Bone Cell Biomechanics, Mechanobiology and Bone Diseases

1st Edition - August 28, 2023
Imprint: Academic Press
Editors: Ai-Rong Qian, Lifang Hu
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 9 6 1 2 3 - 3
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 9 4 8 4 - 2

Bone Cell Biomechanics, Mechanobiology and Bone Diseases provides a comprehensive overview of recent knowledge and advances of bone cell biomechanics and related bone diseases,… Read more

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Bone Cell Biomechanics, Mechanobiology and Bone Diseases provides a comprehensive overview of recent knowledge and advances of bone cell biomechanics and related bone diseases, highlighting the cellular basis for bone responding to mechanical stimuli. The book not only provides a general overview of bone cell biology, but also the most recent advances of bone cell biomechanics, mechanobiology, the relationship between bone cell biomechanics and bone diseases, as well as the underlying mechanism. This will be useful in understanding the role of mechanobiology in bone health and bone diseases, as well for investigating novel strategies for diagnosis and therapy of bone diseases.

Cells covered in the book include osteocyte, BM-MSC, osteoblast, osteoclast and chondrocyte. Cone diseases covered are osteoporosis, scoliosis and osteoarthritis. This comprehensive reference is written for researchers, scientists, clinicians and students.

Cover image
Title page
Table of Contents
Copyright
Dedication
Contributors
Preface
Acknowledgments
Part I: Basic knowledge and research methods
Chapter 1: Basic knowledge and research methods
Abstract
Acknowledgments
1.1: Introduction
1.2: Bone structure and its cellular component
1.3: Cartilage structure and its cellular component
1.4: Bone mechanobiology
1.5: Conclusion and perspectives
References
Chapter 2: Methods and models of bone cell mechanobiology
Abstract
Acknowledgments
2.1: Introduction
2.2: Methods and models of bone cell mechanobiology study in vitro
2.3: Methods and models of bone cell mechanobiology study in vivo
2.4: Conclusion and perspectives
References
Chapter 3: The whole bone mechanical properties and modeling study
Abstract
Acknowledgments
3.1: Introduction
3.2: Mechanical properties of cortical bone
3.3: Mechanical property of trabecular bone
3.4: Three-dimensional bone models and techniques in biomechanics
3.5: Finite element analysis (FEM) for bone analysis
3.6: Methods for biomimetic study
3.7: Development of representative volume element
3.8: Modeling and fracture analysis of bone and applications
3.9: Femur bone modeling and meshing
3.10: Conclusion and perspectives
References
Part II: Bone cell mechanobiology
Chapter 4: Mechanobiology of bone marrow mesenchymal stem cells (BM-MSCs)
Abstract
Acknowledgments
4.1: Introduction
4.2: Bone marrow mesenchymal stem cells (BM-MSCs)
4.3: Mechanical stimulation of BM-MSCs
4.4: Mechanism of BM-MSCs mechanotransduction
4.5: Conclusion and perspectives
References
Chapter 5: Mechanobiology of osteoblast
Abstract
Acknowledgments
5.1: Introduction
5.2: Osteoblast
5.3: Mechanical stimulation of osteoblast
5.4: Mechanism of osteoblast mechanotransduction
5.5: Conclusion and perspectives
References
Chapter 6: Mechanobiology of osteoclast
Abstract
Acknowledgments
6.1: Introduction
6.2: Osteoclast characteristics
6.3: Mechanical stimuli of osteoclast
6.4: Osteoclast mechanotransduction
6.5: Conclusion and perspectives
References
Chapter 7: Mechanobiology of osteocytes
Abstract
Acknowledgments
7.1: Introduction
7.2: Osteocytes
7.3: Mechanical stimulation of osteocytes
7.4: Mechanisms of osteocyte mechanotransduction
7.5: Conclusions and future studies
References
Chapter 8: Mechanobiological crosstalk among bone cells and between bone and other organs
Abstract
Acknowledgment
8.1: Introduction
8.2: Subcellular structural basis for mechanosensing and cell communication in bone
8.3: Mechanotransduction between adjacent osteocytes: Immobilized, but active mechanosensitive orchestrator
8.4: Mechanotransduction between osteoblasts and osteoclasts
8.5: Mechanotransduction among osteocytes, osteoblasts, and osteoclasts
8.6: Mechanotransduction between bone and other organs
8.7: Conclusion and perspectives
References
Chapter 9: Mechanobiology of the articular chondrocyte
Abstract
Acknowledgments
9.1: Introduction
9.2: The biomechanical microenvironment of the chondrocyte
9.3: Biomechanical characterization of a single chondrocyte
9.4: Mechanosensitive channels are involved in mechanotransduction
9.5: Conclusion and perspectives
References
Part III: Bone biomechanics and bone diseases
Chapter 10: Bone cell mechanobiology and bone disease
Abstract
Acknowledgments
10.1: Introduction
10.2: Bone cell mechanobiology and osteoporosis
10.3: Bone cell mechanobiology and scoliosis
10.4: Chondrocyte mechanobiology and osteoarthritis
10.5: Conclusion and perspectives
References
Chapter 11: Biomechanics in clinical application for bone diseases
Abstract
Acknowledgments
11.1: Introduction
11.2: Abnormal bone biomechanics involved in bone diseases
11.3: Therapeutic strategies for bone diseases by using mechanical stimuli
11.4: Conclusion and future perspectives
References
Part IV: New technologies for bone disease
Chapter 12: New technologies for bone diseases
Abstract
Acknowledgment
12.1: Introduction
12.2: Artificial intelligence
12.3: Single-cell sequencing
12.4: Genome-wide association study
12.5: Conclusion and perspectives
References
Abbreviations
Index

