Conn's Handbook of Models for Human Aging
- 3rd Edition - July 1, 2027
- Latest edition
- Editors: Mary Ann Ottinger, Julie K Anderson, Pierre Comizzoli, Gordon Lithgow
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 4 5 2 4 6 - 8
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 4 5 2 4 7 - 5
“Conn's Handbook of Models for Human Aging, Third Edition” presents a comprehensive and updated scholarly volume that captures the array of models useful for studying human aging… Read more
Purchase options
“Conn's Handbook of Models for Human Aging, Third Edition” presents a comprehensive and updated scholarly volume that captures the array of models useful for studying human aging. This new edition includes groundbreaking chapters on community and environmental factors impacting aging, providing a synthesis of aging biology that spans fundamental and translational research. Since the last edition in 2018, there have been significant advances in biomedicine, driven by the increasing global aging population and the pressing need to address geriatric issues. This third edition addresses current challenges affecting healthy aging and offers a robust knowledge base for students and professionals in geroscience. With its wide scope, the book covers multiple facets of aging and the utility of models targeting specific aspects of human aging biology. Continuing its multidisciplinary approach, “Conn's Handbook of Models for Human Aging, Third Edition” unravels the problem of understanding the diverse challenges facing aging populations worldwide, including environmental and social exposures. Geroscience has made dramatic advances, providing new insights into aging processes, healthy aging, and the diagnosis and treatment of age-related disorders and diseases. This volume is an indispensable resource for researchers, clinical practitioners, allied industry personnel, students, and trainees, serving as an essential reference text for various levels.
• Encompasses a wide range of topics on aging biology, from fundamental research to translational applications
• Includes the latest advances in geroscience, addressing current challenges in healthy aging and age-related diseases
• Integrates diverse models and perspectives to provide a holistic understanding of aging processes
• Features new chapters on community and environmental factors impacting aging, offering critical insights into external influences
• Serves as a valuable resource for researchers, practitioners, students, and industry professionals in aging biology
• Includes the latest advances in geroscience, addressing current challenges in healthy aging and age-related diseases
• Integrates diverse models and perspectives to provide a holistic understanding of aging processes
• Features new chapters on community and environmental factors impacting aging, offering critical insights into external influences
• Serves as a valuable resource for researchers, practitioners, students, and industry professionals in aging biology
Researchers, clinical practitioners, gerontologists, allied health professionals, industry personnel, students, and trainees in the field of aging biology and geroscience
Section 1: Aging in Humans Subsection A: Longitudinal Studies
1. Longitudinal Study
2. Longevity Cohorts/Ashkenazi
3. New England Centenarian Study
4. Genetics of Human Aging
Subsection B: Longevity and Healthspan
5. Longevity and Healthspan 1
6. Longevity and Healthspan 2
7. Longevity and Healthspan 3
8. Clinical Trials and Human Aging
Subsection C: Interventions and Nutrition
9. Blue Zone Populations
10. Nutritional Interventions
11. Body Composition Analysis in Older Adults
12. Calorie Restriction Studies in Rodents and Non-human Primates
13. CALERIE
14. Nutritional Geometric Framework
15. A Framework for Uncovering the Roles of Calories and Macronutrients in Health and Aging
16. Transferability of Laboratory Studies to Human Health
17. Non-human Primate Studies on Long-term CR
Subsection D: Premature Aging
18. Werner Syndrome as a Model of Human Aging
19. Premature Aging Syndrome
20. Genetics of Progeria and Aging
21. Progeria Mouse Models
Subsection E: Reproductive Aging
22. Reproductive Performance and Senescence
23. Female Reproductive Aging: From Consequences to Mechanisms, Markers, and Treatments
24. Rodent Models of Ovarian Failure
25. Andropause in Males
26. Leydig Cell Development and Aging in the Brown Norway Rat: Mechanisms and Consequences
Subsection F: Circadian Rhythms and Physiological Clocks
27. Circadian Rhythms and Neuroendocrine Function
28. The Circadian Clock and the Aging Process
29. Physiological Clocks
30. Aging and Rhythms
Subsection G: Tissue and Organ Changes with Aging
31. Cardiovascular
32. Renal Tissue Aging
33. Aging of the Skin
34. Adipose
35. Immune/Inflammaging Inflammation
36. Lung
37. Bone
38. Alopecia
39. Gut
40. Role of Sex and Aging in Mucosal Health
41. CNS
42. Liver/Pancreas
43. Microbiomes
Section 2: Cellular Mechanisms in Aging
44. Cellular Senescence
45. Telomeres
46. Mitochondria
47. Dielectric Properties of Biological Tissues
48. Aging of Human Mesenchymal Stem Cells
49. NSCs
50. Helicases and Their Relevance to Aging
51. Stem Cells
52. Super DNAging
53. Model of Chaperones in Aging Chaperone-mediated Autophagy
54. Chaperone-mediated Autophagy
55. Chaperones in Aging
56. Multi-omic, Correlative
57. Lysosome/Peroxisome
58. Lysosomes and Aging
59. Transposons
Section 3: Community, Societal Perception of Aging and Future Needs (Adapted Healthcare Services, Quality of Life)
60. Vulnerability and Experiential Health in Old Age
- Qualitative Perspective
61. What Sets Iceland Apart in Understanding Human Aging
62. Strategies for Optimizing Healthy Aging in Communities
63. One Health and Community Strategies
64. Optimizing Coalitions of Farmers and Conservation Programs for Healthy Communities
65. Microbiomes Reflect Community Health
Section 4: Mammalian Models of Aging
66. Overview of Mammalian Models
Subsection A: Primates
67. Great Apes
68. Rhesus Macaque Models
69. Primate Neuroendocrine Systems
70. Reproductive Tract Lesions in Aged Chimpanzees
71. Age-related Changes to the Bony Structure and Musculature of the Shoulder in a Nonhuman Primate Model
72. Aging in Capuchins
73. Baboons
74. Marmoset Monkeys (Callithrix jacchus), an Emerging Model in Aging
Subsection B: Studies of Aging in Dogs
75. Dog Aging Project
76. The Dog as a Model for Aging Research
77. Dogs as a Spontaneous Model for Early Alzheimer's Disease
Subsection C: Rodents and Cornerstone Studies
78. Longitudinal Studies in Murine Models
79. Multiple Murine Models for Aging Research
80. Rodent Studies on Aging
81. Genomic Population Analyses
82. Genomic Related Differences in Aging
83. Aging in Mutant Mouse Models
84. Determining Cause of Death and Contributing Causes of Death in Rodent Aging Studies
85. Life Extension in Dwarf Mice
86. Extension of Lifespan in Laboratory Mice
87. Development and Validation of ECG Analysis Algorithm in Mice
88. Genotype and Sex Differences in Life Expectancy in Transgenic AD Mice
89. Female Reproductive Aging in Rats
90. Rat Models of Cognitive Aging
Subsection D: Other Mammalian Models
91. Pig Model Mini Pig Model
92. Sheep and Neuroendocrine Aging
93. Cetaceans and Whales
94. Elephants
95. Bats
96. Naked Mole Rat
97. Old Mouse Lemur: Behavior, Cognition and Neuropathology
98. Sheep and Other Models
Section 5: Comparative Vertebrate Aging
Subsection A: Birds
99. Hair Cell Regeneration in Aging Quail
100. Reproduction and Neuroendocrine Aging in Japanese Quail
101. Retinoids and Visual Acuity in Birds
102. Comparing Data from Long-lived Birds in Captivity to Wild Populations
103. Birds as Models for the Biology of Aging and Aging-related Disease: An Update
104. Telomeres and Telomerase in Birds: Measuring Health, Environmental Stress and Longevity
Subsection B: Salamanders, Axolotls, Frogs
105. Salamanders/Axolotls
106. Frogs Regeneration
Subsection C: Fish Models
107. Transgenic Zebrafish and the Killifish Models for Aging Research
108. Zebrafish Model for Investigating the Integrated Control of Reproduction
109. Modelling Aging and Age-associated Pathology in Zebrafish
110. The Use of Mature Zebrafish (Danio rerio) as a Model for Human Aging and Disease
111. Piscine Polemics; Small Tropical Fish Species as Models for Aging Research
112. The short-lived African Turquoise Killifish (Nothobranchius furzeri): A New Model System for Research on Aging
113. Phenotypic Screening to Explore Organ Specific Mechanisms (Yeast, Killifish, etc.)
Section 6: Aging in Invertebrates and Models for Aging Research
114. C. elegans—Dauer to Daf (IIS), Reproduction, Ontogeny, Intergenerational Affairs, Diet and the Complexities
115. Drosophila
116. Yeast—Aging, Models, Mitochondria, Retrograde Mechanisms, SIRs Viz Aging (Genome Stability Context, Metabolism—Homeostasis and Plasticity)
