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2nd Edition - October 27, 2023
Editors: William B. Coleman, Gregory J. Tsongalis
Diagnostic Molecular Pathology: A Guide to Applied Molecular Testing, Second Edition assembles a group of experts to discuss the molecular basis and mechanisms of major human… Read more
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Section 1 – Introduction to Molecular Testing
1. Introduction to Molecular Testing in Human Disease
William B. Coleman, Ph.D., and Gregory J. Tsongalis, Ph.D.
2. The Polymerase Chain Reaction and Other Amplification Methodologies
William B. Coleman, Ph.D., and Gregory J. Tsongalis, Ph.D.
3. Whole-exome and Whole Genome Sequencing in the Molecular Diagnostic Laboratory
Wahab A. Khan, Ph.D.
4. Long-read Sequencing
Robert Hamilton, M.D., and Samantha Stephen, D.O.
Section 2 – Molecular Testing in Infectious Disease
5. Molecular Testing for Human Immunodeficiency Virus
Thomas Bourlet, Pharm.D., Ph.D., Sylvie Pillet, Pharm.D., Ph.D., Meriam Memmi, Ph.D., and Bruno Pozzetto, M.D., Ph.D.
6. Molecular Testing in Hepatitis Virus-related Disease
Patricia M. Mulrooney-Cousins, Ph.D., and Tomasz I. Michalak, M.D., Ph.D.
7. Molecular Testing for Human Papilloma Viruses
Katie M. Bennett, Ph.D.
8. Molecular Testing for Parvoviruses
Giorgio Gallinella, M.D., Ph.D.
9. Molecular Testing for Polyomaviruses
Gary W. Procop, M.D. and Belinda Yen-Lieberman, Ph.D.
10. Molecular Testing for Respiratory Viruses
Margaret V. Powers-Fletcher, Ph.D. and Eleanor A. Powell, Ph.D.
11. Molecular Testing for Diseases Associated with Bacterial Infection
Cecilia M. Thompson, Ph.D.
12. Agents Associated with Sexually-transmitted Infections
Paul O. Verhoeven, M.D., Ph.D., Sylvie Gonzalo, Meriam Memmi, Ph.D., Bruno Pozzetto, M.D., Ph.D., and Florence Grattard
13. Molecular Methods for Healthcare-Acquired Infections
Zachary Yetmar, M.D., and Elena Beam, M.D.
14. Molecular Testing in Emerging Infectious Diseases
Jianli Dong, M.D., Ph.D., Nahed Ismail, M.D., Ph.D., Eric Fitts, M.D., and David H. Walker, M.D.
15. Molecular and Serological Testing in the Setting of a Global Pandemic
Max Weidmann, M.D., Ph.D., Alex J. Rai, Ph.D., M. Shaheen Malick, M. Shaheen Malick, M.D., Anjali Saqi, MD, MBA, Matthias J. Szabolcs, M.D., Susan Hsiao, M.D., Ph.D., and Helen Fernandes, Ph.D.
Section 3 – Molecular Testing in Genetic Disease
16. Non-invasive Prenatal Screening (NIPS) for Fetal Aneuploidies
Linda Hasadsri, M.D., Ph.D. and Megan A. Allyse, Ph.D.
17. Molecular Testing in Cardiomyopathies
Heather McLaughlin, Ph.D., and Matteo Vatta, Ph.D.
18. Molecular Diagnostics for Coagulopathies
Matthew Smolkin, M.D. and Aaron Shmooker, M.D.
19. Molecular Diagnosis of Cystic Fibrosis
Makenzie L. Fulmer, Ph.D., Yue Si, M.D., Ph.D., and D. Hunter Best, Ph.D.
20. Molecular Testing in Hemochromatosis
Alberto Piperno, M.D.
21. Molecular Testing for Spinal Muscular Atrophy
Diana M. Toledo, Ph.D.
22. Molecular Testing for Autism Spectrum Disorders
Bridget A. Fernandez, M.D., Christian Marshall, Ph.D., Jacob A.S. Vorstman, M.D., Ph.D., and Stephen W. Scherer, Ph.D., D.Sc.,
Section 4 – Molecular Testing in Oncology
23. Molecular Testing in Breast Cancer
Kimberly H. Allison, M.D.
24. Molecular Testing in Lung Cancer
Carolyn J Shiau, M.D., and Ming-Sound Tsao, M.D.
25. Molecular Testing in Colorectal Cancer
Jessica S. Thomas, M.D., Ph.D, M.P.H. and Chanjuan Shi, M.D., Ph.D.
26. Molecular Pathology and Testing in Melanocytic Tumors
Aravindhan Sriharan, M.D.
27. Molecular Testing for Glioblastoma
Dimitri G. Trembath, M.D. (Confirmed)
28. Molecular Testing in Pancreatic Cancer
Neil Sood, M.D., Saraswathi Cappelle, D.O., Massimo Raimondo, M.D., and Michael J. Bartel, M.D., Ph.D.
29. Molecular Testing in Gynecologic Cancer
Sarah E. Kerr, M.D. and Maryam Shahi, M.D.
30. The Emerging Genetic Landscape in Renal Cell Carcinoma
Grace Lee, M.D, Brian M. Shinder, M.D., Evita Sadimin, M.D., Ryan D. Stephenson, D.O., and Eric A. Singer, M.D.
31. Molecular Testing in Thyroid Cancer
John M. Skaugen, M.D. and Yuri E. Nikiforov, M.D., Ph.D.
32. Molecular Testing for Pediatric Cancers
Kristy R. Cooks, Ph.D. and Stephen J. Wicks, Ph.D.
33. Molecular Pathogenesis of Soft Tissue and Bone Tumors
Ourania Parra, M.D., and Konstantinos Linos, M.D.
34. Molecular Pathology of Gastrointestinal Stromal Tumors
Julianna Andrici, M.B.B.S., Ph.D.
35. Molecular Pathology of Liver Cancer
Juliana Andrici, M.B.B.S, Ph.D., and Arief A. Suriawinata, M.D.
Section 5 – Molecular Testing in Hematopathology
36. Molecular Testing in Myeloproliferative Neoplasms
Larissa V. Furtado, M.D., Noah A. Brown, M.D., and Bryan L. Betz, Ph.D.
37. Molecular Testing in Myelodysplastic Syndromes
Noah A. Brown, M.D., and Bryan Betz, Ph.D.
38. Molecular Testing in Acute Myeloid Leukemia
Amir Behdad, M.D., and Bryan Betz, Ph.D.
39. Molecular Testing in the Assessment of Bone Marrow Transplant Engraftment
Jessica K. Booker, Ph.D.
Section 6 – Molecular Testing in Personalized Medicine
40. Pharmacogenomics in Cardiovascular Disease
Richard M. Turner, Ph.D., and Munir Pirmohamed, Ph.D.
41. Personalized Medicine for Disorders of Hemostasis and Thrombosis
Deborah L. Ornstein, M.D,
42. Personalized Medicine in Cancer Treatment
Victoria M. Pratt, Ph.D., and Stuart A. Scott, Ph.D.
Section 7 – The Future of Molecular Testing
43. Imaging Mass Spectroscopy in Clinical Pathology
Jeremy L. Norris, Ph.D., Danielle B. Gutierrez, Ph.D., Nathan Heath Patterson, Ph.D., and Richard M. Caprioli, Ph.D.
44. Artificial Intelligence and Deep Learning in Molecular Testing
Joshua J. Levy, Ph.D., and Louis J. Vaickus, M.D., Ph.D.
45. Nanotechnology in Molecular Diagnostics
Amogha Tadimety, Ph.D., John H. Molinski, M.Sc., and John X.J. Zhang, Ph.D.
46. Chip-based Nanotechnology in the Molecular Pathology Laboratory and Beyond
Lars B. Laurentius, Ph.D., Eamonn Clarke, Christopher Lambert, M.S., Dhruv Patel, M.S., Tawsif Mahmood, M.S., Ling Zang, Ph.D., Himanshu Sant, Ph.D., Bruce K. Gale, Ph.D., and Marc D. Porter, Ph.D.
47. Translational and Clinical Applications of the GeoMx® Digital Spatial Profiling Platform
Sarah E. Church, Ph.D., Jessica Perez, Ph.D., Breana Murphy, M.B.A., Hiromi Sato, Sarah Warren, Ph.D., and Joseph M. Beechem, Ph.D.
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