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Chromatin Readers in Health and Disease
- 1st Edition, Volume 35 - September 22, 2023
- Editors: Trygve O Tollefsbol, Olivier Binda
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 2 3 3 7 6 - 4
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 0 3 1 4 - 1
Chromatin Readers in Health and Disease, Volume 35, a new release in the Translational Epigenetics series, gathers and makes actionable our current understanding of how chroma… Read more
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Request a sales quoteChromatin Readers in Health and Disease, Volume 35, a new release in the Translational Epigenetics series, gathers and makes actionable our current understanding of how chromatin readers regulate access to genetic information, and how their aberrant regulation can contribute to human pathologies. Chromatin readers discussed include 14-3-3 Dinshaw, ADD, Ankyrin, BAH, BET, BIR, BRCT, bromodomains and Kac readers, chromodomains and chromobarrel readers, citrullination readers, macrodomains and poly-ADP-ribose readers, MBT, PHD and double PHD, PWWP, SUMO (H4K12) readers, Tudor and TTD, UDR and ubiquitin, WD40, YEATS (crotonyl reader), MBD, SRA, and Methyl-RNA readers.
In the book, more than a dozen leaders in the field examine a range of protein readers, their relationship to human disease, and the early therapeutics that act as chromatin signaling factors to treat cancers and Huntington's disease, among other disorders.
In the book, more than a dozen leaders in the field examine a range of protein readers, their relationship to human disease, and the early therapeutics that act as chromatin signaling factors to treat cancers and Huntington's disease, among other disorders.
- Enables researchers and clinicians to understand chromatin signaling mechanisms that regulate gene expression through chromatin readers
- Highlights the role of chromatin readers in a variety of human pathologies, as well as early therapeutics that act on chromatin signaling
- Includes chapter contributions from international leaders in the field
Human geneticists, human genomicists, translational researchers in genomic medicine, epigenetics, biochemistry, molecular biology, oncology, neurology, and bioinformatics, life science researchers, developmental biologists
- Cover image
- Title page
- Table of Contents
- Front Matter
- Copyright
- Contributors
- Preface
- Summary
- Chromatin
- Histone modifiers
- Histone mark readers
- Trending methods
- References
- Section 1: Histone mark readers
- Chapter 1: ADD domains—A regulatory hub in chromatin biology and disease
- Abstract
- Acknowledgments
- Structure of the ATRX-ADD domain
- Histone tail interaction and structures of DNMT3-ADD domains
- Histone tail interaction of the ATRX-ADD domain
- Allosteric regulation of DNMT3A activity by the ADD domain
- Protein-protein interaction of ADD domains
- Disease connections of ADD domains
- Conclusions
- References
- Chapter 2: The BAH domain: A versatile histone modification reader
- Abstract
- Identification of the BAH domain as a modification-sensitive histone H4 amino terminus reader
- Structural insights
- Structures of the free Sir3 BAH domain
- Structures of the Sir3-BAH and Orc1-BAH bound to the nucleosome
- Nucleosome and histone H3 binding by the Rsc2 BAH domain
- Recognition of methylated histone H3 and H4 tails
- Nonhistone protein-protein interactions
- Concluding remarks
- References
- Chapter 3: BRCT domains as chromatin readers: Structure, function, and clinical implications
- Abstract
- Acknowledgments
- Discovery of BRCT domains as regulators of p53 function and phospho-dependent binders of chromatin-associated DNA repair proteins
- BRCT domain involvement in chromatin signaling after DNA damage and in specific types of DNA repair
- Mutations in BRCT domain-containing proteins cause human disease
- References
- Chapter 4: The bromodomain acyl-lysine readers in human health and disease
- Abstract
- Acknowledgments
- Lysine acylation and the bromodomain
- Metabolism and its links to acyl-lysine biology
- The structure and biological functions of the bromodomain
- Pharmacological targeting of bromodomains
- Bromodomains and human diseases
- Conclusions
- References
- Chapter 5: CHROMO domain readers: A rainbow of opportunities
- Abstract
- Introduction
- Structural insights of chromodomains and their interactions with methylated histone residues
- Classification and functions of the chromodomain-containing protein family
- CD-containing proteins and human disease
- Current advances in targeting CD-containing proteins
- Conclusions and perspectives
- References
- Chapter 6: The MBT proteins: Methyl-lysine readers for stem cells, development, and tumors
- Abstract
- Acknowledgments
- Introduction
- Structure of the MBT repeated domain
- Conclusion
- References
- Chapter 7: Epigenetically decipherING the genome: A role for PHDs
- Abstract
- Regulation of gene expression defines cell type and function
- PHD finger proteins regulate gene expression
- Forms of readers of the histone code
