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Chromatin Readers in Health and Disease
1st Edition - September 29, 2023
Editors: Trygve O Tollefsbol, Olivier Binda
Paperback ISBN:
9 7 8 - 0 - 1 2 - 8 2 3 3 7 6 - 4
Chromatin Readers in Health and Disease, Volume 35, a new release in the Translational Epigenetics series, gathers and makes actionable our current understanding of how chromatin… Read more
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Chromatin Readers in Health and Disease, Volume 35, a new release in the Translational Epigenetics series, gathers and makes actionable our current understanding of how chromatin readers regulate access to genetic information, and how their aberrant regulation can contribute to human pathologies. Chromatin readers discussed include 14-3-3 Dinshaw, ADD, Ankyrin, BAH, BET, BIR, BRCT, bromodomains and Kac readers, chromodomains and chromobarrel readers, citrullination readers, macrodomains and poly-ADP-ribose readers, MBT, PHD and double PHD, PWWP, SUMO (H4K12) readers, Tudor and TTD, UDR and ubiquitin, WD40, YEATS (crotonyl reader), MBD, SRA, and Methyl-RNA readers.In the book, more than a dozen leaders in the field examine a range of protein readers, their relationship to human disease, and the early therapeutics that act as chromatin signaling factors to treat cancers and Huntington's disease, among other disorders.
- Enables researchers and clinicians to understand chromatin signaling mechanisms that regulate gene expression through chromatin readers
- Highlights the role of chromatin readers in a variety of human pathologies, as well as early therapeutics that act on chromatin signaling
- Includes chapter contributions from international leaders in the field
Human geneticists, human genomicists, translational researchers in genomic medicine, epigenetics, biochemistry, molecular biology, oncology, neurology, and bioinformatics, life science researchers, developmental biologists
1. ADD domains – a regulatory hub in chromatin biology and disease
2. BAH
3. BIR
4. BRCT Domains as Chromatin Readers: Structure, Function, and Clinical Implications
5. The bromodomain acyl-lysine readers in human health and disease
6. Chromodomains
7. CW-type zinc fingers
8. Macrodomains and PAR readers
9. MBT
10. PHD and double PHD finger
11. PWWP
12. SPIN repeats and human pathologies
13. Tudor and TTD
14. UDR and Ubiquitin
15. WD40
16. YEATS
17. Multivalent readers and interplay among different readers
18. DNA Methylation and Reader- or Writer-Proteins: Differentiation and Disease
19. R-loops readers
20. CUT&RUN and CUT&Tag: Low-input methods for genome-wide mapping of chromatin proteins
2. BAH
3. BIR
4. BRCT Domains as Chromatin Readers: Structure, Function, and Clinical Implications
5. The bromodomain acyl-lysine readers in human health and disease
6. Chromodomains
7. CW-type zinc fingers
8. Macrodomains and PAR readers
9. MBT
10. PHD and double PHD finger
11. PWWP
12. SPIN repeats and human pathologies
13. Tudor and TTD
14. UDR and Ubiquitin
15. WD40
16. YEATS
17. Multivalent readers and interplay among different readers
18. DNA Methylation and Reader- or Writer-Proteins: Differentiation and Disease
19. R-loops readers
20. CUT&RUN and CUT&Tag: Low-input methods for genome-wide mapping of chromatin proteins
- No. of pages: 420
- Language: English
- Published: September 29, 2023
- Imprint: Academic Press
- Paperback ISBN: 9780128233764
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Trygve O Tollefsbol
Dr. Tollefsbol is a Distinguished Professor of Biology and a Senior Scientist in the O’Neal Comprehensive Cancer Center, Integrative Center for Aging Research, Nutrition Obesity Research Center, University Wide Microbiome Center, and the Comprehensive Diabetes Center at the University of Alabama at Birmingham (UAB). He is Director of the UAB Cell Senescence Culture Facility which he established in 1999. Dr. Tollefsbol trained as a Postdoctoral Fellow and Assistant Research Professor with members of the National Academy of Science at Duke University and the University of North Carolina. He earned doctorates in molecular biology and osteopathic medicine from the University of North Texas Health Sciences Center and his bachelor’s degree in Biology from the University of Houston. He has received prior funding from the NCI, NHLBI, NIMH and other federal institutes as well as the Glenn Foundation for Medical Research, Susan G. Komen for the Cure, the American Federation for Aging Research (AFAR), and the American Institute for Cancer Research (AICR) among many other sources.
Affiliations and expertise
Distinguished Professor of Biology, University of Alabama at Birmingham, AL, USAOB
Olivier Binda
Dr. Olivier Binda is a Principal Investigator at Newcastle Cancer Centre at the Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, England, specializing in epigenetics and gene expression as it relates to human disease. Dr. Binda co-edited Chromatin Signaling and Diseases (Elsevier 2016), a volume in Elsevier’s Translational Epigenetics series, and has published 20 scientific papers in such peer reviewed journals as the Journal of Biological Chemistry, Biochemistry, Epigenetics, Oncogene, Scientific Reports, and Stem Cell Research. In past positions he has served as a postdoctoral fellow at McGill University and Stanford University, and he completed his PhD in Biochemistry at McGill University in 2007.
Affiliations and expertise
Principal Investigator, Newcastle Cancer Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK