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Elsevier

Books in Life sciences

  • Side Effects of Drugs Annual

    • 1st Edition
    • Volume 22
    • English
    Based on the results of an extensive literature search, an international team of authors have collected the latest information on adverse drug effects from the world literature. New adverse effects are reported and evaluated and previously reported adverse effects are re-evaluated in the light of the most recent information. The book provides the reader with a critical and up-to-date overview of the most recent developments in the field. Selected adverse effects are discussed in the special reviews. Two separate indexes enhance the book and allow the author to enter the text by drug name or by adverse effect. The Annual can be used independently or as a supplement to the standard Encyclopedic work in this field, Meyler's Side effects of Drugs, of which, thehttp://www.elsevi... Fourteenth Edition was published in December 2000.

  • Advances in Cancer Research

    • 1st Edition
    • Volume 78
    • English
    Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here once again, outstanding and original reviews are presented.

  • Women and Health

    • 1st Edition
    • Marlene B. Goldman + 1 more
    • English
    Women and Health is a comprehensive reference which addresses health issues affecting women of all ages--adolescence through maturity. It goes far beyond other books on this topic which concentrate only on reproductive health, and has a truly international perspective. It covers key issues ranging from osteoporosis to breast cancer and other cancers, domestic violence, sexually transmitted diseases, occupational hazards, eating disorders, heart disease and other chronic illnesses, substance abuse, and societal and behavioral influences on health. Women and Health covers not only those conditions that are unique to or occur more frequently in women, but also those that present differently or are treated differently in women.

  • The Rhesus Monkey Brain in Stereotaxic Coordinates

    • 1st Edition
    • George Paxinos + 2 more
    • English
    The Rhesus Monkey Brain in Stereotaxic Coordinates is the most comprehensive, detailed atlas of the monkey brain ever constructed. The first chapter, "Photographic and Diagrammatic Atlas of the Rhesus Monkey Brain," presents 151 plates illustrating the subcortex and parts of the cortex in high magnification, and 151 corresponding diagrams complementing each image. The second chapter, "Delineation of the Rhesus Monkey Cortex on the Basis of the Distribution of a Neurofilament Protein," consists of 64 fully labeled plates depicting an entire hemisphere. Jointly, the two chapters constitute the most serious morphological work ever undertaken on the monkey.

  • Primate Anatomy

    An Introduction
    • 2nd Edition
    • Friderun Ankel-Simons
    • English
    Primates include a wide variety of mammals from the relatively ancient lineages of lemurs on Madagascar and tiny tarsiers of Southeast Asia to the gorillas of montane Africa. Of course, humankind are also primates - one twig on the primate evolutionary tree. Primate Anatomy: An Introduction, Second Edition is a succinct and readable survey of primatology focusing particularly on the anatomy of primates. Following an introduction, the chapters are organized by organ system. Also included are chapters dealing with reproduction, chromosomes, blood groups, and molecular studies of primate evolution. This book would be ideal for an introductory course in primatology and should appeal to both faculty and students who need a brief treatment of the essentials of primatology.

  • Antisense Technology, Part B: Applications

    • 1st Edition
    • Volume 314
    • John N. Abelson + 1 more
    • English
    Antisense technology is the ability to manipulate gene expression within mammalian cells providing powerful experimental approaches for the study of gene function and gene regulation. For example, methods which inhibit gene expression permit studies probing the normal function of a specific product within a cell. Such methodology can be used in many disciplines such as pharmacology, oncology, genetics, cell biology, developmental biology, molecular biology, biochemistry, and neurosciences. This volume will be a truly important tool in biomedically-oriente... research.The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today-truly an essential publication for researchers in all fields of life sciences.

  • Human Gene Evolution

    • 1st Edition
    • English
    Presents the principles of human gene evolution in a concise and easy to understand fashion. Uses examples of how evolutionary processes have molded present day genes, drawn from the evolution of humans and other primates, as well as from more primitive organisms. With increasing attention in this expanding area, this review forms a timely publication of our current knowledge of this important field.