- Structural bases for PTM recognition by PHD finger proteins
- Major physiological and biochemical pathways regulated by PHD finger proteins
- References
- Chapter 8: Recognition of histone methylation and DNA by the PWWP domain: Mechanism and function
- Abstract
- Introduction
- Biochemical and structural studies of PWWP domains
- Functional roles of PWWP domains in biology and disease
- Conclusion
- References
- Chapter 9: Spin repeats and human pathologies
- Abstract
- Acknowledgment
- Introduction
- Molecular functions of Spin repeats
- Functions of Spin repeat proteins in gametogenesis and early development
- The multifaceted roles of SPIN1 in cancer
- Role of SPIN1 in hepatitis B virus infection
- Small molecules designed for SPIN1
- Conclusion
- References
- Chapter 10: Chromatin readers of the WD-repeat containing protein family
- Abstract
- Acknowledgments
- Conflict of Interest
- Introduction
- Histone chaperones
- Histone-modifying and chromatin-remodeling complexes
- Implications of a binary methylarginine switch
- Conclusions and perspectives
- References
- Chapter 11: The multifunctional YEATS domain in chromatin biology
- Abstract
- Introduction
- YEATS domains are readers of lysine acylation
- YEATS domain binding preferences
- Structural features of the acyl-lysine binding site
- Modular organization of YEATS domain-containing proteins
- Roles of YEATS domain-containing proteins in chromatin-modifying and transcription factor complexes
- Genes encoding YEATS domain-containing proteins are putative oncogenes
- Inhibitors that target YEATS domains
- YEATS domain-containing proteins in other diseases
- Emerging topics in YEATS domain biology
- Conclusions
- References
- Section 2: Methyl-DNA and -RNA readers
- Chapter 12: DNA methylation and reader or writer proteins: Differentiation and disease
- Abstract
- Introduction to DNA methylation
- Caveats about DNA methylation’s roles in regulating gene expression and modulating recognition by DNA-binding proteins
- DNA methylation: Overview of relationship to mammalian differentiation, disease, and aging
- Effects of DNA methylation at promoters on transcription
- Maintenance of CGI promoters in the unmethylated state: CXXC-domain DNA-binding proteins and other transcription factors
- Effects on transcription of DNA methylation at enhancers
- Transcription factors and DNA methylation
- DNA methylation readers and writers in disease
- Conclusions
- References
- Section 3: Recent methods in chromatin signaling
- Chapter 13: CUT&RUN and CUT&Tag: Low-input methods for genome-wide mapping of chromatin proteins
- Abstract
- Introduction
- CUT&RUN
- CUT&Tag
- Before you begin
- Step-by-step method details
- References
- Index
- No. of pages: 420
- Language: English
- Edition: 1
- Volume: 35
- Published: September 22, 2023
- Imprint: Academic Press
- Paperback ISBN: 9780128233764
- eBook ISBN: 9780323903141
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Trygve O Tollefsbol
Dr. Tollefsbol is a Distinguished Professor of Biology and a Senior Scientist in the O’Neal Comprehensive Cancer Center, Integrative Center for Aging Research, Nutrition Obesity Research Center, University Wide Microbiome Center, and the Comprehensive Diabetes Center at the University of Alabama at Birmingham (UAB). He is Director of the UAB Cell Senescence Culture Facility which he established in 1999. Dr. Tollefsbol trained as a Postdoctoral Fellow and Assistant Research Professor with members of the National Academy of Science at Duke University and the University of North Carolina. He earned doctorates in molecular biology and osteopathic medicine from the University of North Texas Health Sciences Center and his bachelor’s degree in Biology from the University of Houston. He has received prior funding from the NCI, NHLBI, NIMH and other federal institutes as well as the Glenn Foundation for Medical Research, Susan G. Komen for the Cure, the American Federation for Aging Research (AFAR), and the American Institute for Cancer Research (AICR) among many other sources.
Affiliations and expertise
Distinguished Professor of Biology, University of Alabama at Birmingham, AL, USAOB
Olivier Binda
Dr. Olivier Binda is a Researcher at the University of Ottawa, specializing in epigenetics and gene expression as it relates to human diseases. Dr. Binda co-edited Chromatin Signaling and Diseases (Elsevier 2016), a volume in Elsevier’s Translational Epigenetics series, and has published 20 scientific papers in such peer reviewed journals as the Molecular Cell, Journal of Biological Chemistry, Biochemistry, Epigenetics, Oncogene, Scientific Reports, and Stem Cell Research. In past positions he has served as a postdoctoral fellow at McGill University and Stanford University, and he completed his PhD in Biochemistry at McGill University in 2007.
Affiliations and expertise
University of Ottawa, Department of Cellular and Molecular Medicine, Ottawa, CANADA.
Affiliations and expertise
Principal Investigator, Newcastle Cancer Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK