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Elsevier

Books in Life sciences

  • Unity and Diversity in Biochemistry

    An Introduction to Chemical Biology
    • 1st Edition
    • Marcel Florkin
    • P. Alexander + 1 more
    • English
    International Series of Monographs on Pure and Applied Biology, Volume 1: Unity and Diversity in Biochemistry focuses on the advancements of processes, techniques, methodologies, and approaches involved in biochemistry. The publication first offers information on the constituents of the biosphere, modes of linkage by covalent bonds and macromolecules, general principles of biochemical energetics, and enzymes. The text then examines the destructive and non-destructive methods in modern biochemistry, priming reactions, and biosynthesis. Discussions focus on the mechanisms for the breakdown of amino acids, glycolysis and the hexosemonophosphate shunt, interrelations between priming reactions, respiratory chains, biochemical investigation and use of isotopes, and use of mutant strains micro-organisms. The manuscript takes a look at cellular topochemistry and regulation, aspects of biochemical diversity, inheritance of biochemical characteristics, and biochemical evolution. Topics include evolution of biochemical systems and constituents, control of biochemical characteristics by genes, biochemical differentiation of cells in a single organism, and factors which determine the velocity and path of enzymatic reaction chains. The selection is a dependable source of data for biochemists and readers interested in the different aspects of biochemistry.

  • Speech Motor Control

    Proceedings of an International Symposium on Speech Motor Control, Held at the Wenner-Gren Center, Stockholm, May 11 and 12, 1981
    • 1st Edition
    • Sten E. Grillner + 2 more
    • English
    Wenner-Gren Center International Symposium Series, Volume 36: Speech Motor Control covers the papers presented at an interdisciplinary conference on Speech Motor Control, held at the Wenner-Gren Center in Stockholm on May 11 to 12, 1981. The book focuses on the methodologies, approaches, processes, and techniques employed in speech motor control. The selection first offers information on the interdisciplinary challenge of speech motor control and analogies between central motor programs for speech and for limb movements. Discussions focus on regulation of cerebral motor cortex output by afferent input, goal-orientation and voluntary movement, interaction of transcortical and segmental reflexes, plasticity of speech gestures, and the task of the speech motor system. The text then takes a look at speech production mechanisms in aphasia and functional landscapes in the cerebral cortex related to speech, as well as motor errors and phonetic transcription studies and correlational analysis of consonant preferences in infants, languages, and aphasic errors. The publication ponders on functional landscapes in the cerebral cortex related to speech; comment on the partial roles of the cerebral hemispheres for speech; and speech breathing kinematics and mechanism inferences. The text also ponders on the aspects of voice production and motor control, vocal fold kinesiology, and oral mechanoreceptors. The text is a dependable reference for readers interested in speech motor control.

  • Omega-3 Fatty Acids in Brain and Neurological Health

    • 1st Edition
    • Ronald Ross Watson
    • English
    Research has clearly established a link between omega-3 fatty acids and general health, particularly cardiovascular health. Omega-3 Fatty Acids in Brain and Neurological Health is the first book to focus exclusively on the role of omega-3 fatty acids on general brain health. The articles in this collection illustrate omega-3 fatty acids' importance in longevity, cognitive impairment, and structure and function of the brain's neurons. Research has established links between omega-3 fatty acids and the developing brain, aging, dementia, Alzheimer's disease and multiple sclerosis. This book encompasses some of the most recent research, including the role of omega-3 fatty acid supplements on hippocampal neurogenesis, substantia nigra modulation, migraine headaches, the developing brain in animals, sleep, and neurodegenerative diseases. This collection helps to push research forward toward a complete understanding of omega-3 fatty acids' relationship to brain and neurological health.

  • Quantitative Imaging in Cell Biology

    • 1st Edition
    • Volume 123
    • English
    This new volume, number 123, of Methods in Cell Biology looks at methods for quantitative imaging in cell biology. It covers both theoretical and practical aspects of using optical fluorescence microscopy and image analysis techniques for quantitative applications. The introductory chapters cover fundamental concepts and techniques important for obtaining accurate and precise quantitative data from imaging systems. These chapters address how choice of microscope, fluorophores, and digital detector impact the quality of quantitative data, and include step-by-step protocols for capturing and analyzing quantitative images. Common quantitative applications, including co-localization, ratiometric imaging, and counting molecules, are covered in detail. Practical chapters cover topics critical to getting the most out of your imaging system, from microscope maintenance to creating standardized samples for measuring resolution. Later chapters cover recent advances in quantitative imaging techniques, including super-resolution and light sheet microscopy. With cutting-edge material, this comprehensive collection is intended to guide researchers for years to come.

  • Applied Dermatotoxicology

    Clinical Aspects
    • 1st Edition
    • Howard I. Maibach + 1 more
    • English
    Applied Dermatotoxicology: Clinical Aspects provides concise, systematic, and state-of-the-art information on the toxicological effects of substances on skin, and recent advances in dermal toxicity testing. This book specifically addresses the clinical presentations borne out of exposure to a variety of chemicals. It begins with an overview of skin biology to provide toxicologists with a basic understanding of its anatomy and physiology. Next it presents a variety of dermatotoxicological effects, as well at the toxic agents that cause them, with color photographs to illustrate these effects. Applied Dermatotoxicology: Clinical Aspects is an essential reference for toxicologists in industry, and for those medical professionals who encounter cases of dermal exposure to toxic agents.

