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Elsevier

Books in Life sciences

  • Accelerated Predictive Stability (APS)

    Fundamentals and Pharmaceutical Industry Practices
    • 1st Edition
    • Fenghe Qiu + 1 more
    • English
    Accelerated Predictive Stability (APS): Fundamentals and Pharmaceutical Industry Practices provides coverage of both the fundamental principles and pharmaceutical industry applications of the APS approach. Fundamental chapters explain the scientific basis of the APS approach, while case study chapters from many innovative pharmaceutical companies provide a thorough overview of the current status of APS applications in the pharmaceutical industry. In addition, up-to-date experiences in utilizing APS data for regulatory submissions in many regions and countries highlight the potential of APS in support of registration stability testing for certain regulatory submissions. This book provides high level strategies for the successful implementation of APS in a pharmaceutical company. It offers scientists and regulators a comprehensive resource on how the pharmaceutical industry can enhance their understanding of a product’s stability and predict drug expiry more accurately and quickly.

  • Advances in Agronomy

    • 1st Edition
    • Volume 150
    • Donald L. Sparks
    • English
    Advances in Agronomy, Volume 150, continues to be recognized as a leading reference and first-rate source for the latest research in agronomy. Each volume contains an eclectic group of reviews by leading scientists throughout the world. As always, the subjects covered are rich, varied, and exemplary of the abundant subject matter addressed by this long-running serial.

  • Diagnostic and Therapeutic Applications of Exosomes in Cancer

    • 1st Edition
    • Mansoor M. Amiji + 1 more
    • English
    Diagnostic and Therapeutic Applications of Exosomes in Cancer evaluates the potential of exosome content manipulation in the development of novel therapeutics. In recent years, exosomes, the small vesicles produced by all cell types, have been identified as contributors to cancer growth and metastasis. However, due to their unique biophysical properties, they are also being tested for use in therapeutic design and delivery, as well as in diagnostics. This book presents a comprehensive analysis on exosomes, with a main emphasis on their biogenesis and signaling, use as biomarkers, and as tools for imaging, drug delivery and the treatment of cancer.

  • Advances in Parasitology

    • 1st Edition
    • Volume 100
    • English
    Advances in Parasitology, Volume 100, the latest in a series first published in 1963, contains comprehensive and up-to-date reviews on all areas of interest in contemporary parasitology. The series includes medical studies of parasites of major influence, along with reviews of more traditional areas, such as zoology, taxonomy, and life history, which help to shape current thinking and applications. This new release includes sections on Human Parasitology and Parasitic Diseases: Heading Towards 2050, Environmental aspects, Structural and Physical Properties of Schistosome Eggs, and Interventions against parasitic diseases to safeguard childhood development.

  • Polyunsaturated Fatty Acid Metabolism

    • 1st Edition
    • Graham C. Burdge
    • English
    Polyunsaturated Fatty Acid Metabolism explores a number of major roles of PUFA in the body, including its role as a component of cell membranes and how it provides substrates for the synthesis of lipid second messengers. Recent studies are unraveling the effect of interactions between diet and endocrine factors and genetic and epigenetic variation on the regulation of PUFA biosynthesis in animals. Together, these recent findings provide novel insights into the impact of differences in PUFA supply on health. This book captures these findings in a manner that marks the state-of-the-art, placing them in the wider context of PUFA metabolism and nutritional science. Users will find a comprehensive discussion on the topic that presents the contributions of leading researchers who combine their knowledge to create a cohesive academic resource for researchers, those involved in production, and health policymakers.

  • Advances in Immunology

    • 1st Edition
    • Volume 138
    • English
    Advances in Immunology, Volume 138, the latest in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, with this release including chapters on Eosinophil Development, Disease Involvement, and Therapeutic Suppression, Immunoglobulin A responses to the microbiota, Unexpected roles for intracellular complement in the regulation of TH1 responses, Magnesium in T cell signaling, and immunological synapse and T cell signaling.

  • Handbook of Ultrasonic Vocalization

    A Window into the Emotional Brain
    • 1st Edition
    • Volume 25
    • Stefan M Brudzynski
    • English
    Handbook of Ultrasonic Vocalization: Window into the Mammalian Brain, Volume 25, is an exhaustive resource on ultrasonic vocalizations in vertebrates, providing full coverage of all aspects of these vocalizations. The book also demonstrates the usefulness of ultrasonic vocalizations in studies of animal communication, sociobiological states, and in mammalian models of affective disorders, addictions and neurodevelopmental disorders, making it an indispensable resource for researchers using animal models. The book begins with the evolution of vocal communication before discussing mechanisms of ultrasound production, perception and the brain systems involved in emotional arousal that are responsible for the generation of vocalization and emotional states. In addition, the book covers studies of neuroactive agents and sociopsychological conditions that can regulate the outcome of ultrasonic vocalization and provide clues about animals’ internal states. Critically, the book also includes thorough coverage of pharmacological investigations using ultrasonic vocalizations, increasingly being utilized for studies in affective disorders, psychoses, addiction and alcoholism. No other book provides such extensive coverage of this rapidly growing field of study.