117. Modeling Aging and Longevity in Yeast
118. The Budding and Fission Yeast Model Systems for Aging Biology: Rapid Advancement with New Technologies
119. Podospora Anserina: A Filamentous Fungus with a Strong Mitochondrial Etiology of Aging
120. Invertebrates as Model Organisms for Research on Aging Biology
121. Invertebrate Models for Study of the Effects of Age on Neurotransmitter Release
122. Impact of Chronic Exercise on Invertebrate Functional Aging
123. Seahorse as a Model of Aging
124. Rotifers as a Model for the Biology of Aging
125. The Potential of Comparative Biology to Reveal Mechanisms of Aging in Rotifers
126. Hydra, a Model System for Deciphering the Mechanisms of Aging and Resistance to Aging
127. Regeneration and Aging in the Tunicate Ciona Intestinalis
128. Sea Urchins
129. Social Insects: Queen/Worker Bees. Honeybee Workers as Models of Aging 130. Social Insects: Ants
131. Social Insects: Termites and Extreme Longevity
Section 7: Epidemiological and Demographic Methods in Aging Research
132. Comparative Mortality Dynamics
133. Epigenetics and Reprogramming
134. Epigenetics and Aging
135. Epigenetics of Brain Aging
136. DNA Damage
137. World of Big Data and Multi-omic Data
138. Using Artificial Intelligence to Generate Information, the Predictive Disease Potential and the Need to Integrate with Stressors
139. Using Computational Models to Study Aging and the Potential Role of AI
Section 8: Aging and Disease
Subsection A: Fragility and Muscle Loss
140. Fragility
141. Muscle Deconditioning and Aging: Experimental Models
142. Approaches to the Assessment of Frailty in Animal Models
143. Models, Definitions, and Criteria of Frailty Subsection B: Physiological Systems and Aging
144. The Role of the Tumor Microenvironment in Pancreatic Ductal Adenocarcinoma and Preclinical Models
145. Age-associated Changes in Structure and Function of the Aging Human Lung
146. Leptin and Aging in Animal Models
147. Age-related Changes to Bone Structure and Quality in Rodent Models
148. Age-related Changes to Bone 2
149. Osteoporosis and Cardiovascular Disease in the Elderly
150. Glucose, Insulin and Brain Aging
151. Models of Hypertension in Aging
152. Models of Immune Aging
153. Sex and the Aging Immune System
154. Immunological Methods and the Concept of Inflamm-aging in the Study of Human Aging
155. Macroautophagy
Subsection C: Brain and Cognitive Aging
156. The Virtues and Challenges of Multidimensional Analyses of Whole Brains During Aging with Single Cell Resolution
157. Animal Models of Vascular Cognitive Impairment and Dementia
158. Alzheimer’s Dementia Drug Discovery: Targeting Synaptic Glutamate Uptake
159. A Transgenic Monkey Model of Huntington’s Disease
160. Parkinson’s Disease in Humans and in Non-human Primate Aging and Neurotoxin Models
161. Genetic Models of Parkinson’s Disease and their Study in Non-human Primates
162. Impact of the Aged Brain Environment on Gene Therapy for Parkinson’s Disease
163. Cell Therapy for Parkinson's Disease
164. Pathology of Brain Aging and Animal Models of Neurodegenerative Diseases
165. Experimental Models of Tau Aggregation
166. Alzheimer’s Disease and Dementia
167. Lewy Body Dementia
Section 9: Environmental Impacts on Aging in Humans and Animal Models
