Bone Cell Biomechanics, Mechanobiology and Bone Diseases
- 1st Edition - August 31, 2023
- Imprint: Academic Press
- Editors: Ai-Rong Qian, Lifang Hu
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 9 6 1 2 3 - 3
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 9 4 8 4 - 2
Bone Cell Biomechanics, Mechanobiology and Bone Diseases provides a comprehensive overview of recent knowledge and advances of bone cell biomechanics and related bone diseases,… Read more
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Bone Cell Biomechanics, Mechanobiology and Bone Diseases provides a comprehensive overview of recent knowledge and advances of bone cell biomechanics and related bone diseases, highlighting the cellular basis for bone responding to mechanical stimuli. The book not only provides a general overview of bone cell biology, but also the most recent advances of bone cell biomechanics, mechanobiology, the relationship between bone cell biomechanics and bone diseases, as well as the underlying mechanism. This will be useful in understanding the role of mechanobiology in bone health and bone diseases, as well for investigating novel strategies for diagnosis and therapy of bone diseases.
Cells covered in the book include osteocyte, BM-MSC, osteoblast, osteoclast and chondrocyte. Cone diseases covered are osteoporosis, scoliosis and osteoarthritis. This comprehensive reference is written for researchers, scientists, clinicians and students.
- Presents a comprehensive introduction of current knowledge and recent advances of bone cell biomechanics
- Introduces new technologies for bone cell research
- Discusses the bone cell mechanotransduction, mechanism and bone diseases
Research scientists, clinicians, professional engineers, and students
1 Introduction
Abstract
Keywords
1.1 Bone structure
1.2 Cartilage: articular cartilage
1.3 The cellular component of bone
1.4 The cellular component of cartilage
1.5 The relationship between bone and cartilage
References
2 Methods and models for the study of bone cell mechanobiology
Abstract
Keywords
2.1 Introduction
2.2 Methods and models for in vivo study of bone cell mechanobiology
2.3 Methods and models for in vitro study of bone cell mechanobiology
2.4 Methods for measurement of bone cell mechanics and bone mechanics
References
3 Osteocyte Mechanobiology
Abstract
Keywords
3.1 Introduction
3.2 Osteocyte characteristics
3.3 Mechanical stimuli
3.4 Osteocyte mechanotransduction
3.5 Mechanism of osteocyte mechanotransduction
References
4 Bone marrow mesenchymal stem cell (BM-MSC) Mechanobiology
Abstract
Keywords
4.1 Introduction
4.2 Bone marrow mesenchymal stem cell (BM-MSCs) characteristics
4.3 Mechanical stimuli
4.4 BM-MSC mechanotransduction
4.5 Mechanism of BM-MSC mechanotransduction
References
5 Osteoblast Mechanobiology
Abstract
Keywords
5.1 Introduction
5.2 Osteoblast characteristics
5.3 Mechanical stimuli
5.4 Osteoblast mechanotransduction
5.5 Mechanism of osteoblast mechanotransduction
References
6 Osteoclast Mechanobiology
Abstract
Keywords
6.1 Introduction
6.2 Osteoclast characteristics
6.3 Mechanical stimuli
6.4 Osteoclast mechanotransduction
6.5 Mechanism of osteoclast mechanotransduction
References
7 Crosstalk among bone cells mechanotransduction
Abstract
Keywords
7.1 Introduction
7.2 Crosstalk between osteocyte and osteoblast mechanotransduction
7.3 Crosstalk between osteocyte and osteoclast mechanotransduction
7.4 Crosstalk between osteocyte and BM-MSC mechanotransduction
7.5 Crosstalk between osteoblast and osteoclast mechanotransduction
References
8 Bone cell biomechanics and the whole bone mechanic property
Abstract
Keywords
8.1 Introduction
8.2 The effects of bone cell biomechanics on bone structure
8.3 The effects of bone cell biomechanics on bone function
8.4 Mechanism underlying the effects of bone cell biomechanics on bone structure and function
References
9 Chondrocyte mechanobiology
Abstract
Keywords
9.1 Introduction
9.2 Chondrocyte characteristics
9.3 Mechanical stimuli
9.4 Chondrocyte mechanotransduction
9.5 Mechanism of chondrocyte mechanotransduction
References
10 Bone cell and chondrocyte mechanobiology in bone diseases
Abstract
Keywords
10.1 Introduction
10.2 Bone cell biomechanics, mechanotransduction and altered function involved in disused osteoporosis
10.3 Bone cell biomechanics, mechanotransduction and altered function involved in Scoliosis
10.4 The altered interaction between bone cell and chondrocyte biomechanics, mechanotransduction involved in Osteoarthritis
References
11 New technologies for bone cell study
Abstract
Keywords
11.1 Introduction
11.2 Artificial intelligence
11.3 Single cell sequence
11.4 Genome Wide Association Study
References
Abstract
Keywords
1.1 Bone structure
1.2 Cartilage: articular cartilage
1.3 The cellular component of bone
1.4 The cellular component of cartilage
1.5 The relationship between bone and cartilage
References