  • International Review of Cell and Molecular Biology

    • 1st Edition
    • Volume 311
    • Kwang W. Jeon
    • English
    International Review of Cell and Molecular Biology presents comprehensive reviews and current advances in cell and molecular biology. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. The series has a world-wide readership, maintaining a high standard by publishing invited articles on important and timely topics authored by prominent cell and molecular biologists. Impact factor for 2012: 4.973.

  • Transgenic Animal Technology

    A Laboratory Handbook
    • 3rd Edition
    • Carl A. Pinkert
    • English
    Transgenic animal technologies and the ability to introduce functional genes into animals have revolutionized our ability to address complex biomedical and biological questions. This well-illustrated handbook covers the technical aspects of gene transfer — from molecular methods to whole animal considerations — for important laboratory and domestic animal species. It describes methodologies as employed by leading laboratories and is a key resource for researchers, as well as a tool for training technicians and students. This second edition incorporates updates on a variety of genetic engineering technologies ranging from microinjection and ES cell transfer to nuclear transfer in a broad range of animal modeling systems.

  • Introductory Immunology

    Basic Concepts for Interdisciplinary Applications
    • 1st Edition
    • Jeffrey K. Actor
    • English
    Introductory Immunology quickly acquaints readers with natural immune responses manifesting in diseases and disorders. The book presents a complete picture of natural defenses to infectious agents, as well as the mechanisms that lead to autoimmune dysfunction. In addition, it examines immunologically based diseases, giving the reader sufficient knowledge to make sound clinical decisions leading to better treatment outcomes. Introductory Immunology is aimed at researchers, postgraduates, or any scientifically inclined reader interested in immunology. No prior expertise in medical, biochemical, or cellular science is needed to benefit from the clear presentation of immunology concepts in this book.

  • The Molecular Genetics of Floral Transition and Flower Development

    • 1st Edition
    • Volume 72
    • English
    Advances in Botanical Research publishes in-depth and up-to-date reviews on a wide range of topics in plant sciences. Currently in its 72nd volume, the series features several reviews by recognized experts on all aspects of plant genetics, biochemistry, cell biology, molecular biology, physiology and ecology. This thematic volume features reviews on the molecular genetics of floral transition and flower development.

  • Pharmacology and Therapeutics of Constitutively Active Receptors

    • 1st Edition
    • Volume 70
    • Ya-Xiong Tao
    • English
    Volume 70 of Advances in Pharmacology presents the pharmacology and therapeutics of constitutively active receptors. With a variety of chapters and the best authors in the field, the volume is an essential resource for pharmacologists, immunologists, and biochemists alike. Advances in Pharmacology provides a rich collection of reviews on timely topics. The series places emphasis on the molecular bases of drug action, both applied and experimental.

  • Integrative Cardiovascular Chinese Medicine

    A Prevention and Personalized Medicine Perspective
    • 1st Edition
    • Anika Niambi Al-Shura
    • English
    Combining the research and study of integrative Chinese and Western Medicine, Integrative Cardiovascular Chinese Medicine: A Prevention and Personalized Medicine Perspective presents a clear, structured base to guide clinical practice and encourage collaboration between Chinese medicine and Western medicine practitioners. This complete reference work thoroughly covers the pathophysiology of cardiology-related diseases, and compares, juxtaposes, and integrates Western and traditional Chinese medicine (TCM). Anika Niambi Al-Shura provides a realistic scope of cardiology treatment and the integration of Western and Chinese medicine, establishing a basis for standardization and a rationale for the inclusion of TCM in cardiology, and identifying and inspiring ideas for future research.

  • Advances in Parasitology

    • 1st Edition
    • Volume 85
    • English
    First published in 1963, Advances in Parasitology contains comprehensive and up-to-date reviews in all areas of interest in contemporary parasitology. Advances in Parasitology includes medical studies on parasites of major influence, such as Plasmodium falciparum and trypanosomes. The series also contains reviews of more traditional areas, such as zoology, taxonomy, and life history, which shape current thinking and applications. Eclectic volumes are supplemented by thematic volumes on various topics, including control of human parasitic diseases and global mapping of infectious diseases. The 2012 impact factor is 3.778.

  • Cell-wide Metabolic Alterations Associated with Malignancy

    • 1st Edition
    • Volume 543
    • English
    This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods providing a a theoretical overview on metabolic alterations of cancer cells and a series of protocols that can be employed to study oncometabolism, in vitro, ex vivo and in vivo. Malignant cells exhibit metabolic changes when compared to their normal counterparts, owing to both genetic and epigenetic alterations. Although such a metabolic rewiring has recently been indicated as "yet another" general hallmark of cancer, accumulating evidence suggests that the metabolic alterations of each neoplasm rather represent a molecular signature that intimately accompanies, and hence cannot be severed from, all facets of malignant transformation.

  • Cellular and Molecular Immunology

    • 8th Edition
    • Abul K. Abbas + 2 more
    • English
    Popular for its highly visual, straightforward approach, Cellular and Molecular Immunology delivers an accessible yet thorough understanding of this active and fast-changing field. Drs. Abul K. Abbas, Andrew H. Lichtman, and Shiv Pillai present key updates in this new edition to cover the latest developments in antigen receptors and signal transduction in immune cells, mucosal and skin immunity, cytokines, leukocyte-endothelia... interaction, and more. With additional online features, this is an ideal resource for medical, graduate and undergraduate students of immunology who need a clear, introductory text for immunology courses.

