Nanotechnology for Drug Delivery and Pharmaceuticals

1st Edition - January 10, 2023
Editors: Ravindra Pratap Singh, Kshitij RB Singh, Jay Singh, Charles Oluwaseun Adetunji
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 9 5 3 2 5 - 2
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 5 3 2 6 - 9

Nanotechnology for Drug Delivery and Pharmaceutical Sciences presents various drug-delivery techniques that utilize nanotechnology for the biomedical domain, highlighting both ther… Read more

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Nanotechnology for Drug Delivery and Pharmaceutical Sciences presents various drug-delivery techniques that utilize nanotechnology for the biomedical domain, highlighting both therapeutic and diagnostic applications. The book provides important facts and detailed studies on different promising nanocarriers like liposomes, exosomes and virus-based nanocarriers. Moreover, it explores these nanocarriers' utilization in the therapeutic applications of various diseases such as cancer, inflammation, neurodegenerative disorders like Huntington’s disease, Alzheimer's disease, human immunodeficiency virus (HIV), and inflammatory bowel disease. In addition, the book describes how nanotechnology has efficiently overtaken conventional dosage forms and provided comfort and ease to patients.

Relevant information regarding market trends, patents and social-economic factors are also provided, making this the perfect reference for doctors, researchers and scientists working in the fields of medicine, biochemistry, biotechnology, nanobiotechnology and the pharmaceutical sciences.