168. An Overview of the Exposome
169. The Toxic Coin: Aging and Exposure Effects
170. Human Studies on the Exposome
171. Heavy Metals
172. Environmental Influences Affecting Aging Processes and Onset of Disease
173. Pollutants Linked to Aging Diseases (Parkinson’s, AD, Lewy Bodies)
Section 10: Aging Processes and Interventions
174. GWAS Analyses for Drug Targets in Aging
175. The NIA Interventions Testing Program and Pathway to Clinical Trials
176. Resveratrol in Aging and Age-Related Diseases
177. Resveratrol in Experimental Models and Humans
178. The Controversy About Resveratrol and Path Forward
179. Exercise and Aging
180. Heterochronic Parabiosis and Related Interventions
181. Neurodegenerative Disease and Stem Cells
182. Cellular Mechanisms and Neurodegenerative Disease
183. Nutraceuticals and Dietary Additives
Section 11: Conclusions
184. Wild Animal Species
185. Interactive Effects of Mixtures of Environmental Stressors and Lifelong Health
186. Volume Summary
1. Longitudinal Study
2. Longevity Cohorts/Ashkenazi
3. New England Centenarian Study
4. Genetics of Human Aging
Subsection B: Longevity and Healthspan
5. Longevity and Healthspan 1
6. Longevity and Healthspan 2
7. Longevity and Healthspan 3
8. Clinical Trials and Human Aging
Subsection C: Interventions and Nutrition
9. Blue Zone Populations
10. Nutritional Interventions
11. Body Composition Analysis in Older Adults
12. Calorie Restriction Studies in Rodents and Non-human Primates
13. CALERIE
14. Nutritional Geometric Framework
15. A Framework for Uncovering the Roles of Calories and Macronutrients in Health and Aging
16. Transferability of Laboratory Studies to Human Health
17. Non-human Primate Studies on Long-term CR
Subsection D: Premature Aging
18. Werner Syndrome as a Model of Human Aging
19. Premature Aging Syndrome
20. Genetics of Progeria and Aging
21. Progeria Mouse Models
Subsection E: Reproductive Aging
22. Reproductive Performance and Senescence
23. Female Reproductive Aging: From Consequences to Mechanisms, Markers, and Treatments
24. Rodent Models of Ovarian Failure
25. Andropause in Males
26. Leydig Cell Development and Aging in the Brown Norway Rat: Mechanisms and Consequences
Subsection F: Circadian Rhythms and Physiological Clocks
27. Circadian Rhythms and Neuroendocrine Function
28. The Circadian Clock and the Aging Process
29. Physiological Clocks
30. Aging and Rhythms
Subsection G: Tissue and Organ Changes with Aging
31. Cardiovascular
32. Renal Tissue Aging
33. Aging of the Skin
34. Adipose
35. Immune/Inflammaging Inflammation
36. Lung
37. Bone
38. Alopecia
39. Gut
40. Role of Sex and Aging in Mucosal Health
41. CNS
42. Liver/Pancreas
43. Microbiomes
Section 2: Cellular Mechanisms in Aging
44. Cellular Senescence
45. Telomeres
46. Mitochondria
47. Dielectric Properties of Biological Tissues
48. Aging of Human Mesenchymal Stem Cells
49. NSCs
50. Helicases and Their Relevance to Aging
51. Stem Cells
52. Super DNAging
53. Model of Chaperones in Aging Chaperone-mediated Autophagy
54. Chaperone-mediated Autophagy
55. Chaperones in Aging
56. Multi-omic, Correlative
57. Lysosome/Peroxisome
58. Lysosomes and Aging
59. Transposons
Section 3: Community, Societal Perception of Aging and Future Needs (Adapted Healthcare Services, Quality of Life)