  • Biological Complexity and the Dynamics of Life Processes

    • 1st Edition
    • Volume 34
    • J. Ricard
    • English
    The aim of this book is to show how supramolecular complexity of cell organization can dramatically alter the functions of individual macromolecules within a cell. The emergence of new functions which appear as a consequence of supramolecular complexity, is explained in terms of physical chemistry.The book is interdisciplinary, at the border between cell biochemistry, physics and physical chemistry. This interdisciplinarity does not result in the use of physical techniques but from the use of physical concepts to study biological problems.In the domain of complexity studies, most works are purely theoretical or based on computer simulation. The present book is partly theoretical, partly experimental and theory is always based on experimental results. Moreover, the book encompasses in a unified manner the dynamic aspects of many different biological fields ranging from dynamics to pattern emergence in a young embryo.The volume puts emphasis on dynamic physical studies of biological events. It also develops, in a unified perspective, this new interdisciplinary approach of various important problems of cell biology and chemistry, ranging from enzyme dynamics to pattern formation during embryo development, thus paving the way to what may become a central issue of future biology.

  • Sphingolipid Metabolism and Cell Signaling, Part A

    • 1st Edition
    • Volume 311
    • John N. Abelson + 1 more
    • English
    Sphingolipids are found in all eukaryotic and in some prokaryotic organisms and provide structure for cell membranes, lipoproteins, and other biological materials as well as participate in the regulation of cell growth, differentiation, and diverse cell functions, including cell-cell communication, cell-substratum interactions, and intracellular signal transduction. This volume presents methods used in studying enzymes of sphingolipid biosynthesis and turnover, including inhibitors of some of these enzymes, genetic approaches, and organic and enzymatic syntheses of sphingolipids and analogs. Its companion Volume 312 will contain information on analyzing sphingolipids, sphingolipid transport and trafficking, and sphingolipid-protein interactions and cellular targets.The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.

  • Biomedical Applications of Microprobe Analysis

    • 1st Edition
    • Peter Ingram + 3 more
    • English
    Biomedical Applications of Microprobe Analysis is a combination reference/laboratory manual for the use of microprobe analysis in both clinical diagnostic and research settings. Also called microchemical microscopy, microprobe analysis uses high-energy bombardment of cells and tissue, in combination with high resolution EM or confocal microscopy to provide a profile of the ion, metal, and mineral concentrations present in a sample. This allows insight into the physiology and pathophysiology of a wide variety of cells and tissues.This book describes methods for obtaining detailed information about the identity and composition of particles too small to be seen with the naked eye and describes how this information can be useful in diagnostic and biomedical research.

  • The Complement FactsBook

    • 1st Edition
    • Scott R. Barnum
    • English
    The Complement FactsBook contains entries on all components of the Complement System, including C1q and Lectins, C3 Family, Serine Proteases, Serum Regulators of Complement Activation, Cell Surface Proteins, and Terminal Pathway Proteins. Domain Structure diagrams are incorporated to clearly illustrate the relationships between all the complement proteins, both within families and between families. The FactsBook also includes the cDNA sequences, marked with intron/exon boundaries, which will facilitate genetic studies.

  • Biofilms

    • 1st Edition
    • Volume 310
    • John N. Abelson + 1 more
    • English
    Volume 310 of Methods in Enzymology is the first volume devoted solely to biofilm research methods. It provides a contemporary source book for virtually any kind of experimental approach involving biofilms. It includes bioengineering, molecular, genetic, microscopic, chemical, continuous culture, and physical methods. This volume will serve as a starting point for future developments.The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.

