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Autophagy and Cardiometabolic Diseases: From Moleculer Mechanisms to Translational Medicine covers the science of autophagy in relation to cardiometabolic diseases and the futur… Read more
LIMITED OFFER
Immediately download your ebook while waiting for your print delivery. No promo code needed.
Autophagy and Cardiometabolic Diseases: From Moleculer Mechanisms to Translational Medicine covers the science of autophagy in relation to cardiometabolic diseases and the future therapeutic potentials of autophagy regulation in these processes. Processes are not described in isolation, but in concert with other cellular and/or metabolic processes, such as lipogenesis, glucose, energy metabolism and apoptosis. This approach recognizes the multifactorial nature of cardiometabolic diseases, including obesity, diabetes, insulin resistance, hypertension and dyslipidemia. The book provides explanations, while also distinguishing the delicate role for autophagy in pathogenesis and exploring complications for cardiometabolic diseases.
By targeting autophagy, it offers new avenues for drug discovery and treatment for cardiometabolic anomalies. It is a perfect resource for cardiology researchers, scientists and medical practitioners.
Researchers from both academia and industry working in the field of cardiovascular disease and biomedical sciences, medical practitioners, pharmaceutical industry workers, and health professional students
Section I. Cell biology of cardiometabolic syndrome and autophagy1. Overview of autophagy and cardiometabolic syndrome Annayya R. Aroor, Guanghong Jia and James R. Sowers2. Overview of autophagy and its molecular regulation Xi Ma, Linsen Li, Ting He, Michael A. Brown and Qing Zhong3. Interplay among oxidative stress, redox signaling, ER stress, autophagy, and protein ubiquitylation in cardiometabolic disorders Taixing Cui and Xuejun Wang4. Mechanism and regulation of selective mitophagy in cardiometabolic disease Zhi Yang, Jianjun Lv, Jun Ren and Dongdong Sun 5. Experimental models and measurement of autophagy Wei Zhu, Yong Sun, Yao-liang Tang, Chen Wang, Chang-Chen Xiao, Jing-Hai Chen, Hong Yu, Xin-Yang Hu and Jian’an Wang6. Role of autophagy in cardiac physiology and pathophysiology Valerie P. Tan and Shigeki Miyamoto
Section II. Autophagy and pathogenesis of cardiometabolic disease7. Autophagy and diabetes mellitus Yingmei Zhang8. Autophagy and hypertension Feng Cao and Sai Ma9. Myocardial insulin signaling and autophagy Jordan Bartlett, Trivedi Purvi, Brian Rodrigues and Thomas Pulinilkunnil10. Autophagy as a therapeutic target for cardiovascular complications in obesity - concepts, controversies, and challenges Jun Ren and Yingmei Zhang11. Autophagy and lipid metabolism in cardiometabolic diseases Mingjie Yang, Yingmei Zhang and Jun Ren12. Autophagy and stroke Pei Wang and Chao-Yu Miao13. Polycystic ovary syndrome and cardiometabolic disease Shuyi Wang, Amy M. Navratil and Jun Ren 14. The role of autophagy in vascular biology and atherosclerosis Ida Perrotta15. Autophagy and proteostasis in cardiac aging Dai Dao-Fu and Peter S. Rabinovitch16. Novel pathways of autophagy for the treatment of nervous system disorders Kenneth Maiese
Section III. Autophagy and complications of cardiometabolic disease17. Autophagy and liver disease Sergi Guixé-Muntet and Jordi Gracia-Sancho18. Chaperone-mediated autophagy and kidney disease Lu Wang, Ying Han and Jun Ren19. Autophagy and fetal programming Alina Maloyan20. Autophagy, oxidative stress and redox regulation Jipeng Ma, Lifang Yang, Jun Ren and Jian Yang
Section IV. Translational approach of autophagy21. Autophagy-driven cancer drug development Amine Belaid, Barnabé Roméo, Harilaos Filippakis, Mickael Meyer, Guillemette Crépeaux, Romain K Gherardi, Dominique Lagadic-Gossmann, Martin Von Bergen, Abderrahman Chargui, Eric Gilson, Delphine Benarroch-Popivker, Patrick Brest, Paul Hofman and Baharia Mograbi22. Autophagy: a new therapeutic target Asli F. Ceylan23. Autophagy regulates control of intracellular energy stores Michael N. Sack24. Autophagy and epigenetics Xu-Dong Wang, Thomas G. Gillette and Zhao V. Wang25. Autophagy, exercise and life style modification Donny Camera and William J. Smiles
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