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Elsevier

Books in Life sciences

  • New Developments in Phosphate Fertilizer Technology

    Proceedings of the 1976 Technical Conference of ISMA Ltd., The Hague, The Netherlands, 13-16 September, 1976
    • 1st Edition
    • L.J. Carpentier
    • English
    New Developments in Phosphate Fertilizer Technology compiles all the papers presented at the 1976 Technical Conference of ISMA Ltd. Topics covered by this book include process for recycling H2 SiF6 solutions recovered by gas washing; safety in rotary dryer operation; valorization of phospho-gypsum; investigation of an aerosol with pilot units installed on site; windmill Holland and its environment; and agglomerate granulation as an equilibrium process. This book also provides discussions on hygroscopicity of fertilizer materials; handling and distribution of compound fertilizers; slurry ammoniation in complex fertilizers production; full-scale operating experience of the Fisons HDC phosphoric acid process; innovations in slurry process granulation plants; and production of synthetic fluor-spar from waste fluosilicilic acid. Included in each chapter are summaries, analysis of the performance data, suggestions for further research, list of symbols, references, and conclusions. This text is beneficial to students or scientists conducting research on the field of agricultural, consumer, and environmental sciences.

  • Pathogens, Vectors, and Plant Diseases

    Approaches to Control
    • 1st Edition
    • Kerry F. Harris + 1 more
    • English
    Pathogens, Vectors, and Plant Diseases: Approaches to Control is a collection of papers that discusses how vector host interactions, vector ecology, and disease epidemiology can be applied to disease prevention and control. The book deals with innovative strategies pertaining to control of vector-borne viruses and viral infections in plants. One paper discusses nonpesticidal control of vector-borne viruses including soil solarization that uses solar energy for crop protection, and insect sterilization through radiation, chemosterilants or genetic modifications. Another paper discusses chemicals that interfere with nucleic acid and protein synthesis; as these interactions pose no hazards to animal (mammals), the chemicals are suitable for controlling viral diseases. One author examines the use of oil sprays and reflective surfaces as a means of controlling plant viruses transmitted by insects. In the United States, the entry of vector-borne plant pathogens is controlled by plant quarantine. One author lists several ways in effective quarantine procedures, as well as, the safe importation of potential vectors as cultures. This book is suitable for environmentalists, biologists, conservationists, agriculturists, botanists, and researchers in botany and plant genealogy.

  • Antibiotics

    Origin, Nature and Properties
    • 1st Edition
    • Tadeusz Korzybski + 2 more
    • English
    Antibiotics; Origin, Nature and Properties, Volume II focuses on the principles of the classification of antibiotic substances. This volume is divided into four main topics—antibiotics produced by Fungi imperfecti, antibiotics produced by fungi belonging to the basidiomycetes and ascomycetes, antibiotics produced by lichens and algae, and antibiotics from higher plants. The antibiotics covered in this book include penicillin, viridicatin, cyclopaldic acid, cephalosporin P, bongkrek acid, chlamydosporine, and flammulin. The diploicin, chlorellin, chlorophorin, ethyl gallate, anacardic acid, and echinacosid are also described. Other antibiotics include the tuberosine, antifungal substance from field corn, fulvoplumerin, plumericin, and chinoc acid. This publication is recommended for pharmacists and specialists interested in the classification of antibiotics.

  • Molecular Genetic Modification of Eucaryotes

    • 1st Edition
    • Irwin Rubenstein + 2 more
    • English
    Molecular Genetic Modification of Eucaryotes reviews the current state of knowledge and techniques potentially useful for the molecular genetic modification of eucaryotes. The book interfaces molecular genetics, plant cell and tissue culture, and plant improvement. Topics include cell and tissue culture, protoplasts, somatic cell fusion, cellular mutagenesis, regeneration of new plant types, and the applicability of these techniques to plant improvements. Viruses and viral integration; integration and expression of foreign genetic material in human cells, Drosophila, plant cells, and legumes; biophysical studies of DNA uptake by plants; and genetic engineering for plant protection against diseases are also discussed in detail. The book will be of interest to geneticists, cell biologists, plant breeders, plant physiologists, plant pathologists, and biochemists.

  • Progress in Theoretical Biology

    Volume 1
    • 1st Edition
    • Fred M. Snell
    • English
    Progress in Theoretical Biology, Volume 1 brings together the significant and timely theoretical developments in particular areas of biology. Topics range from chemical evolution and biological self-replicating systems to quantitative aspects of goal-seeking self-organizing systems. An essay on Erwin Schrödinger (1887-1961) and his work on genetics and quantum mechanics, as well as its influence on molecular biology, is also included. Comprised of five chapters, this volume first discusses chemical evolution in terms of organic geochemistry and prebiotic chemistry. Dehydration condensation reactions as well as the generation of order and new information are also considered. The next chapter deals with biological self-replicating systems and focuses on such topics as the minimum system capable of self-replication; the minimum system capable of self-replication in terms of the generalizations of terrestrial biology; and which biological systems most nearly approach this limiting behavior. A series of definitions that provide a framework for examining minimal reproducing systems are also presented. The final three chapters explore the quantitative aspects of goal-seeking self-organizing systems; statistical thermodynamics of polymerization and polymorphism of proteins; and the importance of models in theoretical biology. This book is intended for both biological and physical scientists.