  • Cerebellar Learning

    • 1st Edition
    • Volume 210
    • English
    Progress in Brain Research is the most acclaimed and accomplished series in neuroscience, firmly established as an extensive documentation of the advances in contemporary brain research. The volumes, some of which are derived from important international symposia, contain authoritative reviews and original articles by invited specialists. The rigorous editing of the volumes assures that they will appeal to all laboratory and clinical brain research workers in the various disciplines: neuroanatomy, neurophysiology, neuropharmacology, neuroendocrinology, neuropathology, basic neurology, biological psychiatry, and the behavioral sciences. This volume, The Cerebellum and Memory Formation: Structure, Computation and Function, covers topics including feedback control of cerebellar learning; cortico-cerebellar organization and skill acquisition; cerebellar plasticity and learning in the oculomotor system, and more.

  • The Role of Chromosomes in Development

    • 1st Edition
    • Michael Locke
    • English
    The Role of Chromosomes in Development is a collection of papers that deals with structural patterns and functional organization of chromosomes. Some papers discuss chromosomal proteins, DNA replication sequences in higher animals, and the implications of localized DNA synthesis in polytene chromosomes. Several papers describe chromosomal RNA, nuclear RNA fractions, genetic control, and the regulation of developmental pathways. One paper concerns the "bithorax" series that controls the development of certain body segments of the fly in a polarized and coordinated manner reminiscent of the genes in the operons of microorganisms. The bithorax genes evidently exploit and amplify a gradient arising from an anteroposterior gradient during mitotic division rates. The bithorax genes produces a whole set of new substances that repress certain systems of cellular differentiation, letting other systems to emerge and develop. Another paper investigates the hypothesis of diploid subnuclei as the architectural subunit of the ciliate macronucleus, as well as the hypothesis of "allelic repression" as the basis for certain examples of subnuclear differentiation. The collection can prove beneficial for biochemists, micro-biologists, bio-physicists, cellular researchers, and academicians involved in the study of cellular biology.

  • Enzymes

    • 2nd Edition
    • Malcolm Dixon + 1 more
    • English
    Enzymes, Second Edition provides information pertinent to the developments in the field of enzymology. This book presents the properties of enzymes as chemical catalysts or simply as chemical substances. Organized into 13 chapters, this edition begins with an overview of the range of action or specificity of enzymes. This text then discusses the special techniques employed in the isolation of enzymes and explores the considerable progress in the study of the properties and functions of enzymes. Other chapters consider the mechanism of enzyme catalysis by more direct methods, including the use of isotopes. This book discusses as well the mechanism of the biosynthesis of enzymes and the means by which their chemical structure is determined by the genetic material of the chromosomes. The final chapter deals with the essential aspects of the enzymatic system linking energy-producing processes with energy-utilizing processes. This book is a valuable resource for biochemists, physical chemists, and research workers.

  • A Text-Book of Bacteriology

    • 9th Edition
    • R. W. Fairbrother + 1 more
    • English
    Fairbrother's Textbook of Bacteriology, Tenth Edition provides an outline of the medical aspects of bacteriology. This book emphasizes the biological relationship of allied organisms. This edition begins with an overview of the various elements of the bacterial cell in detail, starting with external features such as flagella and capsules, and working inwards to the cytoplasm. This text then describes the principal toxic effects of the different groups of anti-bacterial substances. Other chapters consider the relationship of the different types of hypersensitivity to classical immune responses. This book discusses as well the earliest application of a specific chemical substance to the treatment of microbial disease. This book is a valuable resource for medical students. Bacteriologists, chemists, pathologists, and microbiologists will also find this book useful.

  • Lymphokines

    A Forum for Immunoregulatory Cell Products
    • 1st Edition
    • Edgar Pick
    • English
    Lymphokines: A Forum for Immunoregulatory Cell Products deals with immunoregulatory cell products that produce lymphokines. Topics covered include the purification and characterization of transfer factor; activation of cytotoxicity and/or suppressor activity in murine macrophages by lymphokines, lipopolysaccharide, and polyinosinic-polycyt... acid; and the role of clotting processes in the action of lymphokines on macrophages. A comparison of the immune-modulating effects of interferon and interferon inducers is also presented. Comprised of 13 chapters, this volume begins with a discussion on transfer factor and its ability to react specifically with antigens. The clinical uses of transfer factor are considered with special emphasis on its value as a prophylactic agent. The reader is then introduced to the subject of T cell regulation of the immunoglobulin E (IgE) response via potentiating and suppressor lymphokines, together with the possible clinical application of IgE suppressive factors in the treatment of atopic diseases. Subsequent chapters examine the evidence in favor of the existence of T cell-derived polyclonal B cell activator (PBA) playing a role in both normal antibody responses and autoimmune diseases; the role of suppressor T cells and the associated lymphokines in contact sensitivity in mice; and lymphokine action on macrophages. The book also analyzes the genetics of the response of human and mouse cells to interferons. This monograph will be helpful to practitioners and researchers in the fields of microbiology and immunology.

  • Biomechanics and Related Bio-Engineering Topics

    Proceedings of a Symposium Held in Glasgow, September 1964
    • 1st Edition
    • R. M. Kenedi
    • English

  • Lipid Analysis

    Isolation, Separation, Identification and Structural Analysis of Lipids
    • 1st Edition
    • William W. Christie
    • English
    Lipid Analysis: Isolation, Separation, Identification, and Structural Analysis of Lipids focuses on the methods, principles, and approaches involved in the isolation, identification, separation, and structural analysis of lipids. The publication first elaborates on the structure, chemistry and occurrence of lipids, isolation of lipids from tissues, and chromatographic and spectroscopic analysis of lipids. Discussions focus on equipping a laboratory for lipid analysis, spectroscopy, chromatographic procedures, general principles of solvent extraction procedures, structural features of lipids important in analyses, simple and complex lipids, and fatty acids. The text then examines the preparation of volatile derivatives of lipids and analysis of fatty acids and simple lipid classes. Topics include alkyl diglycerides and neutral plasmalogens, analysis of the hydrolysis products of simple lipids, preparation of large quantities of pure fatty acids, physical characterization of fatty acids, location of double bonds in fatty acid chains, and saponification of lipids. The manuscript covers the analysis and radioassay of isotopically-labelle... lipids, enzymatic hydrolysis of lipids, and analysis of molecular species of lipids. The publication is a primary reference for researchers interested in lipid analysis.

