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Elsevier

Conn's Handbook of Models for Human Aging

  • 2nd Edition - April 5, 2018
  • Latest edition
  • Editors: Jeffrey L. Ram, P. Michael Conn
  • Language: English

Conn's Handbook of Models for Human Aging, Second Edition, presents key aspects of biology, nutrition, factors affecting lifespan, methods of age determination, use in research… Read more

Description

Conn's Handbook of Models for Human Aging, Second Edition, presents key aspects of biology, nutrition, factors affecting lifespan, methods of age determination, use in research and the disadvantages/advantages of use. Using a multidisciplinary approach, this updated edition is designed as the only comprehensive, current work that covers the diversity in aging models. Chapters on comparative models explore age-related diseases, including Alzheimer's, joint disease, cataracts, cancer and obesity. Also included are new tricks and approaches not available in primary publications. This must-have handbook is an indispensable resource for researchers interested in the mechanisms of aging, gerontologists, health professionals, allied health practitioners and students.

Key features

  • Combines both the methods of study for human aging and animal models
  • Provides a historical overview and discussion of model availability, key methods and ethical issues
  • Contains over 200 full color illustrations

Readership

Researchers interested in the mechanisms of aging, gerontologists, health professionals, and allied health professionals and students

Table of contents

I. Aging in Humans

1. Werner Syndrome as a model of human aging

2. Premature aging syndrome

3. Models, Definitions, and Criteria of Frailty

4. Immunological methods and the concept of inflamm-aging in the study of human aging

5. Vulnerability and Experiential Health in Old Age – a qualitative perspective

6. Body composition analysis in older adults

7. Using Computational Models to Study Aging

8. A framework for uncovering the roles of calories and macronutrients in health and aging

9. Female Reproductive Aging: From Consequences to Mechanisms, Markers, and Treatments

10. Adrenopause

11. What sets Iceland apart in understanding human aging

II. Animal models: Vertebrates

12. Reproductive Tract Lesions in Aged Chimpanzees

13. Age-related changes to the bony structure and musculature of the shoulder in a nonhuman primate model

14. The dog as a model for aging research

15. Dogs as a Spontaneous Model for Early Alzheimer's Disease

16. Determining cause of death and contributing causes of death in rodent aging studies

17. Rat Models of Cognitive Aging

18. Life Extension in Dwarf Mice

19. Extension of Lifespan in Laboratory Mice

20. Development and Validation of ECG analysis algorithm in mice

21. Old mouse lemur: behavior, cognition and neuropathology

22. Birds as models for the biology of aging and aging-related disease: an update

23. Telomeres and Telomerase in Birds: Measuring Health, Environmental Stress and Longevity

24. Zebrafish model for investigating the integrated control of reproduction

25. Modelling aging and age-associated pathology in zebrafish

26. The use of mature zebrafish (Danio rerio) as a model for human aging and disease

27. Piscine polemics; Small tropical fish species as models for aging research

28. The short-lived African turquoise killifish (Nothobranchius furzeri): a new model system for research on aging

III. Cellular models and invertebrates

29. A Budding Topic: Modeling Aging and Longevity in Yeast

30. The Budding and Fission Yeast Model Systems for Aging Biology: Rapid Advancement with New Technologies

31. Podospora anserina: a filamentous fungus with a strong mitochondrial etiology of aging

32. Invertebrates as model organisms for research on aging biology

33. Invertebrate models for the study of the effects of age on neurotransmitter release

34. Impact of Chronic Exercise on Invertebrate Functional Aging

35. The virtues and challenges of multidimensional analyses of whole brains during aging with single cell resolution

36. Rotifers as a Model for the Biology of Aging

37. The Potential of Comparative Biology to Reveal Mechanisms of Aging in Rotifers

38. Hydra, a model system for deciphering the mechanisms of aging and resistance to aging

39. Regeneration and Aging in The Tunicate Ciona intestinalis

40. Honeybee Workers as Models of Aging

IV. Disease models

41. Approaches to the Assessment of Frailty in Animal Models

42. Genotype and sex differences in life expectancy in transgenic AD mice

43. Animal models of vascular cognitive impairment and dementia

44. Alzheimer's Dementia Drug Discovery: Targeting Synaptic Glutamate Uptake

45. A Transgenic Monkey Model of Huntington’s Disease

46. Parkinson’s Disease in Humans and in Non-Human Primate Aging and Neurotoxin Models

47. Genetic Models of Parkinson’s Disease and Their Study in Non-Human Primates

48. Impact of the Aged Brain Environment on Gene Therapy for Parkinson’s Disease

49. Cell Therapy for Parkinson's Disease

50. Genetics of progeria and aging

51. Progeria mouse models

52. Models of Hypertension in Aging

53. Osteoporosis and Cardiovascular Disease in the Elderly

54. The role of the tumor microenvironment in pancreatic ductal adenocarcinoma and preclinical models to study it

V. Organ systems

55. Alopecia

56. Experimental Models of human skin aging

57. Muscle deconditioning and aging: experimental models

58. Models of Immune Aging

59. Sex and the aging immune system

60. Rodent Models of Ovarian Failure

61. Role of Sex and Aging in Mucosal Health

62. Leydig Cell Development and Aging in the Brown Norway Rat: Mechanisms and Consequences

63. Models of aging Kidney: Implications on kidney health and disease

64. Age-Associated Changes in Structure and Function of the Aging Human Lung

65. Glucose, insulin and brain aging

66. Pathology of brain aging and animal models of neurodegenerative diseases

67. Leptin and aging in animal models

68. Age-Related Changes to Bone Structure and Quality in Rodent Models

VI. Mechanisms

69. Dielectric properties of biological tissues; variation with age

70. Experimental Models of Tau Aggregation

71. Aging of Human Mesenchymal Stem Cells

72. Helicases and their relevance to aging

73. Genetics of human aging

74. Epigenetics of brain Aging

75. The Circadian Clock and the Aging Process

76. Super DNAging-New insights into DNA integrity, genome stability and telomeres in the oldest old

77. Model of Chaperones in Aging

78. Chaperone-mediated autophagy

79. Resveratrol in Aging and Age-Related Diseases

80. Resveratrol in experimental models and humans

Product details

  • Edition: 2
  • Latest edition
  • Published: April 5, 2018
  • Language: English