  • The Epigenetics of Autoimmunity

    • 1st Edition
    • Volume 5
    • Rongxin Zhang
    • English
    The Epigenetics of Autoimmunity covers a topic directly related to translational epigenetics. Via epigenetic mechanisms, a number of internal and external environmental risk factors, including smoking, nutrition, viral infection and the exposure to chemicals, could exert their influence on the pathogenesis of autoimmune diseases. Such factors could impact the epigenetic mechanisms, which, in turn, build relationship with the regulation of gene expression, and eventually triggering immunologic events that result in instability of immune system. Since epigenetic aberrations are known to play a key role in a long list of human diseases, the translational significance of autoimmunity epigenetics is very high. To bridge the gap between environmental and genetic factors, over the past few years, great progress has been made in identifying detailed epigenetic mechanisms for autoimmune diseases. Furthermore, with rapid advances in technological development, high-throughput screening approaches and other novel technologies support the systematic investigations and facilitate the epigenetic identification. This book covers autoimmunity epigenetics from a disease-oriented perspective and several chapters are presented that provide advances in wide-spread disorders or diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), multiple sclerosis (MS), type 1 diabetes (T1DM), systemic sclerosis (SSc), primary Sjögren's syndrome (pSS) and autoimmune thyroid diseases (AITDs). These emerging epigenetic studies provide new insights into autoimmune diseases, raising great expectations among researchers and clinicians. This seminal book on this topic comprehensively covers the most recent advances in this exciting and rapidly developing new science. They might reveal not only new clinical biomarkers for diagnosis and disease progression, but also novel targets for potential epigenetic therapeutic treatment.

  • Gangliosides in Health and Disease

    • 1st Edition
    • Volume 156
    • English
    Gangliosides in Health and Disease, Volume 156, presents the latest information on Gangliosides, a class of glycolipids that are found on all vertebrate cell surfaces, and are particularly abundant in the brain. Individual chapters in this new volume cover Gangliosides as Toxin Receptors, Gangliosides in Cancer Cell Signaling, Gangliosides in inflammation and neurodegeneration, Gangliosides as functional galectin receptors, Gangliosides in signal transduction, Gangliosides in brain tumor immunology, and Gangliosides in axon regeneration and stability, amongst other related topics. This book brings together world experts in ganglioside structure and function who have been assembled to contribute to this thorough update of the field.

  • Multivariate Analysis in the Pharmaceutical Industry

    • 1st Edition
    • Ana Patricia Ferreira + 2 more
    • English
    Multivariate Analysis in the Pharmaceutical Industry provides industry practitioners with guidance on multivariate data methods and their applications over the lifecycle of a pharmaceutical product, from process development, to routine manufacturing, focusing on the challenges specific to each step. It includes an overview of regulatory guidance specific to the use of these methods, along with perspectives on the applications of these methods that allow for testing, monitoring and controlling products and processes. The book seeks to put multivariate analysis into a pharmaceutical context for the benefit of pharmaceutical practitioners, potential practitioners, managers and regulators. Users will find a resources that addresses an unmet need on how pharmaceutical industry professionals can extract value from data that is routinely collected on products and processes, especially as these techniques become more widely used, and ultimately, expected by regulators.

  • Biomechanics of the Spine

    Basic Concepts, Spinal Disorders and Treatments
    • 1st Edition
    • Fabio Galbusera + 1 more
    • English
    Biomechanics of the Spine encompasses the basics of spine biomechanics, spinal tissues, spinal disorders and treatment methods. Organized into four parts, the first chapters explore the functional anatomy of the spine, with special emphasis on aspects which are biomechanically relevant and quite often neglected in clinical literature. The second part describes the mechanics of the individual spinal tissues, along with commonly used testing set-ups and the constitutive models used to represent them in mathematical studies. The third part covers in detail the current methods which are used in spine research: experimental testing, numerical simulation and in vivo studies (imaging and motion analysis). The last part covers the biomechanical aspects of spinal pathologies and their surgical treatment. This valuable reference is ideal for bioengineers who are involved in spine biomechanics, and spinal surgeons who are looking to broaden their biomechanical knowledge base. The contributors to this book are from the leading institutions in the world that are researching spine biomechanics.