  • The Primate Nervous System, Part III

    • 1st Edition
    • Volume 15
    • Floyd E. Bloom + 2 more
    • English
    This volume is the third and final part of the planned coverage of the neurochemical circuitry of the primate central nervous system. The five chapters included in this volume complement and integrate magnificently with the two prior volumes. Included in the volume are the following: a two-fold exposition on the human forebrain, comprised of a comprehensive overview of the entire human forebrain, and a specific focus on the basal forebrain (a region critical for a wide range of human problems ranging from substance abuse to Alzheimer's disease), a critical synthesis of the primate basal ganglia (a region under intense scrutiny for the organization of motor programs, and for their dysfunctions in Parkinson's disease, Huntington's disease and other malfunctions), the chemical and anatomic details of the primate hippocampal formation in extenso, and lastly, a review of the rapidly growing literature on the mesocortical projection of dopaminergic circuits onto the primate frontal cortex ( a system highly linked to higher order mental abstractions, as well as the dysfunctions of schizophrenia). Scholars will recognize that the laying out of these status reports on our still vastly incomplete examination of the primate brains is an opportunity for progress.

  • Antisense Technology, Part A, General Methods, Methods of Delivery, and RNA Studies

    • 1st Edition
    • Volume 313
    • John N. Abelson + 1 more
    • English
    Antisense technology is the ability to manipulate gene expression within mammalian cells providing powerful experimental approaches for the study of gene function and gene regulation. For example, methods that inhibit gene expression permit studies which probe the normal function of a specific product within a cell. Such methodology can be used in many disciplines such as pharmacology, oncology, genetics, cell biology, developmental biology, molecular biology, biochemistry, and neurosciences. This volume will be a truly important tool in biomedical-oriented research.The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.

  • Advances in Virus Research

    • 1st Edition
    • Volume 54
    • English

  • Advances in Virus Research

    • 1st Edition
    • Volume 53
    • English

  • Handbook of Molecular-Genetic Techniques for Brain and Behavior Research

    • 1st Edition
    • Volume 13
    • Wim E. Crusio + 1 more
    • English
    The book gives a broad overview of recombinant DNA techniques for the behavioral neuroscientist, with illustrative examples of applications. Species covered include rodents (mainly mice), Drosophila melanogaster, Caenorhabditis elegans and Danio rerio. Experimental techniques required to characterize the behavioral phenotypes of mutant animals is provided. Several aspects of novel molecular-genetic techniques are overviewed and possible research strategies are explained. The sections of the book start with general descriptions of techniques followed by illustrative examples.It is divided into six sections. Section 1, bioinformatics and genomics research. Section 2, top-down strategies, where the researcher starts with the phenotype and then analyzes the associated genes; bottom-up strategies, where the physiological chain leading to a phenotype is analyzed starting from the gene product. Section 3, transgenic approaches in rodents including overexpressing foreign genes and gene-targeting; systemic manipulation approaches directly targeting the central nervous system and methods used with invertebrates. Section 4, methods used to evaluate relevant behavioral phenotypes, including learning and aggression. Section 5, examples on molecular brain research in man. Section 6, ethical aspects of research in this field.

  • Adenosine Receptors and Parkinson's Disease

    • 1st Edition
    • Hiroshi Kase + 2 more
    • English
    This book is the first definitive overview on adenosine receptor antagonists and their application to the treatment of Parkinson's Disease. The effect of these novel non-dopamine drugs on vitro and in vivo systems clearly shows their potential for the treatment of this debilitating disease. This book covers how the Parkinson's disease antagonist drug, A2A, has been researched, developed, and tested. It is an essential book for researchers interested in the basal ganglia, purine biology, and Parkinson's Disease.

  • Advances in Carbohydrate Chemistry and Biochemistry

    Cumulative Subject and Author Indexes, and Tables of Contents
    • 1st Edition
    • Volume 54
    • English
    Since its inception in 1945, this serial has provided critical and integrating articles written by research specialists that integrate industrial, analytical, and technological aspects of biochemistry, organic chemistry, and instrumentation methodology in the study of carbohydrates. The articles provide a definitive interpretation of the current status and future trends in carbohydrate chemistry and biochemistry.

  • Veterinary Virology

    • 3rd Edition
    • Frederick A. Murphy + 3 more
    • English
    Completely rewritten, this edition has expanded coverage of zoonotic viruses and the diseases they cause, and viruses and viral diseases of laboratory animals, poultry, fish, and wildlife. The concept of new emerging and reemerging viral diseases reflects the new perspective this concept has brought to veterinary and zoonotic virology and related fields.Part I presents fundamental principles of virology related to animal infection and disease. Part II details the properties and clinical features of the viruses that afflict animals and describes their treatment and control.