60. Vulnerability and Experiential Health in Old Age
- Qualitative Perspective
61. What Sets Iceland Apart in Understanding Human Aging
62. Strategies for Optimizing Healthy Aging in Communities
63. One Health and Community Strategies
64. Optimizing Coalitions of Farmers and Conservation Programs for Healthy Communities
65. Microbiomes Reflect Community Health
Section 4: Mammalian Models of Aging
66. Overview of Mammalian Models
Subsection A: Primates
67. Great Apes
68. Rhesus Macaque Models
69. Primate Neuroendocrine Systems
70. Reproductive Tract Lesions in Aged Chimpanzees
71. Age-related Changes to the Bony Structure and Musculature of the Shoulder in a Nonhuman Primate Model
72. Aging in Capuchins
73. Baboons
74. Marmoset Monkeys (Callithrix jacchus), an Emerging Model in Aging
Subsection B: Studies of Aging in Dogs
75. Dog Aging Project
76. The Dog as a Model for Aging Research
77. Dogs as a Spontaneous Model for Early Alzheimer's Disease
Subsection C: Rodents and Cornerstone Studies
78. Longitudinal Studies in Murine Models
79. Multiple Murine Models for Aging Research
80. Rodent Studies on Aging
81. Genomic Population Analyses
82. Genomic Related Differences in Aging
83. Aging in Mutant Mouse Models
84. Determining Cause of Death and Contributing Causes of Death in Rodent Aging Studies
85. Life Extension in Dwarf Mice
86. Extension of Lifespan in Laboratory Mice
87. Development and Validation of ECG Analysis Algorithm in Mice
88. Genotype and Sex Differences in Life Expectancy in Transgenic AD Mice
89. Female Reproductive Aging in Rats
90. Rat Models of Cognitive Aging
Subsection D: Other Mammalian Models
91. Pig Model Mini Pig Model
92. Sheep and Neuroendocrine Aging
93. Cetaceans and Whales
94. Elephants
95. Bats
96. Naked Mole Rat
97. Old Mouse Lemur: Behavior, Cognition and Neuropathology
98. Sheep and Other Models
Section 5: Comparative Vertebrate Aging
Subsection A: Birds
99. Hair Cell Regeneration in Aging Quail
100. Reproduction and Neuroendocrine Aging in Japanese Quail
101. Retinoids and Visual Acuity in Birds
102. Comparing Data from Long-lived Birds in Captivity to Wild Populations
103. Birds as Models for the Biology of Aging and Aging-related Disease: An Update
104. Telomeres and Telomerase in Birds: Measuring Health, Environmental Stress and Longevity
Subsection B: Salamanders, Axolotls, Frogs
105. Salamanders/Axolotls
106. Frogs Regeneration
Subsection C: Fish Models
107. Transgenic Zebrafish and the Killifish Models for Aging Research
108. Zebrafish Model for Investigating the Integrated Control of Reproduction
109. Modelling Aging and Age-associated Pathology in Zebrafish
110. The Use of Mature Zebrafish (Danio rerio) as a Model for Human Aging and Disease
111. Piscine Polemics; Small Tropical Fish Species as Models for Aging Research
112. The short-lived African Turquoise Killifish (Nothobranchius furzeri): A New Model System for Research on Aging
113. Phenotypic Screening to Explore Organ Specific Mechanisms (Yeast, Killifish, etc.)
Section 6: Aging in Invertebrates and Models for Aging Research
114. C. elegans—Dauer to Daf (IIS), Reproduction, Ontogeny, Intergenerational Affairs, Diet and the Complexities
115. Drosophila
116. Yeast—Aging, Models, Mitochondria, Retrograde Mechanisms, SIRs Viz Aging (Genome Stability Context, Metabolism—Homeostasis and Plasticity)
117. Modeling Aging and Longevity in Yeast
118. The Budding and Fission Yeast Model Systems for Aging Biology: Rapid Advancement with New Technologies
119. Podospora Anserina: A Filamentous Fungus with a Strong Mitochondrial Etiology of Aging
120. Invertebrates as Model Organisms for Research on Aging Biology
121. Invertebrate Models for Study of the Effects of Age on Neurotransmitter Release
122. Impact of Chronic Exercise on Invertebrate Functional Aging
123. Seahorse as a Model of Aging
124. Rotifers as a Model for the Biology of Aging
125. The Potential of Comparative Biology to Reveal Mechanisms of Aging in Rotifers
126. Hydra, a Model System for Deciphering the Mechanisms of Aging and Resistance to Aging
127. Regeneration and Aging in the Tunicate Ciona Intestinalis
128. Sea Urchins
129. Social Insects: Queen/Worker Bees. Honeybee Workers as Models of Aging 130. Social Insects: Ants
131. Social Insects: Termites and Extreme Longevity
Section 7: Epidemiological and Demographic Methods in Aging Research