  • The Composition, Structure and Reactivity of Proteins

    A Laboratory Manual of Analytical Methods of Protein Chemistry (Including Polypeptides)
    • 1st Edition
    • P. Alexander + 1 more
    • English

  • Biased Signaling in Physiology, Pharmacology and Therapeutics

    • 1st Edition
    • Brian J Arey
    • English
    Biased Signaling in Physiology, Pharmacology and Therapeutics is a unique and essential reference for the scientific community concerning how conformational-depen... activation is a common phenomenon across many classes of receptors or signaling molecules. It discusses the role of conformational dynamics in leading to signaling bias across different classes of receptors and signaling molecules. By providing a broader view of signaling bias, this resource helps to explain common mechanisms shared across receptor classes and how this can be utilized to elucidate their cellular activity and better understand their therapeutic potential. Written for both new and established scientists in pharmacology, cell biology, biochemistry, and signal transduction, as well as physicians, this book clearly illustrates how biased receptor signaling can be utilized to develop and understand complex pharmacology. Chapters are each focused on a specific class of receptor or other important topic and make use of real-world examples illustrating how the latest research in signal transduction has led to a better understanding of pharmacology and cell biology. This structure creates a basis for understanding that physiological signalling bias has been selected by nature in order to provide complex and tissue- specific biological responses in the face of limited receptors and signaling pathways. This book provides a framework to reveal that these physiological mechanisms are not restricted to one receptor type or family and thus presents receptor signaling from a newer, more global perspective.

  • Celiac Disease and Gluten

    Multidisciplinary Challenges and Opportunities
    • 1st Edition
    • Peter Koehler + 2 more
    • English
    Celiac Disease and Gluten: Multidisciplinary Challenges and Opportunities is a unique reference work—the first to integrate the insights of the causes and effects of celiac disease from the chemistry of reaction-causing foods to the diagnosis, pathogenesis, and symptoms that lead to proper diagnoses and treatment. With an estimated three million people in the United States alone affected by celiac disease, an autoimmune digestive disease, only five percent are properly diagnosed. Drawing on the connection between foods containing gluten and the resulting symptoms, this resource offers distinctive information that directly explores and links food science, medical diagnostics, and treatment information. A helpful tool for researchers and medical practitioners alike, Celiac Disease and Gluten: Multidisciplinary Challenges and Opportunities helps refine research targets, and provides a comprehensive overview on the multidisciplinary approaches to all crucial aspects related to celiac disease.

  • Mouse Models of the Nuclear Envelopathies and Related Diseases

    • 1st Edition
    • Volume 109
    • English
    Volume 109 of Current Topics in Developmental Biology covers mouse models of the nuclear envelopathies and related diseases, with contributions from an international board of authors. The chapters provide a comprehensive set of reviews covering such topics as mouse models neurodegenerative diseases including Parkinson’s and dystonia, muscle ageing and sarcopenia, cardiac failure and repair, ageing and prospects lifespan extension, lipodystrophy and the significance in fat regulation, also identifying developmental mutations in mammals and nuclear envelope and LINC complex in disease.

  • Joint Replacement Technology

    • 2nd Edition
    • Peter A. Revell
    • English
    This second edition of Joint Replacement Technology provides a thoroughly updated review of recent developments in joint replacement technology. Joint replacement is a standard treatment for joint degradation and has improved the quality of life of millions of patients. Collaboration between clinicians and researchers is critical to its continued success and to meet the rising expectations of patients and surgeons. Part one introduces the advances in joint replacement technology, tribological considerations and experiments, and immune and regenerative responses to joint replacements. Part two covers the materials and techniques used in joint replacement. The advantages and disadvantages of different metals are explained here, as well as the use of ceramics. This section also addresses challenges in joint bearing surfaces, design, and cementless fixation techniques. Biological and mechanical issues are considered in part three, including healing responses to implants and biological causes of prosthetic joint failure, and a new chapter on imaging of joint prostheses. Each chapter in part four describes the clinical challenges of replacing specific joints, with specific focus on hip, knee, intervertebral disc joint, shoulder arthroplasty, elbow arthroplasty, and pyrocarbon small joint arthroplasty. Thanks to its widespread collaboration and international contributors, Joint Replacement Technology is useful for materials scientists and engineers in both academia and biomedical industry. Chemists, clinicians, and other researchers in this area will also find it invaluable.