Cover Image
Title page
Table of Contents
Copyright
Dedication
List of contributors
About the editors
Preface
Acknowledgments
Section 1: Targeted drug delivery
Chapter 1. Introduction to drug-delivery techniques based on nanotechnological approaches
Abstract
Introduction
Synthesis of nanocarriers and nanomedicines for targeted drug delivery
Utility of nanocarriers
Utility of nanomedicines
Targeted drug delivery
Pros of nano-based targeted drug delivery
Toxicity of nanomaterials used for targeted drug delivery applications
Conclusion
References
Chapter 2. Methods of fabricating various nanocarriers for targeted drug delivery
Abstract
Introduction
Various nanocarriers for drug delivery
Fabrication methods/formulation method of nanocarriers
Conclusion and prospects
References
Chapter 3. Biologically synthesized nanocarriers for targeted drug delivery applications
Abstract
Introduction
Biogenic nanocarriers employed in drug delivery
Physicochemical properties of nanocarriers for their use in targeted drug delivery systems
Plant protein–based nanocarriers for targeted drug delivery system
Smart nanocarriers in clinical interventions and translation for targeted therapies or disease treatments
Conclusions and future prospects
References
Chapter 4. Nanomedicine and nanocarriers for cancer treatment
Abstract
Introduction
Nanotechnology in cancer therapy
Nanomedicines for cancer treatment
Nanotechnology to nanomedicine
Emerging vaccine nanotechnology
Enhancing drug delivery to the tumor
Principles involved in the development of nanomedicine
Opportunities: advanced functionalities
Tumor targeting via enhanced permeability and retention
Passive targeting or physical targeting
Active targeting
Stimuli-responsive systems/triggered release
Internally responsive drug delivery
Externally responsive drug delivery
Multifunctionality/theranostics
Antibody-mediated targeting
Antiangiogenesis
Nanomedicine in cancer treatment
Viral nanoparticles for cancer therapy
Organic nanocarriers for cancer therapy
Drug conjugates
Lipid-based nanocarriers
Polymer-based nanocarriers
Inorganic nanoparticles for cancer therapy
Porous inorganic nanomaterials
Combination therapy
Conclusion, challenges, and current limitations
Barriers in physicochemical studies
Safety concern
Regulatory issues
Scale-up and manufacturing issues
Immunological challenges of nanomedicines
References
Chapter 5. Role of nanocarriers for inflammation treatment
Abstract
Introduction
Overview of inflammatory conditions and treatments
Anti-inflammatory treatment with a nanoparticle-based drug delivery system
Treatment of inflammatory diseases using nanoparticles
Clinical trials
Future prospects and conclusions
Acknowledgment
References
Further reading
Chapter 6. Nanodiagnostics and nanomedicines for neurodegenerative disorders
Abstract
Introduction
Etiopathogenesis and pharmacology of neurodegenerative disorders
Nanodiagnostics and manomedicines for neurodegenerative diseases
Translational nanodiagnostics and nanomedicine-based products for neurodegenerative diseases
Conclusion
References
Chapter 7. Potentialities of nanomedicine and nanocarriers for infectious disease treatment
Abstract
Introduction
Different types of infectious diseases
Conventional versus modern approaches
Nanotechnology approaches against microbial resistance
Nanotechnology potential in drug delivery
Nanocarrier-mediated treatment strategies
Sustained systemic delivery
Targeted medication delivery through receptors (active) and stimuli
Local delivery
Strategies used to treat infectious diseases
Antibacterial nanoparticles against planktonic bacteria
Antibacterial nanoparticles against biofilm bacteria
Antibacterial nanoparticles against intracellular bacteria
Animal-based evaluation of antibacterial nanoparticles
Virus-based nanoparticles
Nanoparticles derived from fungal pathogens
Nanoparticles mimicking mammalian cells
Conclusion and perspectives
Acknowledgments
References
Chapter 8. Recent plant-based nanomedicine and nanocarrier for cancer treatment
Abstract
Introduction
Advancement in plant-based nanocarrier systems for cancer treatment
Different plant-based nanocarrier systems for the treatment of cancer
Plant-based compounds used in cancer therapy
Future prospects and barriers of nanomaterials for cancer therapy
Conclusion
Acknowledgment
References
Chapter 9. Utility of nanomedicine and nanocarriers for noninfectious disease treatment
Abstract
Introduction
Chemistry and mechanism of action for nanomedicine and nanocarriers for noninfectious disease treatment
Nanotechnology in central nervous system diseases
Nanotherapies for central nervous system disease
Nanotechnology in diabetes
Nanotechnology in respiratory diseases
Nanomaterials in treatment of autoimmune diseases
Nanocarriers for targeted therapy in cancer treatment
The application of nanomaterials in vaccine design including COVID-19 vaccines
Conclusion and prospects
Acknowledgment
References
Chapter 10. Passive and active targeted drug delivery strategies
Abstract
Introduction
Passive targeted drug delivery
Physiochemical properties of nanocarriers
Active targeted drug delivery
Conclusion
References
Chapter 11. Utility of various drug delivery systems and their advantages and disadvantages
Abstract
Introduction
Nanoparticles as therapeutic administration platforms
Comparison of Various Nanocarrier Systems
Classification on the basis of administration routes
Hazards of nanomedicines
Future tendencies for nanocarriers in drug distribution
Conclusion
References
Chapter 12. Clinical applications and future clinical trials of the drug delivery system
Abstract
Introduction
Clinical applications
Transdermal patches
Pulmonary drug delivery systems
Implantable systems
Future clinical trials
Conclusion
References
Chapter 13. Advantages of nanodrug targeting than conventional dosage system
Abstract
Introduction
Administration of drugs
Conventional dosage systems
Drug delivery systems
Smart drug delivery systems
Polymers
Porous nanostructures
Graphene–quantum dots
Therapeutic proteins delivery
Advantages of the drug delivery systems
Drug delivery systems evolution to micro/nanorobots
Conclusion
Future of nanomedicine and drug delivery systems
References
Chapter 14. Risk assessment of various nanomaterials: health safety perspective
Abstract
Introduction
Exposure assessment to nanoparticles
Risk characterization of nanoparticles in suspension
Nonspecific measure
Specific measure
Nanotoxicity toward bacteria
Associated health risks
Ecotoxicity
Regulation and challenges
Conclusion and future perspectives
Acknowledgment
References
Section 2: Pharmaceuticals
Chapter 15. Introduction to nanotechnological utility in the pharmaceutical industry
Abstract
Introduction
Nanotechnological utility in the pharmaceutical industry
Recent developments in the pharmaceutical industry
Role of pharmaceutical nanoparticles
Advantages
Disadvantages
Synthesis
Patents and market trends of nano-based pharmaceutical products
Safety and legal factors
Conclusion and prospects
References
Chapter 16. Recent development in the pharmaceutical industries
Abstract
Introduction
Development of new drugs
Development of drug delivery systems
Development of drug carrier systems
Oral delivery
Gene therapeutics
Tissue engineering: the development of a novel composite bone substitute
Recent nanocarrier approaches for targeted drug delivery in cancer therapy
Conclusion
References
Chapter 17. Strategies to synthesize, advantages, and disadvantages of pharmaceutical nanoparticles
Abstract
Introduction
Pharmaceutical nanoparticles-based drug designing and drug delivery process and mechanism
Synthesis of pharmaceutical nanomaterials, advantages, and disadvantages
Applications of pharmaceutical nanoparticles
The role of pharmaceutical nanoparticles in drug delivery formulations
Features of pharmaceutical nanoparticles-based drug delivery
Conclusion
References
Chapter 18. Recent patents and market trends of nano-based pharmaceutical products
Abstract
Introduction
Patent analysis
Technology domain distributions
Market trends and future perspectives
Acknowledgments
References
Chapter 19. Perspectives, safety issues, and legal factors of nano-based materials utility in pharmaceutical applications
Abstract
Introduction
Figure and facts of nanomedicine market
Nanodrug design and therapeutics
Nanomedicines in pharmaceutical industries
Safety issues related to nanomedicines
Perspectives
Conclusion
Acknowledgment
References
Index