132. Comparative Mortality Dynamics
133. Epigenetics and Reprogramming
134. Epigenetics and Aging
135. Epigenetics of Brain Aging
136. DNA Damage
137. World of Big Data and Multi-omic Data
138. Using Artificial Intelligence to Generate Information, the Predictive Disease Potential and the Need to Integrate with Stressors
139. Using Computational Models to Study Aging and the Potential Role of AI
Section 8: Aging and Disease
Subsection A: Fragility and Muscle Loss
140. Fragility
141. Muscle Deconditioning and Aging: Experimental Models
142. Approaches to the Assessment of Frailty in Animal Models
143. Models, Definitions, and Criteria of Frailty Subsection B: Physiological Systems and Aging
144. The Role of the Tumor Microenvironment in Pancreatic Ductal Adenocarcinoma and Preclinical Models
145. Age-associated Changes in Structure and Function of the Aging Human Lung
146. Leptin and Aging in Animal Models
147. Age-related Changes to Bone Structure and Quality in Rodent Models
148. Age-related Changes to Bone 2
149. Osteoporosis and Cardiovascular Disease in the Elderly
150. Glucose, Insulin and Brain Aging
151. Models of Hypertension in Aging
152. Models of Immune Aging
153. Sex and the Aging Immune System
154. Immunological Methods and the Concept of Inflamm-aging in the Study of Human Aging
155. Macroautophagy
Subsection C: Brain and Cognitive Aging
156. The Virtues and Challenges of Multidimensional Analyses of Whole Brains During Aging with Single Cell Resolution
157. Animal Models of Vascular Cognitive Impairment and Dementia
158. Alzheimer’s Dementia Drug Discovery: Targeting Synaptic Glutamate Uptake
159. A Transgenic Monkey Model of Huntington’s Disease
160. Parkinson’s Disease in Humans and in Non-human Primate Aging and Neurotoxin Models
161. Genetic Models of Parkinson’s Disease and their Study in Non-human Primates
162. Impact of the Aged Brain Environment on Gene Therapy for Parkinson’s Disease
163. Cell Therapy for Parkinson's Disease
164. Pathology of Brain Aging and Animal Models of Neurodegenerative Diseases
165. Experimental Models of Tau Aggregation
166. Alzheimer’s Disease and Dementia
167. Lewy Body Dementia
Section 9: Environmental Impacts on Aging in Humans and Animal Models
168. An Overview of the Exposome
169. The Toxic Coin: Aging and Exposure Effects
170. Human Studies on the Exposome
171. Heavy Metals
172. Environmental Influences Affecting Aging Processes and Onset of Disease
173. Pollutants Linked to Aging Diseases (Parkinson’s, AD, Lewy Bodies)
Section 10: Aging Processes and Interventions
174. GWAS Analyses for Drug Targets in Aging
175. The NIA Interventions Testing Program and Pathway to Clinical Trials
176. Resveratrol in Aging and Age-Related Diseases
177. Resveratrol in Experimental Models and Humans
178. The Controversy About Resveratrol and Path Forward
179. Exercise and Aging
180. Heterochronic Parabiosis and Related Interventions
181. Neurodegenerative Disease and Stem Cells
182. Cellular Mechanisms and Neurodegenerative Disease
183. Nutraceuticals and Dietary Additives
Section 11: Conclusions
184. Wild Animal Species
185. Interactive Effects of Mixtures of Environmental Stressors and Lifelong Health
186. Volume Summary
- Edition: 3
- Latest edition
- Published: July 1, 2027
- Language: English
MO
Mary Ann Ottinger
Mary Ann Ottinger is Professor Emeritus at the University of Maryland and the University of Houston, holding a Ph.D. in Behavioral Neuroendocrinology. Her research focuses on neuroendocrine function, comparative biology of aging, and the effects of endocrine-disrupting chemicals. Her studies in Japanese quail revealed conserved mechanisms in age-related endocrine decline and highlighted differences in oxidative damage resistance compared to long-lived birds. Her work in non-human primates explored calorie restriction's effects on aging, while studies in transgenic Alzheimer's disease mouse models showed the benefits of selective estrogen receptor modulators. Recent research integrates One Health, the Exposome, and conservation for a comprehensive environmental health perspective. Dr. Ottinger has received the Sigma Xi Research Award, OECD Fellowship, and Gamma Sigma Delta Research Award, and is a Fellow of the Society for the Study of Reproduction, Poultry Science Association, AAAS, and the Explorers Club.
