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Elsevier

Books in Life sciences

  • Advances in Agronomy

    • 1st Edition
    • Volume 66
    • English
    This latest volume contains five reviews covering key contemporary topics in agronomy. As always, the topics covered are varied and exemplary of the panoply of subject matter dealt with by this long-running serial. Advances in Agronomy continues to be recognized as a leading reference and a first-rate source of the latest and best research in agronomy.

  • Physicochemical and Environmental Plant Physiology

    • 2nd Edition
    • Park S. Nobel
    • English
    The functioning of all living systems obeys the laws of physics in fundamental ways. This is true for all physiological processes that occur inside cells, tissues, organs, and organisms. The new edition of Park Nobel's classic text has been revised in an unprecedented fashion, while still remaining user-friendly and clearly presented. Certain to maintain its leading role in teaching general and comparative physiological principles, Physicochemical and Environmental Plant Physiology now establishes a new standard of excellence in teaching advanced physiology.The book covers water relations and ion transport for plant cells, including diffusion, chemical potential gradients, and solute movement in and out of plant cells. It also presents the interconnection of various energy forms, such as light, chlorophyll and accessory photosynthesis pigments, and ATP and NADPH. Additionally, the book describes the forms in which energy and matter enter and leave a plant, for example: energy budget analysis, water vapor and carbon dioxide, and water movement from soil to plant to atmosphere.

  • International Review of Cytology

    A Survey of Cell Biology
    • 1st Edition
    • Volume 187
    • English
    International Review of Cytology presents current advances and comprehensive reviews in cell biology-both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

  • Advances in Cancer Research

    • 1st Edition
    • Volume 76
    • English
    Volume 76 of Advances in Cancer Research continues the series' goal of publishing timely and authoritative reviews in the broad field of cancer research. Ruoslahti begins the volume with a review of fibronectin and its integrin receptors in cancer. Chapter 2 by Ganter and Lipsick discusses Myb and oncogenesis. Biscardi and colleagues present their research on c-Src, receptor tyrosine kinases, and human cancer in Chapter 3. Chapter 4 by Schulz covers epidemiology of Kaposi's sarcoma and associated herpesvirus/human herpesvirus 8. The consensus on synergism between cigarette smoke and other environmental carcinogens in the causation of lung cancer is reviewed by Reif and Heeren in Chapter 5. In Chapter 6, Breivik and Gaudernack discuss perspectives on carcinogenesis and natural selection in the genetics and epigenetics of colorectal cancer. Chapter 7 by Coulie and co-workers concludes the volume with a discussion of anti-tumor immunity at work in a melanoma patient.

  • Vitamins and Hormones

    • 1st Edition
    • Volume 57
    • Gerald Litwack + 1 more
    • English
    Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. In the early days of the Serial, the subjects of vitamins and hormones were quite distinct. Now, new discoveries have proved that several of the vitamins function as hormones and many of the substances inferred by the title of the Serial function in signal transduction processes. Accordingly, the Editor-in-Chief has expanded the scope of the Serial to reflect this newer understanding of function-structure relationships in cellular communication. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms.

  • Ion Channel Regulation

    • 1st Edition
    • Volume 33
    • English
    Volume 33 reviews the current understanding of ion channel regulation by signal transduction pathways. Ion channels are no longer viewed simply as the voltage-gated resistors of biophysicists or the ligand-gated receptors of biochemists. They have been transformed during the past 20 years into signaling proteins that regulate every aspect of cell physiology. In addition to the voltage-gated channels, which provide the ionic currents to generate and spread neuronal activity, and the calcium ions to trigger synaptic transmission, hormonal secretion, and muscle contraction, new gene families of ion channel proteins regulate cell migration, cell cycle progression, apoptosis, and gene transcription, as well as electrical excitability. Even the genome of the lowly roundworm Caenorhabditis elegans encodes almost 100 distinct genes for potassium-selective channels alone. Most of these new channel proteins are insensitive to membrane potential, yet in humans, mutations in these genes disrupt development and increase individual susceptibility to debilitating and lethal diseases.How do cells regulate the activity of these channels? How might we restore their normal function? In Ion Channel Regulation, many of the experts who pioneered these discoveries provide detailed summaries of our current understanding of the molecular mechanisms that control ion channel activity.

