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    • Feldman and Pike’s Vitamin D

      • 5th Edition
      • October 28, 2023
      • Martin Hewison + 5 more
      • English
      • Hardback
        9 7 8 0 3 2 3 9 1 3 3 8 6
      • eBook
        9 7 8 0 3 2 3 9 1 3 3 9 3
      Vitamin D deficiency is a worldwide problem linked to numerous diseases affecting men, women, and children of all ages. Enormous progress in the study of vitamin D has been made since the first edition of this highly-acclaimed book was published nearly 20 years ago, and current research continues to draw headlines. Feldman and Pike’s Vitamin D, Fifth Edition continues to build on the successful formula from previous editions, taking the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics. The two comprehensive volumes provide investigators, clinicians, and students with a comprehensive, definitive, and up-to-date compendium of the diverse scientific and clinical aspects of vitamin D, where each area is covered by both basic and clinical experts in the field. In Volume I: Biochemistry, Physiology and Diagnostics, international experts in endocrinology, bone biology, and human physiology take readers through the basic research of vitamin D. This impressive reference presents a comprehensive review of the multi-faceted actions of vitamin D relating both to skeletal and extra-skeletal action. Researchers from all areas of vitamin D will gain insight into how clinical observations and practices can feed back into the research cycle and will, therefore, be able to develop more targeted genomic and proteomic insights into the mechanisms of disease. Volume II: Health, Disease and Therapy authoritatively covers the evidence for new roles of vitamin D, ranging from organ transplantation to cancer, diabetes, inflammatory bowel disease, multiple sclerosis, and renal disease. The coverage is appropriately broad, drawing on aspects of internal medicine, pediatrics, nutrition, orthopedics, oncology, neurology, obstetrics and gynecology, and immunology, as well as, new areas for vitamin D including sports medicine, opthalmology, veterinary medicine and ICU care – including COVID-19. Clinical researchers will gain a strong understanding of the molecular basis for a particular disease and better understand future directions for research in this still-growing field.

    • Phospholipases in Physiology and Pathology

      • 1st Edition
      • August 17, 2023
      • Sajal Chakraborti
      • English
      • Hardback
        9 7 8 0 3 2 3 9 5 6 8 7 1
      • eBook
        9 7 8 0 3 2 3 9 5 6 8 8 8
      Phospholipases in Physiology and Pathology presents a comprehensive overview on the physiology and pathology of phospholipases. This seven-volume set considers the biochemical and molecular mechanisms of normal and abnormal cell function upon dysregulation of phospholipases in different diseases. Volumes cover signal transduction mechanisms, implications in cancer, infectious diseases, neural diseases, cardiovascular diseases and other diseases, implications in inflammation, apoptosis, gene expression and non-coding RNAs, the role of natural and synthetic compounds, and stem cell therapies, nanotechnology-based therapies, and more. Together, these volumes give researchers critical insight on the mechanistic and therapeutic aspects of phospholipases.

    • Neurostimulation for Epilepsy

      • 1st Edition
      • April 11, 2023
      • Vikram R. Rao
      • English
      • Hardback
        9 7 8 0 3 2 3 9 1 7 0 2 5
      • eBook
        9 7 8 0 3 2 3 9 8 5 6 4 2
      **Association of American Publishers (AAP) PROSE Award Finalist in Biomedicine and Neuroscience, 2024**Neurostimulati... for Epilepsy: Advances, Applications, and Opportunities comprehensively reviews the diverse array of neurostimulation technologies currently in use and in development for the treatment of epilepsy. The book covers basic mechanisms of neurostimulation, technical characteristics of approved and investigational neurostimulation devices, clinical applications and programming considerations of these devices, and progress toward next-generation device technology. Leading experts in the field provide a contemporary appraisal of neurostimulation in epilepsy, one that highlights recent advances, outlines unanswered questions, and proposes future directions.Neurostim... for Epilepsy: Advances, Applications, and Opportunities will be of high interest to clinical, basic, and translational researchers seeking to understand leading-edge applications of neurostimulation in epilepsy and to clinicians managing patients with epilepsy who are treated with implanted and external neurostimulation devices. This book will also be of interest to trainees, to physicians in other areas of neurology where neurostimulation is employed, such as Pain and Movement Disorders, and to general medical practitioners, neurobiologists, and engineers.