Affiliations and expertise
Professor Emeritus of Endocrinology, Research Professor, Department of Biology and Biochemistry, University and Professor Emeritus of Endocrinology, Department of Animal and Avian Sciences, University of MarylandJA
Julie K Anderson
Julie K Andersen is a Professor at the Buck Institute for Research on Aging with a PhD in Biological Chemistry. Her primary expertise is the contribution of hallmarks of aging to age-related neurodegeneration. Recent work from her laboratory in the area of cellular senescence was amongst the first to demonstrate a causative role for this pathway as it relates to age-related neurodegenerative diseases. Her recent studies on mitochondrial function have provided key insights into the conservative role of mitophagy in both health span and lifespan in species ranging from C. elegans to human cell models. Dr. Andersen is the recipient of numerous awards including the following: Brookdale National Leadership in Aging Fellowship, Senior Ellison Medical Foundation Scholarship in Aging, Paul F. Glenn Chair in Molecular and Cellular Gerontology, Fellow of the Society for Free Radical Biology and Medicine, and National Parkinson’s Foundation Pioneer Award.
Affiliations and expertise
Professor, Buck Institute for Research on AgingPC
Pierre Comizzoli
Pierre Comizzoli started his career 30 years ago as a research veterinarian in French Guyana and Northern Africa studying reproductive biology of various animal species. He completed a PhD in 2000 on in vitro fertilization in bovine and deer species. He then worked on the implementation of reproductive biotechnologies and Genome Resource Banking for the conservation of wild ungulates at the National Museum of Natural History of Paris. In 2002, Dr. Comizzoli joined the Smithsonian Institution in Washington, DC as a staff scientist to develop new cryo-banking projects on gametes and gonadal tissues from rare and endangered species. His comparative research on gamete biology and fertility preservation has been supported by multiple grants from the National Institutes of Health. Interestingly, his studies on germplasm cryobiology and alternate preservation methods in non-traditional animal models build new bridges with human reproductive medicine.
Affiliations and expertise
Research Biologist, National Zoo and Conservation Biology Institute, Washington DC; Program Director, Pan-Smithsonian Cryo-Initiative; Senior Program Officer for Science, Office of the Under-Secretary for Science and Research at the SmithsonianGL
Gordon Lithgow
Gordon Lithgow is the Vice President for Academic Affairs at the Buck Institute and an expert in the molecular biology of aging. He is a leader in pharmacological lifespan extension in model organisms. His laboratory uses molecular genetics and biochemistry to define aging processes and collaborates extensively to apply cutting-edge technologies like proteomics and metabolomics. While initially focused on lifespan extension, his research now aims to understand the causes of age-related pathology and chronic diseases, such as Alzheimer’s. Lithgow is particularly interested in the molecular and biochemical aspects of normal aging that make it a risk factor for chronic diseases. Over the past 13 years, his lab has collaborated with Julie Andersen to explore the relationship between age-related diseases and normal aging, discovering multiple interventions that extend lifespan and suppress Alzheimer’s pathology. Lithgow has mentored numerous trainees, many of whom have secured academic positions or leadership roles in biotechnology firms.
Affiliations and expertise
Vice President for Academic Affairs, Buck Institute for Research on Aging