  • International Review of Cytology

    A Survey of Cell Biology
    • 1st Edition
    • Volume 188
    • English
    International Review of Cytology presents current advances and comprehensive reviews in cell biology-both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

  • Advances in Developmental Biochemistry

    • 1st Edition
    • Volume 5b
    • Paul Wassarman
    • English
    This series provides annual reviews of research topics in developmental biology/biochemistry... written from the perspectives of leading investigators in these fields. This volume of Advances in Developmental Biochemistry consists of seven chapters that review specific aspects of development in several different organisms including mollusks, flies and mice.

  • Advances in Magnetic Resonance in Food Science

    • 1st Edition
    • P S Belton + 2 more
    • English
    The highly versatile nature of magnetic resonance techniques in dealing with problems arising in many areas in food science is demonstrated in this book. Topics covered include development of the technique, functional constituents of food, signal treatment and analysis, along with applications of magnetic resonance to food processing and engineering. The international flavour of the contributions to this text aim to make it of value to both academics and industrialists in food science.

  • Advances in Medicinal Chemistry

    • 1st Edition
    • Volume 4
    • B.E. Maryanoff + 1 more
    • English
    Volume 4 of Advances in Medicinal Chemistry is comprised of six chapters on a wide range of topics in medicinal chemistry, including molecular modeling, structure-based drug design, organic synthesis, peptide conformational analysis, biological assessment, structure-activity correlation, and lead optimization. Chapter 1 presents an account about amino acid-based peptide mimetics corresponding to b-turn, loop, helical motifs in proteins as a probe of ligand-receptor and ligand-enzyme molecular interactions. Chapter 2 addresses new facets of the medicinal chemistry of the important anticancer drug Taxol® (paclitaxel). Chapter 3 relates an account of the search for new drugs for the treatment of malaria based on the natural product artemisinin. Chapter 4 applies computational chemistry to the evaluation of compound libraries for biological testing. Chapter 5 describes the construction of a 3-dimensional molecular model of the human thrombin receptor, the first protease-activated G-protein coupled receptor (PAR-1), as a means to explore the intermolecular contacts involved in agonist peptide recognition. Finally, Chapter 6 describes the research conducted at Merck on inhibitors of farnesyl transferase as a potential treatment for human cancers.

  • The Adhesive Interaction of Cells

    • 1st Edition
    • Volume 28
    • David Garrod + 2 more
    • English
    The aim of "The Adhesive Interaction of Cells" has been to assemble a series of reviews by leading international experts embracing many of the most important recent developments in this rapidly expanding field. The purpose of all biological research is to understand the form and function of living organisms and, by comprehending the normal, to find explanations and remedies for the abnormal and for disease conditions. The molecules involved in cell adhesion are of fundamental importance to the structure and function of all multicellular organisms. In this book, the contributors focus on the systems of vertebrates, especially mammals, since these are most relevant to human disease. It would have been equally possible to concentrate on developmental processes and adhesion in lower organisms. A major function of adhesion molecules is to bind cells to each other or to the extracellular matrix, but they are much more than "glue". Adhesions in animal tissues must be dynamic-forming, persisting, or declining in regulated fashion- to facilitate the mobility and turnover of tissue cells. Moreover, the majority of adhesion molecules are transmembrane molecules and thus provide links between the cells and their surroundings. This gives rise to another major function of adhesion molecules, the capacity to transduce signals across the hydrophobic barrier imposed by the plasma membrane. Such signal transduction is crucially important to many aspects of cellular function including the regulation of cell motility, gene expression, and differentiation. The work in this book progresses through four sections. Part I discusses the four major families of adhesion molecules themselves, the integrins (Green and Humphries), the cadherins (Stappert and Kemler), the selectins (Tedder et al.) and the immunoglobulin superfamily (Simmons); part 2 considers junctional complexes involved in cell interactions: focal adhesions and adherens junctions (Ben Ze'ev), desmosomes (Garrod et al.), and tight junctions (Citi and Cordenonsi). The signaling role of adhesion molecules is the focus of part 3, through integrins and the extracellular matrix (Edwards and Streuli), through platelet adhesion (Du and Ginsberg), and in the nervous system (Hemperley). In part 4, the aim is to show how adhesive phenomena contribute to important aspects of cell behavior and human health. Leukocyte trafficking (Haskard et al.), cancer metastasis (Marshall and Hart), cell migration (Paleck et al.), and implantation and placentation (Damsky et al.) are the topics considered in depth.The different sections are, of course, not mutually exclusive: it is both undesirable and impossible to separate structure from function when considering cell adhesion. Each chapter has its unique features, but some overlap is both invevitable and valuable since it provides different perspectives on closely related topics. We hope that the whole contributes a valuable and stimulating consideration of this important topic.