    • Brain Responses to Auditory Mismatch and Novelty Detection

      • 1st Edition
      • July 11, 2023
      • Jos J. Eggermont
      • English
      • Paperback
        9 7 8 0 4 4 3 1 5 5 4 8 2
      • eBook
        9 7 8 0 4 4 3 1 5 5 4 9 9
      Brain Responses to Auditory Mismatch and Novelty Detection: Predictive Coding from Cocktail Parties to Auditory-Related Disorders provides the connections between changes in the ‘error-generating network’ and disorder-specific changes while also exploring its diagnostic properties. The book allows the reader to appreciate the outcomes of predictive coding theory in fields of auditory streaming (including the cocktail-party effect) and psychiatric disorders with an auditory component. These include mild cognitive impairment (MCI), Alzheimer’s disease, attention-deficit and hyperactivity disorder (ADHD), autism spectrum disorder (ASD), schizophrenia and the cognitive aspects of Parkinson’s disease. The book combines animal experiments on adaptation, human auditory evoked potentials, including MMN and their maturational, as well as aging aspects into one comprehensive resource.

    • Modulation of Oxidative Stress

      • 1st Edition
      • August 4, 2023
      • Luciano Saso + 3 more
      • English
      • Paperback
        9 7 8 0 4 4 3 1 9 2 4 7 0
      • eBook
        9 7 8 0 4 4 3 1 9 2 4 8 7
      Modulation of Oxidative Stress: Biochemical, Physiological and Pharmacological Aspects explores the field using an interdisciplinary approach, including chemical, biological, physiological, pharmaceutical, pharmacological and physicochemical perspectives. The book is comprised of three main parts, with the first discussing the biochemical aspects of oxidative stress modulation. Other sections cover physiological and pathophysiological aspects on relevant conditions, including aging, neurological diseases, cerebral cavernous malformation, maternal and early-life malnutrition, Alzheimer’s disease, liver transplant, and cancer. Final content is dedicated to pharmacological aspects and includes chapters on phytotherapy and flavonoids. This book is a strong reference for pharma researchers in academia and industry considering leveraging modulation of oxidative stress as a strategy for the development of new drugs. Biochemists and Nutritionists may also benefit of the foundational understanding of cellular redox processes laid out.

    • Feldman and Pike’s Vitamin D

      • 5th Edition
      • October 28, 2023
      • Martin Hewison + 5 more
      • English
      • Hardback
        9 7 8 0 3 2 3 9 1 3 8 6 7
      • eBook
        9 7 8 0 3 2 3 9 1 3 9 0 4
      **Selected for 2025 Doody’s Core Titles® in Biochemistry**Vitami... D deficiency is a worldwide problem linked to numerous diseases affecting men, women, and children of all ages. Enormous progress in the study of vitamin D has been made since the first edition of this highly-acclaimed book was published nearly 20 years ago, and current research continues to draw headlines. Feldman and Pike’s Vitamin D, Fifth Edition continues to build on the successful formula from previous editions, taking the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics. The two comprehensive volumes provide investigators, clinicians, and students with a comprehensive, definitive, and up-to-date compendium of the diverse scientific and clinical aspects of vitamin D, where each area is covered by both basic and clinical experts in the field.In Volume I: Biochemistry, Physiology and Diagnostics, international experts in endocrinology, bone biology, and human physiology take readers through the basic research of vitamin D. This impressive reference presents a comprehensive review of the multi-faceted actions of vitamin D relating both to skeletal and extra-skeletal action. Researchers from all areas of vitamin D will gain insight into how clinical observations and practices can feed back into the research cycle and will, therefore, be able to develop more targeted genomic, proteomic and metabolomic insights into the mechanisms of disease.Volume II: Health, Disease and Therapy authoritatively covers the evidence for new roles of vitamin D, ranging from organ transplantation to cancer, diabetes, inflammatory bowel disease, multiple sclerosis, and renal disease. The coverage is appropriately broad, drawing on aspects of internal medicine, pediatrics, nutrition, orthopedics, oncology, neurology, obstetrics and gynecology, and immunology, as well as, new areas for vitamin D including liver metabolism, veterinary medicine and ICU care – including COVID-19. Clinical researchers will gain a strong understanding of the molecular basis for a particular disease and better understand future directions for research in this still-growing field.

