Wnt Signaling in Development and Disease
- 1st Edition, Volume 153 - March 23, 2023
- Imprint: Academic Press
- Editors: Terry P. Yamaguchi, Karl Willert
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 8 2 0 1 6 7 - 1
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 0 1 6 4 - 0
Wnt Signaling in Development and Disease, Volume 153, delves into the biology of Wnt signaling in a wide variety of model organisms. Since their first identification in 1982, Wnt… Read more
Purchase options
Institutional subscription on ScienceDirect
Request a sales quoteWnt Signaling in Development and Disease, Volume 153, delves into the biology of Wnt signaling in a wide variety of model organisms. Since their first identification in 1982, Wnt proteins and their downstream effectors have captivated the attention of many researchers in a variety of fields, including developmental biology, cell signaling, structural biology, stem and cancer cell biology and regeneration. Wnt signaling, along with a small number of highly conserved signaling modules including the Hedgehog, FGF, BMP, RA and Notch pathways, orchestrates morphogenesis across all metazoans. Readers will find information on recent discoveries in the Wnt field, including interactions between Wnt and other signaling pathways, and tools and technologies to interrogate the complexity of Wnt signaling. Other chapters cover Wnt signaling in Xenopus neural development, Wnt signaling in hematopoietic stem cell development, Wnt signaling and the maintenance and regeneration of the gut epithelium, Wnt signaling in the skeleton as a basis for Wnt-based regenerative medicine, and Non-canonical Wnt5a-Ror signaling: Insights from human congenital disorders and cancer.
- Presents newest findings on the role of Wnt signaling in a variety of tissues and organisms
- Illustrates the diverse actions of Wnt signaling in development and disease
- Highlight tools and technologies to interrogate Wnt signaling in any biological system
Developmental and stem cell biologists; cancer biologists
- Cover image
- Title Page
- Table of Contents
- Copyright
- Contributors
- Preface
- References
- Chapter One: The logistics of Wnt production and delivery
- Abstract
- 1: Wnt production and delivery: A complex logistical problem
- 2: Lipidation
- 3: Glycosylation
- 4: Progression through the secretory pathway
- 5: Beyond Wls
- 6: Transport and gradient formation
- 7: Wnt interactions with HSPGs and glypicans
- 8: Other means of shielding the Wnt lipid in the extracellular space
- 9: Wnts reach their receptors: Handover and initiation of signaling
- 10: How a lipidated morphogen came to be during evolution
- Acknowledgments
- References
- Chapter Two: Visualizing WNT signaling in mammalian systems
- Abstract
- 1: Introduction
- 2: Imaging individual players at the molecular level
- 3: Imaging signaling output at the cellular level
- 4: Discussion and outlook
- Acknowledgments
- References
- Chapter Three: Wnt signaling and the regulation of pluripotency
- Abstract
- 1: Introduction
- 2: The essentials of Wnt signaling
- 3: Methods to manipulate Wnt signaling
- 4: Introduction to pluripotency
- 5: Regulation of pluripotency by signal transduction pathways
- 6: Transcriptional regulation of pluripotency
- 7: Naïve and primed and in between
- 8: Wnt signaling in reprogramming
- 9: Self-organization of PS cells
- 10: Conclusion
- References
- Chapter Four: Wnt signaling in stem cells during development and cell lineage specification
- Abstract
- 1: Overview of Wnt/β-catenin signaling
- 2: The role of Wnt/β-catenin signaling during embryonic development
- 3: Wnt/β-catenin signaling and pluripotency of ESCs (naïve vs primed)
- 4: Positive and negative regulators of Wnt signaling during embryonic development and stem cell maintenance
- 5: Wnt/β-catenin dependent directed differentiation protocols of embryonic stem cells to specific lineages in vitro
- 6: Conclusions and perspectives
- Acknowledgments
- References
- Chapter Five: The role of Wnt signaling in the development of the epiblast and axial progenitors
- Abstract
- 1: Introduction
- 2: Overview of the Wnt/β-catenin pathway
- 3: Wnts and the pluripotent epiblast
- 4: Role of Wnts in gastrulation
- 5: Closing remarks
- References
- Chapter Six: Role of Wnt signaling and planar cell polarity in left-right asymmetry