  • Ranunculales Medicinal Plants

    Biodiversity, Chemodiversity and Pharmacotherapy
    • 1st Edition
    • Da-Cheng Hao
    • English
    Ranunculales Medicinal Plants: Biodiversity, Chemodiversity and Pharmacotherapy comprehensively covers this order of flowering plants, detailing the phytochemistry, chemotaxonomy, molecular biology, and phylogeny of selected medicinal plants families and genera and their relevance to drug efficacy. The book carries out an exhaustive survey of the literature in order to characterize global trends in the application of flexible technologies. The interrelationship between Chinese species, and between Chinese and non-Chinese species, is inferred through molecular phylogeny and based on nuclear and chloroplast DNA sequencing. The book discusses the conflict between chemotaxonomy and molecular phylogeny in the context of drug discovery and development. Users will find invaluable and holistic coverage on the study of Ranunculales that will make this the go-to pharmaceutical resource.

  • G Protein-Coupled Receptors: Emerging Paradigms in Activation, Signaling and Regulation Part A

    • 1st Edition
    • Volume 338
    • English
    G Protein-Coupled Receptors: Emerging Paradigms in Activation, Signaling and Regulation, Part A, Volume 337 in the International Review of Cell and Molecular Biology series, reviews and details current advances in cell and molecular biology. The IRCMB series has a worldwide readership, maintaining a high standard by publishing invited articles on important and timely topics that are authored by prominent cell and molecular biologists. This new release includes comprehensive sections on the classical paradigms of GCPR signaling and regulation, the family of small GTPases: Beyond heterotrimeric G proteins, GPCR endocytosis: Arrestins, arrestin-like proteins, signaling from internalized G Protein-Coupled Receptors, GPCR kinases, and more.

  • Introductory Review on Sirtuins in Biology, Aging, and Disease

    • 1st Edition
    • Leonard Guarente + 2 more
    • English
    Introductory Review on Sirtuins in Biology and Disease provides key insights for scientists and advanced students who need to understand sirtuins and the current research in this field. This book is ideal for pharmaceutical companies as they develop novel targets using sirtuins for metabolic diseases, cancer and neurodegenerative illnesses. Sirtuins are a diverse family of proteins, with several members in mammals. The functional diversity of sirtuins is rather broad, and they have been implicated in various central biological processes. Thus, they are also highly relevant in the context of various human diseases, from cancer to neurodegeneration.

  • The Auditory System in Sleep

    • 2nd Edition
    • Ricardo Velluti
    • English
    The Auditory System in Sleep, Second Edition presents a view of a sensory system working in a different state, that of the sleeping brain. This updated edition contains new chapters on topics such as implanted deaf patients and sleep and tinnitus treatments. It is written for basic auditory system and sleep researchers, as well as practitioners and clinicians in the Auditory/Sensory Neurosciences and Sleep Medicine. As the auditory system is always “open”, thus receiving information from the environment and the body itself (conscious and unconscious data), the incoming sensory information may alter sleep and waking physiology, and conversely, the sleeping brain. This book draws information from evoked potentials, fMRI, PET, SPECT, lesions, and more.

  • Signal Processing for Neuroscientists

    • 2nd Edition
    • Wim van Drongelen
    • English
    Signal Processing for Neuroscientists, Second Edition provides an introduction to signal processing and modeling for those with a modest understanding of algebra, trigonometry and calculus. With a robust modeling component, this book describes modeling from the fundamental level of differential equations all the way up to practical applications in neuronal modeling. It features nine new chapters and an exercise section developed by the author. Since the modeling of systems and signal analysis are closely related, integrated presentation of these topics using identical or similar mathematics presents a didactic advantage and a significant resource for neuroscientists with quantitative interest. Although each of the topics introduced could fill several volumes, this book provides a fundamental and uncluttered background for the non-specialist scientist or engineer to not only get applications started, but also evaluate more advanced literature on signal processing and modeling.

  • Neurobiology of the Placebo Effect, Part I

    • 1st Edition
    • Volume 138
    • English
    Neurobiology of the Placebo Effect, Part I, Volume 138 in the International Review of Neurobiology series, is the first of two volumes that provide the latest placebo studies in clinically relevant models. Placebo responses effects are not merely a psychological, but a complex psycho-neuro-biologi... process that requires activation of distinct brain areas. This book discusses current research and projects on the involved brain circuitry and neurotransmitter systems. Specific chapters cover such topics as pharmacological conditioning of the endocrine and immune system, expectancy modulation of opioid neurotransmission, nocebo effects in visceral pain, and conditioning as a higher-order cognitive phenomenon, amongst other topics.