  • Handbook of Biochemical Kinetics

    A Guide to Dynamic Processes in the Molecular Life Sciences
    • 1st Edition
    • Daniel L. Purich + 1 more
    • English
    Biochemical kinetics refers to the rate at which a reaction takes place. Kinetic mechanisms have played a major role in defining the metabolic pathways, the mechanistic action of enzymes, and even the processing of genetic material. The Handbook of Biochemical Kinetics provides the "underlying scaffolding" of logic for kinetic approaches to distinguish rival models or mechanisms. The handbook also comments on techniques and their likely limitations and pitfalls, as well as derivations of fundamental rate equations that characterize biochemical processes.

  • Microcompartmentation and Phase Separation in Cytoplasm

    A Survey of Cell Biology
    • 1st Edition
    • Volume 192
    • English
    International Review of Cytology presents current advances and comprehensive reviews in cell biology-both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research.This volume provides an overview of major cytoplasmic properties and events which including cytoarchitecture and the physical properties of cytoplasm, molecular compartmentation and gradients, channeling, sorting, and trafficking. It also addresses physicochemical events, both measured and anticipated, which attend solutions under conditions prevailing in cytoplasm: molecular crowding. It summarizes the current state of knowledge in the field and considers questions such as how molecules in cytoplasm interact.

  • Hormones and Signaling

    • 1st Edition
    • Volume 47
    • English
    Hormones and Signaling focuses on the mechanisms of gene regulation at the cellular level. It also describes the actions of hormones in modulating gene regulation and animal development.

  • Psychology of Learning and Motivation

    Advances in Research and Theory
    • 1st Edition
    • Volume 39
    • English
    Psychology of Learning and Motivation publishes empirical and theoretical contributions in cognitive and experimental psychology, ranging from classical and instrumental conditioning to complex learning and problem solving. Each chapter provides a thoughtful integration of a body of work. Volume 39 includes in its coverage chapters on category learning, relational timing, infant memory, depression and memory, goals and choice, and more.

  • Chemistry and Biology

    • 1st Edition
    • Volume 53
    • English
    Alkaloids are a major group of natural products derived from a wide variety of organisms, which are used as medicinal and biological agents. This series is world-renowned as the leading compilation of current reviews of this vast field.Internationall... acclaimed for more than forty years, The Alkaloids , founded by the late Professor R.H.F. Manske, continues to provide outstanding coverage of the rapidly expanding field of the chemotaxonomy, structure elucidation, synthesis, biosynthesis, and biology of all classes of alkaloids from higher and lower plants, marine organisms, or various terrestrial animals. Each volume provides, through its distinguished authors, up-to-date and detailed coverage of particular classes or sources of alkaloids. Over the years, this series has become the standard in natural product chemistry to which all other book series aspire. The Alkaloids: Chemistry and Biology endures as an essential reference for all natural product chemists and biologists who have an interest in alkaloids, their diversity, and their unique biological profile.

  • Molecular Genetics of Hypertension

    • 1st Edition
    • English
    This is a rapidly expanding research area, with most current publications existing as journal articles, or as single chapters in larger volumes. This will be one of the first books to bring all this information together into a comprehensive review volume, aimed at both researchers and clinicians.Hypertens... is a condition in humans which is characterized by persistently high arterial blood pressure (over 140/90 mm Hg). Affected individuals are at risk from heart disease, stroke and kidney failure. This important disease affects a huge number of people worldwide, and therefore the study of the disease is of vital clinical importance. Hypertension is a genetically determined disease, with many other contributing factors. Research has expanded rapidly in this area, particularly over the last decade, and there are continuing advances in our understanding of the disease.