  • The Stimulated Brain

    Cognitive Enhancement Using Non-Invasive Brain Stimulation
    • 1st Edition
    • Roi Cohen Kadosh
    • English
    The Stimulated Brain—which garnered an Honorable Mention for Biomedicine & Neuroscience at the 2015 PROSE Awards from the Association of American Publishers—presents the first integration of findings on brain stimulation from different research fields with a primary focus on Transcranial Electrical Stimulation (tES), one of the most frequently used noninvasive stimulation methods. The last decade has witnessed a significant increase in the amount of research exploring how noninvasive brain stimulation can not only modulate but also enhance cognition and brain functions. However, although Transcranial Magnetic Stimulation (TMS) and particularly tES have the potential to become more widely applicable techniques (as they come with none of the risks associated with deep brain stimulation) the reference literature on these neurotechnologies has been sparse. This resource provides a broad survey of current knowledge, and also marks future directions in cognitive and neuro-enhancement. It expands our understanding of basic research findings from animals and humans, including clear translational benefits for applied research and the therapeutic use of noninvasive brain stimulation methods. The book's coverage includes a primer that paves the way to a more advanced knowledge of tES and its physiological basis; current research findings on cognitive and neuro-enhancement in animals and typical and atypical human populations, such as neurological patients; and discussions of future directions, including specific neuroethical issues and pathways for collaboration and entrepreneurialism. The Stimulated Brain is the first book to provide a comprehensive understanding of different aspects of noninvasive brain stimulation that are critical for scientists, clinicians, and those who are interested in “stimulating their minds” by exploring this fascinating field of research.

  • Wine Science

    Principles and Applications
    • 4th Edition
    • Ronald S. Jackson
    • English
    Wine Science, Fourth Edition, covers the three pillars of wine science: grape culture, wine production, and sensory evaluation. It discusses grape anatomy, physiology and evolution, wine geography, wine and health, and the scientific basis of food and wine combinations. It also covers topics not found in other enology or viticulture texts, including details on cork and oak, specialized wine making procedures, and historical origins of procedures. New to this edition are expanded coverage on micro-oxidation and the cool prefermentative maceration of red grapes; the nature of the weak fixation of aromatic compounds in wine – and the significance of their release upon bottle opening; new insights into flavor modification post bottle; the shelf-life of wine as part of wine aging; and winery wastewater management. Updated topics include precision viticulture, including GPS potentialities, organic matter in soil, grapevine pests and disease, and the history of wine production technology. This book is a valuable resource for grape growers, fermentation technologists; students of enology and viticulture, enologists, and viticulturalists.

  • Advances in Cancer Research

    • 1st Edition
    • Volume 121
    • Kenneth D. Tew + 1 more
    • English
    Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics.

  • Processing and Impact on Active Components in Food

    • 1st Edition
    • Victor R. Preedy
    • English
    From beef to baked goods, fish to flour, antioxidants are added to preserve the shelf life of foods and ensure consumer acceptability. These production-added components may also contribute to the overall availability of essential nutrients for intake as well as the prevention of the development of unwelcome product characteristics such as off-flavours or colours. However, there are processes that reduce the amount of naturally occurring antioxidants and awareness of that potential is just as important for those in product research and development. There is a practical need to understand not only the physiological importance of antioxidants in terms of consumer health benefit, but how they may be damaged or enhanced through the processing and packaging phases. This book presents information key to understanding how antioxidants change during production of a wide variety of food products, with a focus toward how this understanding may be translated effectively to other foods as well.

  • Rodents

    A Compilation from the GenBank® and EMBL data libraries
    • 1st Edition
    • Edwin J. Atencio + 2 more
    • English

  • Rare Diseases and Orphan Drugs

    Keys to Understanding and Treating the Common Diseases
    • 1st Edition
    • Jules J. Berman
    • English
    Rare Diseases and Orphan Drugs shows that much of what we now know about common diseases has been achieved by studying rare diseases. It proposes that future advances in the prevention, diagnosis, and treatment of common diseases will come as a consequence of our accelerating progress in the field of rare diseases. Understanding the complex steps in the development of common diseases, such as cancer, cardiovascular disease, and metabolic diseases, has proven a difficult problem. Rare diseases, however, are often caused by aberrations of a single gene. In rare diseases, we may study how specific genetic defects can trigger a series of events that lead to the expression of a particular disease. Often, the disease process manifested in a certain rare disease is strikingly similar to the disease process observed in a common disease. This work ties the lessons learned about rare diseases to our understanding of common ones. Chapters covering the number of common diseases are minimized, while rare diseases are introduced as single diseases or as members of diseases classes. After reading this book, readers will appreciate how further research into the rare diseases may lead to new methods for preventing, diagnosing, and treating all diseases, rare or common.

  • Advances in Cephalopod Science: Biology, Ecology, Cultivation and Fisheries

    • 1st Edition
    • Volume 67
    • English
    Advances in Cephalopod Science: Biology, Ecology, Cultivation and Fisheries—volume 67 in the Advances in Marine Biology series—addresses major themes of growing research interest in the field of cephalopod research. The book is composed of four chapters incorporating the latest advances in biology, ecology, life cycles, cultivation, and fisheries of cephalopods. Each chapter is written by a team of internationally recognized authorities to reflect recent findings and understanding. The book represents a breakthrough contribution to the field of cephalopod science. Advances in Marine Biology was first published in 1963 under the founding editorship of Sir Frederick S. Russell, FRS. Now edited by Michael P. Lesser, with an internationally renowned editorial board, the serial publishes in-depth and up-to-date reviews on a wide range of topics that appeal to postgraduates and researchers in marine biology, fisheries science, ecology, zoology, and biological oceanography. Eclectic volumes in the series are supplemented by thematic volumes on such topics as the biology of calanoid copepods.

  • Current Advances in Immunology

    • 1st Edition
    • H. Smith
    • English
    Current Advances in Immunology presents the advances in immunology in an easy-to-use format. The book is split into 51 main areas that are further classified into sections. Where appropriate, cross-referencing to other sections is given. The text also provides a guide on how to use the book. Papers included in the book focus on a variety of topics ranging from immunoglobulins and antigens to interferons, lymphocytes, leukocytes, and macrophages as well as natural killer cells, Langerhans cells, dendritic cells, lymphoid tissue, and humoral mediators of immune responses and immunomodulators. Other papers discuss blood groups, transplantation, anti-bacterial immunity, chronic inflammation, delayed hypersensitivity, and contact sensitivity. Immunodeficiency, immune complexes, tumor immunity, immunopharmacology and immunotoxicology, and the link between nutrition and immunity are also explored. A section devoted to psychoneuroimmunolog... focuses on the effect of stress on graft-versus-host reaction; immunological response to stress in agoraphobia and panic attacks; and anti-beta-endorphin immunoglobulin G in humans. This book will be of interest to working scientists in the field of immunology.

  • Proteinases and Their Inhibitors

    Structure, Function and Applied Aspects
    • 1st Edition
    • V. Turk + 1 more
    • English
    Proteinases and their Inhibitors: Structure, Function, and Applied Aspects documents the proceedings of an international symposium organized by the Department of Biochemistry, Jozef Stefan Institute, E. Kardelj University, Ljubljana, and the Department of Organic Chemistry and Biochemistry, Rudjer Boskovic Institute, Zagreb, held in Portoroz, Yugoslavia, September 29-October 3, 1980. The volume contains 34 papers that are organized into four parts. Part I on biological functions includes studies such as muscle protein breakdown in human catabolic state and age-dependent changes in intracellular protein turnover. The papers in Part II, which deals with properties and structure of enzymes, cover topics such as structures and biological functions of cathepsin B and L; and human erythrocytes peptidases. Part III is devoted to industrial applications, such as exogenous proteinases in dairy technology and the application of immobilized proteinases. Part IV on proteinase inhibitors includes papers on thiol inhibitors of proteases and and intracellular neutral proteinases and inhibitors. The papers in this volume provide new data, concepts, and visions which will not only prove useful, but will also stimulate further investigations of proteinases and their inhibitors.

  • Biotechnology and Nutrition

    Proceedings of the Third International Symposium
    • 1st Edition
    • Donald Bills + 1 more
    • English
    Biotechnology and Nutrition documents the proceedings of the Third International Symposium Biotechnology and Nutrition jointly sponsored by the University of Maryland, the United States Department of Agriculture, and E. I. du Pont de Nemours & Co. The symposium was organized to provide a forum for nutritionists, molecular biologists, animal and plant biochemists, food scientists, policymakers, and others who will influence the improvement of nutrition through the application of biotechnology. The contributions made by researchers at the symposium are organized into five parts. Part I provides a broad consideration of human nutrition and the ability of biotechnology to improve nutrition. Part II presents studies on carbohydrate nutrition, including industry trends and nutritional issues for food uses of starch and human physiological responses to dietary fiber. Part III focuses on proteins, including studies on improving the nutritional quality of legume seed proteins and increasing the lysine content of maize. The studies in Part IV deal with vitamins and minerals, such as genetic improvement of vegetable carotene content and iron uptake and translocation in plants. Part V examines molecular approaches in the modification and production of edible oils.

  • Prostaglandins, Platelets, Lipids

    New Developments in Atherosclerosis
    • 1st Edition
    • Hadley L. Conn + 2 more
    • English
    Prostaglandins, Platelets, Lipids: New Developments in Atherosclerosis focuses on developments pertaining to atherosclerosis and suggested novel approaches for its prevention, treatment, and complications. The selection first underscores the biological importance and therapeutic potential of prostacyclin and rationale for the suppression of platelet aggregation and thrombosis by dietary manipulation of fatty acids. Discussions focus on eicosapentaenoic acid as a potential antithrombotic substance, vascular effects of prostacyclin, antithrombotic and hemostatic effects of prostacyclin, fatty acids, prostacyclin, and thrombosis, and therapeutic uses of prostacyclin. The text then examines prostaglandins and hypertension, role of platelets in stroke and transient ischemic attack, and antiplatelet agents in the prevention of acute coronary events. Topics include thrombosis and clinical complications of atherosclerosis, mechanisms in thrombosis, vascular prostaglandins and antihypertensive mechanisms, and renal prostaglandins and antihypertensive mechanisms. The book ponders on a specific inhibitor of thrombin and cardiovascular actions of prostacyclin in man, including prostacyclin and angina pectoris, prostacyclin therapy for peripheral arterial disease, and hemodynamic changes induced by prostacyclin. The selection is a dependable source of data for researchers interested in atherosclerosis.

  • Development of Auditory and Vestibular Systems

    • 1st Edition
    • Raymond Romand + 1 more
    • English
    Development of Auditory and Vestibular Systems fourth edition presents a global and synthetic view of the main aspects of the development of the stato-acoustic system. Unique to this volume is the joint discussion of two sensory systems that, although close at the embryological stage, present divergences during development and later reveal conspicuous functional differences at the adult stage. This work covers the development of auditory receptors up to the central auditory system from several animal models, including humans. Coverage of the vestibular system, spanning amphibians to effects of altered gravity during development in different species, offers examples of the diversity and complexity of life at all levels, from genes through anatomical form and function to, ultimately, behavior. The new edition of Development of Auditory and Vestibular Systems will continue to be an indispensable resource for beginning scientists in this area and experienced researchers alike.