  • Advances in Parasitology

    • 1st Edition
    • Volume 43
    • English
    Advances in Parasitology is a series of up-to-date reviews of all areas of interest in contemporary parasitology. It includes medical studies on parasites of major influence, such as typanosomeiasis and scabies, and more traditional areas, such as zoology, taxonomy, and life history, which shape current thinking and applications.

  • The Anatomical Basis of Mouse Development

    • 1st Edition
    • Matthew H. Kaufman + 1 more
    • English
    This book is an essential anatomical resource for developmental biologists who need to know about any aspect of mouse developmental anatomy, as well as for geneticists using the mouse embryo as a model. The book is a companion to Kaufman's The Atlas of Mouse Development, and details the developmental anatomy of the early embryo, the transitional tissues, and all the major organ systems. It also provides extensive comparisons with human developmental anatomy, both normal and abnormal. The book has extensive reference indexes detailing developmental stage criteria. The Anatomical Basis of Mouse Development will be a key reference work for anyone who needs to understand developmental anatomy in normal and mutant mice.

  • Platelet Protocols

    Research and Clinical Laboratory Procedures
    • 1st Edition
    • Melanie McCabe White + 1 more
    • English
    Platelets are fragments of blood cells that occur in the blood of vertebrates and are associated with blood clotting. Scientists have made great strides in recent years in understanding what stimulates platelets to form blood clots at the molecular level and in developing drugs to inhibit platelet action. Their work has a direct effect on millions of people who deal with cardiovascular disease, strokes, surgery, physical trauma, and other conditions. While references to platelet function have been included in some large texts, there has not been a basic reference manual that researchers and clinicians can use in their daily work until now.Platelet Protocols fills the need for a straightforward and comprehensive laboratory manual on current procedures for evaluating and analyzing platelet function and abnormalities. It is an easy-to-read, understandable resource which can be kept at the bench and referred to frequently by scientists, clinicians, and laboratory staff involved in platelet related areas. Topics range from the basics of anticoagulants to the latest developments in platelet testing.

  • Advances in the Study of Behavior

    • 1st Edition
    • Volume 28
    • English
    Advances in the Study of Behavior continues to serve scientists across a wide spectrum of disciplines. Focusing on new theories and research developments with respect to behavioral ecology, evolutionary biology, and comparative psychology, these volumes foster cooperation and communication in these diverse fields.

  • Complement Regulatory Proteins

    • 1st Edition
    • B. Paul Morgan + 1 more
    • English
    From small beginnings in the early 1970s, the study of complement regulatory proteins has grown in the last decade to the point where it dominates the complement field. This growth has been fueled by the discovery of new regulators, the cloning of old and new regulators, the discovery that many of the regulators are structurally and evolutionarily related to each other and the development of recombinant forms for use in therapy. There are now more proteins known to be involved in controlling the complement system than there are components of the system and the list continues to grow. The time is ripe for a comprehensive review of our current knowledge of these intriguing proteins. This book does just that. The first few chapters discuss the "nuts-and-bolts" of the complement regulators, describing their structures, functional roles and modes of action. The roles of the complement regulators in vivo are then described, focusing on the consequences of deficiency, roles in the reproductive system, interactions with pathogens and exploitation for therapy. The interesting developments in defining the complement regulators expressed in other species are also discussed. The book is written as a monograph, albeit by two people. The text is as readable as possible without compromising on scientific accuracy and completeness. The conversational style very evident in some sections is deliberate! Placing all references in a single bibliography at the end of the text further improves readability. The reader will go to the book to discover a specific fact but be persuaded to read more and derive pleasure from the process. The authors' enthusiasm for the subject comes over strongly in the text, and this enthusiasm proves infectious.

  • Antioxidant Food Supplements in Human Health

    • 1st Edition
    • Lester Packer + 2 more
    • English
    Antioxidant Food Supplements in Human Health discusses new discoveries in the areas of oxygen and nitric oxide metabolism and pathophysiology, redox regulation and cell signaling, and the identification of natural antioxidants and their mechanisms of action on free radicals and their role in health and disease. An essential resource for researchers, students, and professionals in food science and nutrition, gerontology, physiology, pharmacology, and related areas.

  • Advances in Brain Vasopressin

    • 1st Edition
    • Volume 119
    • I.J.A. Urban + 2 more
    • English
    Advances in Brain Vasopressin elucidates the functions of the regulatory peptide vasopressin in the nervous system, and reviews the current status of this field at different levels.It deals with the cell biology and anatomy of the neurons that produce vasopressin in the brain, and provides an overview on the receptors of vasopressin and the signal transduction pathways that they activate, including the cellular responses that are triggered by vasopressin. Reviews are presented on the modulation of behavior induced by vasopressin in a number of different contexts, such as sex-linked and steroid-dependent behaviors, social behaviors, and learning and memory.Furthermore, the volume deals with several controversial issues in the field by presenting overlapping chapters from different research groups in order to provide the reader with current views.Highly relevant and useful, for those working on this "first" neuropeptide, and for young investigators entering the field, and in addition, shows how important a multidisciplinary approach is to unravelling the function of a neuropeptide in the brain.

  • The Decade of Autoimmunity

    • 1st Edition
    • Yehuda Shoenfeld
    • English
    This book is a direct result of 10 years of the well-known "Autoimmunity Days" in Israel, which are increasingly becoming an international focal point for autoimmunity scientists. Top researchers provide coverage of the most important knowledge generated during the last decade. The volume can therefore be seen almost as a textbook on autoimmunity, projecting from the last decade to the next millennium.A variety of different subjects in autoimmunity, from etiology to pathogenesis, from postulated mechanisms to innovative therapeutic modalities, is handled by noted contributors, while additional authors contribute top papers which significantly enhance a better understanding of autoimmunity.An excellent treatise on the subject, and a worthwhile addition to both clinical and research libraries.

  • Advances in Plant Glycosides, Chemistry and Biology

    • 1st Edition
    • Volume 6
    • Chong-Ren Yang + 1 more
    • English
    In the plant kingdom a variety of chemical constituents occur in a glycoside form (conjugation with sugar). Glycosides are important, secondary metabolites. The structural diversity is a result of the vast amount of varieties and stereochemical configurations of the sugar component. Aglycones belong to terpenoid, steroid, flavonoid, quinonoid, lignan, other simple phenolics, and isothiocyanate. However, biological activities of glycosides are, in many cases, susceptible to the nature of sugar moieties, even though their aglycone is the same.Since the 80s, plant glycosides have been attracting an increasing volume of interest from botanists and phytochemists world-wide for the following reasons:• They are difficult to isolate and purify• They have a very important biological function in plant life and remarkable biological activities• They are a very important resource of natural medicine, health food, cosmetics and food supplements.The first International Symposium on Plant Glycosides (ISPG), held in Kunming, China was attended by more than 150 scientists from 17 countries. During the four day meeting, 96 reports on plant glycosides, including structure elucidation, ethnobotany, pharmacology, quantitative evaluation, synthesis, pharmacology and biotechnology were presented. 54 of these papers are given in this volume. All these papers review recent research results on plant glycosides.

  • Agri-Food Quality II

    Quality Management of Fruit and Vegetables
    • 1st Edition
    • M Hagg + 3 more
    • English
    As consumer demand for high quality products grows, the quality of our food is increasingly under the spotlight. Agri-food quality II addresses the quality management of plant-based food materials throughout the production chain, from field to table. Developments relating to the improvement of vegetable and fruit quality through plant breeding, genetic manipulation, modification of cultivation technology and optimisation of harvesting and storage techniques, are covered in detail. Furthermore, the concept of functional foods and sustainable production are also discussed.With contributors from international experts, Agri-food quality II will be of great interest to food scientists, agriculturalists, or indeed anyone involved with part of the food chain, both in academia and industry.

