles® 2024 in Clinical Genetics**Human Reproductive and Prenatal Genetics, Second Edition provides application-driven coverage of key topics in human reproductive and prenatal genetics, including genetic control underlying the development of the reproductive tracts and gametogenesis, the genetics of fertilization and implantation, the genetic basis of female and male infertility, as well as genetic and epigenetic aspects of assisted reproduction. Also examined are the genetics and epigenetics of the placenta in normal and abnormal pregnancy, preimplantation genetic diagnosis and screening, and cutting-edge advances in noninvasive prenatal screening, prenatal genetic counseling, and bioethical and medicolegal aspects of relevance in the lab and clinic.This new edition has been fully revised to address new and evolving technologies in human reproductive genetics, with new chapters added on chromatin landscapes and sex determination, genetic alterations of placental development and preeclampsia, metabolism and inflammation in PCOS, pre-implantational genetic testing, maternal genetic disorders, bioethics, and future applications.

  • One Health Meets the Exposome

    Human, Wildlife, and Ecosystem Health
    • 1st Edition
    • March 22, 2023
    • Mary Ann Ottinger + 1 more
    • English
    One Health Meets the Exposome: Human, Wildlife, and Ecosystem Health brings together the two powerful conceptual frameworks of One Health and the Exposome to comprehensively examine the myriad of biological, environmental, social, and cultural challenges impacting the interrelated health of humans, wildlife, and ecosystems. One Health as an encompassing concept and collaborative framework recognizes the interconnections among humans, wildlife, and our shared environment with the goal of optimizing health outcomes for all. The Exposome is more specifically oriented to human health and considers cumulative environmental exposures affecting individuals, communities, and populations. This book will provide the broadened and integrative view that considers a more holistic approach needed to confront the complex issues facing us today. One Health Meets the Exposome: Human, Wildlife, and Ecosystem Health is a valuable and cutting-edge resource for researchers and practitioners in medicine, public health, animal science, wildlife and field biology, and for any reader looking to better understand the relationships among human health and the environment.

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