  • From Molecules to Networks

    An Introduction to Cellular and Molecular Neuroscience
    • 3rd Edition
    • John H. Byrne + 2 more
    • English
    An understanding of the nervous system at virtually any level of analysis requires an understanding of its basic building block, the neuron. The third edition of From Molecules to Networks provides the solid foundation of the morphological, biochemical, and biophysical properties of nerve cells. In keeping with previous editions, the unique content focus on cellular and molecular neurobiology and related computational neuroscience is maintained and enhanced. All chapters have been thoroughly revised for this third edition to reflect the significant advances of the past five years. The new edition expands on the network aspects of cellular neurobiology by adding new coverage of specific research methods (e.g., patch-clamp electrophysiology, including applications for ion channel function and transmitter release; ligand binding; structural methods such as x-ray crystallography). Written and edited by leading experts in the field, the third edition completely and comprehensively updates all chapters of this unique textbook and insures that all references to primary research represent the latest results.

  • Conceptual Background and Bioenergetic/Mitochondrial Aspects of Oncometabolism

    • 1st Edition
    • Volume 542
    • English
    Volume 542 of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This new volume covers research methods providing a theoretical overview on metabolic alterations of cancer cells and a series of protocols that can be employed to study oncometabolism, in vitro, ex vivo and in vivo. Malignant cells exhibit metabolic changes when compared to their normal counterparts, owing to both genetic and epigenetic alterations. Although such a metabolic rewiring has recently been indicated as "yet another" general hallmark of cancer, accumulating evidence suggests that the metabolic alterations of each neoplasm rather represent a molecular signature that intimately accompanies, and hence cannot be severed from, all facets of malignant transformation.

  • Stem Cells

    Scientific Facts and Fiction
    • 2nd Edition
    • Christine L. Mummery + 3 more
    • English
    The second edition of Stem Cells: Scientific Facts and Fiction provides the non-stem cell expert with an understandable review of the history, current state of affairs, and facts and fiction of the promises of stem cells. Building on success of its award-winning preceding edition, the second edition features new chapters on embryonic and iPS cells and stem cells in veterinary science and medicine. It contains major revisions on cancer stem cells to include new culture models, additional interviews with leaders in progenitor cells, engineered eye tissue, and xeno organs from stem cells, as well as new information on "organs on chips" and adult progenitor cells. In the past decades our understanding of stem cell biology has increased tremendously. Many types of stem cells have been discovered in tissues that everyone presumed were unable to regenerate in adults, the heart and the brain in particular. There is vast interest in stem cells from biologists and clinicians who see the potential for regenerative medicine and future treatments for chronic diseases like Parkinson's, diabetes, and spinal cord lesions, based on the use of stem cells; and from entrepreneurs in biotechnology who expect new commercial applications ranging from drug discovery to transplantation therapies.

  • Advances in Genetics

    • 1st Edition
    • Volume 85
    • English
    The field of genetics is rapidly evolving, and new medical breakthroughs are occurring as a result of advances in our knowledge of genetics. Advances in Genetics continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines. Volume 85 presents an eclectic mix of articles of use to all human and molecular geneticists on topics including: association mapping in crop plants; miRNA-mediated crosstalk between transcripts; unisexual reproduction; and more.

  • History of Toxicology and Environmental Health

    Toxicology in Antiquity Volume I
    • 1st Edition
    • English
    Toxicology in Antiquity is the first in a series of short format works covering key accomplishments, scientists, and events in the broad field of toxicology, including environmental health and chemical safety. This first volume sets the tone for the series and starts at the very beginning, historically speaking, with a look at toxicology in ancient times. The book explains that before scientific research methods were developed, toxicology thrived as a very practical discipline. People living in ancient civilizations readily learned to distinguish safe substances from hazardous ones, how to avoid these hazardous substances, and how to use them to inflict harm on enemies. It also describes scholars who compiled compendia of toxic agents.

  • The Quality Control of Medicines

    Proceedings of the 35th International Congress of Pharmaceutical Sciences, Dublin, 1975
    • 1st Edition
    • P.B. Deasy + 1 more
    • English
    The Quality Control of Medicines documents the proceedings of the 35th International Congress of Pharmaceutical Sciences, organized by the Pharmaceutical Society of Ireland on behalf of the Federation Internationale Pharmaceutique, held in Dublin, on 1-5 September 1975. The theme chosen for the Congress was ""the basis for the quality control of medicines"", because of the importance and relevance of quality control in the production and distribution of medicines at national and international levels. This volume is arranged according to the manner in which the theme of the Congress was developed by the eminent invited speakers. Following the inaugural address a main symposium was held where five speakers presented a review of the quality control of medicines under the general headings of (i) chemical and physical aspects; (ii) biological aspects; (iii) control of drug delivery systems; (iv) storage problems; and (v) problems of international control. Certain aspects of the content of the main symposium were then developed in greater depth in parallel symposia. In the first parallel symposium some novel physicochemical aspects of the quality control of medicines were treated under the headings of spectrofluorimetry, mass spectrometry, detection in gas chromatography, and automation in pharmaceutical analysis. The second parallel symposium developed certain microbiological aspects of quality control under the headings of sterility testing and microbiological control of non-sterile products and ophthalmic preparations. The final symposium on submissions to regulatory bodies and international aspects of drug control covered aspects of politics in submissions, regulatory problems in small countries, and various pharmacopoeial problems.

  • Structure and Function of Membrane Proteins

    Proceedings of the International Symposium on Structure and Function of Membrane Proteins Held in Selva Di Fasano (Italy), May 23-26, 1983
    • 1st Edition
    • E. Quagliariello + 1 more
    • English
    Structure and Function of Membrane Proteins documents the proceedings of the International Symposium on Structure and Function of Membrane Proteins held in Selva di Fasano on May 23-26, 1983. This compilation makes it possible to obtain more information on the structure of membrane proteins, determining the structure in order to understand the function, and mechanism of action that is only understood by knowledge of the atomic structure. The gathering of data on the function of membrane proteins prior to knowledge of their structure is valuable for characterizing and defining the proteins. Once the structure is known, another stage of research will penetrate to the functional assignments of the structure. Other topics covered include the physical methods for the structure-function relationship; identification and mapping of sites in membrane proteins; and primary structure of transport proteins. Tertiary structure and molecular shape of membrane proteins and structure-function relationship in membrane proteins are also examined. This book is a good source of information for students and individuals conducting research on biochemistry, specifically on membrane proteins.