  • Research Surgery and Care of the Research Animal

    Surgical Approaches to the Organ Systems
    • 1st Edition
    • William I. Gay + 1 more
    • English
    Methods of Animal Experimentation, Volume VII: Research Surgery and Care of the Research Animal, Part B is a collection of papers that deals with methods used in animal experiments concerning surgical approaches to certain organ systems. This collection deals with surgery involving the respiratory, cardiovascular, skeletal, gastrointestinal, genital, and central nervous systems of the test animals. One paper describes the procedures to be followed in thoracic incisions, emphasizing the importance of access to airways and parenchymal resections. In explaining cardiovascular surgery, one paper details the specialized surgical equipment, anesthesia, blood flow, and post-operative care that the test animal needs. Another paper describes the procedures and techniques, as well as limb immobilization or total joint prostheses that should be followed in a surgery involving the skeletal system. One author also considers in detail both research surgeries of the male and female reproductive tracts. The paper on surgery involving the peripheral and central nervous system gives general techniques used in chronic studies of such system. Veterinarians, laboratory workers dealing with test animals, and researchers designing animal and medical experiments will find this book very informative.

  • The Spleen and Some of Its Diseases

    Being the Bradshaw Lecture of the Royal College of Surgeons of England, 1920
    • 1st Edition
    • Berkeley Moynihan
    • English
    The Spleen and Some of its Diseases provides information pertinent to the fundamental aspects of the spleen. This book discusses the role that spleen plays in the etiology of diseases whose most obvious symptoms are evoked by associated or consecutive affections of other organs. Organized into 14 chapters, this book begins with an overview of the anatomy of the spleen, which is entirely covered with peritoneum and is situated behind the fundus of the stomach. This text then describes the first recorded case of splenectomy. Other chapters consider the effect of splenectomy in man and animals upon the general health, upon the blood, and upon the various tissues. This book discusses as well the biochemical investigations upon the spleen and upon the metabolic activities of the body. The final chapter deals with the determination of the functional capacity of all the various organs. This book is a valuable resource for surgeons and physicians.

  • Arthritis and Society

    The Impact of Musculoskeletal Diseases
    • 1st Edition
    • Nortin M. Hadler + 1 more
    • English
    Arthritis and Society examines the interaction between the structure of our society and the impact of rheumatic diseases on the lifestyle of those afflicted. It has drawn the distinction between the private and public experience of illness in order to produce a comprehensive analysis of the impact of musculoskeletal disease on society. This book is organized into three main sections. Section 1 analyzes the personal experience of pain of the groups frequently afflicted and discusses the epidemiology and scope of the systemic rheumatic diseases. Section 2 views the plight of those suffering from rheumatic disease from a different perspective. Section 3 highlights the importance of appropriate care and of establishing a more compassionate society which can help lessen the impact of the disease. It also considers the role of rehabilitation. This book will be of interest to people dealing with studies on arthritis and other rheumatic disease and also those interested in understanding the impact on societal structure on healthcare issues.

  • Zoology

    Proceedings of the Fiftieth Anniversary Meeting of the Society for Experimental Biology
    • 1st Edition
    • P. Spencer Davies + 2 more
    • English
    Perspectives in Experimental Biology, Volume 1: Zoology contains the proceedings of the 50th Anniversary Meeting of the Society for Experimental Biology, held at the University of Cambridge, UK, on July 16-19, 1974. The papers explore research in zoology and cover a wide range of topics such as osmotic and ionic regulation; invertebrate and insect physiology; respiratory physiology; and cell chemistry. Comprised of 43 chapters, this volume begins with an introduction to the history of the Society for Experimental Biology, followed by a discussion on calcium metabolism and acid-base balance in Helix pomatia. Subsequent chapters explore water movement in cells and tissues; ion transport and osmoregulation in marine fish; hormonal control of reproduction in cephalopods; and how hormones affect flight in the locust. Other sections focus on the temperature dependence of the respiratory activity of mitochondria; biochemical mechanisms of tissue injury; laser light scattering from nerve and motile cells; transmitter release from insect motoneurons; and neural consequences of early experience in birds. The final section is devoted to animal locomotion and includes chapters that address undulatory swimming in polychaetes and energy storage in jumping animals. This book is intended for research workers and undergraduates interested in experimental biology.

  • Laboratory Methods in Enzymology: DNA

    • 1st Edition
    • Volume 529
    • English
    Methods in Enzymology volumes provide an indispensable tool for the researcher. Each volume is carefully written and edited by experts to contain state-of-the-art reviews and step-by-step protocols. In this volume, we have brought together a number of core protocols concentrating on DNA, complementing the traditional content that is found in past, present and future Methods in Enzymology volumes.

  • Handbook of Food Powders

    Processes and Properties
    • 1st Edition
    • Bhesh Bhandari + 3 more
    • English
    Many food ingredients are supplied in powdered form, as reducing water content increases shelf life and aids ease of storage, handling and transport. Powder technology is therefore of great importance to the food industry. The Handbook of food powders explores a variety of processes that are involved in the production of food powders, the further processing of these powders and their functional properties.Part one introduces processing and handling technologies for food powders and includes chapters on spray, freeze and drum drying, powder mixing in the production of food powders and safety issues around food powder production processes. Part two focusses on powder properties including surface composition, rehydration and techniques to analyse the particle size of food powders. Finally, part three highlights speciality food powders and includes chapters on dairy powders, fruit and vegetable powders and coating foods with powders.The Handbook of food powders is a standard reference for professionals in the food powder production and handling industries, development and quality control professionals in the food industry using powders in foods, and researchers, scientists and academics interested in the field.

  • From Plant Genomics to Plant Biotechnology

    • 1st Edition
    • Palmiro Poltronieri + 2 more
    • English
    With the appearance of methods for the sequencing of genomes and less expensive next generation sequencing methods, we face rapid advancements of the -omics technologies and plant biology studies: reverse and forward genetics, functional genomics, transcriptomics, proteomics, metabolomics, the movement at distance of effectors and structural biology. From plant genomics to plant biotechnology reviews the recent advancements in the post-genomic era, discussing how different varieties respond to abiotic and biotic stresses, understanding the epigenetic control and epigenetic memory, the roles of non-coding RNAs, applicative uses of RNA silencing and RNA interference in plant physiology and in experimental transgenics and plants modified to specific aims. In the forthcoming years these advancements will support the production of plant varieties better suited to resist biotic and abiotic stresses, for food and non-food applications.This book covers these issues, showing how such technologies are influencing the plant field in sectors such as the selection of plant varieties and plant breeding, selection of optimum agronomic traits, stress-resistant varieties, improvement of plant fitness, improving crop yield, and non-food applications in the knowledge based bio-economy.