  • Nanotechnology-Based Targeted Drug Delivery Systems for Brain Tumors

    • 1st Edition
    • Prashant Kesharwani + 1 more
    • English
    Nanotechnology-Based Targeted Drug Delivery Systems for Brain Tumors addresses brain anatomy and tumors and the progress and challenges in delivering drugs across the blood brain barrier. Several chapters are devoted to the latest technologies and advances in nanotechnology, along with practical solutions on how to design more effective nanocarriers for drug and gene delivery. This valuable resource prepares readers to develop novel drug delivery systems for the treatment of brain tumors that further promote the latest nanomedical technologies.

  • Neuromuscular Junction Disorders, An Issue of Neurologic Clinics

    • 1st Edition
    • Volume 36-2
    • Mazen M. Dimachkie + 1 more
    • English
    This issue of Neurologic Clinics, edited by Dr. Mazen M. Dimachkie and Dr. Richard J. Barohn, focuses on Neuromuscular Junction Disorders. Topics include--but are not limited to--History of myasthenia gravis and neuromuscular junction disorders; Practical immunology of the neuromuscular junction; Practical anatomy of the neuromuscular junction in health and disease; Generalized myasthenia gravis; Ocular myasthenia gravis; Diagnosis of myasthenia gravis; MuSK and myasthenia gravis due to other autoantibodies; Treatment of myasthenia gravis; Evidenced-based approach of thymectomy for myasthenia gravis; Myasthenia gravis and pregnancy; Congenital myasthenic syndromes; Botulism; Lambert-Eaton myasthenic syndrome; and Measuring clinical treatment response in myasthenia gravis.

  • Therapeutic, Probiotic, and Unconventional Foods

    • 1st Edition
    • Alexandru Mihai Grumezescu + 1 more
    • English
    Therapeutic, Probiotic and Unconventional Foods compiles the most recent, interesting and innovative research on unconventional and therapeutic foods, highlighting their role in improving health and life quality, their implications on safety, and their industrial and economic impact. The book focuses on probiotic foods, addressing the benefits and challenges associated with probiotic and prebiotic use. It then explores the most recently investigated and well-recognized nutraceutical and medicinal foods and the food products and ingredients that have both an impact on human health and a potential therapeutic effect. The third and final section explores unconventional foods and discusses intriguing and debated foods and food sources. While research has been conducted on the beneficial biological effects of probiotics and therapeutic food, the use of these foods remains controversial. To overcome the suspicion of the use of alternative, homeopathic and traditional products as therapy, this book reveals and discusses the most recent and scientifically sound and confirmed aspects of the research.

  • Therapeutic Proteins and Peptides

    • 1st Edition
    • Volume 112
    • English
    Therapeutic Proteins and Peptides, Volume 112 in an ongoing series promotes further research in the discovery of new therapeutic targets that can be affected by therapeutic proteins and peptides to cure or manage symptoms of human diseases, with this release focusing on the Rational Design of Stable Liquid Formulations of Biopharmaceuticals, Formulation strategies for peptides, proteins and antibodies using nanotechnology, the Solution structural dynamics of therapeutic peptides and their adsorption on plasmonic nanoparticles, Enzymatic approaches of protein-polymer conjugation, Chimeric small antibody fragments as a strategy to deliver therapeutic payloads, Smart cell-penetrating peptide-based techniques for cytoplasmic delivery of therapeutic macromolecules, and more.

  • Advances in Agronomy

    • 1st Edition
    • Volume 149
    • English
    Advances in Agronomy, Volume 149, the latest release in the series, continues to be recognized as a leading reference and first-rate source for the latest research in agronomy. Each volume contains an eclectic group of reviews by leading scientists throughout the world. As always, the subjects covered are rich, varied and exemplary of the abundant subject matter addressed by this long-running serial.

  • Advances in Applied Microbiology

    • 1st Edition
    • Volume 102
    • English
    Advances in Applied Microbiology, Volume 102, the latest release in one of the most widely read and authoritative review sources in microbiology, contains comprehensive reviews of the most current research in applied microbiology. This latest release includes specific chapters on a variety of topics, most notably, Twenty-five Years of Investigating the Universal Stress Protein: Structure, function and applications, Fungal Genomes and Genotyping, Fungi in deep subsurface environments, Spore germination in pathogenic fungi, Host sensing by pathogenic fungi, Advances in the Microbial Ecology of Biohydrometallurgy, and The mycosphere and turnover of contaminants, amongst others.

  • Pharmacy Education in the Twenty First Century and Beyond

    Global Achievements and Challenges
    • 1st Edition
    • Ahmed Fathelrahman + 3 more
    • English
    Pharmacy Education in the Twenty First Century and Beyond: Global Achievements and Challenges offers a complete reference on global pharmacy education, along with a detailed discussion of future issues and solutions. This book begins with a brief overview of the history of pharmacy education, covering all levels of education and styles of learning, from undergraduate, continuing professional education, and methods for self-learning and development. Teaching strategies such as team-based learning, problem-based learning and interdisciplinary education are also described and compared to conclude why certain pharmacy programs attract students, and why educators prefer particular teaching strategies, assessment tools and learning styles. As a result, this book provides pharmacy educators, administrators, students and practitioners with a comprehensive guide to pharmacy education that will enable readers to choose the best approaches to improve, reform or select a program based on worldwide experience and the latest available evidence and research.