- Abstract
- 1: Canonical Wnt signaling regulates the formation of the node, the left-right organizer
- 2: Non-canonical Wnt signaling and planar cell polarity determines the tilt of motile cilia at the node
- 3: Canonical Wnt signaling in establishing asymmetric nodal activity at the node
- 4: Conclusions
- Acknowledgments
- References
- Chapter Seven: Non-canonical WNT5A-ROR signaling: New perspectives on an ancient developmental pathway
- Abstract
- 1: A brief history of canonical and non-canonical WNT pathways
- 2: Emergence of WNT5A-ROR signaling as a major non-canonical WNT pathway
- 3: Robinow syndrome as a disorder of WNT5A-ROR signaling
- 4: Molecular insights from Robinow syndrome and related disease mutations
- 5: Growing connections to cancer metastasis
- 6: Cell biological functions of WNT5A-ROR signaling
- 7: Concluding remarks
- Acknowledgments
- References
- Chapter Eight: The role of Wnt signaling in Xenopus neural induction
- Abstract
- 1: Introduction
- 2: The arising of embryonic signaling centers
- 3: The Wnt pathway discovery and its impact on X. laevis embryogenesis
- 4: The BMP signaling pathway and the neural default model
- 5: WNT morphogen activity and its impact on Xenopus AP embryonic neural patterning
- 6: Concluding remarks
- Acknowledgments
- References
- Chapter Nine: Wnt regulation of hematopoietic stem cell development and disease
- Abstract
- 1: Hematopoietic stem cells—The source of our blood and immune cell pool
- 2: In vivo models for hematopoietic stem cell development
- 3: Wnt signaling
- 4: Wnt signaling in HSC development and homeostasis
- 5: Wnt signaling and hematological malignancies
- 6: Epigenetic regulation in HSCs and Wnt signaling
- 7: Conclusion
- References
- Chapter Ten: Role of Wnt signaling in the maintenance and regeneration of the intestinal epithelium
- Abstract
- 1: Introduction
- 2: Overview of the Wnt pathway
- 3: Organization of the intestinal epithelium
- 4: Wnt pathway in intestinal homeostasis and regeneration
- 5: Regulation of Wnt signaling by the intestinal niche
- 6: Discussion
- References
- Chapter Eleven: Got WNTS? Insight into bone health from a WNT perspective
- Abstract
- 1: Bone development
- 2: Wnt signaling in limb development
- 3: Wnt signaling and human skeletal malformations
- 4: Wnt signaling and bone homeostasis
- 5: Therapeutics and future directions
- Acknowledgments
- References
- Chapter Twelve: Wnt signaling in whole-body regeneration
- Abstract
- 1: Introduction
- 2: Planarian regeneration is supported by pluripotent adult stem cells
- 3: Planarians have constitutive Wnt positional information specified from muscle
- 4: Injury-induced Wnt signals regulate the polarity of blastema outgrowth
- 5: Constitutive Wnt gradients pattern the AP axis in homeostasis and regeneration
- 6: Wnts control reestablishment of tissue proportionality in planarian regeneration
- 7: Wnt signaling from muscle controls AP regeneration of the Acoel Hofstenia miamia
- 8: Wnt signaling controls oral-aboral identity in whole-body regeneration of Cnidarians
- 9: Concluding remarks
- Acknowledgments
- References
- Chapter Thirteen: From injury to patterning—MAPKs and Wnt signaling in Hydra
- Abstract
- 1: Introduction
- 2: Wnt signaling in Hydra axis formation
- 3: Autocatalytic Wnt activation and Wnt inhibitors in Hydra pattern formation
- 4: Cell cycle dynamics of Hydra regeneration
- 5: Transcriptomic and (phospho-) proteomic profiles of Hydra regeneration
- 6: A dual role of Wnt signaling in regeneration
- 7: The injury signal in Hydra
- 8: Linking injury and patterning
- 9: Maintenance of polarity—Integration of generic into position specific cues
- 10: Perspective and outlook
- Acknowledgments
- References
- Edition: 1
- Volume: 153
- Published: March 23, 2023
- Imprint: Academic Press
- No. of pages: 424
- Language: English
- Hardback ISBN: 9780128201671
- eBook ISBN: 9780128201640
TY
Terry P. Yamaguchi
Terry P. Yamaguchi is at NCI-Frederick, MD, USA
Affiliations and expertise
NCI-Frederick, NIH, Frederick, MD, United StatesKW
Karl Willert
Karl Willert is at Sanford Consortium for Regenerative Medicine, CA, USA
Affiliations and expertise
Department of Cellular and Molecular Medicine, University of California San Diego, San Diego, CA, United StatesRead Wnt Signaling in Development and Disease on ScienceDirect