  • Essentials of Stem Cell Biology

    • 3rd Edition
    • Robert Lanza + 1 more
    • English
    First developed as an accessible abridgement of the successful Handbook of Stem Cells, Essentials of Stem Cell Biology serves the needs of the evolving population of scientists, researchers, practitioners, and students embracing the latest advances in stem cells. Representing the combined effort of 7 editors and more than 200 scholars and scientists whose pioneering work has defined our understanding of stem cells, this book combines the prerequisites for a general understanding of adult and embryonic stem cells with a presentation by the world's experts of the latest research information about specific organ systems. From basic biology/mechanisms, early development, ectoderm, mesoderm, endoderm, and methods to the application of stem cells to specific human diseases, regulation and ethics, and patient perspectives, no topic in the field of stem cells is left uncovered.

  • Benign and Pathological Chromosomal Imbalances

    Microscopic and Submicroscopic Copy Number Variations (CNVs) in Genetics and Counseling
    • 1st Edition
    • Thomas Liehr
    • English
    Benign & Pathological Chromosomal Imbalances systematically clarifies the disease implications of cytogenetically visible copy number variants (CG-CNV) using cytogenetic assessment of heterochromatic or euchromatic DNA variants. While variants of several megabasepair can be present in the human genome without clinical consequence, visually distinguishing these benign areas from disease implications does not always occur to practitioners accustomed to costly molecular profiling methods such as FISH, aCGH, and NGS. As technology-driven approaches like FISH and aCGH have yet to achieve the promise of universal coverage or cost efficacy to sample investigated, deep chromosome analysis and molecular cytogenetics remains relevant for technology translation, study design, and therapeutic assessment. Knowledge of the rare but recurrent rearrangements unfamiliar to practitioners saves time and money for molecular cytogeneticists and genetics counselors, helping to distinguish benign from harmful CG-CNV. It also supports them in deciding which molecular cytogenetics tools to deploy.

  • Cognitive Electrophysiology of Attention

    Signals of the Mind
    • 1st Edition
    • George R. Mangun
    • English
    Cognitive Electrophysiology of Attention explores the fundamental mechanisms of attention and related cognitive functions from cognitive neuroscience perspectives. Attention is an essential cognitive ability that enables humans to process and act upon relevant information while ignoring distracting information, and the capacity to focus attention is at the core of mental functioning. Understanding the neural bases of human attention remains a key challenge for neuroscientists and psychologists, and is essential for translational efforts to treat attentional deficits in a variety of neurological and psychiatric disorders. Cognitive electrophysiology is at the center of a multidisciplinary approach that involves the efforts of psychologists, neuroscientists, neuropsychologists, psychiatrists, and neurologists to identify basic brain mechanisms and develop translational approaches to improve mental health. This edited volume is authored by leading investigators in the field and discusses methods focused on electrophysiological recordings in humans, including electroencephalograp... (EEG) and event-related potential (ERP) methods, and also incorporates evidence from functional magnetic resonance imaging (fMRI). Cognitive Electrophysiology of Attention illuminates specific models about attentional mechanisms in vision, audition, multisensory integration, memory, and semantic processing in humans.

  • Global Clinical Trials for Alzheimer's Disease

    Design, Implementation, and Standardization
    • 1st Edition
    • Menghis Bairu + 1 more
    • English
    Global Clinical Trials for Alzheimer’s Disease is a handy one-stop reference for researchers and physicians planning and conducting global clinical trials in this area. This book addresses important considerations that may arise during the successful design and execution of these trials, including site selection, local regulatory issues, pharmacogenomics, ethical matters and much more. Given the saturation of traditional clinical trial markets and the worldwide progression of Alzheimer’s disease, there is a need to focus on clinical trials in emerging markets and developing countries. This book provides you with a practical approach to recognizing the opportunities and tackling the challenges that are present during the planning and execution of global clinical trials for Alzheimer’s disease.

  • Gene Therapy of Cancer

    Translational Approaches from Preclinical Studies to Clinical Implementation
    • 3rd Edition
    • Edmund C. Lattime + 1 more
    • English
    Gene therapy as a treatment for cancer is at a critical point in its evolution. Exciting new developments in gene targeting and vector technology, coupled with results from the first generation of preclinical and clinical studies have led to the design and testing of new therapeutic approaches. The Third Edition of Gene Therapy of Cancer provides crucial updates on the basic and applied sciences of gene therapy. It offers a comprehensive assessment of the field including the areas of suicide gene therapy, oncogene and suppressor gene targeting, immunotherapy, drug resistance gene therapy, and the genetic modification of stem cells. Researchers at all levels of development, from basic laboratory investigators to clinical practitioners, will find this book to be instructive. Cancer gene therapy, like cancer therapy in general, is evolving rapidly, testing new concepts, targets and pathways, evoking new technologies, and passing new regulatory hurdles. Its essence, however, has not changed: the hope and challenges of returning altered genes to normal, using targeted gene expression to alter the function of both tumor and microenvironment, and in some cases normal cells, and delivering functionally important genes to specific cell types to increase sensitivity to killing or to protect normal cells from cancer therapies. In some instances, gene therapy for cancer forms a continuum from gene repair through the use of molecularly modified cells; the use of viral and non-viral vector based gene delivery to both tumor and tumor microenvironment; the use of viral and gene based vaccines; and development of new gene-based therapeutics. The unique mechanistically chosen vector platforms are at the heart of this technology because they allow for direct and selective cell death and transient to sustained delivery of vaccine molecules or molecules that affect the microenvironment, vasculature, or the immune response.