  • The Bamboos of the World

    Annotated Nomenclature and Literature of the Species and the Higher and Lower Taxa
    • 1st Edition
    • D. Ohrnberger
    • English
    Bamboos constitute one of a few select categories of plants which are taxonomically related, very rich in species and of vital economic and ecological importance. Since the early 20th century the accepted number of species of bamboos, world wide, has tripled. However, until now information was scattered through numerous, often not easily available publications.The Bamboos of the World, is the first comprehensive (taxonomic as well as horticultural) reference work that provides basic information on bamboos world wide, whether they are wild or cultivated, well-known or rather unknown. The work, based on bamboo literature, facilitates access to further data by citation and a comprehensive bibliography. Among the main data included are botanical names with synonyms, and geographical distribution of genera and species, varieties with their distinctive characters, common bamboo names, plant introductions to the West, plant size and uses. The distribution of genera is mapped.The Bamboos of the World presents a wealth of essential information in an accessible and structured manner. It gives the opportunity to check under what names, and where, relevant information on any bamboo can be found. For the researcher with management and development interests it provides a convenient means of basing bamboo resource on a sound understanding of generic and species relationships, with names that appear in earlier literature put into context. The work should prove to be invaluable for those interested in the morphology, taxonomy, distribution and cultivation of bamboos. It should support botanical, forestry, horticultural and ecological research, training and resource management.

  • Advances in Agronomy

    • 1st Edition
    • Volume 65
    • English
    Volume 65 contains six reviews covering key contemporary topics on crop and soil sciences. The topics are varied and exemplary of the array of subjects dealt with by this long-running serial. With this latest volume, Advances in Agronomy continues to be recognized as a leading reference and a first-rate source of the latest and best research in agronomy.

  • Emergency Response Planning

    For Corporate and Municipal Managers
    • 1st Edition
    • Paul A. Erickson
    • English
    Emergencies wreak havoc on businesses and governments on a daily basis. Whether it is a hurricane pounding a coastal community, a terrorist attack on a company's headquarters, or a hazardous chemical spill at a local school, the results can be loss of life, health, and property. How can you prevent or reduce the effects of such occurrences? By planning ahead.Emergency Response Planning is designed to help corporate and municipal managers quickly understand their roles in proactive and reactive emergency management. Author Paul Erickson shows how to develop partnerships with federal, state, and local government agencies, as well as community groups in order to prevent, prepare for, and respond to natural disasters and manmade emergencies.Emergenc... Response Planning provides essential information to help you comply with government regulations, design an emergency response plan, train personnel, use the proper safety equipment, safeguard information systems, and resume normal operations after an emergency as quickly as possible. It will also help consultants design emergency response plans for their clients, and provide practical information for students studying business continuity and emergency issues.

  • Windbreaks

    • 1st Edition
    • Steven Burke
    • English
    Windbreaks is essential reading for anyone interested in improving sustainable agricultural productivity and the rural environment.Steven Burke is a leading expert in the field of windbreaks. He is employed by the Department of Conservation and Natural Resources, Victoria, as Pest Programs Manager.

  • Natural Antioxidants and Anticarcinogens in Nutrition, Health and Disease

    • 1st Edition
    • J T Kumpulainen + 1 more
    • English
    Natural antioxidants and anticarcinogens in nutrition, health and disease represents the most recent information and state-of-the-art knowledge on the role of antioxidative vitamins, carotenoids and flavonoids in ageing, atherosclerosis, and diabetes, as well as the role of natural anticarcinogenic compounds, particularly lignans and isoflavonoids, and cancer prevention. It is highly interdisciplinary, and will be of importance to all scientists working in the medical, biomedical, nutritional and food sciences as well as the academics.

  • Lipids in Health and Nutrition

    • 1st Edition
    • J H P Tyman
    • English
    Lipids have a variety of functions in the human body which have increasingly been under the spotlight in recent years. A multidisciplinary book, Lipids in health and nutrition addresses the chemical, biochemical and physiological aspects of these widely occurring compounds. International experts combine to present research on a variety of topics, including advanced analytical techniques; the role of flavonoids in diet: possible links between dyslexia, dyspraxia and attention deficit disorder and the metabolism of fatty acids; the influence of dietary fatty acids in coronary heart disease; and lipids and obesity.

  • Disinfection By-Products in Drinking Water

    Current Issues
    • 1st Edition
    • M Fielding + 1 more
    • English
    This volume brings together contributors from water regulators, and water suppliers in Europe and North America to discuss the main issues associated with reaching a cost-effective balance between microbial and chemical risks. Overviews of research are presented alongside illuminating case studies of the practical approaches taken by water companies and regulators on both sides of the Atlantic.