Ravindra Pratap Singh

Dr. Singh received his B. Sc. from Allahabad University India and his M.Sc and Ph.D. in Biochemistry from Lucknow University, India. He is currently working as an Assistant Professor in the Department of Biotechnology, Indira Gandhi National Tribal University, India. His work and research interests include biochemistry, biosensors, nanobiotechnology, electrochemistry, material sciences, and biosensors applications in biomedical, environmental, agricultural and forensics sciences.

Affiliations and expertise

Assistant Professor in the Department of Biotechnology, Indira Gandhi National Tribal University, India

Kshitij RB Singh

Kshitij RB Singh obtained his MSc in Biotechnology from Indira Gandhi National Tribal University, India. Currently, he is a doctoral student in the laboratory of Professor Shyam S. Pandey at the Department of Life Science and Systems Engineering, Kyushu Institute of Technology, Japan. His research interests encompass a range of fields, including biotechnology, biochemistry, nanotechnology, nanobiotechnology, biosensors, and materials sciences.

Affiliations and expertise

Research Scholar at the Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, Fukuoka, Japan.

Jay Singh

Dr. Jay is an Assistant Professor at the Department of Chemistry, Institute of Sciences, Banaras Hindu University, India, since 2017. He received his Ph.D. degree in Polymer Science from Motilal Nehru National Institute of Technology in 2010 and did MSc and BSc from Allahabad University, India. He is actively engaged in the development of nanomaterials (CeO2, NiO, rare-earth metal oxide, Ni, Nife2O4, Cu2O, Graphene, RGO etc.), based nanobiocomposite, conducting polymer and self-assembled monolayers based clinically important biosensors for estimation of bioanalaytes such as cholesterol, xanthine, glucose, pathogens and pesticides/toxins using DNA and antibodies. He is actively engaged in fabricating metal oxide-based biosensors for clinical diagnosis, food packaging applications, drug delivery, and tissue engineering applications.

Affiliations and expertise

Assistant Professor at the Department of Chemistry, Institute of Sciences, Banaras Hindu University, India

Charles Oluwaseun Adetunji

Prof. Charles Oluwaseun Adetunji is a full Professor at the Department of Microbiology, Faculty of Sciences and the Director of Research and Innovation, Edo State University Uzairue (EDSU), Edo State, Nigeria. He formerly served as the Acting Director of Intellectual Property and Technology Transfer, Head of the Department of Microbiology, and Sub Dean of the Faculty of Science. Currently, he holds the positions of Chairman of the Grant Committee and Dean of the Faculty of Science at EDSU.

Prof. Adetunji is a Fellow of the Royal Society of Biology in the UK. Additionally, he serves as a Visiting Professor and the Executive Director of the Center for Biotechnology at Precious Cornerstone University, Nigeria. His research centers on applying biological techniques and microbial bioprocesses to achieve Sustainable Development Goals (SDGs) and contribute to advancements in agriculture.

Affiliations and expertise

Full Professor and Lecturer in the Microbiology Department at Faculty of Sciences, Edo State University Uzairue (EDSU), Nigeria

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Nanotechnology for Drug Delivery and Pharmaceuticals

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Ravindra Pratap Singh

Kshitij RB Singh

Jay Singh

Charles Oluwaseun Adetunji