    • Complications of Hysteroscopy

      • 1st Edition
      • November 19, 2023
      • Rahul Manchanda + 1 more
      • English
      • Paperback
        9 7 8 0 4 4 3 2 1 6 1 6 9
      • eBook
        9 7 8 0 4 4 3 2 1 6 1 7 6
      Complications of Hysteroscopy: Diagnosis and Management is a step-by-step reference to explain various problems that can be encountered during a hysteroscopy procedure. It is a complete guide on the diagnosis and management of different causes of hysteroscopy mishaps to master how to diagnose and select the most appropriate strategy of all aspects of what could go wrong and applying that knowledge in different clinical settings. It is an essential reference for anyone in the research and medical field.

    • Drug-delivery systems of phytochemicals as therapeutic strategies in cancer therapy

      • 1st Edition
      • November 7, 2023
      • Akhileshwar Kumar Srivastava + 2 more
      • English
      • Paperback
        9 7 8 0 4 4 3 1 5 9 6 0 2
      • eBook
        9 7 8 0 4 4 3 1 5 9 6 1 9
      Drug-delivery Systems of Phytochemicals as Therapeutic Strategies in Cancer Therapy elucidates the importance of various phytochemicals in cancer therapy and explains various routes/methods to deliver phytochemicals for overcoming the problems associated with delivery systems in cancer treatment. Several nanotechnological methods are presented to enhance drug solubility, sustainability, bioavailability, and gastrointestinal permeability of these phytochemicals. Current understanding of the relevant information presented on therapeutic strategies in cancer therapy fulfils the requirements of oncologists, molecular biologists, pharmacologist and related researchers who want to work in the areas of drug development targeting phytochemicals for cancer therapy.

    • Pharmaceutical Care in Digital Revolution

      • 2nd Edition
      • August 18, 2023
      • Ardalan Mirzaei + 1 more
      • English
      • Paperback
        9 7 8 0 4 4 3 1 3 3 6 0 2
      • eBook
        9 7 8 0 4 4 3 1 3 3 6 1 9
      Pharmaceutical Care in the Digital Revolution: Blending Digital with Human Innovation, Second Edition provides readers with an updated view on how to use technology to improve pharmaceutical care (PC) and enhance drug outcomes with digital tools. Organized into four parts, including Global Healthcare Systems Under Pressure, Digital Advances to Innovate Pharmaceutical Care Journeys, Conditions to Drive Combinatoric Pharma-Digital Innovation, and What to do Tomorrow as a Pharmaceutical Care Leader, the book further examines digital developments that will optimize the PC process and prepare stakeholders for a dynamic future that will optimize the life of patients against a sustainable cost model. This edition also discusses recent advances in the digital health arena that will change the way we approach healthcare and prevention while also providing interactive links to lectures and technologies, tutorials on how to implement advances in your own working environment, and examples of pharmacists who are successful in building synergy between digital and pharma.

    • Improving Stress Resilience in Plants

      • 1st Edition
      • November 23, 2023
      • Mohammad Abass Ahanger + 3 more
      • English
      • Paperback
        9 7 8 0 4 4 3 1 8 9 2 7 2
      • eBook
        9 7 8 0 4 4 3 1 8 9 2 8 9
      Improving Stress Resilience in Plants: Physiological and Biochemical Basis and Utilization in Breeding addresses the urgent need for improved understanding of major plant stress tolerance mechanisms, the identification of the genes, and gene products that are key to improving those mechanisms and means of optimizing those genes through molecular approaches. With a focus on plant physiological and biochemical attributes at both cellular and whole plant levels, this book includes the latest information on crosstalk between the various signaling molecules and quantitative trait locus (QTL). Further, it explores the extension of these mechanisms to breeding approaches, confirming overall understanding and inspiring further research. Written by a team of global experts, and presented in three thematic sections, the book provides insights into physical adaptations, metabolism and pathways, and breeding techniques including CRISPR and conventional approaches to reduce the negative effects of stresses and improve crop yield even under stress conditions. It is an ideal resource for researchers, academics and advanced students seeking to improve stress tolerance among crop plants and developing key future strategies for sustainable food production.

Related subjects

Agricultural and biological sciences

Drug discovery

Immunology

Microbiology and virology

Neuroscience

Pharmaceutical sciences

Pharmacology

Toxicology