
Bone Cell Biomechanics, Mechanobiology and Bone Diseases
- 1st Edition - August 28, 2023
- Imprint: Academic Press
- Editors: Ai-Rong Qian, Lifang Hu
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 9 6 1 2 3 - 3
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 9 4 8 4 - 2
Bone Cell Biomechanics, Mechanobiology and Bone Diseases provides a comprehensive overview of recent knowledge and advances of bone cell biomechanics and related bone diseases,… Read more

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Request a sales quoteBone Cell Biomechanics, Mechanobiology and Bone Diseases provides a comprehensive overview of recent knowledge and advances of bone cell biomechanics and related bone diseases, highlighting the cellular basis for bone responding to mechanical stimuli. The book not only provides a general overview of bone cell biology, but also the most recent advances of bone cell biomechanics, mechanobiology, the relationship between bone cell biomechanics and bone diseases, as well as the underlying mechanism. This will be useful in understanding the role of mechanobiology in bone health and bone diseases, as well for investigating novel strategies for diagnosis and therapy of bone diseases.
Cells covered in the book include osteocyte, BM-MSC, osteoblast, osteoclast and chondrocyte. Cone diseases covered are osteoporosis, scoliosis and osteoarthritis. This comprehensive reference is written for researchers, scientists, clinicians and students.
- Presents a comprehensive introduction of current knowledge and recent advances of bone cell biomechanics
- Introduces new technologies for bone cell research
- Discusses the bone cell mechanotransduction, mechanism and bone diseases
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- Contributors
- Preface
- Acknowledgments
- Part I: Basic knowledge and research methods
- Chapter 1: Basic knowledge and research methods
- Abstract
- Acknowledgments
- 1.1: Introduction
- 1.2: Bone structure and its cellular component
- 1.3: Cartilage structure and its cellular component
- 1.4: Bone mechanobiology
- 1.5: Conclusion and perspectives
- References
- Chapter 2: Methods and models of bone cell mechanobiology
- Abstract
- Acknowledgments
- 2.1: Introduction
- 2.2: Methods and models of bone cell mechanobiology study in vitro
- 2.3: Methods and models of bone cell mechanobiology study in vivo
- 2.4: Conclusion and perspectives
- References
- Chapter 3: The whole bone mechanical properties and modeling study
- Abstract
- Acknowledgments
- 3.1: Introduction
- 3.2: Mechanical properties of cortical bone
- 3.3: Mechanical property of trabecular bone
- 3.4: Three-dimensional bone models and techniques in biomechanics
- 3.5: Finite element analysis (FEM) for bone analysis
- 3.6: Methods for biomimetic study
- 3.7: Development of representative volume element
- 3.8: Modeling and fracture analysis of bone and applications
- 3.9: Femur bone modeling and meshing
- 3.10: Conclusion and perspectives
- References
- Part II: Bone cell mechanobiology
- Chapter 4: Mechanobiology of bone marrow mesenchymal stem cells (BM-MSCs)
- Abstract
- Acknowledgments
- 4.1: Introduction
- 4.2: Bone marrow mesenchymal stem cells (BM-MSCs)
- 4.3: Mechanical stimulation of BM-MSCs
- 4.4: Mechanism of BM-MSCs mechanotransduction
- 4.5: Conclusion and perspectives
- References
- Chapter 5: Mechanobiology of osteoblast
- Abstract
- Acknowledgments
- 5.1: Introduction
- 5.2: Osteoblast
- 5.3: Mechanical stimulation of osteoblast
- 5.4: Mechanism of osteoblast mechanotransduction
- 5.5: Conclusion and perspectives
- References
- Chapter 6: Mechanobiology of osteoclast
- Abstract
- Acknowledgments
- 6.1: Introduction
- 6.2: Osteoclast characteristics
- 6.3: Mechanical stimuli of osteoclast
- 6.4: Osteoclast mechanotransduction
- 6.5: Conclusion and perspectives
- References
- Chapter 7: Mechanobiology of osteocytes
- Abstract
- Acknowledgments
- 7.1: Introduction
- 7.2: Osteocytes
- 7.3: Mechanical stimulation of osteocytes
- 7.4: Mechanisms of osteocyte mechanotransduction
- 7.5: Conclusions and future studies
- References
- Chapter 8: Mechanobiological crosstalk among bone cells and between bone and other organs
- Abstract
- Acknowledgment
- 8.1: Introduction
- 8.2: Subcellular structural basis for mechanosensing and cell communication in bone
- 8.3: Mechanotransduction between adjacent osteocytes: Immobilized, but active mechanosensitive orchestrator
- 8.4: Mechanotransduction between osteoblasts and osteoclasts
- 8.5: Mechanotransduction among osteocytes, osteoblasts, and osteoclasts
- 8.6: Mechanotransduction between bone and other organs
- 8.7: Conclusion and perspectives
- References
- Chapter 9: Mechanobiology of the articular chondrocyte
- Abstract
- Acknowledgments
- 9.1: Introduction
- 9.2: The biomechanical microenvironment of the chondrocyte
- 9.3: Biomechanical characterization of a single chondrocyte
- 9.4: Mechanosensitive channels are involved in mechanotransduction
- 9.5: Conclusion and perspectives
- References
- Part III: Bone biomechanics and bone diseases
- Chapter 10: Bone cell mechanobiology and bone disease
- Abstract
- Acknowledgments
- 10.1: Introduction
- 10.2: Bone cell mechanobiology and osteoporosis
- 10.3: Bone cell mechanobiology and scoliosis
- 10.4: Chondrocyte mechanobiology and osteoarthritis
- 10.5: Conclusion and perspectives
- References
- Chapter 11: Biomechanics in clinical application for bone diseases
- Abstract
- Acknowledgments
- 11.1: Introduction
- 11.2: Abnormal bone biomechanics involved in bone diseases
- 11.3: Therapeutic strategies for bone diseases by using mechanical stimuli
- 11.4: Conclusion and future perspectives
- References
- Part IV: New technologies for bone disease
- Chapter 12: New technologies for bone diseases
- Abstract
- Acknowledgment
- 12.1: Introduction
- 12.2: Artificial intelligence
- 12.3: Single-cell sequencing
- 12.4: Genome-wide association study
- 12.5: Conclusion and perspectives
- References
- Abbreviations
- Index
- Edition: 1
- Published: August 28, 2023
- Imprint: Academic Press
- No. of pages: 420
- Language: English
- Hardback ISBN: 9780323961233
- eBook ISBN: 9780323994842
AQ
Ai-Rong Qian
Dr. Qian received her bachelor’s degree in public health, a Master’s in pathology, and her PhD in cell biology. Her areas of focus are biomechanics, mechanobiology, bone metabolism diseases, space biology, space biotechnology, and nuclear acid drugs research; and she has published more than 200 publications and invented more than 30 patents. Dr. Qian is the Associate Editor of Frontiers in Physiology, an Editorial Board Member of Endocrine, Metabolic & Immune Disorders - Drug Targets, Guest Editor of Seminars in Cell and Developmental Biology, and Guest Editor of Frontiers in Cell and Developmental Biology. She was awarded “New Century Outstanding Talents of the Ministry of Education”, “The 9th Shaanxi Youth Science and Technology Award”, “The 2nd Xi'an Young Science and Technology Talent Award”, and “Elsevier 2021 Most Cited Chinese Researchers”.
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