  • Development and Differentiation in the Cellular Slime Moulds

    Proceedings of the International Workshop Held at Porto Conte, Sardinia on 12—16 April, 1977
    • 1st Edition
    • P. Cappuccinelli + 1 more
    • English
    Developments in Cell Biology, Volume 1: Development and Differentiation in the Cellular Slime Moulds is a collection of papers from the proceedings of the International Workshop held at Porto Conte, Sardinia on April 12-16, 1977. This collection of papers deals with a single group of organisms, the cellular slime molds, particularly with Dictyostelium discoideum. Dictyostelium is dealt, firstly, according to cell differentiation and pattern formation common in this type of organism. These examples are further explored in the Dictyostelium discoideum slug, through the control of morphogenesis. Further research shows that two compounds, 3'5' cyclic AMP and NH3, can affect the course of morphogenesis in D. discoideum. Techniques for cell fusion and mutation induction in D. discoideum, especially as a result of DNA damage following radiation and chemicals, are analyzed. Other studies show that formation and maintenance of stable contacts between cells appear to be necessary for the normal cell cycle involved in the growth of D. discoideum. The changes in plasma membrane protein analyzed using SDS-polyacrylamide gel electrophoresis are examined. Results show that detection and quantitation of tubulin in Dictyostelium discoideum is important when studying the differentiation processes of a wide range of cellular activities. Because many D. discoideum mutants fail to reach proper development, the method for selecting the aggregation of defective mutants of D. discoideum is emphasized. This book is of interest to those whose work involves these organisms and to researchers, professors, and students whose disciplines are in Developmental Biology or Mycology.

  • Sea Plants

    • 1st Edition
    • Volume 71
    • English
    Advances in Botanical Research publishes in-depth and up-to-date reviews on a wide range of topics in plant sciences. The series features several reviews by recognized experts on all aspects of plant genetics, biochemistry, cell biology, molecular biology, physiology and ecology. This thematic volume, number 71, features reviews on sea plants. Its chapters cover topics such as the role of algae in sustainability; the status of kelp exploitation and marine agronomy; potential applications for enzymatic recovery of metabolites from seaweeds; and many more.

  • Human Biology

    A Text Book of Human Anatomy, Physiology and Hygiene
    • 2nd Edition
    • C. J. Wallis
    • English
    Human Biology is a textbook on human biology and presents facts and details about a number of diseases as well as organ transplants, antibiotics, and anesthetics. Other topics include world food, drug addiction, smoking, and lung cancer and the effects of radioactivity. The important subject of environmental pollution is also discussed. Some of the common disorders and diseases of the various systems are mentioned at the end of the chapters in addition to the characteristics of certain specified diseases. Comprised of 34 chapters, this book begins with an overview of man and his origins, as well as human biology and the human body. The discussion then turns to cell structure and tissues; the skin; the skeletal system; and joints. The biochemistry of foodstuffs is also examined, along with digestion and the alimentary system; the cardiovascular system; maintenance of body temperature; the genital system and reproduction; and hormones and the endocrine system. In addition, the book considers antibiotics, drugs, and anesthetics, as well as vectors and other parasites affecting humans. This monograph is intended for student nurses and potential medical students, as well as for non-science students and general readers who wish to learn something about the human body and its health.

  • Mammalian Cell Membranes

    Responses of Plasma Membranes
    • 1st Edition
    • G. A. Jamieson + 1 more
    • English
    Mammalian Cell Membranes, Volume 5: Responses of Plasma Membranes compiles broadly based reviews of specific areas of plasma membranes and introduces concepts and techniques from non-mammalian systems that may be useful in the application to eukaryotic cells. This book discusses about the turnover of mammalian surface membranes; influence of the solute environment on membrane; effects of hydrostatic pressure and radiation on cell membranes; and stimulation by hormones and regulation by nucleotides of adenylyl cyclases. Other topics include endocytosis; cell surface and growth in vitro; membranes and aging; host cell membranes in animal virus reproduction; and cytoplasmic membranes in somatic cell interaction and hybridization. This volume aims to provide a background of information and stimulation of interest to specialists and generalists working on mammalian cell membranes.

  • Fairbrother's Textbook of Bacteriology

    • 10th Edition
    • R. L. Vollum + 2 more
    • English
    Fairbrother's Textbook of Bacteriology, Tenth Edition provides an outline of the medical aspects of bacteriology. This book emphasizes the biological relationship of allied organisms. Organized into three parts encompassing 38 chapters, this edition begins with an overview of the various elements of the bacterial cell in detail, starting with external features such as flagella and capsules, and working inwards to the cytoplasm. This text then describes the principal toxic effects of the different groups of anti-bacterial substances. Other chapters consider the relationship of the different types of hypersensitivity to classical immune responses. This book discusses as well the earliest application of a specific chemical substance to the treatment of microbial disease. The final chapter deals with the various methods used to determine the sensitivity of bacteria to the different sulphonamides. This book is a valuable resource for medical students. Bacteriologists, chemists, pathologists, and microbiologists will also find this book useful.

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