  • Managing Risks of Nitrates to Humans and the Environment

    • 1st Edition
    • W S Wilson + 2 more
    • English
    This volume concentrates on research information on the beneficial effects of nitrates and their fate in the environment. Adopting an integrated approach it covers the agricultural, environmental and medical aspects of this emotive topic. In addition, there is an extensive description of the biochemistry of nitrates in plants, animals and humans including the positive aspects as well as the hazards.

  • Industrial Solvents Handbook, 5th Ed.

    • 5th Edition
    • Ernest W. Flick
    • English
    Completely revised, and vastly expanded, this Fifth Edition is a well-established and successful reference volume designed principally for the chemical and other process industries, but will be found useful by anyone needing the latest pertinent data on industrial solvents. This Fifth Edition is uniquely helpful when it becomes necessary to select a new solvent on a competitive or comparative basis; when the customary solvent, employed hitherto, might no longer be available, or can no longer be used because of environmental reasons; or when prices have risen to such an extent that an existing process must be redesigned to make it economically feasible again.The over 1,200 tables in this book contain basic data on the physical properties of most solvents and on the solubilities of a variety of materials in these solvents. Even phase diagrams for multicomponent systems are included. Particularly valuable are the comparative data for various solvents in the last chapter.

  • Molecular and Cellular Biology of Bone, Part A

    • 1st Edition
    • Volume 5
    • M. Zaidi + 2 more
    • English
    These volumes differ from the current conventional texts on bone cell biology. Biology itself is advancing at breakneck speed and many presentations completely fail to present the field in a truly modern context. This text does not attempt to present detailed clinical descriptions. Rather, after discussion of basic concepts, there is a concentration on recently developed findings equally relevant to basic research and a modern understanding of metabolic bone disease. The book will afford productive new insights into the intimate inter-relation of experimental findings and clinical understanding. Modern medicine is founded in the laboratory and demands of its practitioners a broad scientific understanding: these volumes are written to exemplify this approach. This book is likely to become essential reading equally for laboratory and clinical scientists.

  • The Origin and Evolution of Larval Forms

    • 1st Edition
    • Brian K. Hall + 1 more
    • English
    Larvae represent one of the classic problems of evolutionary biology and may explain how new body plans originate. It has often been suggested that many entirely unique body plans first originated as retained larvae of ancestral organisms.This book covers larval evolution and the developmental and evolutionary forces which shape and constrain them. Intended to contribute to a continuing dialectic, this book represents diverse opinions as well as manifold conclusions from an international team of leading zoologists and developmental biologists. Certain to challenge and intrigue, this book should be a part of the library of every evolutionary and developmental biologist interested in larvae and their significance.

  • Experimental Developmental Biology

    A Laboratory Manual
    • 1st Edition
    • Laura R. Keller + 2 more
    • English
    Experimental Developmental Biology: A Laboratory Manual is designed for use in college-level laboratory courses in developmental biology. It offers challenging experiments for students to perform as independent investigators as they probe developmental processes in living embryos at the organizational, cellular, and subcellular levels.

  • Mitosis and Meiosis

    • 1st Edition
    • Volume 61
    • English
    Mitosis and meiosis are process of nuclear division in cells. This volume is a practical handbook on the modern techniques used to study mitosis and meiosis, with an emphasis on the composition and function of centrosomes, spindle pole bodies, and kinetochore structure. It also includes basic principles used in the selection of cells for specific scientific study, as well as analytical and procedural techniques.

  • Tcl/Tk For Real Programmers

    • 1st Edition
    • Clif Flynt
    • English
    This book will fill a void in the current Tcl/Tk bookshelf. It is written to the latest version of Tcl/Tk (8.0, perhaps 8.1, depending on Sun's release schedule) and addresses Tcl/Tk under Windows as well as Unix. It includes discussions on proper coding techniques, instead of just language syntax. Clif Flynt gives readers a very 'hands on' book, with an emphasis towards allowing a reader to pick up the book as needed to find the answer to a question, instead of assuming that it will be read cover to cover.

  • Evolution!

    Facts and Fallacies
    • 1st Edition
    • J. William Schopf
    • English
    The proceedings of the March 1997 symposium on Evolution! Facts and Fallacies are published in this short, accessible, and profusely-illustrate... text. When Darwin originated his concept of descent with modification by means of natural selection, evolution became the instant focus of uncertainty and debate. In Evolution! noted experts sort facts from fallacies by answering questions most often asked of Darwin's grand theory. Interwoven throughout is the broad theme of how science is done and the answer to the most crucial question of all: How can we be sure that science will uncover the truth? Contributors are key experts on evolution and extraterrestrial life. Written at an easily understandable level, this book is accessible as well as entertaining to the general reader, high school, and college student.