  • Analytical Profiles of Drug Substances and Excipients

    • 1st Edition
    • Volume 26
    • English
    Although the official compendia define a drug substance as to identity, purity, strength, and quality, they normally do not provide other physical or chemical data, nor do they list methods of synthesis or pathways of physical or biological degradation and metabolism. Such information is scattered throughout the scientific literature and the files of pharmaceutical laboratories. Edited by the Associate Director of Analytical Research and Development for the American Association of Pharmaceutical Scientists, Analytical Profiles of Drug Substances and Excipients brings this information together into one source. The scope of the series has recently been expanded to include profiles of excipient materials.

  • Sturkie's Avian Physiology

    • 5th Edition
    • G. Causey Whittow
    • English
    Sturkie's Avian Physiology is the classic comprehensive single volume on the physiology of domestic as well as wild birds. The Fifth Edition is thoroughly revised and updated, and includes new chapters on the physiology of incubation and growth. Chapters on the nervous system and sensory organs have been greatly expanded due to the many recent advances in the field. The text also covers the physiology of flight, reproduction in both male and female birds, and the immunophysiology of birds. The Fifth Edition, like the earlier editions, is a must for anyone interested in comparative physiology, poultry science, veterinary medicine, and related fields. This volume establishes the standard for those who need the latest and best information on the physiology of birds.

  • Ultrasensitive and Rapid Enzyme Immunoassay

    • 1st Edition
    • Volume 27
    • E. Ishikawa
    • English
    Immunoassay techniques have become essential in various fields of pure and applied research. This volume of the well known Laboratory Techniques series will be of assistance to those who have plans or are making efforts to develop ultrasensitive enzyme immunoassays for antigens and antibodies. The volume describes factors limiting the sensitivity of noncompetitive solid phase enzyme immunoassays, methods to overcome difficulties limiting sensitivities, methods to perform ultrasensitive enzyme immunoassays as rapidly as possible, and protocols of enzyme labeling and enzyme assays as well as ultrasensitive enzyme immunoassays. Ultrasensitive and Rapid Enzyme Immunoassay, with its clear presentation and up-to-date information, will be essential to scientists in pharmaceutical companies and in applied research.

  • Introduction to Biomedical Engineering

    • 1st Edition
    • John Enderle + 2 more
    • English
    This is a comprehensive survey of the multi-disciplinary field of biomedical engineering. The book is intended to be the introductory textbook for the first course at the undergraduate junior level and as the introductory textbook in graduate programs in biomedical engineering programs. The book is also intended to be utilized as a professional reference book for engineers and biomedical researchers requiring a knowledge of the basic fundamentals and the latest advances in biomedical engineering. This text/reference will have worked examples throughout the text as well as end-of-chapter homework and self-study problems. In addition to the pedagogy within the book, the authors will maintain a website of relevant laboratory simulations and links to other biomedical engineering web sites.

  • Advances in Parasitology

    • 1st Edition
    • Volume 44
    • English
    There are currently 3-5 million cases of leishmaniasis in the world and the prevalence is rising. The first chapter in this volume reviews the cell biology of the parasite and its transmission and survival. The second review addresses the apicomplexan protozoan parasites Theileria anulaga, T. parva and T. sergenti which globally cost agriculture over one billion US dollars annually. Current research in this area aims to produce effective, stable and cheap subunit viruses requiring only a single application and the authors predict that success will eventually be achieved with 'naked DNA' vaccines containing cytokine genes as immunopotentiators.T... next review is the first in over 30 years to discuss the larva of the class Monogenea.The authors cover morphology, behaviour and structure of many examples providing a detailed reference for researchers. The penultimate chapter discusses the distribution of Schistosoma bovis and considers the reported interactions occurring between parasites and snails. The final chapter reviews one of the most serious parasitic diseases in salmonid aquaculture - sealice. In 1998 the costs due to sealice damage in Scotland alone were estimated at 15-30 million pounds. Discussion of biology and control of these ectoparasites emphasizes the need to understand the basic biology of the parasite.This volume will be essential reading for parasitologists in many branches of the subject.