  • Chemical and Biochemical Approaches for the Study of Anesthetic Function Part B

    • 1st Edition
    • Volume 603
    • English
    Chemical and Biochemical Approaches for the Study of Anesthetic Function, Part B, Volume 603, presents a coherent description of the campaign towards understanding anesthesia. It includes a variety of highly debated topics, including sections on computational approaches, best practices for simulating ligand-gated ion channels interacting with general anesthetics, computational approaches for studying voltage-gated ion channels modulation by general anesthetics, anesthetic parameterization, the kinetic modeling of electrophysiology data, evolving biophysical technologies, fluorescent anesthetics, lipids, membranes and pressure reversal, in vivo technologies, and more.

  • Food Safety and Preservation

    Modern Biological Approaches to Improving Consumer Health
    • 1st Edition
    • Alexandru Mihai Grumezescu + 1 more
    • English
    Food Safety and Preservation: Modern Biological Approaches to Improving Consumer Health explores the most recent and investigated hot topics in food safety, microbial contamination, food-borne diseases and advanced preservation methods. It brings together the significant, evidence-based scientific progress of various approaches to improve the safety and quality of foods, also offering solutions to help address food industry challenges. Recent studies and technological advancements in biological control are presented to control foodborne pathogens. In addition, analytical methods for reducing potential biological hazards make this book essential to researchers, scientists, technologists and grad students.

  • Waste Biorefinery

    Potential and Perspectives
    • 1st Edition
    • Thallada Bhaskar + 4 more
    • English
    Waste Biorefinery: Potential and Perspectives offers data-based information on the most cutting-edge processes for the utilisation of biogenic waste to produce biofuels, energy products, and biochemicals – a critical aspect of biorefinery. The book explores recent developments in biochemical and thermo-chemical methods of conversion and the potential generated by different kinds of biomass in more decentralized biorefineries. Additionally, the book discusses the move from 200 years of raw fossil materials to renewable resources and how this shift is accompanied by fundamental changes in industrial manufacturing technologies (from chemistry to biochemistry) and in logistics and manufacturing concepts (from petrochemical refineries to biorefineries). Waste Biorefinery: Potential and Perspectives designs concepts that enable modern biorefineries to utilize all types of biogenic wastes, and to integrate processes that convert byproduct streams to high-value products, achieving higher cost benefits. This book is an essential resource for researchers and students studying biomass, biorefineries, and biofuels/products/pr... as well as chemists, biochemical/chemical engineers, microbiologists, and biotechnologists working in industries and government agencies.

  • Autophagy and Cardiometabolic Diseases

    From Molecular Mechanisms to Translational Medicine
    • 1st Edition
    • Jun Ren + 2 more
    • English
    Autophagy and Cardiometabolic Diseases: From Moleculer Mechanisms to Translational Medicine covers the science of autophagy in relation to cardiometabolic diseases and the future therapeutic potentials of autophagy regulation in these processes. Processes are not described in isolation, but in concert with other cellular and/or metabolic processes, such as lipogenesis, glucose, energy metabolism and apoptosis. This approach recognizes the multifactorial nature of cardiometabolic diseases, including obesity, diabetes, insulin resistance, hypertension and dyslipidemia. The book provides explanations, while also distinguishing the delicate role for autophagy in pathogenesis and exploring complications for cardiometabolic diseases. By targeting autophagy, it offers new avenues for drug discovery and treatment for cardiometabolic anomalies. It is a perfect resource for cardiology researchers, scientists and medical practitioners.

  • Imaging of Salivary Glands, An Issue of Neuroimaging Clinics of North America

    • 1st Edition
    • Volume 28-2
    • Ahmed Abdel Khalek Abdel Razek
    • English
    This issue of Neuroimaging Clinics of North America focuses on Imaging of Salivary Glands, and is edited by Dr. Ahmed Abdel Khalek Abdel Razek. Articles will include: Cross sectional imaging techniques and normal anatomy of the salivary glands; Imaging of benign salivary gland tumors; Imaging of cancer salivary glands; Imaging of Sjögren's syndrome and immunoglobulin g4-related disorder of salivary glands; Imaging of post treatment of salivary glands; Imaging of pediatric salivary glands; Imaging of submandibular and sublingual salivary glands; Scintigraphy and PET of salivary glands; Imaging of inflammatory disorders of salivary glands; Routine and advanced ultrasound of salivary glands; and more!