2 Methods and models for the study of bone cell mechanobiology
Abstract
Keywords
2.1 Introduction
2.2 Methods and models for in vivo study of bone cell mechanobiology
2.3 Methods and models for in vitro study of bone cell mechanobiology
2.4 Methods for measurement of bone cell mechanics and bone mechanics
References
3 Osteocyte Mechanobiology
Abstract
Keywords
3.1 Introduction
3.2 Osteocyte characteristics
3.3 Mechanical stimuli
3.4 Osteocyte mechanotransduction
3.5 Mechanism of osteocyte mechanotransduction
References
4 Bone marrow mesenchymal stem cell (BM-MSC) Mechanobiology
Abstract
Keywords
4.1 Introduction
4.2 Bone marrow mesenchymal stem cell (BM-MSCs) characteristics
4.3 Mechanical stimuli
4.4 BM-MSC mechanotransduction
4.5 Mechanism of BM-MSC mechanotransduction
References
5 Osteoblast Mechanobiology
Abstract
Keywords
5.1 Introduction
5.2 Osteoblast characteristics
5.3 Mechanical stimuli
5.4 Osteoblast mechanotransduction
5.5 Mechanism of osteoblast mechanotransduction
References
6 Osteoclast Mechanobiology
Abstract
Keywords
6.1 Introduction
6.2 Osteoclast characteristics
6.3 Mechanical stimuli
6.4 Osteoclast mechanotransduction
6.5 Mechanism of osteoclast mechanotransduction
References
7 Crosstalk among bone cells mechanotransduction
Abstract
Keywords
7.1 Introduction
7.2 Crosstalk between osteocyte and osteoblast mechanotransduction
7.3 Crosstalk between osteocyte and osteoclast mechanotransduction
7.4 Crosstalk between osteocyte and BM-MSC mechanotransduction
7.5 Crosstalk between osteoblast and osteoclast mechanotransduction
References
8 Bone cell biomechanics and the whole bone mechanic property
Abstract
Keywords
8.1 Introduction
8.2 The effects of bone cell biomechanics on bone structure
8.3 The effects of bone cell biomechanics on bone function
8.4 Mechanism underlying the effects of bone cell biomechanics on bone structure and function
References
9 Chondrocyte mechanobiology
Abstract
Keywords
9.1 Introduction
9.2 Chondrocyte characteristics
9.3 Mechanical stimuli
9.4 Chondrocyte mechanotransduction
9.5 Mechanism of chondrocyte mechanotransduction
References
10 Bone cell and chondrocyte mechanobiology in bone diseases
Abstract
Keywords
10.1 Introduction
10.2 Bone cell biomechanics, mechanotransduction and altered function involved in disused osteoporosis
10.3 Bone cell biomechanics, mechanotransduction and altered function involved in Scoliosis
10.4 The altered interaction between bone cell and chondrocyte biomechanics, mechanotransduction involved in Osteoarthritis
References
11 New technologies for bone cell study
Abstract
Keywords
11.1 Introduction
11.2 Artificial intelligence
11.3 Single cell sequence
11.4 Genome Wide Association Study
References
- Edition: 1
- Published: August 31, 2023
- Imprint: Academic Press
- Language: English
AQ
Ai-Rong Qian
Dr. Qian received her bachelor’s degree in public health, a Master’s in pathology, and her PhD in cell biology. Her areas of focus are biomechanics, mechanobiology, bone metabolism diseases, space biology, space biotechnology, and nuclear acid drugs research; and she has published more than 200 publications and invented more than 30 patents. Dr. Qian is the Associate Editor of Frontiers in Physiology, an Editorial Board Member of Endocrine, Metabolic & Immune Disorders - Drug Targets, Guest Editor of Seminars in Cell and Developmental Biology, and Guest Editor of Frontiers in Cell and Developmental Biology. She was awarded “New Century Outstanding Talents of the Ministry of Education”, “The 9th Shaanxi Youth Science and Technology Award”, “The 2nd Xi'an Young Science and Technology Talent Award”, and “Elsevier 2021 Most Cited Chinese Researchers”.
Affiliations and expertise
Professor, Laboratory for Bone Metabolism, Xi’an Key Laboratory of Special Medicine and Health Engineering, School of Life Sciences, Northwestern Polytechnical University, Shaanxi, Xi'an, Beilin, ChinaLH
Lifang Hu
Dr. Hu received her bachelor’s degree in biology, a Master’s in biomedical engineering, and her PhD in man-machine and environmental engineering. She focuses on bone biology, biomechanics, mechanobiology, bone diseases, space biology, and cell and molecular biology research and has published more than 50 publications and invented 10 patents. Dr. Hu is the Review Editor of Frontiers in Physiology, Editorial Board Member of BMC Musculoskeletal Disorders, Guest Editor of Seminars in Cell and Developmental Biology, Guest Editor of Frontiers in Cell and Developmental Biology, and Official Peer Reviewer of World Journal of Stem Cells. She was awarded “The Outstanding Paper Award for Young Scientists” by the Committee on Space Research.
Affiliations and expertise
Associate Professor, Laboratory for Bone Metabolism, Xi’an Key Laboratory of Special Medicine and Health Engineering, School of Life Sciences, Northwestern Polytechnical University, Shaanxi, Xi'an, Beilin, ChinaRead Bone Cell Biomechanics, Mechanobiology and Bone Diseases on ScienceDirect