
Epigenetic Regulation of Cancer in Response to Chemotherapy
- 1st Edition, Volume 158 - March 27, 2023
- Editors: Joseph Landry, Swadesh Das, Paul B. Fisher
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 1 9 4 1 8 - 4
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 9 4 1 9 - 1
Epigenetic Regulation of Cancer in Response to Chemotherapy, Volume 158 of the Advances in Cancer Research series, highlights new advances in the field, with this new volume prese… Read more

Purchase options

Institutional subscription on ScienceDirect
Request a sales quoteEpigenetic Regulation of Cancer in Response to Chemotherapy, Volume 158 of the Advances in Cancer Research series, highlights new advances in the field, with this new volume presenting chapters on timely topics, including Epigenetically Programmed Resistance to Chemotherapy and Promotion of Immune Evasion in Cancer, A Role for the Epigenome in Cancer Cell Drug Tolerance, Histone Methylation and X Chromosomal Genes in Metastasis of Breast Cancer, Targeting Epigenetic Regulation Using Small Molecule Inhibitors, Histone Deacetylase Inhibitors as Sanguine Epigenetic Therapeutics against Pugnacious Lung Cancer, From ecology to oncology: To understand cancer stem cell dormancy, ask a Brine shrimp (Artemia), and more.
Additional chapters cover Predictive Models of Chemoresistance Generated by Crunching the Public Drug Screen, Epigenomic and Genomic Profiling Datasets via Regression-, Machine Learning, and Knowledge-Based Methods, Probing on the Mechanisms of lncRNAs on Cancer Drug Resistance, Drug Tolerant Persister Cells in Cancer: Current Knowledge and Therapeutic Perspectives, and much more.
- Provides the authority and expertise of leading contributors from an international board of authors
- Presents the latest release in the Advances in Cancer Research series
- Includes the latest information on the Epigenetic Regulation of Cancer in Response to Chemotherapy
- Cover
- Title page
- Table of Contents
- Copyright
- Contributors
- Preface
- Chapter One: The epigenome and the many facets of cancer drug tolerance
- Abstract
- 1: Principles of non-genetic drug tolerance
- 2: The hallmarks of cancer drug tolerance
- 3: Epigenetics in drug tolerance
- References
- Chapter Two: Epigenetically programmed resistance to chemo- and immuno-therapies
- Abstract
- 1: Epigenetic dysregulation in cancer and therapeutic resistance
- 2: Chemoresistance
- 3: Epigenetic modifications drive cancer progression and chemoresistance
- 4: Epigenetic modifications drive resistance to immunotherapies
- 5: Targeting epigenetic modifications to overcome chemoresistance and immune evasion
- 6: Conclusions
- Competing interests
- References
- Chapter Three: Targeting epigenetic regulation for cancer therapy using small molecule inhibitors
- Abstract
- 1: Introduction
- 2: DNA methylation
- 3: Histone modifications
- 4: Combination epigenetic therapy
- 5: Conclusions
- References
- Further reading
- Chapter Four: Histone deacetylase inhibitors as sanguine epitherapeutics against the deadliest lung cancer
- Abstract
- 1: Lung cancer statistics
- 2: Overview of major types of lung cancer
- 3: Conventional and other lung cancer therapies and their significant limitations
- 4: Surgery and radiation therapy for lung cancer
- 5: Histone deacetylases (HDACs) in lung cancer pathogenesis
- 6: Current scenario and chemistry of HDAC inhibitors
- 7: HDAC inhibitor-based monotherapy toward lung cancer
- 8: HDACi together with other chemotherapeutics against lung cancer
- 9: Clinical studies of HDACi with immune checkpoint inhibitors toward lung cancer
- 10: Conclusion and future suggestions
- Acknowledgments
- References
- Chapter Five: From ecology to oncology: To understand cancer stem cell dormancy, ask a Brine shrimp (Artemia)
- Abstract
- 1: Introduction
- 2: Dormancy, diapause, and quiescence
- 3: Artemia used as an animal model to study cancer dormancy
- 4: Epigenetic regulation of chromatin structure as the central mechanism to the cellular quiescence transition
- 5: Broader factors and signaling pathways conserved between Artemia, mouse, and human cancers
- 6: Conclusion and future perspectives
- Acknowledgment
- References
- Chapter Six: Multi-CpG linear regression models to accurately predict paclitaxel and docetaxel activity in cancer cell lines
- Abstract
- 1: Introduction
- 2: Datasets and methods used to develop predictive multi-marker linear regression models
- 3: Developing the predictive models
- 4: Discussion of linear progression models and applications for gene identification and predictors of taxane therapeutic response
- 5: Future perspectives
- Acknowledgments
- References
- Chapter Seven: Epigenetic adaptations in drug-tolerant tumor cells
- Abstract
- 1: Introduction
- 2: Epigenetic regulations
- 3: Drug tolerant tumor cells (DTPs) and their adaptations
- 4: Epigenetics and associated changes—Key to DTP emergence and survival
- 5: Conclusion and future perspectives
- References
- Chapter Eight: The epigenetic regulation of cancer cell recovery from therapy exposure and its implications as a novel therapeutic strategy for preventing disease recurrence
- Abstract
- 1: Introduction
- 2: A short primer on epigenetics
- 3: The limited success of epigenetic-targeted therapies treating solid tumors
- 4: A proposed novel use for epigenetic-targeted therapies
- 5: States which promote cancer cell recovery from therapy exposure
- 6: Strategies to prevent recovery from therapy exposure
- 7: Future directions
- Acknowledgments
- References
- Chapter Nine: Targeting the super elongation complex for oncogenic transcription driven tumor malignancies: Progress in structure, mechanisms and small molecular inhibitor discovery
- Abstract
- 1: Introduction of SEC structure and function
- 2: Relationship between SEC and transcriptional regulation
- 3: SEC dysregulation and cancer
- 4: Inhibitors targeting SEC or regulating SEC components
- 5: Future perspective
- References
- No. of pages: 438
- Language: English
- Edition: 1
- Volume: 158
- Published: March 27, 2023
- Imprint: Academic Press
- Hardback ISBN: 9780443194184
- eBook ISBN: 9780443194191
JL
Joseph Landry
SD
Swadesh Das
PF