  • Encyclopedia of Food Microbiology

    • 1st Edition
    • Richard K. Robinson + 1 more
    • English
    The Encyclopedia of Food Microbiology, Three-Volume Set is the largest comprehensive reference source of current knowledge available in the field of food microbiology. Consisting of nearly 400 articles, in three volumes, written by the world's leading scientists, the Encyclopedia presents a highly structured distillation of the whole field--from Acetobacter to Zymomonas. Each article in the Encyclopedia is approximately 4000 words in length and contains tables, line drawings, black-and-white photographs, or electron micrographs, where appropriate. The articles critically review the current state of knowledge of the topic in question. A list of suggested further reading is provided at the end of each article allowing the interested reader to research the subject more closely. The Encyclopedia is written at the research/technician level and could be used as a coursebook. Practitioners in industry, analysts, and similar professionals will especially be interested in the methodologies and techniques theme.

  • Advances in Marine Biology

    • 1st Edition
    • Volume 37
    • English
    Walleye Pollock is one of the world's largest fisheries. In this volume, the first review describes the population biology of walleye Pollock including its life history, population dynamics, genetic structure, and metapopulation structure. The second review discusses pollutants and the marine environment using ecotoxicological bioassays with bivalve embryos and larvae. These tests ascertain the effects of pure chemicals and determine the quality of effluents, coastal waters, and sediments sampled in the field.Advances in Marine Biology has always offered marine biologists an in-depth and up-to-date review on a variety of topics. As well as many volumes that provide a selection of important topics, the series also includes thematic volumes that examine a particular field in detail.

  • Disorders of Brain, Behavior, and Cognition: The Neurocomputational Perspective

    • 1st Edition
    • Volume 121
    • J.A. Reggia + 2 more
    • English
    This book contains selected contributions of papers, many presented at the Second International Workshop on Neural Modeling of Brain Disorders, as well as a few additional papers on related topics, including a wide range of presentations describing computational models of neurological, neuropsychological and psychiatric disorders. It is a unique, comprehensive review of the state-of-the-art of modeling cognitive and brain disorders, appealing to a multidisciplinary audience of clinicians, psychologists, neuroscientists, cognitive scientists, computer scientists, and other neural network researchers. The rest of the book is organized along four main themes, involving memory, neuropsychological, neurological and psychiatric disorders. In general, the cognitive disorders and these psychiatric diseases traditionally regarded as "functional" were modeled along functional lines, while those disorders traditionally viewed as "organic" neurological diseases generally drew more from knowledge of the underlying neurobiology and pathophysiology.

  • Amyloid, Prions, and Other Protein Aggregates

    • 1st Edition
    • Volume 309
    • John N. Abelson + 1 more
    • English
    This volume includes a core of methodologies to attack the unique experimental problems presented by protein misassembly. Emphasis is on human biology applications, the area in which there is the most interest, in which most of the work has already been done, and in which there is the best evidence for the structural sophisitication of the protein aggregates.The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.

  • Advances in BioChirality

    • 1st Edition
    • C. Zucchi + 2 more
    • English
    Chirality is a fundamental, persistent, but often overlooked feature of all living organisms on the molecular level as well as on the macroscopic scale. The high degree of preference for only one of two possible mirror image forms in Nature, often called biological homochirality is a puzzling, and not yet fully understood, phenomenon. This book covers biological homochirality from an interdisciplinary approach - contributions range from synthetic chemists, theoretical topologists and physicists, from palaeontologists and biologists to space scientists and representatives of the pharmaceutical and materials industries. Topics covered include - theory of biochirality, origins of biochirality, autocatalysis with amplification of chirality, macroscopic (present) biochirality, fossil records of chiral organisms - paleochirality, extraterrestrial origin of chirality, exceptions to the rule of biological homochirality, D-amino acids, chemical transfer of chirality, PV effects, and polarised radiation chemistry.