Ai-Rong Qian

Dr. Qian received her bachelor’s degree in public health, a Master’s in pathology, and her PhD in cell biology. Her areas of focus are biomechanics, mechanobiology, bone metabolism diseases, space biology, space biotechnology, and nuclear acid drugs research; and she has published more than 200 publications and invented more than 30 patents. Dr. Qian is the Associate Editor of Frontiers in Physiology, an Editorial Board Member of Endocrine, Metabolic & Immune Disorders - Drug Targets, Guest Editor of Seminars in Cell and Developmental Biology, and Guest Editor of Frontiers in Cell and Developmental Biology. She was awarded “New Century Outstanding Talents of the Ministry of Education”, “The 9th Shaanxi Youth Science and Technology Award”, “The 2nd Xi'an Young Science and Technology Talent Award”, and “Elsevier 2021 Most Cited Chinese Researchers”.

Affiliations and expertise

Professor, Laboratory for Bone Metabolism, Xi’an Key Laboratory of Special Medicine and Health Engineering, School of Life Sciences, Northwestern Polytechnical University, Shaanxi, Xi'an, Beilin, China

Lifang Hu

Dr. Hu received her bachelor’s degree in biology, a Master’s in biomedical engineering, and her PhD in man-machine and environmental engineering. She focuses on bone biology, biomechanics, mechanobiology, bone diseases, space biology, and cell and molecular biology research and has published more than 50 publications and invented 10 patents. Dr. Hu is the Review Editor of Frontiers in Physiology, Editorial Board Member of BMC Musculoskeletal Disorders, Guest Editor of Seminars in Cell and Developmental Biology, Guest Editor of Frontiers in Cell and Developmental Biology, and Official Peer Reviewer of World Journal of Stem Cells. She was awarded “The Outstanding Paper Award for Young Scientists” by the Committee on Space Research.

Affiliations and expertise

Associate Professor, Laboratory for Bone Metabolism, Xi’an Key Laboratory of Special Medicine and Health Engineering, School of Life Sciences, Northwestern Polytechnical University, Shaanxi, Xi'an, Beilin, China

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health