  • Integrated Pest Management

    Current Concepts and Ecological Perspective
    • 1st Edition
    • Dharam P. Abrol
    • English
    Integrated Pest Management: Current Concepts and Ecological Perspective presents an overview of alternative measures to traditional pest management practices using biological control and biotechnology. The removal of some highly effective broad-spectrum chemicals, caused by concerns over environmental health and public safety, has resulted in the development of alternative, reduced risk crop protection products. These products, less toxic to the environment and easily integrated into biological control systems, target specific life stages or pest species. Predation — recognized as a suitable, long-term strategy — effectively suppresses pests in biotechnological control systems. Integrated Pest Management covers these topics and more. It explores the current ecological approaches in alternative solutions, such as biological control agents, parasites and predators, pathogenic microorganisms, pheromones and natural products as well as ecological approaches for managing invasive pests, rats, suppression of weeds, safety of pollinators, role of taxonomy and remote sensing in IPM and future projections of IPM. This book is a useful resource to entomologists, agronomists, horticulturists, and environmental scientists.

  • Placebo and Pain

    From Bench to Bedside
    • 1st Edition
    • Luana Colloca + 2 more
    • English
    The placebo effect continues to fascinate scientists, scholars, and clinicians, resulting in an impressive amount of research, mainly in the field of pain. While recent experimental and clinical studies have unraveled salient aspects of the neurobiological substrates and clinical relevance of pain and placebo analgesia, an authoritative source remained lacking until now. By presenting and integrating a broad range of research, Placebo and Pain enhances readers’ knowledge about placebo and nocebo effects, reexamines the methodology of clinical trials, and improves the therapeutic approaches for patients suffering from pain. Review for Placebo and Pain:“This ambitious book is the first comprehensive and unified presentation of the placebo and nocebo phenomena in the area of pain. Written by the international leading experts in the field, the book provides an accurate up-to-date [work] on placebo and pain dealing with current perspectives and future challenging issues.”--Ted Kaptchuk, Associate Professor of Medicine, Harvard Medical School

  • Advances in Planar Lipid Bilayers and Liposomes

    • 1st Edition
    • Volume 18
    • English
    Advances in Planar Lipid Bilayers and Liposomes cover a broad range of topics, including main arrangements of the reconstituted system, namely planar lipid bilayers as well as spherical liposomes. The invited authors present the latest results of their own research groups in this exciting, multidisciplinary field.

  • Genetic Steroid Disorders

    • 1st Edition
    • English
    This is a comprehensive book addressing steroid disorders from hormonal, genetic, psychological, and surgical perspectives. It is meant to educate adult and pediatric endocrinologists, clinical geneticists, genetic counselors, reproductive endocrinologists, neonatologists, urologists, and psychoendocrinologis... It will assist these specialists in the diagnosis and treatment of steroid disorders. The book is written for postgraduate and faculty-level physicians. The content consists of steroid disorders, genetic bases for the disorder and case presentations of each disorder.

  • Microtubules, in vitro

    • 2nd Edition
    • Volume 115
    • John J. Correia + 1 more
    • English
    There continues to be intense interest in the microtubule cytoskeleton; the assembly, structure and regulation of microtubules; and the numerous motors and accessory proteins that control cell cycle, dynamics, organization and transport. The field continues to grow and explore new aspects of these issues driven immensely by developments in optical imaging and tracking techniques. This Second Edition brings together current research and protocols in the field of microtubules in vitro and will serve as a valuable tool for cell biologists, biophysicists and pharmacologists who study the microtubule cytoskeleton, as well as for researchers in the biomedical and biotechnology communities with interest in developing drugs that target microtubules, MAPS and motors.

  • Peripheral Nerve Disorders

    • 1st Edition
    • Volume 115
    • Gérard Said + 1 more
    • English
    Disorders of the peripheral nervous system (PNS) are the cause of prominent neurological symptoms including weakness, sensory loss, pain and autonomic dysfunction associated with deficits, morbidity and mortality. These disorders may be primary hereditary or cryptogenic neurologic disorders confined to the PNS or part of the pathology of both the central nervous system and the PNS. Most PNS disorders are secondary to other system disorders and may be responsive to treatment of the primary disease. Important advances have been obtained in several areas including molecular genetics, biochemistry, immunology, morphology and physiology that have enhanced our understanding of the causes and consequences of damage to peripheral nerve. Understanding of both these groups of PNS diseases has greatly expanded over recent years and has led to important advances of treatment both to protect and to repair damages of peripheral nerve. This volume provides an overview of the state-of-the-art of examination, diagnosis and treatment of these very diverse disorders and will be of interest to both the research and clinical neuroscience and neurology communities.

  • Developmental Timing

    • 1st Edition
    • Volume 105
    • English
    This new volume of Current Topics in Developmental Biology covers developmental timing, with contributions from an international board of authors. The chapters provide a comprehensive set of reviews covering such topics as the timing of developmental programs in Drosophila, temporal patterning of neural progenitors, and environmental modulation of developmental timing.

  • Mathematical Neuroscience

    • 1st Edition
    • Stanislaw Brzychczy + 1 more
    • English
    Mathematical Neuroscience is a book for mathematical biologists seeking to discover the complexities of brain dynamics in an integrative way. It is the first research monograph devoted exclusively to the theory and methods of nonlinear analysis of infinite systems based on functional analysis techniques arising in modern mathematics. Neural models that describe the spatio-temporal evolution of coarse-grained variables—such as synaptic or firing rate activity in populations of neurons —and often take the form of integro-differential equations would not normally reflect an integrative approach. This book examines the solvability of infinite systems of reaction diffusion type equations in partially ordered abstract spaces. It considers various methods and techniques of nonlinear analysis, including comparison theorems, monotone iterative techniques, a truncation method, and topological fixed point methods. Infinite systems of such equations play a crucial role in the integrative aspects of neuroscience modeling.