  • Tetrahymena Thermophila

    • 1st Edition
    • Volume 62
    • English
    Tetrahymena thermophila is emerging as a powerful experimental system for functional genetics. The ciliated protozoan offers numerous advantages, not the least of which is the ability to eliminate any specific gene of interest and then to evaluate the effect of that mutation on the living cell. Past investigations with T. thermophila have yielded several key discoveries, including dynein, catalytic RNA, and telomerase. This volume is a comprehensive resource for using Tetrahymena in the laboratory and is aimed at persons already experienced, as well as newcomers to the organism. It covers both the biological background and essential protocols for investigators rapidly turning to Tetrahymena as the experimental system of choice.

  • Growth Hormone Secretagogues

    Basic Findings and Clinical Implications
    • 1st Edition
    • E. Ghigo + 3 more
    • English
    Growth hormone secretagogues (GHS) administered alone or in combination with growth hormone releasing hexapeptides, are effective probes for the diagnosis of GH deficiency in both children and adults. Current research has developed and tested different GHS compounds that are active by the oral route, and have improved potency and bioavailability, giving rise to exciting therapeutic possibilities.There was an enthusiastic response from experts in this area to the idea of distilling the huge amount of available data into one multi-authored volume. Each contributor has advanced the field of knowledge, and has here emphasized the practical aspects of their work, reviewing the subject in the light of their own experience. Therefore, the theme of the book is a practical one.The volume deals with all aspects of GHS that are relevant to the field, from the chemical structure to the different analogues, to the cloning and expression of the GHS-receptor and the role of these compounds in the physiological control of GH secretion. Also discussed are the most recent advances in relation to the possible role of these compounds in the diagnostic therapeutic settings in different clinical situations, either in children, adults or the elderly.The book meets the requirement of covering most, if not all of the advances in the field. It will enable scientists and clinicians to keep abreast of the rapidly evolving knowledge of the most recent years, and will also prove useful as a review for all interested in this topic.

  • Enzyme Kinetics and Mechanisms, Part E, Energetics of Enzyme Catalysis

    • 1st Edition
    • John N. Abelson + 1 more
    • English
    This volume supplements Volumes 63, 64, 87, and 249 of Methods in Enzymology. These volumes provide a basic source for the quantitative interpretation of enzyme rate data and the analysis of enzyme catalysis. Among the major topics covered are Engergetic Coupling in Enzymatic Reactions, Intermediates and Complexes in Catalysis, Detection and Properties of Low Barrier Hydrogen Bonds, Transition State Determination, and Inhibitors.The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.

  • Toxicology

    • 1st Edition
    • Hans Marquardt + 3 more
    • English
    Toxicology is a comprehensive text for researchers and graduate students in toxicology and public health. It addresses every aspect of the field, starting with the fundamentals and incorporating such areas as organ toxicology, applications, and environmental toxicology. In addition to covering the traditional subject matter of toxicology, special emphasis has been placed on recent areas of interest, such as risk assessment, apoptosis, and methodical developments.

  • International Review of Cytology

    A Survey of Cell Biology
    • 1st Edition
    • Volume 194
    • English
    International Review of Cytology presents current advances and comprehensive reviews in cell biology-both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

  • Advances in Botanical Research

    • 1st Edition
    • Volume 30
    • English
    Advances in Botanical Research is a multi-volume publication that brings together reviews by recognized experts on subjects of importance to those involved in botanical research. For more than thirty years, Advances in Botanical Research has earned a reputation for excellence in the field. Academic Press has merged Advances in Plant Pathology into Advances in Botanical Research. The plant science community will find that the merger of these two serials will provide one comprehensive resource for the field. To ensure complete coverage, John Andrews and Inez Tommerup, the editors of Advances in Plant Pathology, have joined the editorial board of the new series, which will include equal coverage of plant pathology and botany in both thematic and mixed volumes. The first few volumes of the new series will be slanted toward botany or plant pathology; however, future eclectic volumes will be fully integrated.The resulting synergy of these two serials greatly benefits the plant science community by providing a more comprehensive resource under one roof. The joint aim is to continue to include the very best articles, thereby maintaining the status of a high impact factor review series.