  • The Future of Soil Carbon

    Its Conservation and Formation
    • 1st Edition
    • Carlos Garcia + 2 more
    • English
    The Future of Soil Carbon: Its Conservation and Formation provides readers with an integrative approach to understanding the important role of organic carbon in soil functioning and fertility. Terrestrial interactions between SOC and complex human-natural systems require new fundamental and applied research into regional and global SOC budgets. This book provides new and synthesized information on the dynamics of SOC in the terrestrial environment. In addition to rigorous state-of-the art on soil science, the book also provides strategies to avoid risks of soil carbon losses. Soil organic carbon (SOC) is a vital component of soils, with important and far-reaching effects on the functioning of terrestrial ecosystems. Human activities over the last several decades have significantly changed the regional and global balance of SOC, greatly exacerbating global warming and climate change.

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 85
    • English
    Advances in Clinical Chemistry, Volume 85, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry, and is the benchmark for novel analytical approaches in the clinical laboratory.

  • Progress in Medicinal Chemistry

    • 1st Edition
    • Volume 57
    • English
    Progress in Medicinal Chemistry, Volume 57, provides a review of eclectic developments in medicinal chemistry, with this volume including chapters on the CaSR field, CFTR modulators in cystic fibrosis, macrocycles, VMAT2 inhibitors, and Big Data in Drug Discovery.

  • Biochemical, Physiological, and Molecular Aspects of Human Nutrition

    • 4th Edition
    • Martha H. Stipanuk + 1 more
    • English
    A scientific look at the biological bases of human nutrition. Covering advanced nutrition with a comprehensive, easy-to-understand approach, Biochemical, Physiological, and Molecular Aspects of Human Nutrition, 4th Edition, focuses on nutrition at the molecular, cellular, tissue, and whole-body levels. Written by Martha Stipanuk, Marie Caudill, and a team of nutrition experts, the text addresses nutrients by classification, and describes macronutrient function from digestion to metabolism. This edition includes the most current recommendations from the Dietary Guidelines for Americans, plus coverage of the historical evolution of nutrition and information on a wide range of vitamins, minerals, and other food components.

  • Conn's Handbook of Models for Human Aging

    • 2nd Edition
    • Jeffrey L. Ram + 1 more
    • English
    Conn's Handbook of Models for Human Aging, Second Edition, presents key aspects of biology, nutrition, factors affecting lifespan, methods of age determination, use in research and the disadvantages/advant... of use. Using a multidisciplinary approach, this updated edition is designed as the only comprehensive, current work that covers the diversity in aging models. Chapters on comparative models explore age-related diseases, including Alzheimer's, joint disease, cataracts, cancer and obesity. Also included are new tricks and approaches not available in primary publications. This must-have handbook is an indispensable resource for researchers interested in the mechanisms of aging, gerontologists, health professionals, allied health practitioners and students.

  • Biodiversity and Climate Change Adaptation in Tropical Islands

    • 1st Edition
    • Chandrakasan Sivaperuman + 3 more
    • English
    Biodiversity and Climate Change Adaptation in Tropical Islands provides comprehensive information on climate change, biodiversity, possible impacts, adaptation measures and policy challenges to help users rehabilitate and preserve the natural resources of tropical islands. While biodiversity and climate change of tropical islands has previously received less attention, it is ironically one of the most vulnerable regions in this regard. The core content of the work derives largely from the ideas and research output from various reputed scientists and experts who have recorded climate change impacts on aquatic and coastal life in tropical regions. Contributors have direct working experience with the tribes in some of the tropical islands. All of their expertise and information is compiled and presented in the work, including coverage related to climate change. This work highlights the ever-growing need to develop and apply strategies that optimize the use of natural resources, both on land and in water and judicious use of biodiversity. It functions as a critical resource on tropical island biodiversity for researchers, academicians, practitioners and policy makers in a variety of related disciplines.

  • Illustrated Toxicology

    With Study Questions
    • 1st Edition
    • PK Gupta
    • English
    Illustrated Toxicology: With Study Questions is an essential, practical resource for self-study and guidance catering to a broad spectrum of students. This book covers a range of core toxicological areas, including pesticides, radioactive materials and poisonous plants, also presenting a section on veterinary toxicology. Across 16 chapters, the book presents key concepts with the aid of over 250 detailed, full-color illustrations. Each section is supplemented with practical exercises to support active learning. This combination of clear illustrations and sample testing will help readers gain a deeper understanding of toxicology. This book is useful for toxicology, pharmacy, medical and veterinary students, and also serves as a refresher for academics and professionals in the field, including clinical pharmacists, forensic toxicologists, environmentalists and veterinarians.