  • Dynamics of Proteins and Nucleic Acids

    • 1st Edition
    • Volume 92
    • English
    Published continuously since 1944, Advances in Protein Chemistry and Structural Biology has been a continuous, essential resource for protein chemists. Covering reviews of methodology and research in all aspects of protein chemistry, including purification/express... proteomics, modeling and structural determination and design, each volume brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics.

  • Toxoplasma Gondii

    The Model Apicomplexan - Perspectives and Methods
    • 2nd Edition
    • Louis M. Weiss
    • English
    This 2e of Toxoplasma gondii reflects the significant advances in the field in the last 5 years, including new information on the genomics, epigenomics and proteomics of T. gondii as well as a new understanding of the population biology and genetic diversity of this organism. T. gondii remains the best model system for studying the entire Apicomplexa group of protozoans, which includes Malaria, making this new edition essential for a broad group of researchers and scientists. Toxoplasmosis is caused by a one-celled protozoan parasite known as T. gondii. The infection produces a wide range of clinical syndromes in humans, land and sea mammals, and various bird species. Most humans contract toxoplasmosis by eating contaminated, raw or undercooked meat (particularly pork), vegetables, or milk products; by coming into contact with the T. gondii eggs from cat feces; or by drinking contaminated water. The parasite damages the ocular and central nervous systems, causing behavioral and personality alterations as well as fatal necrotizing encephalitis. It is especially dangerous for the fetus of an infected pregnant woman and for individuals with compromised immune systems, such as HIV-infected patients.

  • Fundamentals of Weed Science

    • 4th Edition
    • Robert L Zimdahl
    • English
    This book addresses herbicides and their use as an important aspect of modern weed management and strives to place them in an ecological framework. Many weed scientists believe agriculture is a continuing struggle with weeds--without good weed control, good and profitable agriculture is impossible. Each agricultural discipline sees itself as central to agriculture's success and continued progress, and weed science is no exception. While not denying the importance of weed management to successful agriculture, this book places it in a larger ecological context. The roles of culture, economics, and politics in weed management are also discussed, enabling scientists and students to understand the larger effects on society.

  • Inhibitors of the Ras Superfamily G-proteins, Part A

    • 1st Edition
    • Volume 33
    • English
    This special volume of The Enzymes is targeted toward researchers in biochemistry, molecular and cell biology, pharmacology, and cancer. This thematic volume discusses inhibitors of the Ras superfamily G-proteins.

  • Advances in Applied Microbiology

    • 1st Edition
    • Volume 85
    • English
    Published since 1959, Advances in Applied Microbiology continues to be one of the most widely read and authoritative review sources in microbiology. The series contains comprehensive reviews of the most current research in applied microbiology. Recent areas covered include bacterial diversity in the human gut, protozoan grazing of freshwater biofilms, metals in yeast fermentation processes and the interpretation of host-pathogen dialogue through microarrays. Eclectic volumes are supplemented by thematic volumes on various topics, including Archaea and sick building syndrome. Impact factor for 2011: 5.233.

  • Digital Microscopy

    • 4th Edition
    • Volume 114
    • Greenfield Sluder + 1 more
    • English
    The previous edition of this book marked the shift in technology from video to digital camera use with microscope use in biological science. This new edition presents some of the optical fundamentals needed to provide a quality image to the digital camera. Specifically, it covers the fundamental geometric optics of finite- and infinity-corrected microscopes, develops the concepts of physical optics and Abbe’s theory of image formation, presents the principles of Kohler illumination, and finally reviews the fundamentals of fluorescence and fluorescence microscopy. The second group of chapters deals with digital and video fundamentals: how digital and video cameras work, how to coordinate cameras with microscopes, how to deal with digital data, the fundamentals of image processing, and low light level cameras. The third group of chapters address some specialized areas of microscopy that allow sophisticated measurements of events in living cells that are below the optical limits of resolution.

  • Advances in Molecular Toxicology

    • 1st Edition
    • Volume 7
    • English
    Advances in Molecular Toxicology features the latest advances in all of the subspecialties of the broad area of molecular toxicology. Toxicology is the study of poisons, and this series details the study of the molecular basis by which a vast array of agents encountered in the human environment and produced by the human body itself manifest themselves as toxins. Not strictly limited to documenting these examples, the series is also concerned with the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events will also be reviewed by leading workers in the field. Advances in Molecular Toxicology will report progress in all aspects of these rapidly evolving molecular aspects of toxicology with a view toward detailed elucidation of progress on the molecular level and on advances in technological approaches employed.

  • Novel Psychoactive Substances

    Classification, Pharmacology and Toxicology
    • 1st Edition
    • Paul I. Dargan + 1 more
    • English
    Novel Psychoactive Substances: Classification, Pharmacology and Toxicology provides readers with background on the classification, detection, supply and availability of novel psychoactive substances, otherwise known as "legal highs." This book also covers individual classes of novel psychoactive substances that have recently emerged onto the recreational drug scene and provides an overview of the pharmacology of the substance followed by a discussion of the acute and chronic harm or toxicity associated with the substance. Written by international experts in the field, this multi-authored book is a valuable reference for scientists, clinicians, academics, and regulatory and law enforcement professionals.