  • Lipids in Nutrition and Health

    A Reappraisal
    • 1st Edition
    • M I Gurr
    • English
    Since 80% of the global production of oils and fats is consumed as food and a further 6% is eaten by animals to produce more human food, it is not surprising that nutrition is one of the active areas in lipid science. For 10 years, Mike Gurr has written nutrition articles in lipid technology amounting to nearly 60 reviews. The result is a powerful and critical survey of important aspects of lipid nutrition which will be appreciated by lipid technology readers and should be compulsory reading for those not familiar with the original articles.Areas covered include: influence of dietary fats on the concentrations of lipids carried in the blood and the significance for health, the nutritional and biological properties of the polyunsaturated fatty acids, and lipids in foods and raw materials, among other topics.

  • Advances in Microbial Physiology

    • 1st Edition
    • Volume 41
    • English
    This volume contains advances in microbial physiology, particularly: factors affecting the production of l-phenylacetylcarbin... by yeast.

  • Progress in Nucleic Acid Research and Molecular Biology

    • 1st Edition
    • Volume 63
    • English

  • International Review of Cytology

    A Survey of Cell Biology
    • 1st Edition
    • Volume 193
    • English
    International Review of Cytology presents current advances and comprehensive reviews in cell biology-both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

  • Genetic Databases

    • 1st Edition
    • English
    Computer access is the only way to retrieve up-to-date sequences and this book shows researchers puzzled by the maze of URLs, sites, and searches how to use internet technology to find and analyze genetic data. The book describes the different types of databases, how to use a specific database to find a sequence that you need, and how to analyze the data to compare it with your own work. The content also covers sequence phenotype, mutation, and genetic linkage databases; simple repetitive DNA sequences; gene feature identification; and prediction of structure and function of proteins from sequence information. This book will be invaluable to those starting a career in life sciences research as well as to established researchers wishing to make full use of available resources.

  • Nucleotides and their Receptors in the Nervous System

    • 1st Edition
    • Volume 120
    • P. Illes + 1 more
    • English
    The study of purinergic mechanisms has for long been focused on the actions of the nucleoside adenosine, whereby the contribution of nucleotides to the signaling systems has been underestimated.Based on the proceedings of a IUPHAR Satellite Conference held in Leipzig, Germany, this book offers a comprehensive update and overview of nucleotide release, the structure and function of nucleotide receptors, nucleotide-metaboliz... ecto-enzymes as well as the physiological functions of nucleotides in the nervous system. The physiology and molecular biology of receptors for ATP and other nucleotides are examined, as are the physiology and molecular biology of enzymes that hydrolyze extracellular nucleotides.At present, a pharmacology of the nucleotide signaling system is being developed. Of particular interest is the production of receptor subtype-specific antagonists and of drugs that selectively affect the extracellular lifetime of the nucleotide.An excellent source of reference for institutes of pharmacology, biochemistry, neurology, zoology, and physiology, and for the pharmaceutical industry.

  • Confocal Microscopy

    • 1st Edition
    • Volume 307
    • John N. Abelson + 1 more
    • English
    This volume supplements Volumes 63, 64, 87, and 249 of Methods in Enzymology. These volumes provide a basic source for the quantitative interpretation of enzyme rate data and the analysis of enzyme catalysis. Among the major topics covered are Engergetic Coupling in Enzymatic Reactions, Intermediates and Complexes in Catalysis, Detection and Properties of Low Barrier Hydrogen Bonds, Transition State Determination, and Inhibitors.The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.

  • The Biochemical Ecology of Marine Fishes

    • 1st Edition
    • Volume 36
    • English
    This volume is dedicated to an in-depth discussion of the biochemical ecology of marine fishes. The authors review fish biology with regard to the environment and the world's fisheries. They show how fish can be assessed for harvesting at the best time in their life cycles and in the correct condition for marketing, freezing, and preserving. In this context, they include coverage of adaptations of fish to the environment, life cycles, and metabolism. This volume will be of interest to biochemists, marine ecologists, and fishery scientists.Advances in Marine Biology has always offered marine biologists an in-depth and up-to-date review on a variety of topics. As well as many volumes that provide a selection of important topics, the series also includes thematic volumes that examine a particular field in detail.

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