  • Intestinal Stem Cell Niche

    • 1st Edition
    • Volume 2
    • English
    Advances in Stem Cells and Their Niches addresses stem cells during development, homeostasis, and disease/injury of the respective organs, presenting new developments in the field, including new data on disease and clinical applications. Video content illustrates such areas as protocols, transplantation techniques, and work with mice.

  • Biopolymers for Food Design

    • 1st Edition
    • Volume 20
    • Alexandru Mihai Grumezescu + 1 more
    • English
    Biopolymers for Food Design, Volume 20 in the Handbook of Bioengineering series, describes how biopolymers have made a major impact in the food industry, from food design, to food control and safety. Biopolymers can be used in the development of novel nutritional alternatives, to replace difficult to obtain food products, or for foods inaccessible or inappropriate for a particular population (i.e. allergic to specific components). In addition, some polymers can be used as functional ingredients, and can also represent efficient scaffolds for food ingredients with therapeutic values. This valuable reference is ideal for those looking for new solutions for the food industry.

  • The Neurology of HIV Infection

    • 1st Edition
    • Volume 152
    • English
    The Neurology of HIV Infection covers all aspects of nervous system involvement and pathology in HIV-infected individuals. Specialists in this field cover epidemiology, global aspects, pathology and pathogenesis of nervous system disease in HIV-infection. All complications, including the pathology caused by HIV itself and all opportunistic infections of the nervous system are reviewed in detail. Both central nervous and peripheral nervous system complications, including neuropathies and myopathies, are discussed. Key chapters on global developments, HIV-associated neurocognitive disorders, IRIS, stroke and neuro-aids in children complete this volume.

  • Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy

    • 2nd Edition
    • Herbert B. Newton
    • English
    Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy, Second Edition, provides a comprehensive overview of the molecular methodologies in the neuro-oncology field. There have been profound changes in the landscape of approaches to brain tumor therapy since the first edition—mainly in the areas of molecular biology and molecular therapeutics, as well as in the maturation of immunotherapy approaches (e.g., vaccines). This updated edition has a new, primary focus on multidisciplinary molecular methods, and is broadened to include the latest cutting-edge molecular biology, therapeutics, immunobiology and immunotherapy approaches. As the first comprehensive book to address the molecular research into these concepts, users will find it to be an invaluable resource on the topics discussed.

  • Targeting Cell Survival Pathways to Enhance Response to Chemotherapy

    • 1st Edition
    • Volume 3
    • English
    Targeting Cell Survival Pathways to Enhance Response to Chemotherapy encompasses recently developed molecular targeting agents and approaches that suppress cell survival signaling. Cell survival signaling attenuates the effectiveness of conventional chemotherapy and numerous mechanisms have been described, and continue to be described, which contribute to cell survival in the face of chemotherapy treatment. Key pathways leading to chemoresistance emanate from growth factor receptors, PI3K, STAT3, anti-apoptotic Bcl-2 family members, autophagy, and the DNA damage response pathway. New advances have underscored the potential of targeting each of these cell survival mechanisms to improve responsiveness to chemotherapy. This book reviews these recent advances and provides a foundational background and hints of new opportunities for basic, translational, and clinical investigators focused on improving therapeutic responses to chemotherapy.

  • Brugada Phenocopy

    The Art of Recognizing the Brugada ECG Pattern
    • 1st Edition
    • Adrian Baranchuk
    • English
    Brugada Phenocopy: The Art of Recognizing the Brugada ECG Pattern details all aspects associated with alternative diagnosis to Brugada Syndrome (BrS). Coverage includes how to identify the proper ECG pattern, what to do to investigate for BrP, and how to avoid misinterpretations and the use of unnecessary and expensive treatments. Chapters are written by experienced professionals, many of whom are colleagues that initially described this condition. This easy to use volume is a must have reference for researchers of cardiology, cardiologists, electrocardiologists... internists, emergency care doctors and students, residents and fellows.

  • Surgery in Rheumatic and Musculoskeletal Disease

    • 1st Edition
    • Volume 15
    • Fabiola Atzeni + 4 more
    • English
    Surgery in Systemic Autoimmune Disease, Volume 15, describes the state-of-the-art of the use of surgery in treating the most common systemic autoimmune diseases (SADS). The volume consists of an introductory chapter concerning the impact of surgery on SADs, follow by eight chapters describing the use of surgery in the treatment of specific diseases in various areas (cardiology, gastroenterology, orthopedics, neurology. etc.) and the possible difficulties and complications. The final five chapters deal with the possible complications arising during the course of biological and non-biological treatment, also providing recommendation concerning their management. International in scope, the list of more than 20 contributors from Europa and America reads like a who’s who of clinical researchers in the field.