  • The Zebrafish: Genetics and Genomics

    Genetics and Genomics
    • 1st Edition
    • Volume 60
    • English
    This is the second volume of a two-volume, comprehensive treatment of the methodologies used in researching the Zebrafish, an emerging vertebrate model system. The text includes discussions on development, genetic methodologies, and model applications.

  • Advances in Immunology

    • 1st Edition
    • Volume 71
    • English
    Advances in Immunology presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

  • Myocardial Preservation and Cellular Adaptation

    • 1st Edition
    • Volume 6
    • D.K. Das
    • English
    Living organisms exhibit specific responses when confronted with sudden changes in their environmental conditions. The ability of the cells to acclimate to their new environment is the integral driving force for adaptive modification of the cells. Such adaptation involves a number of cellular and biochemical alteration including metabolic homeostasis and reprogramming of gene expression. Changes in metabolic pathways are generally short-lived and reversible, while the consequences of gene expression are a long-term process and may lead to permanent alternation in the pattern of adaptive responses. The heart possesses remarkable ability to adapt itself against any stressful situation by increasing resistance to the adverse consequences. Stress composes the foundation of many degenerative heart diseases including atherosclerosis, spasm, thrombosis, cardiomyopathy, and congestive heart failure. Based on the concept that excessive stress may play a crucial role in the pathogenesis of ischemic heart disease, attempts were made to design methods for preventing of myocardial injury. Creation of stress reactions by repeated ischemia and reperfusion or subjecting the hearts to heat or oxidative stress enables them to meet the future stress challenge. Repeated stress exposures adapt the heart to withstand more severe stress reactions probably by upregulating the cellular defense and direct accumulation of intracellular mediators, which presumably constitute the material basis of increased adaptation to stress. Thus, the powerful cardioprotective effect of adaptation is likely to originate at the cellular and molecular levels that compose fundamental processes in the prophylaxis of such diseases. Volume six of the Advances in Organ Biology series contains state-of-the-art reviews on myocardial preservation and cellular adaptation from the leading authorities in this subject.

  • Mitosis and Meiosis

    • 1st Edition
    • Volume 61
    • English
    Mitosis and Meiosis details the wide variety of methods currently used to study how cells divide as yeast and insect spermatocytes, higher plants, and sea urchin zygotes. With chapters covering micromanipulation of chromosomes and making, expressing, and imaging GFP-fusion proteins, this volume contains state-of-the-art "how to" secrets that allow researchers to obtain novel information on the biology of centrosomes and kinetochores and how these organelles interact to form the spindle.

  • Principles of Fermentation Technology

    • 2nd Edition
    • A. Whitaker
    • English
    This second edition has been thoroughly updated to include recent advances and developments in the field of fermentation technology, focusing on industrial applications. The book now covers new aspects such as recombinant DNA techniques in the improvement of industrial micro-organisms, and includes comprehensive information on fermentation media, sterilization procedures, inocula, and fermenter design. Chapters on effluent treatment and fermentation economics are also incorporated. The text is supported by numerous clear, informative diagrams.The book is of great interest to final year and post-graduate students of applied biology, biotechnology, microbiology, biochemical and chemical engineering.

  • The Histamine H<INF>3</INF> Receptor

    A Target for New Drugs
    • 1st Edition
    • Volume 30
    • R. Leurs + 1 more
    • English
    In the early eighties when the H3 receptor was identified, many thought that an H3 ligand, an agonist or an antagonist, would become available as a therapeutic agent. This has not occurred. The reason for this could be the fact that many investigators consider histamine mainly, if not only, as a mediator present in for example mast cells being released during allergic events. However, it has become apparent that histamine is an important neurotransmitter. Its role in the nervous system, especially in the central part of it, is rather extensive.The H3 receptor is mainly found as a presynaptic one, both on histaminergic neurons (the auto-type) and on other neuronal systems (the hetero-type). Both the H3 agonist and the H3 antagonist cause important pharmacological effects. Several ligands have become available now, including radiolabelled analogues.In this book, the current state of affairs with regards to the medicinal chemistry and pharmacology of the H3 receptor and the several ligands available are presented by a number of experts in the field. The book presents an extended review of what has happened since the first H3 paper appeared. The editors hope that publication of this work will lead to an increase in interest of both academia and industry for the H3 receptor, especially as a target for drug development.