  • Antibody Fc

    Linking Adaptive and Innate Immunity
    • 1st Edition
    • Margaret Ackerman + 1 more
    • English
    Antibody Fc is the first single text to synthesize the literature on the mechanisms underlying the dramatic variability of antibodies to influence the immune response. The book demonstrates the importance of the Fc domain, including protective mechanisms, effector cell types, genetic data, and variability in Fc domain function. This volume is a critical single-source reference for researchers in vaccine discovery, immunologists, microbiologists, oncologists and protein engineers as well as graduate students in immunology and vaccinology. Antibodies represent the correlate of protection for numerous vaccines and are the most rapidly growing class of drugs, with applications ranging from cancer and infectious disease to autoimmunity. Researchers have long understood the variable domain of antibodies, which are responsible for antigen recognition, and can provide protection by blocking the function of their target antigen. However, recent developments in our understanding of the protection mediated by antibodies have highlighted the critical nature of the antibody constant, or Fc domain, in the biological activity of antibodies. The Fc domain allows antibodies to link the adaptive and innate immune systems, providing specificity to a wide range of innate effector cells. In addition, they provide a feedback loop to regulate the character of the immune response via interactions with B cells and antigen-presenting cells.

  • Introduction to Diffusion Tensor Imaging

    And Higher Order Models
    • 1st Edition
    • Susumu Mori + 1 more
    • English
    The concepts behind diffusion tensor imaging (DTI) are commonly difficult to grasp, even for magnetic resonance physicists. To make matters worse, a many more complex higher-order methods have been proposed over the last few years to overcome the now well-known deficiencies of DTI. In Introduction to Diffusion Tensor Imaging: And Higher Order Models, these concepts are explained through extensive use of illustrations rather than equations to help readers gain a more intuitive understanding of the inner workings of these techniques. Emphasis is placed on the interpretation of DTI images and tractography results, the design of experiments, and the types of application studies that can be undertaken. Diffusion MRI is a very active field of research, and theories and techniques are constantly evolving. To make sense of this constantly shifting landscape, there is a need for a textbook that explains the concepts behind how these techniques work in a way that is easy and intuitive to understand—Introduct... to Diffusion Tensor Imaging fills this gap.

  • Introduction to Food Engineering, Enhanced

    • 5th Edition
    • R. Paul Singh + 1 more
    • English
    Ranging from basic engineering principles, based on fundamental physics, to several applications in food processing, this newly revised and updated enhanced ebook edition of Introduction to Food Engineering continues to be a valuable teaching and professional reference tool. Within the first four chapters, the concepts of mass and energy balance, thermodynamics, fluid flow and heat transfer are introduced. A significant addition to this section is an introduction to the concepts of sustainability in Chapter 3 on Resource Sustainability, introducing students to the latest terminology used to describe the efficiencies of processes and operations. The next four chapters include applications of thermodynamics and heat transfer to preservation processes, refrigeration, freezing processes and evaporation processes used in concentration of liquid foods. Following the introduction of the principles of psychrometrics and mass transfer, the chapters present application of engineering concepts to membrane separation processes, dehydration processes, extrusion, packaging and supplemental processes, including filtration, centrifugation and mixing. Long recognized as the bestselling textbook for teaching food engineering to food science students, this enhanced ebook transitions with today’s students from traditional textbook learning to an integrated and interactive presentation of the key concepts of food engineering. Using carefully selected examples, Singh and Heldman demonstrate the relationship of engineering to the chemistry, microbiology, nutrition and processing of foods in a uniquely practical blend. In addition, interactive tools throughout the book take the learning experience far beyond that of a print book, or even most ebooks. This approach facilitates comprehensive learning that has proven valuable beyond the classroom as a lifetime professional reference.

  • Transparency for Sustainability in the Food Chain

    Challenges and Research Needs EFFoST Critical Reviews #2
    • 1st Edition
    • Gerhard Schiefer + 1 more
    • English
    Transparency for Sustainability in the Food Chain lays out the key issues and challenges in food safety, food quality, chain integrity, the link with consumers, and the technological base of tracking and tracing systems. This succinct volume brings readers up to speed on the state of the art in these areas, and the research trends in specific domains. Transparency in the food sector, especially to consumers, is one of the priority issues on the agenda of consumer policy representatives. Food scandals and deficiencies in consumer communication have drawn increasing demands for food policies that ensure that food is safe and of the quality consumers expect. Further, consumers increasingly expect that food production processes limit negative impacts on the environment and consider social concerns. Moving toward improved transparency requires action by stakeholders of the food chain but also knowledge on where and how to move. Researchers and professionals working in food sourcing, regulation, safety, and distribution will benefit from this clear overview.

  • Advances in Microbial Food Safety

    • 1st Edition
    • J Sofos
    • English
    New research, outbreaks of foodborne disease and changes to legislation mean that food microbiology research is constantly evolving. Advances in microbial food safety: Volume 1 summarises the key trends in this area for the food industry.The book begins with an introductory chapter discussing food safety management systems from the past to the present day and looking to future directions. The book moves on to provide updates on specific pathogens including Salmonella, Listeria monocytogenes and Bacillus species. New developments in the area are explored with chapters on emerging parasites in food, advances in separation and concentration of microorganisms from food samples, new approaches in microbial pathogen detection, and an update on novel methods for pathogen control in livestock preharvest.With its distinguished editor and international team of expert contributors, Advances in microbial food safety: Volume 1 is a standard reference for researchers, consultants and managers in the food industry responsible for food safety, analytical laboratories testing the safety of the food we eat, and researchers in academia working on food microbial safety.

  • Standardisation in Cell and Tissue Engineering

    Methods and Protocols
    • 1st Edition
    • V Salih
    • English
    The increased use of biodegradable synthetic or natural scaffolds combined with cells and/or biological molecules, in order to create functional replacement tissue in a damaged tissue site, has led to the need for the development of ‘best practice’ methods in the area of tissue engineering to help ensure the creation of safe, high quality products. Standardisation in cell and tissue engineering introduces concepts and current practice in the field of cell and tissue engineering to a wide audience and aims to provide awareness of the importance of standardisation in this area while suggesting directions for further investigation.Part one provides an overview of methods for cell and tissue engineering and includes chapters on the fundamentals of cell and matrix biology for tissue engineering, 3D collagen biomatrix development, and control and vascularisation of tissue-engineered constructs. Part two begins with a chapter exploring the methods and protocols of standardisation in cell and tissue engineering before moving on to highlight issues of quality control in cell and tissue engineering, standardised chemical analysis and testing of biomaterials and principles of good laboratory practice (GLP) for in vitro cell culture applications.Standar... in cell and tissue engineering is a standard reference for leading research groups, government agencies, regulatory bodies, and researchers and technicians at all levels across the whole range of disciplines using cell culture within the pharmaceutical, biotechnology and biomedical industries.

  • Food Enrichment with Omega-3 Fatty Acids

    • 1st Edition
    • Charlotte Jacobsen + 3 more
    • English
    Omega-3 fatty acids provide many health benefits, from reducing cardiovascular disease to improving mental health, and consumer interest in foods enriched with omega-3 fatty acids is increasing. Formulating a product enriched with these fatty acids that is stable and has an acceptable flavour is challenging. Food enrichment with omega-3 fatty acids provides an overview of key topics in this area.Part one, an introductory section, reviews sources of omega-3 fatty acids and their health benefits. Chapters in part two explore the stabilisation of both fish oil itself and foods enriched with omega-3 fatty acids. Part three focuses on the fortification of different types of foods and beverages with omega-3 fatty acids, including meat products, by the modification of animal diets and other methods, infant formula and baked goods. Finally, part four highlights new directions in the field and discusses algal oil as a source of omega-3 fatty acids and labelling and claims in foods containing omega-3 fatty acids.Food enrichment with omega-3 fatty acids is a standard reference for professionals in the functional foods industry involved with research, development and quality assessment and for researchers in academia interested in food lipids, oxidation and functional foods.

  • Computer-Aided Vaccine Design

    • 1st Edition
    • Joo Chuan Tong + 1 more
    • English
    Computational pre-screening of antigens is now routinely applied to the discovery of vaccine candidates.Computer-... vaccine design is a comprehensive introduction to this exciting field of study. The book is intended to be a textbook for researchers and for courses in bioinformatics, as well as a laboratory reference guide. It is written mainly for biologists who want to understand the current methods of computer-aided vaccine design. The contents are designed to help biologists appreciate the underlying concepts and algorithms used, as well as limitations of the methods and strategies for their use. Chapters include: MHC and T cell responses; Immunoglobulins and B cell responses; Scientific publications and databases; Database design; Computational T cell vaccine design; Computational B cell vaccine design; infectious disease informatics; Vaccine safety and quality assessments; and Vaccine adjuvant informatics.

  • Bioinformatics for Biomedical Science and Clinical Applications

    • 1st Edition
    • K-H Liang
    • English
    Contemporary biomedical and clinical research is undergoing constant development thanks to the rapid advancement of various high throughput technologies at the DNA, RNA and protein levels. These technologies can generate vast amounts of raw data, making bioinformatics methodologies essential in their use for basic biomedical and clinical applications.Bioinfo... for biomedical science and clinical applications demonstrates what these cutting-edge technologies can do and examines how to design an appropriate study, including how to deal with data and address specific clinical questions. The first two chapters consider Bioinformatics and analysis of the human genome. The subsequent three chapters cover the introduction of Transcriptomics, Proteomics and Systems biomedical science. The remaining chapters move on to critical developments, clinical information and conclude with domain knowledge and adaptivity.

  • Biomaterials and Medical Tribology

    Research and Development
    • 1st Edition
    • J. Paulo Davim + 1 more
    • English
    Medical tribology can be defined as the science of tribological phenomena in the human body, both those that naturally occur in the tissues or organs and those that arise after implantation of an artificial device, while biomaterials are inert substances designed to be incorporated into living systems. Biomaterials and medical tribology brings together a collection of high quality articles and case studies focussing on new research and developments in these two important fields.The book provides details of the different types of biomaterial available and their applications, including nanoparticles for biomedical applications, synergism effects during fiction and fretting corrosion experiments, application of biomedical-grade titanium alloys in trabecular bone and artificial joints, fatigue strengthening of an orthopaedic Ti6AI4V alloy, wear determination on retrieved metal-on-metal hip arthoplasty, natural articular joints, the importance of bearing porosity in engineering and natural lubrication, tribological characterization of human tooth enamel, and finally, liposome-based carrier systems and devices used for pulmonary drug delivery.Biomaterial... and medical tribology is an essential reference for materials scientists, engineers, and researchers in the field of medical tribology. The title also provides an overview for academics and clinicians in this area.

  • Year Book of Endocrinology 2013

    • 1st Edition
    • Volume 2013
    • Matthias Schott
    • English
    The Year Book of Endocrinology brings you abstracts of the articles that reported the year's breakthrough developments in endocrinology carefully selected from more than 500 journals worldwide. Expert commentaries evaluate the clinical importance of each article and discuss its application to your practice. Topics such as Diabetes, Lipoproteins and Ahterosclerosis, Obesity, Thyroid, Calcium and Bone Metabolism, Adrenal Cortex, and Neuroendocrinology are represented highlighting the most current and relevant articles in the field.

  • Medical Imaging Technology

    • 1st Edition
    • Victor I. Mikla + 1 more
    • English
    Medical Imaging Technology reveals the physical and materials principles of medical imaging and image processing, from how images are obtained to how they are used. It covers all aspects of image formation in modern imaging modalities and addresses the techniques, instrumentation, and advanced materials used in this rapidly changing field. Covering conventional and modern medical imaging techniques, this book encompasses radiography, fluoroscopy, computed tomography, magnetic resonance imaging, ultrasound, and Raman spectroscopy in medicine. In addition to the physical principles of imaging techniques, the book also familiarizes you with the equipment and procedures used in diagnostic imaging.

  • Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging

    Volume 1 - Molecular Mechanisms
    • 1st Edition
    • M. A. Hayat
    • English
    Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward thinking, these books offer a valuable guide to both cellular processes while inciting researchers to explore their potentially important connections. Considering that autophagy is associated with numerous biological processes, including cellular development and differentiation, cancer (both antitumor and protumor functions), immunity, infectious diseases, inflammation, maintenance of homeostasis, response to cellular stress, and degenerative diseases such as Alzheimer’s, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and prion diseases, there is a great need to understanding its role. Cell homeostasis is achieved by balancing biosynthesis and cellular turnover. In spite of the increasing importance of autophagy in various pathophysiological situations (conditions) mentioned above, this process remains underestimated and overlooked. As a consequence, its role in the initiation, stability, maintenance, and progression of these and other diseases (e.g., autoimmune disease) remains poorly understood. Volumes in the Series Volume 1: Molecular Mechanisms. Elucidates autophagy’s association with numerous biological processes, including cellular development and differentiation, cancer, immunity, infectious diseases, inflammation, maintenance of homeostasis, response to cellular stress, and degenerative diseases such as Alzheimer’s, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and prion diseases. Volume 2: Role in General Diseases. Describes the various aspects of the complex process of autophagy in a myriad of devastating human diseases, expanding from a discussion of essential autophagic functions into the role of autophagy in proteins, pathogens, immunity, and general diseases. Volume 3: Role in Specific Diseases. Explores the role of autophagy in specific diseases and developments, including: Crohn’s Disease, Gaucher Disease, Huntington’s Disease, HCV infection, osteoarthritis, and liver injury, with a full section devoted to in-depth exploration of autophagy in tumor development and cancer, as well as the relationship between autophagy and apoptosis.Volume 4: Mitophagy. Presents detailed information on the role of mitophagy, the selective autophagy of mitochondria, in health and disease, by delivering an in-depth treatment of the molecular mechanisms involved in mitophagy initiation and execution, as well as the role of mitophagy in Parkinson Disease, cardiac aging, and skeletal muscle atrophy. Volume 5: Role in Human Diseases. Comprehensively describes the role of autophagy in human diseases, delivering coverage of the antitumor and protumor roles of autophagy; the therapeutic inhibition of autophagy in cancer; and the duality of autophagy’s effects in various cardiovascular, metabolic, and neurodegenerative disorders.Volume 6: Regulation of Autophagy and Selective Autophagy. Provides coverage of the mechanisms of regulation of autophagy; intracellular pathogen use of the autophagy mechanism; the role of autophagy in host immunity; and selective autophagy. Volume 7: Role of Autophagy in Therapeutic Applications. Provides coverage of the latest developments in autophagosome biogenesis and regulation; the role of autophagy in protein quality control; the role of autophagy in apoptosis; autophagy in the cardiovascular system; and the relationships between autophagy and lifestyle. Volume 8: Autophagy and Human Diseases. Reviews recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities, and introduces new, more effective therapeutic strategies, in the development of targeted drugs and programmed cell death, providing information that will aid on preventing detrimental inflammation.Volume 9: Necrosis and Inflammation in Human Diseases. Emphasizes the role of Autophagy in necrosis and inflammation, explaining in detail the molecular mechanism(s) underlying the formation of autophagosomes, including the progression of Omegasomes to autophagosomes.

  • Flavour Science

    Proceedings from XIII Weurman Flavour Research Symposium
    • 1st Edition
    • Vicente Ferreira + 1 more
    • English
    Flavor science is continually evolving. Remaining current with the latest research and establishing a broad and sound understanding of the major developments and breakthroughs can be a challenge. The Weurman Flavour Research Symposium has long been regarded as the premier professional meeting focused on the science of flavor. Flavour Science, an extensive review of the most recent symposium, presents the latest in flavor research, enriching the chemistry-based vision of most flavorists and flavor chemists with understanding from a broad range of fields, including human physiology, ethology, psychophysics, genetics, bioinformatics or metabolomics. This book is ideal for all flavor scientists, food chemists and sensory scientists and has a strong audience among enologists as well.

  • Chronobiology: Biological Timing in Health and Disease

    • 1st Edition
    • Volume 119
    • English
    This special volume of Progress in Molecular Biology and Translational Science focuses on chronobiology.

  • New Light on Alkaloid Biosynthesis and Future Prospects

    • 1st Edition
    • Volume 68
    • English
    Advances in Botanical Research publishes in-depth and up-to-date reviews on a wide range of topics in plant sciences. Currently in its 68th volume, the series features varied reviews by recognized experts on all aspects of plant genetics, biochemistry, cell biology, molecular biology, physiology and ecology. This thematic volume features reviews on a new light on alkaloid biosynthesis and future prospects.

  • Nutrition and Enhanced Sports Performance

    Muscle Building, Endurance, and Strength
    • 1st Edition
    • Debasis Bagchi + 2 more
    • English
    Nutrition and Enhanced Sports Performance: Muscle Building, Endurance, and Strength provides a comprehensive overview to understanding the integrated impact of nutrition on performance. The book is divided into five main themes: An introductory overview of the role of nutrition in human health Various types of physical exercises, including cardiovascular training, resistance training, aerobic and anaerobic exercise, bioenergetics, and energy balance. This section also covers the nutritional requirements associated with various fitness programs, as well as exercise and nutritional requirements in special populations, including the pre-pubertal, young, elderly, and disabled. Sports and nutritional requirements. The molecular mechanisms involved in muscle building A thorough review of various food, minerals, supplements, phytochemicals, amino acids, transition metals, small molecules and other ergogenic agents that have been implicated in muscle building and human performance This book is an ideal resource for nutritionists, dietitians, exercise physiologists, health practitioners, researchers, students, athletes, trainers, and all those who wish to broaden their knowledge of nutrition and its role in human performance.

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