About the editors

JR

Jeffrey L. Ram

Jeffrey L. Ram is Professor of Physiology at the Wayne State University School of Medicine and the Director of the Belle Isle Aquarium Laboratory in Detroit, MI USA. After receiving a B.A. Magna cum Laude degree in Physics from the University of Pennsylvania (1967) and being a Thouron Scholar at Cambridge University (1967-1968), he earned a Ph.D. degree in Biochemistry and Neurophysiology from the California Institute of Technology (1974). Following post-doctoral research at the University of California Santa Cruz, and a fellowship at the Marine Biological Laboratory in Woods Hole, MA USA, he joined the faculty in the Department of Physiology of Wayne State University in 1977. Ram is known for his studies of the endocrine, neural, and pharmacological control of reproduction, muscle, and digestive physiology in invertebrate model systems, especially Aplysia, his research on invasive mussels, and recent studies on aquatic biodiversity. Together with Dr. Mahadev Murthy (NIH) he developed symposia and publications on the use of model systems for the study of aging, an activity that he has continued as President of the International Society for Invertebrate Reproduction and Development (2014 – 2017). Ram’s collaborations on vertebrate systems have included biodiversity studies of the fecal and oral microbiome of animals and people. He has authored or co-authored over 150 publications in these areas and edited the proceedings of several symposia, including a 10 paper issue on model systems for the study of aging for the Journal of Invertebrate Reproduction and Development. The work of his laboratory has been recognized by numerous grants from NIH, NSF, EPA, and various foundations such as the American Heart Association and the Myasthenia Gravis Foundation. Ram is an elected fellow of the American Association for the Advancement of Science. As head of an NSF project to promote the interest of public school students in science and science careers, Ram works closely with the Belle Isle Aquarium and the Detroit Public Schools Community District to increase the public understanding of how scientists work and the importance and place of science in protecting the environment.
Affiliations and expertise
Wayne State University School of Medicine, Detroit, USA

PC

P. Michael Conn

P. Michael Conn is the Senior Vice President for Research and Associate Provost, Texas Tech Health Sciences Center. He is The Robert C. Kimbrough, Professor of Internal Medicine and Cell Biology/Biochemistry. He was previously Director of Research Advocacy and Professor of Physiology and Pharmacology, Cell Biology and Development and Obstetrics and Gynecology at Oregon Health and Science University and Senior Scientist of the Oregon National Primate Research Center (ONPRC). He served for twelve years as Special Assistant to the President and Associate Director of the ONPRC. After receiving a B.S. degree and teaching certification from the University of Michigan (1971), a M.S. from North Carolina State University (1973), and a Ph.D. degree from Baylor College of Medicine (1976), Conn did a fellowship at the NIH, then joined the faculty in the Department of Pharmacology, Duke University Medical Center where he was promoted to Associate Professor in 1982. In 1984, he became Professor and Head of Pharmacology at the University of Iowa College of Medicine, a position he held for eleven years. Conn is known for his research in the area of the cellular and molecular basis of action of gonadotropin releasing hormone action in the pituitary and therapeutic approaches that restore misfolded proteins to function. His work has led to drugs that have benefitted humans and animals. Most recently, he has identified a new class of drugs, pharmacoperones, which act by regulating the intracellular trafficking of receptors, enzymes and ion channels. He has authored or co-authored over 350 publications in this area and written or edited over 200 books, including texts in neurosciences, molecular biology and endocrinology. Conn has served as the editor of many professional journals and book series (Endocrinology, Journal of Clinical Endocrinology and Metabolism, Endocrine, Methods, Progress in Molecular Biology and Translational Science and Contemporary Endocrinology). Conn served on the National Board of Medical Examiners, including two years as chairman of the reproduction and endocrinology committee. The work of his laboratory has been recognized with a MERIT award from the NIH, the J.J. Abel Award of the American Society for Pharmacology and Experimental Therapeutics, the Weitzman, Oppenheimer and Ingbar Awards of the Endocrine Society, the National Science Medal of Mexico (the Miguel Aleman Prize) and the Stevenson Award of Canada. He is the recipient of the Oregon State Award for Discovery, the Media Award of the American College of Neuropsychopharmacology and was named a distinguished Alumnus of Baylor College of Medicine in 2012. Conn is a previous member of Council for the American Society for Cell Biology and the Endocrine Society and is a prior President of the Endocrine Society, during which time he founded the Hormone Foundation and worked with political leadership to heighten the public’s awareness of diabetes. Conn’s students and fellows have gone on to become leaders in industry and academia. He is an elected member of the Mexican Institute of Medicine and a fellow of the American Association for the Advancement of Science. He is the co-author of The Animal Research War (2008) and many articles for the public and academic community on the value of animal research and the dangers posed by animal extremism. His op/eds have appeared in The Washington Post, The LA Times, The Wall Street Journal, the Des Moines Register, and elsewhere. Conn consults with organizations that are influenced by animal extremism and with universities and companies facing challenges from these groups.
Affiliations and expertise
Senior Vice President for Research and Associate Provost, Texas Tech Health Sciences Center, TX, USA

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