  • Automation: Genomic and Functional Analyses

    • 1st Edition
    • Volume 28
    • English
    Automation is the major future trend for many areas in microbiology, molecular biology, and biochemistry, among other disciplines. It is an enormously exciting area, where techniques and assays that were once repetitive, tedious, and time consuming can be performed robotically, liberating the time of researchers and hospital laboratory workers for more interesting work. Many techniques have now been automated and often miniaturized, including PCR analysis, DNA/RNA preparation, diagnostic test (e.g., Pap tests), compound screening, and of course, sequencing. Some major advances, notably in Professor Leroy Hood's group, have resulted in the ability to perform thousands of assays simultaneously on a normal microscope slide. Automation, edited by two of the leading experts in the field, presents the very latest experimental techniques explained in detail. This book has succeeded in bringing together researchers at the forefront of clone library construction, genome analysis, sequencing, computational data evaluation and functional analysis, to provide insight into this "new age" of research based on genomic and chemical screening.

  • Side Effects of Drugs Annual

    • 1st Edition
    • Volume 21
    • English
    The Side Effects of Drugs Annual has been published each year since 1977. It is designed to provide a critical and up-to date account of new information relating to adverse drug reactions and interactions from the clinician's point of view. The Annual can be used independently or as a supplement to the standard encyclopedic work in this field, Meyler's Side Effects of Drugs, of which, the http://www.elsevier.... Edition was published in December 2000.The present Annual reviews all reports presenting significant new information on adverse reactions to drugs from July 1996 to June 1997. During the production of this Annual, more recent papers have been included. The use of the book is enhanced by two separate indexes, allowing the reader to enter the text by drug name, adverse effect name, or drug interaction.

  • The Zebrafish: Genetics and Genomics

    The Zebrafish, Volume II Genetics and Genomics
    • 1st Edition
    • Volume 60
    • English
    This is the second volume of a two-volume, comprehensive treatment of the methodologies used in researching the zebrafish, an emerging vertebrate model system. The text includes discussions on development, genetic methodologies, and model applications.

  • The Zebrafish: Biology

    • 1st Edition
    • Volume 59
    • English
    This is the first in a two-volume, comprehensive treatment of the methodologies used in researching the Zebrafish, an emerging vertebrate model system. The text includes discussions on development, genetic methodologies, and model applications.

  • Progress in Nucleic Acid Research and Molecular Biology

    • 1st Edition
    • Volume 62
    • English

  • Advances in Parasitology

    • 1st Edition
    • Volume 42
    • English
    Advances in Parasitology is a series of up-to-date reviews of all areas of interest in contemporary parasitology. It includes medical studies on parasites of major influence, such as typanosomiasis and scabies, and more traditional areas, such as zoology, taxonomy, and life history, which shape current thinking and applications.

  • Gene Expression Systems

    Using Nature for the Art of Expression
    • 1st Edition
    • Joseph M. Fernandez + 1 more
    • English
    Gene Expression Systems: Using Nature for the Art of Expression offers detailed information on a wide variety of gene expression systems from an array of organisms. It describes several different types of expression systems including transient, stable, viral, and transgenic systems. Each chapter is written by a leader in the field. The book includes timelines and examples for each expression system, and provides an overview of the future of recombinant protein expression.

  • Nutritional Biochemistry

    • 2nd Edition
    • Tom Brody
    • English
    Nutritional Biochemistry takes a scientific approach to nutrition. It covers not just "whats"--nutritional requirements--but why they are required for human health, by describing their function at the cellular and molecular level. Each case study either leads to a subsequent discovery or enables an understanding of the physiological mechanisms of action of various nutrition-related processes. The text is "picture-oriented" and the commentary is directed towards explaining graphs, figures, and tables. Nutritional Biochemistry includes a discussion of relevant aspects of physiology, food chemistry, toxicology, pediatrics, and public health. Experimental techniques for nutritional science are emphasized, and primary data is included to help give students a feel for the nutrition literature. This "real-world" approach provides students with a realistic view of the basis for much of our understanding of nutritional biochemistry.

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