  • Chemical and Biochemical Approaches for the Study of Anesthetic Function, Part A

    • 1st Edition
    • Volume 602
    • English
    Chemical and Biochemical Approaches for the Study of Anesthetic Function, Part A, Volume 602 assembles new information on our understanding of anesthesia. This latest release in the series includes sections on how physical accuracy leads to biological relevance, best practices for simulating ligand-gated ion channels interacting with general anesthetics, computational approaches for studying voltage-gated ion channels modulation by general anesthetics, anesthetic parameterization, pharmacophore QSAR, QM, ONIOM, and kinetic modeling of electrophysiology data.

  • Plant Micronutrient Use Efficiency

    Molecular and Genomic Perspectives in Crop Plants
    • 1st Edition
    • Mohammad Anwar Hossain + 4 more
    • English
    Plant Micronutrient Use Efficiency: Molecular and Genomic Perspectives in Crop Plants presents information on the complex mechanisms regulating micronutrient use efficiency in plants. Understanding this science is essential for the development of new varieties of crop plants that are more resilient to micronutrient stress, as well as plants with increased bioavailable concentrations of essential micronutrients. This book explores the discovery of novel genes and key metabolic pathways associated with micronutrient use efficiency in plants, gives an analyses of the gene expression patterns in plants in response to low and/or high nutrient levels, and investigates the potential functions of these genes and their products. Strategies to enhance micronutrient use efficiency and stress tolerance, to develop bio-fortified crop, and to improve the sustainable utilization of natural resources are critically evaluated. The book contains both fundamental and advanced information as well as critical commentaries that are useful for those involved in the various fields that make up the plant sciences.

  • Biodiversity and Evolution

    • 1st Edition
    • Philippe Grandcolas + 1 more
    • English
    Biodiversity and Evolution includes chapters devoted to the evolution and biodiversity of organisms at the molecular level, based on the study of natural collections from the Museum of Natural History. The book starts with an epistemological and historical introduction and ends with a critical overview of the Anthropocene epoch.

  • Ischemic and Traumatic Brain and Spinal Cord Injuries

    Mechanisms and Potential Therapies
    • 1st Edition
    • Akhlaq A. Farooqui
    • English
    Ischemic and Traumatic Brain and Spinal Cord Injuries: Mechanisms and Potential Therapies presents readers with comprehensive and cutting-edge information on molecular mechanisms, including the signal transduction processes associated with neurodegeneration and neuroprotection in ischemic, spinal cord, severe and mild brain injuries. The book also covers the molecular mechanisms of drugs used for the treatment of neurotraumatic disease. Chapters are organized by molecular aspects and neuroprotective strategies by disease, including ischemic injury, spinal cord injury, traumatic brain injury, and chronic traumatic encephalopathy. The book integrates and consolidates knowledge on neurotraumatic diseases, with the hope of bringing forth more dramatic advances and developments, not only on molecular mechanisms, but also on the causes of, and treatments for, neurotraumatic diseases.

  • Lipid Modification by Enzymes and Engineered Microbes

    • 1st Edition
    • Uwe T. Bornscheuer
    • English
    Lipid Modification by Enzymes and Engineered Microbes covers the state-of-the art use of enzymes as natural biocatalysts to modify oils, also presenting how microorganisms, such as yeast, can be designed. In the past ten years, the field has made enormous progress, not only with respect to the tools developed for the development of designer enzymes, but also in the metabolic engineering of microbes, the discovery of novel enzyme activities, and in reaction engineering/process development. For the first time, these advances are covered in a single-volume that is edited by leading enzymatic scientist Uwe Borchscheuer and authored by an international team of experts.

  • Stem Cells

    Therapeutic Innovations under Control
    • 1st Edition
    • Nicole Arrighi
    • English
    Stem Cells: Therapeutic Innovations under Control traces the discovery of stem cells and induced pluripotent cells. It establishes the link between knowledge about cell development and tissue engineering, and presents perspectives in regenerative medicine. Cell proliferation and tissue architecture open up unexpected applications in tissue engineering, with the development of tissues or organs. In this context emerges the need to address the issue of bioethics and regulatory considerations. Because stem cells can multiply and differentiate into cells specific to a particular tissue or organ, they represent vast potential in the health field.

  • Plant Metabolites and Regulation under Environmental Stress

    • 1st Edition
    • Parvaiz Ahmad + 5 more
    • English
    Plant Metabolites and Regulation Under Environmental Stress presents the latest research on both primary and secondary metabolites. The book sheds light on the metabolic pathways of primary and secondary metabolites, the role of these metabolites in plants, and the environmental impact on the regulation of these metabolites. Users will find a comprehensive, practical reference that aids researchers in their understanding of the role of plant metabolites in stress tolerance.

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